59results about How to "Fast release rate" patented technology

The invention discloses a trace element-doped porous calcium carbonate ceramic, and a preparation method and application thereof, belonging to the field of medical materials for bone repair. The preparation method disclosed by the invention comprises the following steps: doping Mg, Sr, Zn, Si, Cu and other trace elements in a human body into calcium carbonate through a chemical precipitation method, or doping trace elements into low-temperature phosphate bioglass used as a sintering binder, uniformly mixing the trace element-doped calcium carbonate powder, the glass binder and pore forming agent, then forming, performing isostatic pressing treatment, sintering, and removing the pore forming agent to obtain the trace element-doped porous calcium carbonate ceramic. The trace element-doped porous calcium carbonate ceramic prepared by the invention has high strength and porosity, controllable degradation rate, long-term slow release of the doped trace element ions and favorable bone conductibility and inductivity, and is a novel artificially synthesized bone repair material.

The invention provides a method for preparing a tiny mesoporous silica drug sustained-release material and a tiny mesoporous hollow tubular silicon dioxide material obtained through the method. The drug loading capacity, calculated through a TG method, of the tiny mesoporous hollow tubular silicon dioxide material for aspirin model drugs is 15%, the sustained-release stage is the time of six hours of the initial stage of an experiment, and the drug releasing rate is high; after six hours, the stage of release balancing is achieved, and the amount of balanced release is 73.6%.

The invention discloses an anti-bacterial composition as well as a controlled-release anti-bacterial film and an implant material prepared from the anti-bacterial composition. The anti-bacterial composition comprises first-class macromolecule selected from polylactic acid, polycaprolactone, polylactic acid-hydroxy acetic acid copolymer and polycaprolactone-hydroxy acetic acid copolymer, second-class macromolecule selected from polylactic acid-polyethyleneglycol block copolymer, polycaprolactone-polyethyleneglycol block copolymer, polyethylene oxide, polyvinyl alcohol, gelatin and hyaluronic acid, and an antimicrobial agent. The controlled-release anti-bacterial film prepared from the anti-bacterial composition which is provided by the invention can be adopted to achieve the purpose of releasing the antimicrobial agent in a controllable manner.

The invention discloses a risperidone nano-suspension temperature sensitive gel and its preparation method. Each 100ml of the nanosuspension temperature sensitive gel contains 0.1-10g of risperidone, 0.1-5g of a stabilizer, 1-50g of a temperature sensitive gel material, 0-5g of an additive, and the balance of a water-based solvent. The risperidone nano-suspension temperature sensitive gel is a temperature sensitive controlled-release in situ gel. The above dosage form makes risperidone highly dispersed, so the gel has the advantages of good drug load and good stability; after the gel is administrated in a liquid form, phase transition occurs in applied sites, and the liquid becomes non-chemically-crosslinked semisolid gel, so the gel has good histocompatibility and improves the drug dissolution rate; and the administrated gel has a long retention time in the applied sites as a drug reservoir, so the gel has a slow release effect, prolongs the drug release time, improves the drug bioavailability, reduces the administration frequency and improves the drug effect and the patient compliance.

The invention discloses a method for preparing double medicine-carrying composite fibrous membrane through an emulsion electrospinning technology. The method includes the following steps that 1, a polylactic acid solution is prepared, an emulsifying agent I is added, the mixture is stirred evenly, hydrophobic medicine is added, an oil-phase solution is obtained after stirring, a gelatin solution is prepared, filtering is performed, an emulsifying agent II is added, the mixture is stirred evenly, hydrophilic medicine is added, and a water-phase solution is obtained after stirring; 2, under thecondition that stirring speed is 800 rpm-1000 rpm, the water-phase solution is dropwise added into the oil-phase solution, stirring is continued after dripping is completed, and then O/W emulsion is obtained; 3, PEG or PVA with the molecular weight being 8000 is added, and a spinning solution is obtained after even mixing is performed; 4, by the utilization of the electrostatic spinning method, the spinning solution is prepared into the double medicine-carrying composite fibrous membrane of a yarn and bead coexisting structure. In the method, the oil-in-water type emulsion is prepared througha phase reversal method; by adjusting polyethylene glycol, yarn-bead coexisting fibers can be prepared through emulsion electrospinning, the preparation method is simple, and the medicine-carrying effect is good.

The invention discloses a preparation method for nano-sized zirconium-based cation metal organic framework (Zr-MOFs) materials carrying an anionic medicine. According to the method, firstly, cation functionalized Zr-MOFs are obtained, then, the anionic medicine is loaded to the Zr-MOFs, and the releasing effect of the Zr-MOFs is controlled through pH. After an n-donor ligand of the synthesized Zr-MOFs materials is subjected to cationization, due to the coulomb force, very strong acting force is exerted to the anionic medicine, a large loading capacity can be reached, and the nano-sized Zr-MOFs materials carrying the anionic medicine have a pH controlled-release effect in the medicine slow-release process. Thus, the materials have potential application prospects in the aspects of anionic medicine loading and controlled releasing.

A dosage form is described that gives an extended release of active ingredients using unloaded ion exchange resins, that does not require the manufacture of a resinate.

A release controllable film coating material targetting to colon is prepared from modified starch through adding the modified starch to coating solvent, and adding plasticizer. Its application is also disclosed.

The invention discloses a calcium-based adsorbent for defluorination and an application thereof and belongs to the field of wastewater treatment. Dolomite and coal ash are taken as raw materials and are compounded into the calcium-based adsorbent for defluorination, provided by the invention, according to a hydrothermal method. The application steps are as follows: (1) compounding calcined products of dolomite dust with the coal ash at the compounding temperature of 170-200 DEG C for 6h, so as to obtain the calcium-based adsorbent; and (2) adding the calcium-based adsorbent into wastewater at the dosage of 1.25-25g/L, magnetically stirring for 10min-30min, precipitating or centrifuging, and then separating solid from water. The calcium-based adsorbent for defluorination can effectively absorb fluorine pollutants under a low pH condition, and has physical and chemical absorption effects. The effluent meets GB8978-1996 class-1 emission standard.

The invention provides a curcumin carrier with temperature response. A lyotropic liquid crystal (hexagonal phase and three-dimensional phase) is built in a water medium with non-ionic surfactants (Brij97 and Tween40) and oleic acid to serve as a drug carrier of curcumin. When the temperature of the drug carrier provided by the application rises, the releasing rate of a sample increases, and the highest releasing rate is reached when the temperature of the drug carrier is approximate to the temperature of human body. The drug carrier can be released rapidly after being taken, and facilitates rapid treatment of diseases with drug. Moreover, the carrier has a better slow-releasing effect on the curcumin, and can reduce the taking times of the curcumin.

The invention provides slimming cream and a preparation method thereof. The slimming cream is prepared from 2 to 6 parts by weight of cactus extract, 1 to 5 parts by weight of lotus leaf extract, 1 to 5 parts by weight of tea extract, 0.2 to 1 part by weight of guarana extract, 0.2 to 1 part by weight of cassia bark extract, and 0.1 to 0.5 parts by weight of menthol. The slimming cream contains above 45% of general flavone. Through synergism of the cactus extract, the lotus leaf extract, the tea extract, the guarana extract, the cassia bark extract and the menthol, the slimming cream has a high drug release rate. Results of little white mouse weight losing experiments show that body weights of little white mice taking the slimming cream which is O/W type cream, the slimming cream which isW/O type cream and the slimming cream which is water soluble are lower than those of control groups; the three types of the slimming cream can delay body weight increase; blister, measles and rednessof parts applying the three types of the slimming cream do not produced; and the three types of the slimming cream do not irritate the skin.

The gum removing material capable of being injected contains bloom-shaped fiber with thickening effect, corrective, pigment, kaolin as stuffing and other excipient. It is paste with viscosity of (31-71) E6 cP. It is injected to fill into affected gum trough to expand the gum trough properly, control tissue fluid in gum trough, arrest bleeding and ensure dryness in gum trough, so as to facilitate the subsequent operation of obtaining complete impression and making precise false tooth.

The invention discloses a staphylococcus lysozyme local sustained release preparation, a preparation method and application thereof. The preparation comprises the following components in percentage by weight: 1 to 10 percent of staphylococcus lysozyme, 1 to 10 percent of mannite, 0 to 90 percent of polylactic acid (PLA), and 5 to 95 percent of polylactide-co-glycolide (PLGA). The preparation takes the staphylococcus lysozyme as a bactericidal active component to obtain polylactide-co-glycolide (PLA-PLGA) polymer microspheres containing the staphylococcus lysozyme through supercritical fluid microparticle preparation technology. The preparation has good physical and chemical properties and strong sterilization effect, has adjustable time during the in vitro medicament release, ensures that the medicament release process can reach three days to three months, and has steady release rate.

The invention provides a pH-sensitive agricultural microbial agent. The microbial agent is prepared from a microorganism, a binder, a dopamine or a salt thereof, and a pH-sensitive high polymer molecule. The pH-sensitive high polymer molecule is a high polymer molecule polymerized by an acrylic acid by using graphene oxide as a crosslinking agent. According to the invention, the dopamine is attached to a surface of the living granulating agent, then the pH-sensitive high polymer molecule are covered on a surface of the dopamine, so as to prepare the pH-sensitive agricultural microbial agent that a release of living bacteria of the agent can be adjusted according to the pH of the environment. In the saline-alkaline soil, by applying the pH-sensitive agricultural microbial agent provided bythe invention, the living bacteria can be quickly released, so as to accelerate the improvement of soil salinization problem; while applying the pH-sensitive agricultural microbial agent provided by the invention in the acidic soil, the release rate of the live bacteria can be effectively slowed down, so as to prevent the loss of the organic fertilizer produced by the decomposition of the living bacteria in the acidic soil, and to improve the utilization efficiency of the fertilizer.

The invention provides pH sensitive organic bacterial manure. The bacterial manure comprises organic matters, bacteria beneficial to the growth of plants, dopamine or salt thereof, and pH sensitive polymer molecules synthesized from acrylate by adopting graphene oxide as a cross-linking agent. The dopamine is attached to the surface of the organic matter and beneficial bacteria, the surface of thedopamine is coated with the pH sensitive polymer molecules, so that the pH sensitive organic bacterial manure provided in the invention capable of adjusting the release amount of organic bacterial fertilizer wrapped therein can be prepared. By applying the pH sensitive organic bacterial manure provided in the invention in the salinization soil, the organic fertilizer and live bacteria in the organic bacterial manure can be rapidly released, so that the salinization problem of the soil can be rapidly improved; and by applying the pH sensitive organic bacterial manure in the acidified soil, therelease rate of the fertilizer can be effectively retarded, the loss of the fertilizer in the acidic soil can be prevented, and the utilization efficiency of the fertilizer can be improved.