Applications of gelsemine, koumine and 1-methoxyl gelsemine to preparation of medicine for treating anxiety
A technology of Glycosin A and Glycosine, which is applied to the application field of Gycosin A, Glycosine, and 1-methoxycryphrine in the preparation of medicines for treating anxiety disorders, and can solve problems such as uninvolved, etc., Achieve no tolerance, expand the safe treatment window, and achieve the effect of less side effects
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Embodiment 1
[0040] Inhibitory effects of coxomorphine A, coxomorphin and 1-methoxycphrine on the anxiety behavior of elevated plus maze in mice by subcutaneous injection on the back of the neck.
[0041] 1.1 Drugs and Reagents:
[0042] Glycosin A, Glycosine, and 1-methoxycyphrine were obtained by the applicant of the present invention by extracting, separating and purifying from the natural plant G. japonica, and the purity was >98.5% (accurately weighing G. Methoxychamnosine was dissolved in 1 mol / l HCl, diluted with normal saline, adjusted to pH with 1 mol / l NaOH (4<pH<7), and diluted with normal saline to the solution required for each dose group). Midazolam hydrochloride injection (5mg / ml), Jiangsu Enhua Pharmaceutical Group Co., Ltd., batch number H19990027.
[0043] 1.2 Animals:
[0044] Kunming mice, male, 18-22g, provided by the Experimental Animal Center of Fujian Medical University. The animals were reared under a light-dark cycle of 12 / 12 h at room temperature at 25°C, with...
Embodiment 2
[0058] Inhibitory effects of coxomorphine A, coxomorphin, and 1-methoxycphrine on the anxiety behavior of light and dark boxes in mice by subcutaneous injection on the back of the neck.
[0059] 2.1 Drugs and Reagents:
[0060] Glycosin A, Glycosine, and 1-methoxycyphrine were obtained by the applicant of the present invention by extracting, separating and purifying from the natural plant G. japonica, and the purity was >98.5% (accurately weighing G. Methoxychamnosine was dissolved in 1 mol / l HCl, diluted with normal saline, adjusted to pH with 1 mol / l NaOH (4<pH<7), and diluted with normal saline to the solution required for each dose group). Midazolam hydrochloride injection (5mg / ml), Jiangsu Enhua Pharmaceutical Group Co., Ltd., batch number H19990027.
[0061] 2.2 Animals:
[0062] Kunming mice, male, 18-22g, provided by the Experimental Animal Center of Fujian Medical University. The animals were reared under a light-dark cycle of 12 / 12 h at room temperature at 25°C, w...
Embodiment 3
[0076] Experiment on the median lethal dose of total alkaloids, arginine A, glucosamine and 1-methoxy argonine by subcutaneous injection on the back of the neck of mice
[0077] 2.1 Drugs and Reagents:
[0078] The total alkaloids of Gonchospermia, Glycosin A, Glycosin A, 1-methoxycrysphrine were obtained by the applicant of the present invention by extracting, separating and purifying from the natural plant G. archaea, and the purity was more than 98.5% (accurately weighing Glycosin A, Glycosin and 1-methoxycryphrine were dissolved in 1 mol / l HCl, diluted with normal saline, adjusted to pH (4<pH<7) with 1 mol / l NaOH, and diluted with normal saline to the level required for each dose group solution).
[0079] 2.2 Animals:
[0080] Kunming mice, male, 18-22g, provided by the Experimental Animal Center of Fujian Medical University. The animals were reared under a light-dark cycle of 12 / 12 h at room temperature at 25°C, with free food, and adapted to the laboratory for 3 days ...
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