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59 results about "Mucoadhesion" patented technology
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Bioadhesion is the mechanism by which two biological materials are held together by interfacial forces. When relating this mechanism to the pharmaceutical sciences, mucoadhesion describes the attractive forces between a biological material and mucus or mucous membrane. Mucous membranes adhere to epithelial surfaces such as the gastrointestinal tract (GI-tract), the vagina, the lung, the eye, etc. They are generally hydrophilic as they contain many hydrogen macromolecules due to the large amount of water (approximately 95%) within its composition. However, mucin also contains glycoproteins that enable the formation of a gel-like substance. Understanding the hydrophilic bonding and adhesion mechanisms of mucus to biological material is of utmost importance in order to produce the most efficient applications. For example, in drug delivery systems, the mucus layer must be penetrated in order to effectively transport micro- or nanosized drug particles into the body.
Probiotic-polyphenol nanoparticle colon-targeted co-delivery system as well as preparation method and application thereof
PendingCN120899768AAntibacterial agentsHydroxy compound active ingredientsBiotechnologyClostridium difficile infections
The invention discloses a probiotic-polyphenol nanoparticle colon-targeted co-delivery system as well as a preparation method and application thereof, and belongs to the field of biological medicines. The FCPs and hyaluronic acid (HA) are combined through non-covalent interaction, so that the hydrogel has colon targeting property and mucosal adhesion at the same time, and delivery of probiotics is facilitated. The hydrogel (HF) based on polysaccharide has good biocompatibility, and can be used for effectively encapsulating the probiotics and the natural products. Then, the PDA-TH NPs and BA are incorporated into the polysaccharide chain network of HF, and finally the BA-HF-PDAT targeted co-delivery system is constructed. The BA (at) HF-PDAT targeted co-delivery system can protect BA from serious gastrointestinal stress, and is jointly assembled with PDT-TH NPs to realize dual slow release of thymol (Thy), so that the treatment effect of BA and Thy is improved, and the BA (at) HF-PDAT targeted co-delivery system contributes to treatment of clostridium difficile infection (CDI).
Owner:NORTHWEST A & F UNIV
Methods for treating treatment resistant depression
The present disclosure provides methods and dosing regimens for the treatment of depression (e.g., treatment resistant depression) with a mucoadhesive composition comprising N, N-dimethyltryptamine (DMT) or a pharmaceutically acceptable salt thereof.
Owner:ATAI THERAPEUTICS INC
Chimeric protein comprising an anti-influenza virus antibody moiety and a mucoadhesive peptide fragment for preventing or treating influenza infections
ActiveUS12459988B2Antibody mimetics/scaffoldsPeptide/protein ingredientsAnti-Influenza Virus AntibodyChimera Protein
The present application provides chimeric proteins comprising an antibody moiety that specifically binds to a component of an influenza virus or a variant thereof, and a positively charged mucoadhesive peptide fragment. Compositions comprising the chimeric proteins described herein are useful for preventing or treating an infection caused by an influenza virus or a variant thereof in an individual.
Owner:INVISISHIELD TECHNOLOGIES LTD
Enteric coating for targeting the duodenum
A system for targeted delivery of a medicament to the gastrointestinal tract (e.g., selectively to the duodenum) of a subject. The system includes a medicament, a mucoadhesive layer at least partially surrounding the medicament, and an enteric coating encasing the medicament and mucoadhesive layer. The enteric coating comprises a material degradable by a pH of the GI tract and a material digestible by a lipase. Also provided are method of making and using the system for targeted delivery of a medicament to the gastrointestinal tract. Also provided are a system for deploying a medicament-containing needle system using an expanding element. The system includes a medicament-containing needle system and an expanding element within a capsule. The capsule is initially coated with an enteric coating. As the enteric coating degrades the expanding element absorbs fluid that enters the capsule and expands to deploy the medicament-containing needle system from the capsule.
Owner:VERILY HEALTH INC
Muco-adhesive, controlled release formulation of levodopa and / or esters of levodopa and uses thereof
ActiveUS12491164B2Organic active ingredientsGranular deliveryImmediate releasePharmaceutical medicine
The invention provides an oral solid formulation comprising (a) a plurality of controlled release components comprising (i) a core comprising a mixture of levodopa and at least one pharmaceutically acceptable excipient, (ii) a controlled release coating surrounding the core, (iii) a muco-adhesive coating surrounding the controlled release coating and (iv) an enteric coating surrounding the muco-adhesive coating; and (b) one or more immediate release components comprising levodopa. The oral solid formulation also contains carbidopa and about 80% to 100% of the carbidopa in the oral solid formulation is present in the one or more immediate release components.
Owner:IMPAX LABORATORIES LLC
Muco-adhesive, controlled release formulation of levodopa and / or esters of levodopa and uses thereof
The invention provides an oral solid formulation comprising (a) one or more controlled release components comprising a core comprising levodopa, esters or salts thereof and wherein the one or more controlled release components; and (b) one or more immediate release components comprising levodopa, esters or salts thereof. The oral solid formulation also contains a decarboxylase inhibitor and about 80% to 100% of the decarboxylase inhibitor present in the oral solid formulation is present in the one or more immediate release components.
Owner:IMPAX LABORATORIES LLC
Inhalation formulation of amoxicillin clavulanate
PCT designated stage expiredWO2025141531A1Dispersion deliveryAerosol deliverySide effectAntibiotic resistance
This invention provides a novel nebulization suspension comprising amoxicillin and clavulanate for the effective treatment of pneumonia. The formulation is specifically designed for pulmonary delivery, offering several advantages over traditional oral antibiotics. Key features include mucoadhesive properties that enhance drug retention 5 in the lungs, sustained release characteristics for prolonged therapeutic action, and potential biofilm disruption to combat antibiotic resistance. This localized delivery approach aims to minimize systemic side effects, improve treatment efficacy, and address the growing challenge of antibiotic resistance in pneumonia.
Owner:AODH LIFESCI PTE LTD
A functionalized tamarind seed polysaccharide and a preparation process thereof
PCT designated stageWO2026033304A1Organic active ingredientsCosmetic preparationsPolymer sciencePharmacy medicine
A functionalized tamarind seed polysaccharide, and a process for its preparation. In particular, said functionalized tamarind seed polysaccharide is a TSP having a selected functionalization degree and molecular weight, showing improved mucoadhesive properties, as well as stability and compatibility with pharmaceutical ingredients. Therefore, the invention also relates to a pharmaceutical composition, as well as a biomaterial, comprising said f-TSP.
Owner:FARMIGEA SPA
Compositions comprising chlorhexidine and a depigmenting complex
PCT designated stageWO2026047527A1Cosmetic preparationsToilet preparationsActive agentPhosphorylcholine
A complex consisting of lipoic acid or a salt thereof, a chelating agent such as a salt of ethylene diamine tetraacetic acid (EDTA) or analogous compounds and an ester of ascorbic acid with long-chain fatty acids, in particular ascorbyl palmitate inhibits the pigmentation of teeth induced by chlorhexidine and salts thereof. In addition to the depigmenting complex, the formulations of the invention, in the form of gels, mouthwashes, toothpastes or periodontal sprays, may contain other ingredients such as hyaluronic acid or hyaluronates, glycerophosphocholine, sweeteners, flavourings, buffering agents, viscosifying agents, mucoadhesive and filming agents, solvents, co-solvents, surfactants.
Owner:RICERFARMA
Orodispersible solid composition in the form of film for oral administration of thyroid hormones
PCT designated stageWO2025253253A1Organic active ingredientsSheet deliveryThyroid hormonesOral medication
Solid orodispersible compositions in the form of thin films for the oral administration of thyroid hormones are described, characterized by a high stability, and by the bioavailability of the active ingredient for oral absorption. The film compositions described are designed for rapid disintegration in the mouth, for sublingual administration, or to be held in the mouth for longer times before they disintegrate, but in any case without being mucoadhesive films. All the examples described are characterized by being thin and flexible and are suitable for administration even to patients who are not conscious, dysphagic or otherwise unable to swallow.
Owner:IBSA INSTITUT BIOCHIMIQUE SA
Liposome drug carrier with mucosal adhesion and its preparation method and application
ActiveCN116617405BImprove stabilityImprove adhesionOrganic active ingredientsSenses disorderEpitheliumCyclosporins
The application discloses a liposome drug carrier with mucosal adhesion, a preparation method and application thereof, and specifically, the drug carrier is DSPE-PEG-PBA, which can be used for loading cyclosporine A and crocin I, and the carrier of the application is used for loading cyclosporine A and crocin I. The liposome loaded with the two drugs has good stability and adhesion, can inhibit the side effect of cyclosporine A on the increase of ROS level, and has a wide application prospect in the treatment of inflammation and epithelial tissue damage.
Owner:SICHUAN UNIV
Bioadhesive film and methods of use thereof
A film and a method for use thereof such as for the administration of a biologically active agent or for therapy are provided. Specifically, a film, composed of a biodegradable material having a mucoadhesive surface comprising a plurality of mushroom-type structures is provided.
Owner:AZRIELI COLLEGE OF ENG JERUSALEM +1
Amoxicillin clavulanate nasal spray
PCT designated stage expiredWO2025141532A1Aerosol deliveryPharmaceutical non-active ingredientsPatient complianceTreatment options
This invention describes a novel, stable, fixed-dose, aqueous suspension of Amoxicillin Clavulanate for nasal administration to treat post-surgical nasal infections. The formulation leverages a unique combination of excipients, including mucoadhesive agents like chitosan, to enhance drug delivery and efficacy. Key features include targeted delivery to the infection site, sustained release for reduced dosing frequency, and the ability to disrupt bacterial biofilms. This innovative approach addresses the limitations of current treatment options by providing effective local drug delivery, minimizing systemic side effects, and improving patient compliance.
Owner:AODH LIFESCI PTE LTD
Mucoadhesive microgel compositions and methods for using the same
Mucoadhesive microgel compositions, which include an active agent (such as HB-EGF), are provided. Aspects of the invention include a microgel comprising a crosslinked poly(ethylene glycol) methyl ether methacrylate polymer comprising a mucoadhesive functionality. Also provided are methods of making and using the mucoadhesive microgel compositions, e.g., in therapeutic applications. In one embodiment, HB-EGF loaded mucoadhesive microgel compositions are provided, e.g., for prevention or treatment of mucositis conditions, such as therapy induced oral mucositis conditions.
Owner:CENT NAT DE LA RECH SCI (C N R S) +1
Film delivery system with perforations
The present invention relates to a film delivery system comprising a mucoadhesive layer, wherein the mucoadhesive layer comprises a film-forming agent and is provided with perforations.
Owner:LTS LOHMANN THERAPIE SYST AG
Formulations comprising seletracetam and methods of use
Provided herein are methods of treating a seizure disorder in a subject in need thereof comprising administering seletracetam to the subject intranasally, buccally, or sublingually. Also provided are methods of treating a pain, neurological, or psychiatric disorder, and methods of administering seletracetam to a subject comprising administering seletracetam to the subject intranasally, buccally, or sublingually. Various pharmaceutical formulations comprising seletracetam, e.g., an orally disintegrating tablet and a mucoadhesive film, and a nasal spray device or oromucosal spray device comprising seletracetam are also provided.
Owner:PREVEP LLC
Compositions and methods for preventing the spread of viruses
PCT designated stageWO2026030503A3Peptide/protein ingredientsImmunoglobulins against virusesChimera ProteinViral infection
The present application relates to compositions and methods for: (a) preventing or treating viral infections; and / or (b) preventing the transmission and / or spread of infections. In some embodiments, the present application provides chimeric proteins comprising a target-binding moiety that specifically binds to a virus, and a positively charged mucoadhesive peptide fragment. Compositions comprising the chimeric proteins described herein are useful for preventing or treating viral infections, preventing the transmission of a viral infection from an infected individual to a non-infected individual, and for preventing the spread of a viral infection within a population of individuals.
Owner:INVISISHIELD TECHNOLOGIES LTD +6
Methods of treating treatment resistant depression
PCT designated stageWO2026030301A1Nervous disorderPharmaceutical delivery mechanismDosing regimenRegimen
The present disclosure provides methods and dosing regimens for the treatment of depression (e.g., treatment resistant depression) with a mucoadhesive composition comprising N, N-dimethyltryptamine (DMT) or a pharmaceutically acceptable salt thereof.
Owner:ATAI THERAPEUTICS INC
Modified carboxymethyl cellulose, their compositions and the uses thereof
Disclosed is a modified carboxylated polysaccharide, more particularly a modified carboxymethyl cellulose (CMC) functionalized with at least one mono-valent (M+) cation and at least one di-valent (M++) cation. Further disclosed herein is a mucoadhesive composition comprising the modified carboxymethyl cellulose (CMC) functionalized with at least one mono-valent (M+) cation and at least one di-valent (M++) cation. Further disclosed is application of the mucoadhesive composition in denture adhesives and toothpaste compositions.
Owner:ISP INVESTMENTS LLC
BIFUNCTIONAL PEPTIDE WITH MUCOADHESIVE AND VIRUS-BINDING PROPERTIES
Owner:FORSCHUNGSVERBUND BERLIN EV +1
Method for preparing an active layer and apparatus comprising the active layer
The present disclosure relates to methods for preparing an active layer, typically a layer comprising a mucoadhesive material and one or more pharmaceutically active compounds or nutrients, and devices comprising such active layers. The method is designed to maintain the mucoadhesive material in a non-activated form during the preparation of the active layer and to allow the mucoadhesive material to be activated once near the target site.
Owner:TULIP MEDICAL LTD
Mucoadhesive pharmaceutical compositions of corticosteroids
Described herein are mucoadhesive pharmaceutical compositions of corticosteroids, as well as methods of making such pharmaceutical compositions, and therapeutic methods using them. The compositions typically comprise a corticosteroid in a mucoadhesive system, wherein the mucoadhesive system comprises a rheology-modifying agent and a vehicle for the corticosteroid. The compositions are particularly useful for treating inflammatory conditions of the esophagus, such as eosinophilic esophagitis, or inflammatory bowel disease.
Owner:FERRING BV
Applicator for arranging mucoadhesive surface on nasal or oral mucosa of patient and disposable component for use therewith
The present invention relates to an applicator (100) for arranging a mucoadhesive surface (202), in particular a mucoadhesive film (204) loaded with an active agent (e.g., a drug), on the nasal or oral mucosa, in particular buccal mucosa of a patient, the invention also relates to a disposable component for use with an applicator for arranging a mucoadhesive surface on a nasal mucosa or oral mucosa of a patient, and to a kit, the kit includes a disposable component having a mucoadhesive surface and an applicator for disposing the mucoadhesive surface on a nasal or oral mucosa of a patient.
Owner:IQ MEDICAL CO LTD
Mucoadhesive oral tablet for symptomatic treatment of xerostomia, mouth ulcers and inflammations of the oral cavity
Disclosed are formulations in the form of mucoadhesive tablets useful for treating symptoms caused by xerostomia (dry mouth). The tablets according to the invention comprise hyaluronic acid, choline alfoscerate and ascorbyl palmitate, and are characterised by two concave surfaces that adapt to the oral and gingival mucosa so as to adhere to the oral vestibules or the palate.
Owner:RICERFARMA
A nanoparticular drug delivery system with mucoadhesion properties and the synthesis method thereof
PCT designated stageWO2026024242A1Powder deliveryPharmaceutical non-active ingredientsPropanoic acidMucoadhesion
The invention relates to a nanoparticle for use as a drug carrier and the synthesis method of this nanoparticle. In the invention, magnesium / aluminium (Mg / AI) mucoadhesive thiolated layered double hydroxide (nLDHT) nanoparticles are thiolated with L-cysteine and / or thioglycolic acid and / or 2-iminothiolane hydrochloride and / or glutathione and / or N-acetyl cysteine and / or 3-mercaptopropionic acid and / or 6- mercaptohexanoic acid. Thus, nLDHT interacts with the mucin on the surface of the targeted mucosal tissue for a longer period of time and acts with fewer side effects in the target tissues.
Owner:ISTANBUL UNIVSI CERRAHPASA REKTORLUGU +1
Hydrophobically modified biopolymers with benzenediol functionality and oxidized forms thereof
The present invention provides hydrophobically modified biopolymers comprising a hydrophobically modified chitosan comprising benzenediol groups, optionally a portion of which is oxidized to the corresponding quinones. The biopolymers exhibit a surprising ability to modulate mucosal adhesion, material cohesiveness, and material hemostatic effects to provide next generation hemostatic agents and the like. Accordingly, in other aspects, the invention provides compositions comprising the modified biopolymers of the invention and methods for the treatment of bleeding and wounds.
Owner:MEDCURA INC
Mucoadhesive composition for vaginal use
The present invention describes a composition for vaginal, preferably intravaginal, use for the prevention and treatment of vaginal conditions, with mucoadhesive, soothing, moisturizing and pH-regulating properties. By remaining adherent to the vaginal mucosa for prolonged periods, the composition according to the invention is therefore able to alleviate pain, burning and itching, often resulting from vaginal dryness, to promote the rebalancing of the vaginal bacterial flora, to restore the natural pH, to combat vaginal atrophy, vaginosis, vaginitis, to reduce local irritation of the tissues and to combat the proliferation of pathogens.
Owner:NIRIAL PHARMA SRL
A mucoadhesive film comprising a pharmaceutically active agent and uses thereof
PendingEP4518855A4Nervous disorderHydroxy compound active ingredientsPolymer sciencePharmacy medicine
A mucoadhesive composition and method for the administration of the pharmaceutically effective agents is provided. Specifically, a mucoadhesive composition, composed of a mucoadhesive polymer and a plurality of active agents having different water solubility embedded therewithin; and use thereof such as for the treatment of a disease is provided.
Owner:SHORT WAVE PHARMA INC
Mucoadhesive gel composition
A pharmaceutical mucoadhesive gel composition for delivering therapeutic agents (such as progesterone) by buccal, nasal, vaginal and rectal administration, thereby avoiding the hepatic first-pass metabolism. The gel composition comprises a vehicle with a gel-forming agent and a bioadhesive agent; and a therapeutic agent dispersed or suspended in the vehicle.
Owner:VIRAMAL LTD
Topical antiviral compositions comprising hyaluronic acid and carrageenan
Disclosed are topical compositions comprising hyaluronic acid or salts thereof and iota-carrageenan, preferably in a mucoadhesive matrix containing ascorbyl palmitate and choline alfoscerate. The compositions according to the invention are useful for topical treatment of Herpesvirus infections.
Owner:RICERFARMA