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Applications of gelsemine, koumine and 1-methoxyl gelsemine to preparation of medicine for treating anxiety

A technology of Glycosin A and Glycosine, which is applied to the application field of Gycosin A, Glycosine, and 1-methoxycryphrine in the preparation of medicines for treating anxiety disorders, and can solve problems such as uninvolved, etc., Achieve no tolerance, expand the safe treatment window, and achieve the effect of less side effects

Active Publication Date: 2011-11-16
FUJIAN MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the existing research on the activity of kinesin alkaloid monomers does not involve the research on its anti-anxiety effect. The anxiolytic effects of kinesin A, kelesin, 1-methoxykelesine and their possible uses Unseen literature and patent reports

Method used

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  • Applications of gelsemine, koumine and 1-methoxyl gelsemine to preparation of medicine for treating anxiety
  • Applications of gelsemine, koumine and 1-methoxyl gelsemine to preparation of medicine for treating anxiety
  • Applications of gelsemine, koumine and 1-methoxyl gelsemine to preparation of medicine for treating anxiety

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] Inhibitory effects of coxomorphine A, coxomorphin and 1-methoxycphrine on the anxiety behavior of elevated plus maze in mice by subcutaneous injection on the back of the neck.

[0041] 1.1 Drugs and Reagents:

[0042] Glycosin A, Glycosine, and 1-methoxycyphrine were obtained by the applicant of the present invention by extracting, separating and purifying from the natural plant G. japonica, and the purity was >98.5% (accurately weighing G. Methoxychamnosine was dissolved in 1 mol / l HCl, diluted with normal saline, adjusted to pH with 1 mol / l NaOH (4<pH<7), and diluted with normal saline to the solution required for each dose group). Midazolam hydrochloride injection (5mg / ml), Jiangsu Enhua Pharmaceutical Group Co., Ltd., batch number H19990027.

[0043] 1.2 Animals:

[0044] Kunming mice, male, 18-22g, provided by the Experimental Animal Center of Fujian Medical University. The animals were reared under a light-dark cycle of 12 / 12 h at room temperature at 25°C, with...

Embodiment 2

[0058] Inhibitory effects of coxomorphine A, coxomorphin, and 1-methoxycphrine on the anxiety behavior of light and dark boxes in mice by subcutaneous injection on the back of the neck.

[0059] 2.1 Drugs and Reagents:

[0060] Glycosin A, Glycosine, and 1-methoxycyphrine were obtained by the applicant of the present invention by extracting, separating and purifying from the natural plant G. japonica, and the purity was >98.5% (accurately weighing G. Methoxychamnosine was dissolved in 1 mol / l HCl, diluted with normal saline, adjusted to pH with 1 mol / l NaOH (4<pH<7), and diluted with normal saline to the solution required for each dose group). Midazolam hydrochloride injection (5mg / ml), Jiangsu Enhua Pharmaceutical Group Co., Ltd., batch number H19990027.

[0061] 2.2 Animals:

[0062] Kunming mice, male, 18-22g, provided by the Experimental Animal Center of Fujian Medical University. The animals were reared under a light-dark cycle of 12 / 12 h at room temperature at 25°C, w...

Embodiment 3

[0076] Experiment on the median lethal dose of total alkaloids, arginine A, glucosamine and 1-methoxy argonine by subcutaneous injection on the back of the neck of mice

[0077] 2.1 Drugs and Reagents:

[0078] The total alkaloids of Gonchospermia, Glycosin A, Glycosin A, 1-methoxycrysphrine were obtained by the applicant of the present invention by extracting, separating and purifying from the natural plant G. archaea, and the purity was more than 98.5% (accurately weighing Glycosin A, Glycosin and 1-methoxycryphrine were dissolved in 1 mol / l HCl, diluted with normal saline, adjusted to pH (4<pH<7) with 1 mol / l NaOH, and diluted with normal saline to the level required for each dose group solution).

[0079] 2.2 Animals:

[0080] Kunming mice, male, 18-22g, provided by the Experimental Animal Center of Fujian Medical University. The animals were reared under a light-dark cycle of 12 / 12 h at room temperature at 25°C, with free food, and adapted to the laboratory for 3 days ...

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Abstract

The invention discloses applications of gelsemine, koumine and 1-methoxyl gelsemine to the preparation of a medicine for treating the anxiety, especially an application of gelsemium alkaloid monomer gelsemine as the sole active ingredient or a pharmaceutically acceptable salt thereof to the preparation of the medicine for treating the anxiety, an application of gelsemium alkaloid monomer koumine as the sole active ingredient or the pharmaceutically acceptable salt thereof to the preparation of the medicine for treating the anxiety, and an application of gelsemium alkaloid monomer 1-methoxyl gelsemine as the sole active ingredient or the pharmaceutically acceptable salt thereof to the preparation of the medicine for treating the anxiety; and the gelsemine, the koumine and the 1-methoxyl gelsemine can play significant roles in treating the murine anxiety in far below the toxic dose so that the safe therapeutic window is remarkable expanded, have no tolerance, low addiction and side effect, and are more suitable for the preparation of the medicine for treating the anxiety in comparison with gelsemium total alkaloids.

Description

technical field [0001] The present invention relates to the application of gelsemine alkaloid monomers, in particular to the application of gelsemine A (Gelsemine), gelsemine seed (Koumine) and 1-methoxygelsemine in the preparation of drugs for treating anxiety. Background technique [0002] Anxiety disorder, also known as anxiety neurosis, is a common disease, which can be divided into two types: panic disorder and generalized anxiety according to clinical manifestations. According to relevant reports in the United States, more than 490 million people worldwide suffer from anxiety disorders, and the lifetime prevalence rate among the population is 5%; the prevalence rate reported in China has reached 2% to 3%. If anxiety disorders are left untreated for a long time, 40% to 50% of patients may develop into depression. Anti-anxiety drugs are currently one of the main means of clinically treating patients' anxiety disorders. A research report entitled "Anti-Anxiety: Strategic...

Claims

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Application Information

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IPC IPC(8): A61K31/439A61P25/22
Inventor 俞昌喜刘铭许盈苏燕评杨渐
Owner FUJIAN MEDICAL UNIV
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