The present invention provides a metal-ICG complex, a preparation method of the complex, metal-ICG complex albumin nanoparticles and a preparation method and application of the nanoparticles, and relates to the technical field of nano-drugs. Metal ions of the metal-ICG complex are selected from at least one of gold, platinum, zinc, copper, cobalt, iron, nickel and manganese. The technical problemsof few types, short maximum illumination wavelength and narrow therapeutic window of an existing acoustic sensitive agent are improved; and the metal ions and ICG in the metal-ICG complex provided bythe invention are complexed by coordination bonds, so that the type of acoustic sensitive agents is expanded, the illumination wavelength of the acoustic sensitive agents is increased, the therapeutic window is extended, and the metal-ICG complex has double functions of photosensitivity and acoustic sensitivity and can effectively promote the development of photothermal and sonodynamic therapy.