103results about How to "Improve medication safety" patented technology

The invention relates to the field of antitumor drugs, in particular to a pharmaceutical composition of a KRAS G12C inhibitor and camptothecin and application of the pharmaceutical composition. The camptothecin and the KRAS G12C inhibitor are combined to play a synergistic effect, a DNA damage repair pathway is inhibited, a better inhibition effect is generated on tumor cells containing KRAS G12C mutation, the dosage required for achieving the same anti-tumor effect is greatly reduced, and the medication safety is improved.

The invention provides an integrated dynamic drug metabolism monitoring and early warning system, and relates to the technical field of drug metabolism monitoring and early warning, the integrated dynamic drug metabolism monitoring and early warning system comprises a data acquisition module, a data processing module, a model construction module, an early warning mechanism module and a user interaction module, the data acquisition module is composed of an optical sensor, a chemical sensor and an electrophysiological sensor, according to the system, the concentration of drugs and related physiological parameters are monitored in real time, different types of biological signals are captured, and the sensitivity and selectivity of the sensors are considered in the design of the data acquisition module so as to ensure the stability and accuracy in different physiological states. Drug concentration and physiological parameters are monitored in real time from multiple dimensions, sensors select and cooperate to form an efficient acquisition network according to performance expression, data quality is optimized in combination with a multi-source data fusion algorithm (such as Kalman filtering and a weighted average method), and a data processing module adopts a statistical analysis algorithm to clean standardized data.

The invention provides an automatic determination method and system for an individualized medication adjustment dosage, and the method comprises the steps: calculating an initial administration scheme through employing a weighting result of a first atrioventricular model and a second atrioventricular model based on the physiological data and medication types of a patient; meanwhile, when the initial administration scheme of the patient is poor in effect or has adverse reaction, the administration scheme of the patient is adjusted. Compared with the prior art, the method has the advantages that the medication dosage can be accurately predicted and adjusted, adjustment suggestions can be given in real time through a feedback mechanism, and the safety and the curative effect of individualized medication are ensured.

The invention belongs to the field of artificial intelligence and digital medical treatment, and relates to a drug recommendation method, which comprises the following steps: preprocessing medical record data and gene data according to a preset data standard specification to obtain standard medical record data and standard gene data, and fusing the standard medical record data and the standard gene data through a health analysis model for prediction to obtain a drug recommendation result. And analyzing the health analysis result, the standard medical record data and the standard gene data through a drug recommendation model to obtain a drug recommendation scheme. The invention further provides a drug recommendation device, computer equipment and a storage medium. In addition, the invention also relates to a block chain technology, and the medical record data and the gene data can be stored in a block chain. According to the method, the efficiency and accuracy of drug recommendation can be improved, the personalized level of drug recommendation is remarkably improved, drug treatment is more targeted and effective, and the drug use safety of patients is improved.

The invention discloses a safe medication system and a safe medication method for elderly patients, which can monitor whether the elderly take medicine according to medical advice or not and monitor the health state of the elderly. The physiological data of the patient is monitored by the wearable end, so that the health state of the patient can be roughly judged by combining data such as heart rate, electrocardio, respiratory rate and blood pressure, and whether the patient is in danger or not can be found in time; and meanwhile, whether the drug effect of the patient is exerted and whether the patient has drug safety can be known by monitoring the physiological data for a period of time after drug use. According to the invention, the medical advice is uploaded or issued through the medical care terminal, and the medication information in the medical advice is analyzed into the medicine type counting quantity and the medication mode of the medication, so that the medication plan of the patient is planned, and then the patient is prompted to take the medication on time according to the plan. And the medicines are distributed through the intelligent terminal module, and the intelligent terminal module communicates through the system, so that the medicines can be distributed according to the control of the medical care terminal, the management terminal and the system to prevent the patient from eating by mistake, and the medication safety is greatly improved.

The invention discloses a quality control method of a traditional Chinese medicine preparation based on an IV-catfish orifice-freeing prescription, and relates to the technical field of analysis of traditional Chinese medicine preparations, and the quality control method comprises the following steps: carrying out microscopic identification on traditional Chinese medicine components in the IV-catfish orifice-freeing prescription, and determining a pharmacodynamic material basis. According to the quality control method for the traditional Chinese medicine preparation based on the IVV orifice-freeing prescription, various evaluation means such as a drug effect equivalent evaluation index, a stability test, a quality test and a clinical test are comprehensively applied, the consistency and reliability of the curative effect of the traditional Chinese medicine preparation can be remarkably improved, and the drug effect equivalent evaluation index is analyzed from the two factors of drug effect intensity and action time; the method ensures the equivalence of the medicinal component group and the original traditional Chinese medicine preparation, comprehensively detects the raw material medicines and the preparation, including characters, identification, inspection and content determination items, and ensures that the quality of each batch of samples meets the standard, so that the curative effect of the traditional Chinese medicine preparation is effectively guaranteed, and the efficacy of the traditional Chinese medicine preparation is improved.

The invention relates to a medical clinical nursing aid decision making system and method, and belongs to the technical field of medical clinical nursing information. Comprising a screening module used for obtaining case information, extracting case variable codes of the case information, matching the case variable codes with pre-stored variable codes, and screening out matched pre-stored feature codes; the nursing evaluation decision module is used for calculating the ratio of pre-stored feature codes and judging whether a nursing diagnosis and treatment scheme and path service meet nursing requirements or not; when the requirements are met, characteristic factors of the case information are extracted, and the nursing problem of the patient is obtained; according to the problem, a nursing target and plan are made; the nursing plan execution module is used for assigning nursing personnel according to the nursing target and plan; wherein the nurse updates the nursing problem according to the current nursing state of the patient; and the doctor advice execution module is used for automatically outputting a medicine use prompt according to the inquired medicine information. Balanced distribution of workload and nursing tasks of nursing personnel can be realized.

The invention provides a pharmaceutical composition and a preparation method thereof. The pharmaceutical composition comprises Y-3, hydroxypropyl-beta-cyclodextrin, mannitol, Tween 80 and the like. The Y-3 pharmaceutical composition for injection provided by the invention is high in solubility, good in stability and few in free drugs, and can effectively improve patient compliance and medication safety.

The invention relates to the technical field of drug analysis and detection, and particularly discloses a method for detecting the residual quantity of glucose in an irinotecan hydrochloride liposome injection. According to the method, irinotecan hydrochloride in the liposome is fully separated from small molecular substances such as glucose and sodium chloride by adopting an ultrafiltration method, then, a Waters XBridge BEH HILIC chromatographic column is adopted, a mixed solution of an acetate buffer solution with the pH value of 3.8-4.2 and acetonitrile is used as a mobile phase, and the content of irinotecan hydrochloride in the liposome is detected in an isocratic elution mode by adopting a high performance liquid chromatography method. The effective separation of glucose, sodium chloride, 4-hydroxyethylpiperazine, sucrose octasulfate potassium and other substances is realized, and the condition of the glucose residue in the irinotecan hydrochloride liposome is accurately detected. The invention provides a reliable guarantee for improving and better controlling the quality of the irinotecan hydrochloride liposome injection product, and has very important significance for improving the medication safety.

The invention discloses an impurity analysis method for a budesonide inhalation solution, and relates to the technical field of budesonide impurity analysis, and the method comprises the following steps: weighing 50mg of a budesonide inhalation solution sample, placing the budesonide inhalation solution sample in a 10mL volumetric flask, adding a diluent (such as acetonitrile and methanol) to a scale line, and fully shaking to dissolve the diluent to prepare a 5mg / mL sample solution; and filtering the diluted sample by using a filter so as to remove insoluble impurities. According to the budesonide inhalation solution impurity analysis technology, the product quality, the market competitiveness and the research and development capability of enterprises can be remarkably improved, meanwhile, the requirements of laws and regulations are met, and time and cost are saved; by analyzing the impurities, the product quality and safety can be improved, and by accurately analyzing and controlling the impurity content in the medicine, the purity and quality of the product can be remarkably improved, so that the risk of adverse reaction and side effect can be reduced, and the medication safety of a patient is improved.

The invention belongs to the field of medicines, and particularly discloses a dapagliflozin pharmaceutical composition, the pharmaceutical composition contains dapagliflozin, a stabilizer and at least one pharmaceutically acceptable excipient, and the weight ratio of dapagliflozin to the stabilizer is not less than 20000: 1. The invention also comprises preparation and application of the pharmaceutical composition. According to the dapagliflozin pharmaceutical composition disclosed by the invention, the dapagliflozin pharmaceutical composition has excellent stability.

The invention provides a preparation method of a nitrosamine impurity, and belongs to the technical field of heterocyclic compounds. The clarithromycin related nitrosamine impurity is 3 '-N-demethyl-3'-N-nitroso-6-O-methyl erythromycin, and is prepared by carrying out demethylation and nitrosation on clarithromycin. The clarithromycin intermediate erythromycin oxime related nitrosamine impurity is 3 '-N-demethyl-3'-N-nitroso erythromycin A (E)-9-oxime, and the clarithromycin intermediate erythromycin oxime related nitrosamine impurity is prepared from erythromycin A (E)-9-oxime through demethylation, etherification, nitrosation and hydrolysis.

The invention discloses an eperisone hydrochloride-containing pharmaceutical composition capable of effectively controlling the content of an impurity D and a preparation method of the eperisone hydrochloride-containing pharmaceutical composition. The eperisone hydrochloride-containing pharmaceutical composition comprises eperisone hydrochloride, hydrochloric acid, a filler, an adhesive, a disintegrating agent and a lubricant, and the hydrochloric acid can inhibit the eperisone hydrochloride in the eperisone hydrochloride-containing pharmaceutical composition from being degraded into the impurity D. The preparation process is simple, hydrochloric acid is adopted as a pH regulator, eperisone hydrochloride in the pharmaceutical composition can be effectively inhibited from being degraded into the impurity D, the content of the impurity D in the prepared pharmaceutical composition can be zero, and the impurity D is still not detected under the high-temperature condition; according to the pharmaceutical composition containing eperisone hydrochloride, the stability of the pharmaceutical composition containing eperisone hydrochloride can be greatly improved, the impurity level of the pharmaceutical composition is better controlled, the product quality is better, the safety to patients is higher, and the medication safety and effectiveness of the pharmaceutical composition are greatly improved.

The present application relates to the technical field of medical apparatus, particularly relates to wearable and vibration control nail base nanocrystal microneedle transdermal drug delivery device, including shell, both sides of the shell are provided with a group of positioning notches respectively, a group of positioning notches are provided with a threaded hole respectively, the inside four corners of the shell are provided with a group of support seats respectively, still include controller assembly, nanocrystal microneedle assembly, vibration assembly, power supply assembly and fixed ring assembly, the controller assembly is detachably installed in the shell, the shell is provided with vibration assembly and battery assembly respectively, the bottom end of the shell is detachably provided with nanocrystal microneedle assembly, the both ends of the fixed ring assembly are detachably connected with a group of positioning notches respectively, the nanocrystal microneedle assembly is used for lightly pricking nail base epidermis and nail plate edge to form microchannel, the power supply assembly provides power for vibration assembly and controller assembly;It makes drug directly contact focus.

This invention relates to the application of a dual-active-component drug in the preparation of a drug for treating double-hit lymphoma. The active ingredients in the dual-active-component drug consist of a first active component and a second active component. The first active component is selected from homoharringtonine or a pharmaceutically acceptable salt thereof; the second active component is selected from veneclade or a pharmaceutically acceptable salt thereof. This invention demonstrates that homoharringtonine combined with veneclade can significantly inhibit the proliferation of DHL cell lines and induce apoptosis in DHL cell lines. Using a CDX mouse model, it was demonstrated that homoharringtonine combined with veneclade can inhibit the tumorigenesis process of mouse DHL. The combined use of the two active components not only reduces the dosage of each drug and improves drug safety, but also has a more significant effect on improving or treating double-hit lymphoma (DHL) than a single active component, exhibiting a synergistic effect.

The application provides a gradient temperature difference processing method for preventing and controlling rancidity and deterioration of rice bran decoction pieces, comprising the following steps: sequentially subjecting newly harvested rice bran to low-temperature rapid cooling, medium-temperature roasting, high-temperature roasting and second ultra-low-temperature rapid cooling after removing impurities by primary screening, so as to prevent and control rancidity and deterioration of rice bran decoction pieces. The application utilizes rapid and strong temperature difference change to prevent and control the reaction after grinding contact oxidation, destroys the autoxidation system of rice bran, effectively prevents and controls the generation of oxidized toxic substances and the breeding and pollution of harmful microorganisms, and ensures the safety and effectiveness of medication.

The invention provides a traditional Chinese medicine composition for treating hypertension and a preparation method and application thereof, and relates to the technical field of traditional Chinese medicines. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 20 to 30 parts of rhizoma alismatis, 20 to 30 parts of fructus crataegi, 20 to 30 parts of poria cocos, 10 to 15 parts of persimmon leaves, 10 to 15 parts of folium mori, 20 to 30 parts of phellinus igniarius, 20 to 30 parts of bitter radix puerariae, 20 to 30 parts of ramulus uncariae cum uncis, 20 to 30 parts of rhizoma chuanxiong, 10 to 15 parts of spica prunellae, 20 to 30 parts of radix salviae miltiorrhizae, 10 to 15 parts of rhizoma gastrodiae and 10 to 15 The traditional Chinese medicine composition has the effect of reducing blood pressure, and is remarkable in curative effect and low in adverse reaction rate.

The invention discloses a HPLC determination method of tyloxapol content, comprising: preparing a tyloxapol inerting column solution, a tyloxapol reference solution, and a sample solution to be tested, respectively, wherein the concentration of the tyloxapol inerting column solution is greater than the concentration of the tyloxapol reference solution; firstly injecting the tyloxapol inerting column solution into a high performance liquid chromatograph for specific adsorption on the chromatographic column; then respectively performing high performance liquid analysis on the tyloxapol reference solution and the sample solution to be tested, and using an external standard method to determine the content of tyloxapol in the sample to be tested. The HPLC determination method of tyloxapol content of the invention is simple, fast, accurate, and highly sensitive, greatly shortening the time for testing, and is particularly suitable for determining the content of tyloxapol in a super-strong moisturizing lubricating eye drop, helping to improve the quality control and medication safety of tyloxapol liquid preparations, and can be used as an effective method for evaluating the quality of tyloxapol-containing preparations.

The present invention provides a Chinese medicine monomer drug combination preparation for treating neurotransmitter imbalance and its application, belonging to the field of medical technology. The combination preparation is composed of ferulic acid and verbascoside, wherein the mass ratio of ferulic acid to verbascoside is 1:9, 1:1 or 9:1, preferably 2.5μM ferulic acid and 22.5μM verbascoside. Studies have found that the combination preparation can significantly reduce the abnormal increase in glutamate (Glu) secretion, increase the abnormal decrease in γ-aminobutyric acid (GABA) secretion, and restore the balance of excitatory and inhibitory neurotransmitters. Through synergistic effects, the combination preparation achieves better efficacy and reduces side effects while reducing the dosage of the drug. Compared with traditional treatment methods, the present invention has the advantages of a clear mechanism of action and controllable quality, and has a wide range of clinical application prospects.

This application discloses a traditional Chinese medicine preparation for intestinal repair and antiviral immunity in pigeons, its preparation method and application, belonging to the field of traditional Chinese veterinary medicine technology. This traditional Chinese medicine preparation for intestinal repair and antiviral immunity in pigeons comprises the following components by weight: 5-10 parts Sophora flavescens, 6-12 parts Andrographis paniculata, 3-8 parts Sanguisorba officinalis (charred), 2-4 parts Lonicera japonica, 2-4 parts Forsythia suspensa, 1-4 parts Coptis chinensis, 3-6 parts Codonopsis pilosula, 5-10 parts Astragalus membranaceus, 2-6 parts Ligusticum chuanxiong, 1-6 parts Ganoderma lucidum, 3-8 parts Ganoderma lucidum, 5-10 parts Isatis indigotica, 3-6 parts Scrophularia ningpoensis, 2-6 parts Buffalo horn, 2-6 parts Dryopteris crassirhizoma (charred), 2-6 parts Sanguisorba officinalis, 5-15 parts Three Needles (charred), 2-10 parts Scutellaria baicalensis, 6-12 parts Lonicera japonica, 6-12 parts Pteris multifida, 4-10 parts Artemisia annua, 4-10 parts Atractylodes lancea, 4-14 parts Gypsum fibrosum, 6-12 parts Glycyrrhiza uralensis (tip), 2-5 parts Prunus armeniaca, 2-8 parts Epimedium brevicornu, and 2-5 parts Rhodiola rosea. By limiting the composition and ratio of the ingredients, the various medicinal materials complement each other in terms of their cold and heat properties and work together to break through the limitations of conventional Chinese medicine's single heat-clearing function. It can simultaneously improve viral infections, watery enteritis, and emaciation, and is suitable for use in the feed of meat pigeons and racing pigeons at all stages.

This invention discloses a compound preparation for treating vascular dementia and its preparation method. The active pharmaceutical ingredient consists of protopanaxadiol and gallic acid in a 1:1 mass ratio, and the dosage form is liposomes. The preparation method includes extraction, mixing, liposome preparation, and optional freeze-drying steps: protopanaxadiol and gallic acid are extracted and purified from ginseng rhizome and Terminalia chebula fruit, respectively. After mixing, they are combined with phospholipids and cholesterol to prepare a lipid membrane. The membrane is then homogenized by hydration, low-temperature ultrasound, and high-pressure microfluidic jet to obtain a homogeneous liposome suspension, which can be further freeze-dried into a freeze-dried powder. The 1:1 composition of protopanaxadiol and gallic acid targets multiple points on the pathological mechanism of vascular dementia, showing significant therapeutic effects and broad application prospects. This preparation uses a liposome dosage form to improve the bioavailability of the active ingredient, the preparation process parameters are controllable, the active ingredient has high purity, the liposomes have uniform particle size, high encapsulation efficiency, and good stability.

The utility model discloses a pair of glass ampoule cutting pliers which comprises a first pliers handle and a second pliers handle, a connecting mechanism is arranged in the middle of the outer surface of the first pliers handle and the middle of the outer surface of the second pliers handle, and one end of each of the first pliers handle and the second pliers handle is fixedly connected with a pliers mouth. According to the glass ampoule cutting pliers, through the arrangement of the clamping groove and the scribing piece, the clamping groove ensures that the bottleneck of the glass ampoule is firmly fixed in the pliers mouth during cutting, the bottleneck is prevented from sliding or shifting in the cutting process, the accuracy of the cutting position is guaranteed, and the scribing piece is located in the middle of the clamping groove and just corresponds to the cutting point of the bottleneck of the glass ampoule; according to the utility model, non-uniform cutting traces caused by unfixed scribing positions are avoided, the cutting process is more stable, the generation and splashing of glass fragments are reduced, the risk that medical personnel are scratched by the glass fragments is reduced, the possibility of liquid medicine leakage or pollution caused by improper cutting is avoided, and the working efficiency is improved. And the working efficiency of nursing personnel and the medication safety of patients are improved.

The utility model discloses a kind of quantitative bottles, including upper cover, inner bottle, outer bottle, bottom cover.The utility model fastens with buckle to bottle cap and outer bottle, connect through protruding point and limit card slot to inner bottle, outer bottle, and 180 ° rotation opening and closing of bottle is realized by bottle cap partition pushing inner bottle partition, pass through rotation to make medicine hole and inner bottle quantitative storehouse present through and dislocation, repeatedly push product in medicine storage and fall into quantitative storehouse by inner bottle partition, and product can be smoothly poured out by turning on inner bottle partition.The structure has the advantages such as quantitative medicine, easy to carry and reusable.

The invention discloses a method for determining the residual quantity of petroleum ether in an isonicotinamide benzonate bulk drug by using capillary gas chromatography, and belongs to the technical field of drug analysis. According to the method, an external standard method is adopted for quantification, a 6% cyanopropyl phenyl-94% dimethyl polysiloxane capillary column is used as a chromatographic column, and an FID detector is adopted for detection; the residual quantity of the petroleum ether is the total residual quantity of normal hexane, 2-methylpentane and 3-methylpentane in the petroleum ether. The method disclosed by the invention is good in specificity, good in linearity, reliable in accuracy and high in sensitivity; the gas chromatographic method can be used for rapidly, effectively, accurately and reliably separating and detecting the residual amount of petroleum ether in the isopropylamine bulk drug, and is beneficial to improving the product quality of the isopropylamine bulk drug and improving the medication safety of a patient.

The utility model provides a medicine packaging assembly which comprises a barrel-shaped piece, a feeding port and a discharging port which are communicated with each other are formed in the two ends of the barrel-shaped piece respectively, and a medicine storage cavity is formed in the barrel-shaped piece and used for containing solid medicine. A piston is arranged at the position, close to the feeding port, of the barrel-shaped piece, the piston is detachably connected with the barrel-shaped piece, the outer circumferential wall of the piston is matched with the inner circumferential wall of the barrel-shaped piece, and the piston is configured to be capable of sliding relative to the barrel-shaped piece. Before the medicine packaging assembly is used, the solid medicine and the solvent are mixed and blended into a solution for administration, and due to the fact that the stability of active ingredients of the dry solid medicine is good, a large number of stabilizers do not need to be added, and cost is saved; the solid medicine occupies a small volume and is convenient to store and transport; a solvent is directly guided into the medicine storage cavity through the feeding port, the administration medicine can be formed after simple shaking, operation is convenient, and self administration of a patient can be achieved.

This application discloses the use of itaconic acid derivatives in the preparation of drugs for treating candidemia, belonging to the field of biomedical technology. The itaconic acid derivatives proposed in this application are dimethyl itaconic acid and / or 4-octyl itaconic acid. Dimethyl itaconic acid exhibits a dose-dependent therapeutic effect in model mice, with an optimal dose of 1200 mg / kg improving survival rate and reducing kidney damage; 4-octyl itaconic acid can enhance the anti-Candida albicans ability of macrophages and regulate the expression of inflammatory factors. The application of the itaconic acid derivatives proposed in this application in the treatment of candidemia works through immunomodulation, circumventing fungal resistance. Furthermore, the drugs are low in toxicity, have good biocompatibility, and use a universal experimental system, providing a new approach for the clinical treatment of candidemia with broad application prospects. This application also protects pharmaceutical compositions for treating candidemia with dimethyl itaconic acid and / or 4-octyl itaconic acid as active ingredients.

The invention relates to the field of drug utilization value analysis, and particularly discloses a data stream-based drug utilization value analysis system, which comprises a data layer, an application layer and a user layer, according to the method, the multi-source drug data stream is constructed and stored in the multi-source drug database, and based on systematic management of drug information, drug use errors caused by drug name confusion, dosage errors and dosage form confusion can be reduced, the drug use safety is improved, and the method is beneficial to quickly and accurately retrieving and querying specific types of drug information; by integrating the elderly physiological features and the drug feature information, the drug utilization value analysis model is constructed, the elderly physiological features and the drug features are comprehensively considered, the utilization value of the drug on the elderly can be comprehensively evaluated, and the influence of the drug on the elderly patient can be predicted more accurately.

The present invention discloses an oral film with a customizable drug release curve and a preparation method thereof, belonging to the technical field of pharmaceutical preparations. The preparation method of the oral film comprises: (1) preparing a double-layer drug film including a barrier layer and a drug sustained-release layer, wherein the barrier layer is a metal film capable of reacting with an acidic solution, the drug sustained-release layer comprises a water-soluble small molecule drug and a sustained-release polymer, and the drug sustained-release layer is edge-sealed and fixed on the barrier layer; (2) folding the double-layer drug film to obtain an oral film with an origami structure, realizing the customization of the drug release curve of the oral film, and preparing the oral film with a customizable drug release curve. The oral film can customize the drug release curve, improve patient compliance, and reduce health risks and medical costs.

The invention discloses an application of maggot in preparation of a medicine for treating psoriasis, belongs to the technical field of medicines, and comprises an application of the maggot in preparation of the medicine for treating psoriasis and an application of the maggot in preparation of the medicine for treating psoriasis. The maggot is a whole worm and contains maggot active ingredients: protein, fatty acid and chitin, the mass percent of the protein in the maggot is not less than 7%, the mass percent of the fatty acid in the maggot is not less than 6%, the mass percent of the chitin in the maggot is not less than 7%, and the administration dosage of the maggot is 0.05-30mg / cm < 2 > * d when the medicine for treating the psoriasis is used; according to the application of the maggot in treating the psoriasis, compared with existing treatment medicines and methods, the maggot can achieve an unexpected curative effect, and the new application is an innovation for treating the psoriasis.

The utility model discloses a driving mechanism which is arranged in a second space formed by a shell and a lower sleeve body and comprises a rotary body, a pipe frame, a push rod, a spring and an actuating piece. The rotary body is rotationally arranged on the inner side of the shell, and the rotary body partially extends into the lower sleeve body and is connected with the lower sleeve body; the pipe frame is arranged on the inner side of the rotary body, rotates along with the rotary body all the time and can only move up and down in the axial direction of the rotary body. The push rod extends to the position above the shell from the pipe frame and is used for applying thrust to a target object; the spring is arranged below the pipe frame; the actuating piece is arranged above the rotary body and can reciprocate in the shell in the radial direction; the driving mechanism is convenient to operate, more stable pushing force can be provided by using a spring instead of a lifting handle, the atomization effect of the device is remarkably improved, the consistency of each spraying of the device is good by using a disposable medicine bottle to be matched with stable pushing force output, and daily precise medicine taking of a patient is facilitated.