35results about How to "Improve medication safety" patented technology

The present application relates to the technical field of medical apparatus, particularly relates to wearable and vibration control nail base nanocrystal microneedle transdermal drug delivery device, including shell, both sides of the shell are provided with a group of positioning notches respectively, a group of positioning notches are provided with a threaded hole respectively, the inside four corners of the shell are provided with a group of support seats respectively, still include controller assembly, nanocrystal microneedle assembly, vibration assembly, power supply assembly and fixed ring assembly, the controller assembly is detachably installed in the shell, the shell is provided with vibration assembly and battery assembly respectively, the bottom end of the shell is detachably provided with nanocrystal microneedle assembly, the both ends of the fixed ring assembly are detachably connected with a group of positioning notches respectively, the nanocrystal microneedle assembly is used for lightly pricking nail base epidermis and nail plate edge to form microchannel, the power supply assembly provides power for vibration assembly and controller assembly;It makes drug directly contact focus.

This invention relates to the application of a dual-active-component drug in the preparation of a drug for treating double-hit lymphoma. The active ingredients in the dual-active-component drug consist of a first active component and a second active component. The first active component is selected from homoharringtonine or a pharmaceutically acceptable salt thereof; the second active component is selected from veneclade or a pharmaceutically acceptable salt thereof. This invention demonstrates that homoharringtonine combined with veneclade can significantly inhibit the proliferation of DHL cell lines and induce apoptosis in DHL cell lines. Using a CDX mouse model, it was demonstrated that homoharringtonine combined with veneclade can inhibit the tumorigenesis process of mouse DHL. The combined use of the two active components not only reduces the dosage of each drug and improves drug safety, but also has a more significant effect on improving or treating double-hit lymphoma (DHL) than a single active component, exhibiting a synergistic effect.

The application provides a gradient temperature difference processing method for preventing and controlling rancidity and deterioration of rice bran decoction pieces, comprising the following steps: sequentially subjecting newly harvested rice bran to low-temperature rapid cooling, medium-temperature roasting, high-temperature roasting and second ultra-low-temperature rapid cooling after removing impurities by primary screening, so as to prevent and control rancidity and deterioration of rice bran decoction pieces. The application utilizes rapid and strong temperature difference change to prevent and control the reaction after grinding contact oxidation, destroys the autoxidation system of rice bran, effectively prevents and controls the generation of oxidized toxic substances and the breeding and pollution of harmful microorganisms, and ensures the safety and effectiveness of medication.

This application discloses a traditional Chinese medicine preparation for intestinal repair and antiviral immunity in pigeons, its preparation method and application, belonging to the field of traditional Chinese veterinary medicine technology. This traditional Chinese medicine preparation for intestinal repair and antiviral immunity in pigeons comprises the following components by weight: 5-10 parts Sophora flavescens, 6-12 parts Andrographis paniculata, 3-8 parts Sanguisorba officinalis (charred), 2-4 parts Lonicera japonica, 2-4 parts Forsythia suspensa, 1-4 parts Coptis chinensis, 3-6 parts Codonopsis pilosula, 5-10 parts Astragalus membranaceus, 2-6 parts Ligusticum chuanxiong, 1-6 parts Ganoderma lucidum, 3-8 parts Ganoderma lucidum, 5-10 parts Isatis indigotica, 3-6 parts Scrophularia ningpoensis, 2-6 parts Buffalo horn, 2-6 parts Dryopteris crassirhizoma (charred), 2-6 parts Sanguisorba officinalis, 5-15 parts Three Needles (charred), 2-10 parts Scutellaria baicalensis, 6-12 parts Lonicera japonica, 6-12 parts Pteris multifida, 4-10 parts Artemisia annua, 4-10 parts Atractylodes lancea, 4-14 parts Gypsum fibrosum, 6-12 parts Glycyrrhiza uralensis (tip), 2-5 parts Prunus armeniaca, 2-8 parts Epimedium brevicornu, and 2-5 parts Rhodiola rosea. By limiting the composition and ratio of the ingredients, the various medicinal materials complement each other in terms of their cold and heat properties and work together to break through the limitations of conventional Chinese medicine's single heat-clearing function. It can simultaneously improve viral infections, watery enteritis, and emaciation, and is suitable for use in the feed of meat pigeons and racing pigeons at all stages.

This invention discloses a compound preparation for treating vascular dementia and its preparation method. The active pharmaceutical ingredient consists of protopanaxadiol and gallic acid in a 1:1 mass ratio, and the dosage form is liposomes. The preparation method includes extraction, mixing, liposome preparation, and optional freeze-drying steps: protopanaxadiol and gallic acid are extracted and purified from ginseng rhizome and Terminalia chebula fruit, respectively. After mixing, they are combined with phospholipids and cholesterol to prepare a lipid membrane. The membrane is then homogenized by hydration, low-temperature ultrasound, and high-pressure microfluidic jet to obtain a homogeneous liposome suspension, which can be further freeze-dried into a freeze-dried powder. The 1:1 composition of protopanaxadiol and gallic acid targets multiple points on the pathological mechanism of vascular dementia, showing significant therapeutic effects and broad application prospects. This preparation uses a liposome dosage form to improve the bioavailability of the active ingredient, the preparation process parameters are controllable, the active ingredient has high purity, the liposomes have uniform particle size, high encapsulation efficiency, and good stability.

The utility model discloses a pair of glass ampoule cutting pliers which comprises a first pliers handle and a second pliers handle, a connecting mechanism is arranged in the middle of the outer surface of the first pliers handle and the middle of the outer surface of the second pliers handle, and one end of each of the first pliers handle and the second pliers handle is fixedly connected with a pliers mouth. According to the glass ampoule cutting pliers, through the arrangement of the clamping groove and the scribing piece, the clamping groove ensures that the bottleneck of the glass ampoule is firmly fixed in the pliers mouth during cutting, the bottleneck is prevented from sliding or shifting in the cutting process, the accuracy of the cutting position is guaranteed, and the scribing piece is located in the middle of the clamping groove and just corresponds to the cutting point of the bottleneck of the glass ampoule; according to the utility model, non-uniform cutting traces caused by unfixed scribing positions are avoided, the cutting process is more stable, the generation and splashing of glass fragments are reduced, the risk that medical personnel are scratched by the glass fragments is reduced, the possibility of liquid medicine leakage or pollution caused by improper cutting is avoided, and the working efficiency is improved. And the working efficiency of nursing personnel and the medication safety of patients are improved.

The utility model discloses a kind of quantitative bottles, including upper cover, inner bottle, outer bottle, bottom cover.The utility model fastens with buckle to bottle cap and outer bottle, connect through protruding point and limit card slot to inner bottle, outer bottle, and 180 ° rotation opening and closing of bottle is realized by bottle cap partition pushing inner bottle partition, pass through rotation to make medicine hole and inner bottle quantitative storehouse present through and dislocation, repeatedly push product in medicine storage and fall into quantitative storehouse by inner bottle partition, and product can be smoothly poured out by turning on inner bottle partition.The structure has the advantages such as quantitative medicine, easy to carry and reusable.

This application discloses the use of itaconic acid derivatives in the preparation of drugs for treating candidemia, belonging to the field of biomedical technology. The itaconic acid derivatives proposed in this application are dimethyl itaconic acid and / or 4-octyl itaconic acid. Dimethyl itaconic acid exhibits a dose-dependent therapeutic effect in model mice, with an optimal dose of 1200 mg / kg improving survival rate and reducing kidney damage; 4-octyl itaconic acid can enhance the anti-Candida albicans ability of macrophages and regulate the expression of inflammatory factors. The application of the itaconic acid derivatives proposed in this application in the treatment of candidemia works through immunomodulation, circumventing fungal resistance. Furthermore, the drugs are low in toxicity, have good biocompatibility, and use a universal experimental system, providing a new approach for the clinical treatment of candidemia with broad application prospects. This application also protects pharmaceutical compositions for treating candidemia with dimethyl itaconic acid and / or 4-octyl itaconic acid as active ingredients.

The invention relates to the field of drug utilization value analysis, and particularly discloses a data stream-based drug utilization value analysis system, which comprises a data layer, an application layer and a user layer, according to the method, the multi-source drug data stream is constructed and stored in the multi-source drug database, and based on systematic management of drug information, drug use errors caused by drug name confusion, dosage errors and dosage form confusion can be reduced, the drug use safety is improved, and the method is beneficial to quickly and accurately retrieving and querying specific types of drug information; by integrating the elderly physiological features and the drug feature information, the drug utilization value analysis model is constructed, the elderly physiological features and the drug features are comprehensively considered, the utilization value of the drug on the elderly can be comprehensively evaluated, and the influence of the drug on the elderly patient can be predicted more accurately.

The utility model discloses a driving mechanism which is arranged in a second space formed by a shell and a lower sleeve body and comprises a rotary body, a pipe frame, a push rod, a spring and an actuating piece. The rotary body is rotationally arranged on the inner side of the shell, and the rotary body partially extends into the lower sleeve body and is connected with the lower sleeve body; the pipe frame is arranged on the inner side of the rotary body, rotates along with the rotary body all the time and can only move up and down in the axial direction of the rotary body. The push rod extends to the position above the shell from the pipe frame and is used for applying thrust to a target object; the spring is arranged below the pipe frame; the actuating piece is arranged above the rotary body and can reciprocate in the shell in the radial direction; the driving mechanism is convenient to operate, more stable pushing force can be provided by using a spring instead of a lifting handle, the atomization effect of the device is remarkably improved, the consistency of each spraying of the device is good by using a disposable medicine bottle to be matched with stable pushing force output, and daily precise medicine taking of a patient is facilitated.

The invention provides an adverse drug reaction monitoring management analysis method, which comprises the following steps: collecting drug use information and health data of a patient through a smart phone application program and wearable equipment, and periodically uploading the health data and the drug use information to a cloud database for storage; processing the health data and the medication information by adopting a data cleaning and standardization step, and eliminating abnormal values and missing values; identifying the occurrence probability of adverse drug reactions through analyzing the processed data; a threshold value of the adverse reaction occurrence rate is set, and when the adverse reaction occurrence rate of a certain medicine exceeds the threshold value, an alarm is generated in real time, and an analysis result is fed back to a patient and medical staff. Through the combination of the smart phone application program and the wearable device, real-time monitoring and automatic feedback of the adverse drug reaction are realized, the adverse drug reaction can be accurately identified, an alarm is timely generated, a visual report is provided, and the medication safety of a patient and the decision-making efficiency of medical personnel are improved.

This invention belongs to the field of traditional Chinese medicine external preparation technology, specifically providing a traditional Chinese medicine ointment for treating chronic osteomyelitis, bone tuberculosis, and persistent sinus tracts, as well as its preparation method. The traditional Chinese medicine ointment provided by this invention comprises 3-10 parts of *Achyranthes bidentata*, 5-15 parts of dried ginger, 0.3-1 part of red mercury sulfate, 20-50 parts of calcined gypsum, 4-12 parts of gecko, 5-15 parts of buffalo hide, and 40-100 parts of medicinal ointment base. This invention selects *Achyranthes bidentata*, red mercury sulfate, calcined gypsum, gecko, dried ginger, and buffalo hide as the main ingredients, achieving a combination of warming and cooling properties, and a tonifying and purging effect. It can effectively clear deep pus, necrotic tissue, and dead bone, while also warming and unblocking meridians, improving local blood circulation, promoting wound healing, and reducing the irritation of the medication.

This invention relates to the field of medical assistive devices, specifically to an intelligent interactive care medicine box for elderly care and rehabilitation. The box includes a housing with a detachable top cover; a rotating medicine cylinder rotatably fitted to the upper part of the housing, with several medicine storage compartments arranged circumferentially within the rotating medicine cylinder; a counting compartment fixedly connected to the inner wall of the housing, with an opening at the bottom of each medicine storage compartment communicating with the counting compartment; a counting disc rotatably fitted to the inner wall of the counting compartment; and several counting grooves of different contours arranged circumferentially on the counting disc, each groove being used to accommodate different specifications of medication. A carrying compartment is detachably connected to the bottom of the housing, with the bottom of the counting compartment communicating with the carrying compartment. A linkage mechanism is also provided within the housing to drive the rotating medicine cylinder and the counting disc to rotate synchronously, thereby conveying medications of different specifications adapted to the counting grooves to the carrying compartment. This invention enables the dispensing of different medications, reducing the difficulty of operation for the elderly.

The invention relates to the technical field of sterilization, in particular to sterilization equipment for landiolol hydrochloride injection production and a sterilization method.The sterilization equipment comprises a box body, a bearing mechanism is arranged at the lower end of an inner cavity of the box body, a rotating mechanism is arranged at the top of the bearing mechanism, and the bearing mechanism comprises a rotating table of a hollow structure; a plurality of air supply pipes are arranged above the rotating table in a communicating mode, the outer sides of the air supply pipes are sleeved with injection medicine bottles with downward bottle openings, neutral gas is filled into the inverted injection medicine bottles through a connecting structure between the rotating mechanism and the bearing mechanism, and plasma airflow is generated through plasma excitation electrodes in the injection medicine bottles; the plasma flows along the inner wall of the injection medicine bottle from top to bottom in the injection medicine bottle, the flowing path of the plasma directly acts on the injection medicine bottle area, direct sinking caused by density is avoided, sterilization dead angles are reduced, meanwhile, sterilization gas flows from a bottle opening of the injection medicine bottle, and efficient sterilization operation is emphasized on the complex structure of the bottle opening.

The invention provides a family safe medication management method, system and device and a medium, and relates to the technical field of medical health management, and the method comprises the steps: generating a first medication reminding scheme of a user according to a medication file of the user; generating a second medication reminding scheme according to the biological characteristic data of the user sent by the intelligent equipment; identifying drug combinations with interaction conflicts in the first drug use reminding scheme and the second drug use reminding scheme; according to a preset drug safety rule, adjusting drug use parameters of drug combinations with interaction conflicts, and generating a third drug use reminding scheme; and obtaining medicine basic information in the AI medicine box, adjusting the third medicine taking reminding scheme according to the medicine basic information, generating a target medicine taking reminding scheme of the user, and reminding the user to take medicine according to the target medicine taking reminding scheme. The technical effect of the invention is that the deviation between the medication reminding scheme and the actual medication demand of the user is reduced.

The invention provides a kidney-tonifying and capsule-eliminating preparation as well as a preparation method and application thereof, and relates to the technical field of medicines, and the kidney-tonifying and capsule-eliminating preparation is prepared from the following raw materials: semen cuscutae, radix rehmanniae preparata, raw radix astragali, leech, semen litchi and roasted rhizoma atractylodis macrocephalae. According to the invention, the leech and the lychee seed are compatible, and the leech is used as a monarch drug, has the functions of breaking blood and removing blood stasis, and directly attacks local blood stasis of an ovary; the lychee seeds are used as ministerial drugs, have the effects of promoting qi circulation and removing stasis, soothing liver-meridian stasis and eliminating phlegm-dampness condensation, supplement each other, treat qi and blood at the same time, and jointly achieve the effect of dredging Chong and Ren channels and uterus; if only the leeches break blood, blood stasis is dispersed but qi stagnation and phlegm coagulation are not removed, and pathological products are easy to regenerate; if only the lychee seeds are used for promoting qi circulation, the qi is circulated, deep blood stasis is difficult to eliminate, and symptoms do not move at all, and only monarch and ministerial materials are matched, so that the pathological barrier can be effectively broken, the polycystic ovarian syndrome can be treated, and normal ovulation and menstrual cycle of ovaries can be recovered.

This invention relates to the field of traditional Chinese medicine (TCM) composition technology. It discloses a TCM formula for treating gout using a warming and dampness-eliminating approach. The TCM composition is made from the following raw materials: kudzu root, yam, cinnamon twig, dioscorea hypoglauca, corydalis rhizome, poria cocos, atractylodes macrocephala, cistanche deserticola, morinda officinalis, and licorice root. Cistanche deserticola and morinda officinalis are the principal herbs to warm and tonify kidney yang, while poria cocos and atractylodes macrocephala are the assistant herbs to strengthen the spleen and eliminate dampness. This warming and dampness-eliminating TCM formula for gout breaks through the limitations of traditional heat-clearing and dampness-eliminating methods, focusing on the pathogenesis of spleen and kidney yang deficiency and internal dampness, treating both the root cause and symptoms, and significantly reducing the recurrence of gout attacks. The entire formula is warming without being drying, does not harm spleen and kidney yang, has high safety, and is suitable for long-term use. The formula is carefully formulated, quickly relieving pain and lowering uric acid, while improving yang deficiency symptoms, with side effects far lower than Western medicine. It has various dosage forms, simple processing, and is easy to produce and promote, providing a safe and effective new solution for gout treatment.

This invention discloses a pharmaceutical composition for alleviating sotorasidib-induced intestinal injury and its uses, belonging to the field of pharmaceutical technology. This invention proposes an intervention strategy to prevent and / or alleviate sotorasidib-induced intestinal injury by activating the cAMP signaling pathway. The cAMP signaling pathway activator can restore PKA activity and / or CREB phosphorylation levels, reduce sotorasidib-induced intestinal epithelial cell apoptosis, improve cell proliferation, and alleviate intestinal barrier damage. This invention also provides a combination of the cAMP signaling pathway activator and sotorasidib for the preparation of antitumor drugs. Cell model verification showed that the combined strategy did not significantly weaken the antitumor effect of sotorasidib, suggesting that this combined strategy has the potential for application as an adjuvant protective measure.

The application belongs to the technical field of medicine detection, and particularly relates to a detection method of impurities in 2-(3-formyl-4-hydroxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester. The method uses high performance liquid chromatography to detect related substances in 2-(3-formyl-4-hydroxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester, and the content of each impurity is calculated by a principal component self-control method with a correction factor. Methodology verification shows that the detection method provided by the application is good in specificity, high in accuracy and sensitivity, and can be used for quality control of related substances in 2-(3-formyl-4-hydroxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester, so that the product quality can be effectively controlled, and the medication safety of febuxostat medicine is improved.

The application provides a compound omeprazole dry suspension and a preparation method thereof, and relates to the technical field of pharmaceutical preparations.The compound omeprazole dry suspension comprises the following raw materials: omeprazole, sodium bicarbonate, magnesium silico-aluminate, hard stearic acid modified hydrotalcite, low acyl gellan gum, hydroxypropyl methyl cellulose and trehalose.The application provides a compound omeprazole dry suspension and a preparation method thereof, and the compound omeprazole dry suspension with specific particle size is prepared through specific proportioning of auxiliary materials and a specific preparation process, and the stability and solubility are significantly improved.

The invention provides an acetaminophen ointment and a preparation method thereof. According to the ointment composition disclosed by the invention, the medicine can better play a role in local positioning treatment of arthralgia and neuralgia diseases, and meanwhile, the side effect of liver injury caused by oral medicine can be avoided. The ointment composition is good in spreadability, basically free of granular sensation, resistant to heat and stable, the preparation method is simple, the production cost is low, and the ointment composition is especially suitable for large-scale industrial production.

The invention relates to a preparation containing pravastatin sodium enteric-coated pellets as well as a preparation method and application thereof, and relates to the technical field of biological medicines. According to the preparation disclosed by the invention, the unification of enteric protection and patient-friendly administration is realized, and the bioavailability of the medicine and the convenience and compliance of taking the medicine are remarkably improved; according to the preparation disclosed by the invention, the structure of the enteric-coated pellet is specially designed aiming at the processing and using characteristics of the dry suspension and the orally disintegrating tablet, so that the obtained enteric-coated pellet can be stably applied to the dry suspension or the orally disintegrating tablet while being not released in the stomach, and the medicine taking convenience and compliance of old people and patients with dysphagia are remarkably improved. According to the invention, the technical contradiction that an enteric preparation is difficult to be compatible with a patient-friendly dosage form in the prior art is solved, and a pravastatin administration scheme which gives consideration to enteric protection, bioavailability improvement and ease of administration is provided for old people or patients with dysphagia.

The invention discloses a stable low-viscosity budesonide nasal spray and a preparation method thereof, and relates to the technical field of pharmaceutical preparations, the stable low-viscosity budesonide nasal spray comprises the following raw materials by weight: 0.062-0.130 part of budesonide, 1.0-2.5 parts of a suspending aid, 4.0-5.0 parts of an osmotic pressure regulator, 0.016-0.048 part of a surfactant, 0.001-0.05 part of a stabilizer, 0.10-0.15 part of a bacteriostatic agent, 0.001-5 parts of a pH regulator, and 5-100 parts of purified water; according to the budesonide nasal spray, specific metal elements or metal ions are introduced into the raw materials, so that the total impurity content in the budesonide nasal spray can be remarkably reduced under the condition of not adopting a nitrogen charging and dissolved oxygen removing process, and the chemical stability and the medication safety of the preparation are remarkably improved; by adopting a heat dispersion suspending aid process, the viscosity of the liquid medicine is less than or equal to 20mPa. S and is obviously lower than that of a normal-temperature dispersion preparation process, and fog drops are finer during spraying.

The application belongs to the field of pharmaceutical chemistry, and particularly relates to an oxaliplatin prodrug and a preparation and application thereof. The structure of the oxaliplatin prodrug is specifically shown as formula (I). The oxaliplatin prodrug can be dissolved in physiological saline to form a nano preparation, which not only solves the instability problem of oxaliplatin in physiological saline, but also reduces the systemic toxicity of oxaliplatin, and achieves the effect of reducing toxicity and increasing efficiency. The oxaliplatin prodrug can be reduced in a reducing environment in tumor cells to release oxaliplatin to kill tumor cells, and achieve an antitumor effect superior to that of oxaliplatin. The synthesis method of the oxaliplatin prodrug and the preparation method of the nano preparation are simple and easy to implement, which are conducive to solving the poor stability problem of oxaliplatin in physiological saline, and are expected to realize clinical transformation.

This invention relates to the field of traditional Chinese medicine preparation technology, specifically to a blood-activating and meridian-clearing traditional Chinese medicine composition with agarwood as the principal ingredient. The composition comprises the following raw materials in parts by weight: 5-15 parts modified agarwood complex, 40-60 parts compound extract powder, 1-3 parts broken-cell-wall scorpion powder, 20-50 parts filler, and 0.5-2 parts lubricant. This invention improves the efficient release of the effective components of agarwood as the principal ingredient by using the modified agarwood complex, ensuring the stability of the core efficacy of agarwood and extending the retention time of its core components. The addition of compound extract powder scientifically combines blood-activating and blood-nourishing herbs, ensuring powerful meridian clearing while replenishing qi and blood, reducing the side effects of long-term medication, and improving patient safety. The broken-cell-wall scorpion powder reduces the risk of sensitization and poisoning, breaking the cell walls of the scorpion to fully release the core analgesic peptides and antithrombotic peptides, thus improving gastrointestinal absorption efficiency.

The application relates to the fields of agricultural biotechnology and pesticide preparation technology, and discloses a preparation method and application of 2,4-di-tert-butyl phenol nanoemulsion, which comprises the following steps: 2,4-di-tert-butyl phenol is dissolved in ethyl acetate to form an oil phase mixture; the obtained oil phase mixture is mixed with Tween 80 under magnetic stirring, stirring is performed until the mixture is fully mixed, an oil phase-emulsifier system is obtained after internal gas is removed through ultrasonic treatment, then the oil phase-emulsifier system is slowly added into 8 times the volume of deionized water under magnetic stirring at 45 DEG C, and mutual dissolution of the water phase and the oil phase is promoted through ultrasonic treatment for 40 min to obtain a pre-emulsion. The obtained pre-emulsion is emulsified through a high-pressure homogenizer, 20000 psi, and circulation is performed for 8 times to obtain the nanoemulsion. The nanoemulsion prepared by the application has a nanoscale particle size, the system presents good kinetic stability, is not prone to delamination, precipitation or Ostwald ripening, and shows high storage stability.