Kitasamycin microcapsule preparation and preparation and application thereof

A kitasarmycin preparation technology, applied in the field of preparation of antibacterial and growth-promoting agents for livestock and poultry, can solve the problems of poor antibacterial and growth-promoting effects, need to contact organic solvents, long coating process time, etc., to achieve the advantages of mixing, Good fluidity, avoiding hepatic first-pass effect

Inactive Publication Date: 2008-08-06
GUANGDONG HINAPHARM PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to small particles and long coating process time, it is not easy to industrialize
At the same time, it is released rapidly in the intestinal tract, and the drug concentration in the middle and back end of the intestinal tract at the effective site of antibacterial and growth promotion is low, and the effect of antibacterial and growth promotion is poor
[0007] In addition, the above three forms of dosage forms still have defects such as large amount of dust, need to contact organic solvents, large material consumption, high cost and large environmental pollution during the production process.

Method used

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  • Kitasamycin microcapsule preparation and preparation and application thereof
  • Kitasamycin microcapsule preparation and preparation and application thereof
  • Kitasamycin microcapsule preparation and preparation and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Referring to accompanying drawing 1, select auxiliary material 1 stearic acid 225kg to drop into material tank 3, be heated to 55-120 ℃, keep stirring, until auxiliary material 1 is all melted; Melted stearic acid is pumped into batching tank 4 from chemical material tank, Simultaneously, 100 kg of kitasamycin (kitasamycin raw material 2) of titer 1636 μ / mg that has been accurately weighed is dropped into batching tank 4, high-speed emulsification shearing and stirring for 5 minutes, temperature will be controlled at 80 ℃-100 during the meantime; The good material is introduced into the storage tank 5, and heated to 55-120°C; the material delivery spray device 6 is started, and the material in the storage tank 5 is sprayed and granulated, and the material delivery speed is controlled at 0.5-0.8m 3 / min, atomizing disk rotation speed 4000~6000n / min, when the ambient temperature is above 30°C, control the inlet air temperature ring at 10~12°C, when the ambient temperature ...

Embodiment 2

[0034] Select auxiliary material 1 stearic acid 368kg into chemical material tank 3, heat to 80-100°C, stir continuously, until the auxiliary material is completely melted; pump the melted stearic acid from chemical material tank into compounding tank 4, and accurately weigh 25kg of kitasamycin (raw material 2) of kitasamycin with a titer of 1582μ / mg is put into the batching tank 4, high-speed emulsification, shearing and stirring for 60 minutes, during which the temperature will be controlled at 80°C-100°C; Material tank 5, and heat the temperature to 80°C-100°C; start the conveying spray device 6, spray and granulate the material in the material storage tank 5, and control the material conveying speed to 0.5-0.8m 3 / min, atomizing disk rotation speed 4000~6000n / min, when the ambient temperature is above 30°C, control the inlet air temperature ring at 10~12°C, when the ambient temperature is 20~29°C, control the inlet air temperature at 15~22°C, and when the ambient temperatur...

example 3

[0037] 400kg of auxiliary material 1 stearic acid is selected and put into chemical tank 3, heated to 80°C, and stirred continuously, until the auxiliary material is completely melted; Put 50kg of kitamycin (raw material 2) of kitamaycin with a price of 1617μ / mg into batching tank 4, high-speed emulsification, shearing and stirring for 12 minutes, during which the temperature should be controlled at 80°C-100°C; the prepared materials are imported into the storage tank 5, and heat the temperature to 80°C-100°C; start the conveying spray device 6, and spray and granulate the material in the storage tank 5, wherein the material conveying speed is controlled at 0.5-0.8m 3 / min, atomizing disk rotation speed 4000~6000n / min, when the ambient temperature is above 30°C, control the inlet air temperature ring at 10~12°C, when the ambient temperature is 20~29°C, control the inlet air temperature at 15~22°C, and when the ambient temperature is below 19°C Control the inlet air temperature ...

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Abstract

The invention provides kitasamycin microcapsule and a preparation method and application thereof, which pertains to a feed drug additive field, in particular relates to novel kitasamycin preparation and a preparation technique thereof, and the application thereof in the preparation of livestock and poultry antibiotic growth promoter. The kitasamycin microcapsule of the invention comprises the kitasamycin and medical auxiliary materials; the weight of the medical auxiliary materials is 2-16 times of that of the kitasamycin material; the microcapsule is prepared through mixing the kitasamycin with heated and melted medical auxiliary materials and spray cooling. The kitasamycin microcapsule eliminates the bitterness of kitasamycin, intensifies the delayed release function of kitasamycin, reduces the stimulation of the kitasamycin to the stomach and the damage and decomposition degree thereof in the stomach, and enhances the effective intestines concentration and the functioning time of kitasamycin; the method for preparing the kitasamycin microcapsule is a wholly close manufacturing process and a wholly close material conveying system, thus decreasing flying of dust and material loss with has high yield of the products.

Description

technical field [0001] The invention belongs to the field of feed pharmaceutical additives, and in particular relates to a novel preparation of kitasamycin, a preparation method thereof, and an application thereof in preparing an antibacterial and growth-promoting agent for livestock and poultry. Background technique [0002] Kitamycin, an antibacterial growth-promoting agent against Gram-positive bacteria, has a very bitter taste and is unstable in acid. It is an antibiotic approved by the Ministry of Agriculture that can be added to feed for a long time, and has been widely used as a veterinary antibiotic feed additive. In feed enterprises, kitasamycin is used as a good antibacterial and growth-promoting drug additive to prevent and treat digestive tract and respiratory tract diseases of livestock and poultry such as chickens and pigs. Because harmful bacteria mostly parasitize in the middle and back of the small intestine or the large intestine, an excellent antibacteria...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/50A61K31/7048A61P31/00A23K1/17A23K20/195
CPCA61K9/1617A61K9/1694A61K31/7048A61P31/00A61P31/04
Inventor 周玉岩
Owner GUANGDONG HINAPHARM PHARMA CO LTD
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