28 results about "Hormone replacement" patented technology

The application relates to application of semaglutide in preparation of a medicine for treating or delaying ovarian aging, and through a natural aging mouse model, a cell aging model and transcriptome analysis, it is first proved that semaglutide can significantly increase the number of follicles and reduce the level of aging markers, and from a molecular level, it is revealed that the mechanism of realizing multi-target point delay of ovarian aging is that semaglutide realizes multi-target point delay of ovarian aging through regulating an adipocyte cytokine signal pathway, inhibiting excessive cell division and regulating an NF-kappa B signal pathway. As a marketed drug, semaglutide has clear safety, a long half-life and high patient compliance, and has a significant clinical conversion prospect. The application breaks through the limitation that existing hormone replacement therapy and assisted reproductive technology can only treat symptoms or solve the problem of fertility, provides a first drug intervention strategy which can fundamentally delay the process of follicle depletion, and fills the blank in the field of ovarian aging treatment.

The invention discloses a comprehensive climacteric woman health management system, and belongs to the technical field of health management. A comprehensive climacteric woman health management system comprises an information acquisition module, a health prediction module, a health guidance module and an information storage module. The problems that in the prior art, only the current health state of the climacteric woman can be evaluated, and hidden health problems and trends are difficult to find are solved, the information of the climacteric woman is stored by establishing the distributed storage area, the safety of long-term storage of the information of the climacteric woman is guaranteed, the resource utilization rate is optimized, and the user experience is improved. Potential risks of osteoporosis, hypertension, coronary heart disease and other diseases can be recognized, timely intervention is performed to delay or avoid disease development, the overall health level is improved, early psychological intervention is facilitated, common mood troubles in climacteric are relieved, the estrogen decline degree can be determined, a hormone replacement therapy scheme can be made in an assisted mode, and the development period of the disease is shortened. And the living quality of climacteric women is improved.

Estrogen and progesterone replacement therapies are provided herein. Among others, the following formulations are provided herein: solubilized estradiol without progesterone; micronized progesterone without estradiol; micronized progesterone with partially solubilized progesterone; solubilized estradiol with micronized progesterone; solubilized estradiol with micronized progesterone in combination with partially solubilized progesterone; and solubilized estradiol with solubilized progesterone.

This invention belongs to the field of biomedical technology, specifically involving the application of the MRPL41 gene / protein in the preparation of drugs for treating age-related sarcopenia. This invention is the first to demonstrate that MRPL41 is a key rate-limiting factor in the assembly of mitochondrial ribosomes in aging muscle satellite cells, establishing it as a core target for the treatment of age-related sarcopenia. Overexpression of MRPL41 can promote the assembly of mitochondrial 55S holoenzymes, improve the translation efficiency of mitochondrial-encoded proteins, repair mitochondrial dysfunction at its source, thereby promoting muscle repair, improving muscle atrophy, and achieving the treatment of age-related sarcopenia. This invention provides a precise microscopic target for the treatment of age-related sarcopenia, overcoming the limitations of existing clinical therapies (such as hormone replacement and simple nutritional supplementation) due to significant side effects and "anabolism resistance," providing a new direction for the development of innovative drugs specifically for the treatment of age-related sarcopenia, and has excellent application prospects.

The invention pertains to pharmaceutical formulations, particularly sustained-release nanoparticle injections of nomegestrol acetate. These formulations are designed as lyophilized powder, enhancing the solubility, bioavailability, and therapeutic efficacy of nomegestrol acetate for medical applications. These pharmaceutical formulations are intended for diseases responsive to nomegestrol treatment, such as hormone replacement therapy. The lyophilized powder formulation is easily reconstituted and administered, improving overall patient experience and treatment outcomes

The present invention relates to a subcutaneous implant for hormone replacement therapy, comprising a shell and a core. The shell wraps around the outside of the core and is columnar as a whole. The shell comprises estrogen and a biodegradable polymer, and the core comprises an estrogen receptor inhibitor and a biodegradable polymer. When implanted into the body, the estrogen in the shell starts to continuously and stably release a fixed amount of drug daily. As the drug in the shell dissolves and diffuses and the material degrades, the active drug in the core gradually and slowly releases after a certain period of drug administration, realizing sequential combined administration of two active substances in a single implant.

The present invention relates to a subcutaneous implant for hormone replacement therapy, which comprises a shell and a core. The shell wraps around the outside of the core and has an overall columnar structure. The shell comprises an androgen and a biodegradable polymer, and the core comprises an enzyme inhibitor and a biodegradable polymer. The enzyme inhibitor comprises a 5-α reductase inhibitor and an aromatase inhibitor. When implanted into the body, the androgen in the shell continuously releases a fixed amount of drug stably every day. As the drug in the shell dissolves and diffuses and the material degrades, the active drug in the core gradually releases slowly after a certain period of drug administration, realizing sequential combined administration of two active substances in a single implant.

The present disclosure comprises a combination solid oral dosage form comprising 40 mg of N-(4-(1-(2,6-difluorobenzyl)-5-((dimethylamino)methyl)-3-(6-methoxy-3-pyridazinyl)-2,4-dioxo-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidin-6-yl)phenyl)-N'-methoxyurea or a corresponding amount of a pharmaceutically acceptable salt thereof, and a hormone replacement agent. Also provided are methods for preparing and using the solid oral dosage form.

The present invention relates to therapeutic and non-therapeutic use of combinations of bacterial strains. In particular the use is for preventing or alleviating symptoms of menopause or climacteric symptom in a female mammal. Also disclosed herein are specific combinations of bacterial strains and their use in, as well as methods for reducing the need for estrogen replacement therapy, or for use in combination with estrogen replacement therapy, or other menopausal hormone replacement therapies.

The invention relates to the technical field of biology, in particular to application of a composition in preparation of drugs for preventing inflammatory aging and related diseases thereof. The composition provided by the invention is used for preventing atopic dermatitis (AD) recurrence, senile dermatitis and other BCAA metabolic disorder related skin diseases by selectively enhancing BCAT1 mediated branched chain amino acid (BCAA) degradation and reversing skin inflammatory aging. Clinical data show that after the composition provided by the invention is used for treatment, the recurrence rate of AD is reduced to 16.3% from 35.7%. The invention provides a non-hormone replacement therapy, which makes up the defects of the existing medicines, and the composition can be combined with the existing therapy during treatment, has high safety and no serious adverse reaction, and is suitable for long-term maintenance treatment.

The application relates to a traditional Chinese medicine composition for nourishing kidney and relieving depression as well as a preparation method and application thereof. The application relates to a traditional Chinese medicine composition and a preparation method and application thereof. In order to solve the problems that long-term hormone replacement therapy not only has more adverse reactions, but also has potential risks of causing endometrial lesions, thrombosis and tumors, the traditional Chinese medicine composition comprises radix codonopsis, radix ophiopogonis, taxilli herba, radix dioscoreae, ligustri fructus, anemarrhena asphodeloides, herba ecliptae, radix paeoniae alba, radix bupleuri, pericarpium citri reticulatae, fritillaria, poria cocos, semen ziziphi spinosae and schisandra chinensis. The traditional Chinese medicine composition is applied to preparation of a medicine for preventing and / or treating perimenopausal syndrome and premature ovarian failure. The application belongs to the technical field of medicines.

This document offers estrogen and progesterone replacement therapies. These include, among others, the following formulations: solubilized estradiol without progesterone; micronized progesterone without estradiol; micronized progesterone with partially solubilized progesterone; solubilized estradiol with micronized progesterone; solubilized estradiol with micronized progesterone in combination with partially solubilized progesterone; and solubilized estradiol with solubilized progesterone.

A method of providing a culture of oogonia stem cells comprising oogonia stem cells is provided. The method may further include culturing the oogonia stem cells with granulosa and theca cells to differentiate the oogonia stem cells into oocytes. In some embodiments, the culturing comprises including the oogonia stem cells in an in vitro follicle construct or a microcapsule comprising said granulosa and theca cells. Further described herein is a method of forming a bioengineered follicle construct capable of releasing a mature oocyte. An in vitro fertilization method using the mature oocyte is also provided.

The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition for treating climacteric-like symptoms as well as a preparation method and application of the traditional Chinese medicine composition. The traditional Chinese medicine composition comprises the following raw materials: prepared rehmannia root, Chinese yam, wine-processed fructus corni, fried spina date seed, moutan bark, gardenia, white paeony root, rhizoma alismatis, angelica sinensis, poria cocos, blighted wheat, radix bupleuri and honey-fried licorice root, and the traditional Chinese medicine composition has the effects of nourishing yin, tonifying kidney, clearing heat and soothing liver, can effectively treat climacteric-like symptoms, and almost has no influence on sex hormone level, so that the traditional Chinese medicine composition has no toxic or side effect. Compared with hormone replacement treatment medicines, the medicine is safer. Especially for tumor patients with climacteric-like symptoms after receiving ovarian function inhibition treatment, the traditional Chinese medicine composition can improve the symptoms and avoid tumor recurrence caused by estrogen fluctuation at the same time.

The invention discloses a preparation method and application of a medicine for preventing and treating premature ovarian failure, the medicine comprises the following components in parts by weight: 3-10 parts of eucommia ulmoides, 2-8 parts of salvia miltiorrhiza and 1-6 parts of ligusticum wallichii. The premature ovarian failure (POF) is also called ovarian insufficiency, refers to ovarian function decline, follicle-stimulating hormone level increase and estrogen level decrease of women before 40 years old, and shows secondary amenorrhea and infertility, and is often accompanied with menopausal symptoms such as sweating, insomnia, hypomnesis and the like in a night sleep process; at present, hormone replacement treatment is a main treatment method for premature ovarian failure, but the side effect is large after hormone is taken for a long time, and the probability of suffering from breast cancer and endometrial cancer can be increased; the medicine composition disclosed by the invention can be further developed into a molecular traditional Chinese medicine for preventing POF and delaying the POF process, so that the comprehensive utilization of the composition is promoted, and a new choice is provided for patients with POF.

The present invention relates to a hormone replacement therapy, to the associated compounds and to the associated packaging units, for alleviating menopause-associated symptoms which is based on the administration to a female mammal of an estetrol component at specified daily doses, optionally in combination with a progestogenic component.The therapy enjoys a statistically significant efficacy combined with a favourable profile for side effects compared to currently available methods for alleviating menopause-associated symptoms.

The invention belongs to the technical field of medicines, and relates to a new application of a wolfberry-phellodendron hypoglycemic capsule medicine, in particular to an application of a wolfberry-phellodendron hypoglycemic capsule in preparation of a medicine for treating or preventing climacteric syndrome. According to the invention, it is found for the first time that the wolfberry-huang hypoglycemic capsule can significantly improve various typical symptoms of the climacteric syndrome and regulate the in-vivo estrogen level; the traditional Chinese medicine composition is free of obvious toxic and side effects after being used for a long time, high in safety and free of drug dependence, and compared with hormone replacement treatment drugs, the risks of inducing tumors, thrombus and the like are avoided, and the patient tolerance is better; the wolfberry-huang hypoglycemic capsule used in the invention is an existing mature preparation, the preparation process is stable, the quality is controllable, a new preparation technology does not need to be developed, industrial conversion is easy to realize, and the clinical popularization value is good.

The present invention relates to a hormone replacement therapy, to the associated compounds and to the associated packaging units, for alleviating menopause-associated symptoms which is based on the administration to a female mammal of an estetrol component at specified daily doses, optionally in combination with a progestogenic component.The therapy enjoys a statistically significant efficacy combined with a favourable profile for side effects compared to currently available methods for alleviating menopause-associated symptoms.

1. A drug delivery device for use in treating one or more menopausal symptoms in a subject, comprising intravaginal insertion of an indwelling drug delivery device into the subject, wherein the drug delivery device comprises an estrogen and a progestin, and further provides a baseline-adjusted steady-state plasma estrogen concentration in the subject of about 15 pg / mL to about 50 pg / mL.

The invention discloses a biological preparation for treating ovarian function decline, and belongs to the technical field of biomedicine. The active component of the biological agent is adipose-derived stem cells obtained by pretreatment of a pretreatment culture medium containing calycosin and morroniside. Through the synergistic effect of calycosin and morroniside, the proliferation activity and migration homing ability of stem cells are remarkably enhanced. Experiments show that the preparation can effectively regulate E2, AMH and FSH levels in POI mice, the repair effect is obviously better than that of traditional hormone replacement therapy and unpretreated stem cells, and an efficient and safe novel biological medicine scheme is provided for clinical treatment of ovarian function decline.

A drug delivery device for treating one or more symptoms of menopausal in a subject comprising intravaginal insertion of an implantable drug delivery device into the subject wherein the implantable drug delivery device comprises an estrogen and a progesterone, and further wherein the implantable drug delivery device provides a baseline adjusted homeostatic plasma estrogen concentration of from about 15 pg / mL to about 50 pg / mL in the subject.

The present invention relates to the use of compositions comprising estradiol and progesterone. The compositions are for use in preventing a major adverse cardiovascular event (MACE) in a woman, or decreasing the risk of MACE associated with combined hormone replacement therapy (HRT). The compositions may be used in combined HRT and / or methods of treating menopause related symptoms.

The present disclosure includes combination solid oral dosage forms having 40 mg of N-(4-(1-(2,6-difluorobenzyl)-5-((dimethylamino)methyl)-3-(6-methoxy-3-pyridazinyl)-2,4-dioxo-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidin-6-yl)phenyl)-N′-methoxyurea, or a corresponding amount of a pharmaceutically acceptable salt thereof, and hormone replacement medicaments. Also provided are processes for making and using the solid oral dosage forms.

Featured are compositions, methods, and apparatuses for biosynthetic organs, or organoids, that replicate tissues of the human female reproductive system (e.g., ovarian or uterine tissues). In particular, the disclosure features methods of culturing or 2024 / 054644 producing organoids or uteroids from pluripotent stem or progenitor cells and using the resulting organoids or uteroids to screen for safe and effective pharmaceutical interventions for diseases of interest. Such methods and compositions are particularly useful for the treatment of patients undergoing hormone replacement therapy (HRT) and / or assisted reproduction technology (ART) procedures, such as in vitro fertilization and in vitro oocyte maturation.WO

Stable pharmaceutical compositions are provided, comprising a pharmaceutically effective amount of testosterone or a pharmaceutically acceptable ester thereof, a pharmaceutically acceptable oil vehicle, and a stabilizing amount of benzyl alcohol, for example, about 1% to 3% weight / volume of benzyl alcohol. The present invention also provides a process for stabilizing testosterone-containing pharmaceutical compositions by ageing them at a temperature of about 20° C. to about 60° C. for at least 48 hours, e.g., prior to secondary packing and labeling. These compositions were stable over the shelf life of the product, without exhibiting crystal formation, even upon storing at temperatures of about 2° C. to about 8° C. Other aspects of the invention relate to methods for making such pharmaceutical compositions and methods of using such pharmaceutical compositions for hormone replacement therapy, e.g., in a male patient having a condition associated with symptoms of deficiency or absence of endogenous testosterone.

The present invention relates to a hormone replacement therapy, to the associated compounds and to the associated packaging units, for alleviating menopause-associated symptoms which is based on the administration to a female mammal of an estetrol component at specified daily doses, optionally in combination with a progestogenic component.The therapy enjoys a statistically significant efficacy combined with a favourable profile for side effects compared to currently available methods for alleviating menopause-associated symptoms.

A method of providing a culture of oogonia stem cells comprising oogonia stem cells is provided. The method may further include culturing the oogonia stem cells with granulosa and theca cells to differentiate the oogonia stem cells into oocytes. In some embodiments, the culturing comprises including the oogonia stem cells in an in vitro follicle construct or a microcapsule comprising said granulosa and theca cells. Further described herein is a method of forming a bioengineered follicle construct capable of releasing a mature oocyte. An in vitro fertilization method using the mature oocyte is also provided.

A green light osteoporosis treatment device is provided. The device comprises a light irradiation chamber (1) (dimensions: 105 cm x 80 cm), multiple green LED light sources (with an emission wavelength of 520-525 nm) arranged within the chamber, and a light source control module (characterized by the module being able to adjust the illuminance of the LED light source to 400 lx). The green light with a wavelength of 520-525 nm and an illuminance of 400 lx is scientifically compatible with the GnIH hormone control mechanism, effectively suppressing osteoclast activity and preventing bone loss from the upstream stage. Compared to conventional drug therapy or electromagnetic therapy, this therapy has no chemical side effects and avoids the potential risks associated with hormone replacement therapy (HRT).