60results about How to "Fast release rate" patented technology

A stabilized solid controlled release dosage form having a coating derived from an aqueous dispersion of ethylcellulose is obtained by overcoating a substrate including a therapeutically active with an aqueous dispersion of ethylcellulose and then curing the coated substrate at a temperature and relative humidity elevated to a suitable level above ambient conditions until the coated dosage form attains a stabilized dissolution profile substantially unaffected by exposure to storage conditions of elevated temperature and / or elevated relative humidity.

The present disclosure relates to an oral pouched snuff product and a method for its production. The oral pouched snuff product comprises a filling material and a saliva-permeable pouch enclosing the filling material, the saliva-permeable pouch comprising at least one elongated seal and the saliva-permeable pouch comprising a mesh material being elastic in at least one direction and comprising fibres of thermoplastic polyamide, wherein the at least one elongated seal has a seal strength of at least 0.10 N / mm as measured in dry state as well as in wet state. The at least one elongated seal may be an ultrasonically provided weld.

The invention discloses a trace element-doped porous calcium carbonate ceramic, and a preparation method and application thereof, belonging to the field of medical materials for bone repair. The preparation method disclosed by the invention comprises the following steps: doping Mg, Sr, Zn, Si, Cu and other trace elements in a human body into calcium carbonate through a chemical precipitation method, or doping trace elements into low-temperature phosphate bioglass used as a sintering binder, uniformly mixing the trace element-doped calcium carbonate powder, the glass binder and pore forming agent, then forming, performing isostatic pressing treatment, sintering, and removing the pore forming agent to obtain the trace element-doped porous calcium carbonate ceramic. The trace element-doped porous calcium carbonate ceramic prepared by the invention has high strength and porosity, controllable degradation rate, long-term slow release of the doped trace element ions and favorable bone conductibility and inductivity, and is a novel artificially synthesized bone repair material.

The invention provides a method for preparing a tiny mesoporous silica drug sustained-release material and a tiny mesoporous hollow tubular silicon dioxide material obtained through the method. The drug loading capacity, calculated through a TG method, of the tiny mesoporous hollow tubular silicon dioxide material for aspirin model drugs is 15%, the sustained-release stage is the time of six hours of the initial stage of an experiment, and the drug releasing rate is high; after six hours, the stage of release balancing is achieved, and the amount of balanced release is 73.6%.

The invention discloses an anti-bacterial composition as well as a controlled-release anti-bacterial film and an implant material prepared from the anti-bacterial composition. The anti-bacterial composition comprises first-class macromolecule selected from polylactic acid, polycaprolactone, polylactic acid-hydroxy acetic acid copolymer and polycaprolactone-hydroxy acetic acid copolymer, second-class macromolecule selected from polylactic acid-polyethyleneglycol block copolymer, polycaprolactone-polyethyleneglycol block copolymer, polyethylene oxide, polyvinyl alcohol, gelatin and hyaluronic acid, and an antimicrobial agent. The controlled-release anti-bacterial film prepared from the anti-bacterial composition which is provided by the invention can be adopted to achieve the purpose of releasing the antimicrobial agent in a controllable manner.

The invention relates to a hierarchical pore zeolite molecular sieve and a preparation method, which belongs to the fine chemical and inorganic material field. The invention relates to a ZSM-12 zeolite molecular sieve having intergranular mesoporous and macroporous and a preparation method, the invention is characterized in that a traditional template tetraethyl ammonium bromide TEABr or a tetraethyl ammonium hydroxide TEAOH synthesized by zeolite are taken as a template to synthesize the hierarchical pore zeolite molecular sieve, the problem that the synthesis of the hierarchical pore zeolite molecular sieve employs post-treatment or expensive hard template to prepare the mesoporous can be solved, according to the material, the diffusion path is substantially shortened and the acid site accessibility is enhanced, and the material has important utility value on fine chemical, catalysis of petroleum chemical, adsorption and separating.

The invention discloses a silymarin nano-crystal self-stabilizing Pickering emulsion and a preparation method thereof. The emulsion is an oil-in-water type Pickering emulsion consisting of silymarin nano-crystal, an oil phase and water. According to the preparation method of the Pickering emulsion, nano-crystal is prepared from silymarin by utilizing a high pressure homogenization method, so that silymarin nano-crystal is adsorbed to the surface of an oil drop, the oil drop is coated with a medicine, the medicine is partially dissolved in the oil phase and partially adsorbed to the surface of the oil drop in a nano-crystal mode, and the oil drop can be stably distributed in water to form a stable emulsion; the medicine in the emulsion is an effective component, and can play a role in stabilizing the emulsion. The emulsion prepared by the method does not contain a surfactant or an organic solvent, and has stability, quick release speed and excellent bioavailability.

The invention discloses a risperidone nano-suspension temperature sensitive gel and its preparation method. Each 100ml of the nanosuspension temperature sensitive gel contains 0.1-10g of risperidone, 0.1-5g of a stabilizer, 1-50g of a temperature sensitive gel material, 0-5g of an additive, and the balance of a water-based solvent. The risperidone nano-suspension temperature sensitive gel is a temperature sensitive controlled-release in situ gel. The above dosage form makes risperidone highly dispersed, so the gel has the advantages of good drug load and good stability; after the gel is administrated in a liquid form, phase transition occurs in applied sites, and the liquid becomes non-chemically-crosslinked semisolid gel, so the gel has good histocompatibility and improves the drug dissolution rate; and the administrated gel has a long retention time in the applied sites as a drug reservoir, so the gel has a slow release effect, prolongs the drug release time, improves the drug bioavailability, reduces the administration frequency and improves the drug effect and the patient compliance.

The invention discloses a method for preparing double medicine-carrying composite fibrous membrane through an emulsion electrospinning technology. The method includes the following steps that 1, a polylactic acid solution is prepared, an emulsifying agent I is added, the mixture is stirred evenly, hydrophobic medicine is added, an oil-phase solution is obtained after stirring, a gelatin solution is prepared, filtering is performed, an emulsifying agent II is added, the mixture is stirred evenly, hydrophilic medicine is added, and a water-phase solution is obtained after stirring; 2, under thecondition that stirring speed is 800 rpm-1000 rpm, the water-phase solution is dropwise added into the oil-phase solution, stirring is continued after dripping is completed, and then O / W emulsion is obtained; 3, PEG or PVA with the molecular weight being 8000 is added, and a spinning solution is obtained after even mixing is performed; 4, by the utilization of the electrostatic spinning method, the spinning solution is prepared into the double medicine-carrying composite fibrous membrane of a yarn and bead coexisting structure. In the method, the oil-in-water type emulsion is prepared througha phase reversal method; by adjusting polyethylene glycol, yarn-bead coexisting fibers can be prepared through emulsion electrospinning, the preparation method is simple, and the medicine-carrying effect is good.

The invention discloses a preparation method for nano-sized zirconium-based cation metal organic framework (Zr-MOFs) materials carrying an anionic medicine. According to the method, firstly, cation functionalized Zr-MOFs are obtained, then, the anionic medicine is loaded to the Zr-MOFs, and the releasing effect of the Zr-MOFs is controlled through pH. After an n-donor ligand of the synthesized Zr-MOFs materials is subjected to cationization, due to the coulomb force, very strong acting force is exerted to the anionic medicine, a large loading capacity can be reached, and the nano-sized Zr-MOFs materials carrying the anionic medicine have a pH controlled-release effect in the medicine slow-release process. Thus, the materials have potential application prospects in the aspects of anionic medicine loading and controlled releasing.

A dosage form is described that gives an extended release of active ingredients using unloaded ion exchange resins, that does not require the manufacture of a resinate.

A release controllable film coating material targetting to colon is prepared from modified starch through adding the modified starch to coating solvent, and adding plasticizer. Its application is also disclosed.

This disclosure features a system for processing microspheres. A vessel contains a suspension of solidified microspheres comprising polymer and an active agent. A hydrocyclone has a fluid inlet, a first fluid outlet and a second fluid outlet. The fluid inlet is in fluid communication with the vessel and receives the suspension. The second fluid outlet contains a flow of the suspension having concentrated microspheres. The first fluid outlet contains a flow of a relatively large amount of liquid compared to the flow from the second fluid outlet. Also featured is a method of processing the microspheres using the hydrocyclone.

The invention discloses a calcium-based adsorbent for defluorination and an application thereof and belongs to the field of wastewater treatment. Dolomite and coal ash are taken as raw materials and are compounded into the calcium-based adsorbent for defluorination, provided by the invention, according to a hydrothermal method. The application steps are as follows: (1) compounding calcined products of dolomite dust with the coal ash at the compounding temperature of 170-200 DEG C for 6h, so as to obtain the calcium-based adsorbent; and (2) adding the calcium-based adsorbent into wastewater at the dosage of 1.25-25g / L, magnetically stirring for 10min-30min, precipitating or centrifuging, and then separating solid from water. The calcium-based adsorbent for defluorination can effectively absorb fluorine pollutants under a low pH condition, and has physical and chemical absorption effects. The effluent meets GB8978-1996 class-1 emission standard.

The invention provides a curcumin carrier with temperature response. A lyotropic liquid crystal (hexagonal phase and three-dimensional phase) is built in a water medium with non-ionic surfactants (Brij97 and Tween40) and oleic acid to serve as a drug carrier of curcumin. When the temperature of the drug carrier provided by the application rises, the releasing rate of a sample increases, and the highest releasing rate is reached when the temperature of the drug carrier is approximate to the temperature of human body. The drug carrier can be released rapidly after being taken, and facilitates rapid treatment of diseases with drug. Moreover, the carrier has a better slow-releasing effect on the curcumin, and can reduce the taking times of the curcumin.

The invention discloses a radiating heating furnace with an annular flue. The radiating heating furnace comprises a furnace body, an air supply channel with an air inlet is arranged on the upper portion of the furnace body, a plurality of primary air inlet holes are formed in the bottom of the air supply channel, a plurality of secondary air inlet holes are formed in the inner wall of the air supply channel, a primary air inlet channel is formed between the outer wall of a hearth and the inner wall of the furnace body, the primary air inlet holes are communicated with the bottom of the hearth through the primary air inlet channel, the secondary air inlet holes are directly communicated with the hearth, the annular flue is arranged on the upper portion of the air supply channel, the flue is communicated with the hearth through a smoke inlet, a plurality of thermoelectricity modules generating electricity through temperature difference are arranged between the flue and the air supply channel, and an air blower powered by the thermoelectricity modules is arranged on the air inlet. The radiating heating furnace with the annular flue has the good combustion and heating effects in high-altitude regions, and is suitable for being used in the high-altitude regions. According to the radiating heating furnace with the annular flue, when smoke passes through the secondary air inlet holes, unburned smoke is combusted again, the hearth and smoke temperature rises, the radiating efficiency of the annular flue is improved, the heating efficiency is high, and the using and maintenance cost is low.

The invention belongs to the pharmaceutical technical field, relates to a solid pharmaceutical composition of an EGFR inhibitor, and in particular, relates to a solid pharmaceutical composition prepared with a compound represented by the formula (I) or a pharmaceutically acceptable salt as raw material and a preparation method thereof. On one hand, the solid pharmaceutical composition includes a diluent, a disintegrating agent and a lubricant; on the other hand, a carrier material is selected from a solid dispersion body of a cellulose compound. The solid pharmaceutical composition obviously improves the water solubility and stability of the compound, has faster release rate, and helps to improve the bioavailability.

The invention provides slimming cream and a preparation method thereof. The slimming cream is prepared from 2 to 6 parts by weight of cactus extract, 1 to 5 parts by weight of lotus leaf extract, 1 to 5 parts by weight of tea extract, 0.2 to 1 part by weight of guarana extract, 0.2 to 1 part by weight of cassia bark extract, and 0.1 to 0.5 parts by weight of menthol. The slimming cream contains above 45% of general flavone. Through synergism of the cactus extract, the lotus leaf extract, the tea extract, the guarana extract, the cassia bark extract and the menthol, the slimming cream has a high drug release rate. Results of little white mouse weight losing experiments show that body weights of little white mice taking the slimming cream which is O / W type cream, the slimming cream which isW / O type cream and the slimming cream which is water soluble are lower than those of control groups; the three types of the slimming cream can delay body weight increase; blister, measles and rednessof parts applying the three types of the slimming cream do not produced; and the three types of the slimming cream do not irritate the skin.

The invention provides a pH sensitive bacillus subtilis fungicide. The fungicide comprises bacillus subtilis and / or spore, dopamine or salt thereof and pH sensitive polymer macromolecules. The dopamine is attached to the surface of the bacillus subtilis, and the surface of the dopamine is coated with the pH sensitive polymer molecules, so that the pH sensitive bacillus subtilis fungicide capable of adjusting the release amount of live bacteria wrapped therein according to the pH vale of the environment can be prepared. In the salinization soil, by applying the pH sensitive bacillus subtilis fungicide provided in the invention, the live bacteria can be rapidly released, so that the soil salinization problem of the soil can be rapidly improved; and by applying the pH sensitive bacillus subtilis fungicide provide in the acidified soil, the release rate of the live bacteria in the fungicide can be effectively retarded, the loss of organic fertilizer generated by the decomposition of live bacteria in the acid soil can be prevented, and the utilization efficiency of the fertilizer can be improved.

The invention provides slow-controlled release fertilizer. The slow-controlled release fertilizer includes a fertilizer core, a binder and an outer coating film, wherein the fertilizer core includes chemical fertilizer and bentonite, the binder includes a polyvinyl alcohol solution, and the outer coating film also includes magnesium ammonium phosphate, super absorbent resin and rooting powder. Theraw materials of the slow-controlled release fertilizer comprise, in parts by mass, 50-85 parts of the chemical fertilizer, 5-10 parts of bentonite, 10-15 parts of the binder, 15-25 parts of magnesium ammonium phosphate, 10-20 parts of the super absorbent resin and 1-3 parts of the rooting powder, and the chemical fertilizer includes nitrogen fertilizer, potassium fertilizer and phosphorus fertilizer at a mass ratio of (25-38):(12-20):(15-24). The slow-controlled release fertilizer has a good slow-release effect.

The gum removing material capable of being injected contains bloom-shaped fiber with thickening effect, corrective, pigment, kaolin as stuffing and other excipient. It is paste with viscosity of (31-71) E6 cP. It is injected to fill into affected gum trough to expand the gum trough properly, control tissue fluid in gum trough, arrest bleeding and ensure dryness in gum trough, so as to facilitate the subsequent operation of obtaining complete impression and making precise false tooth.

The invention discloses an essential oil nano emulsion emulsified by xanthan gum. The essential oil nano emulsion mainly consists of the following components in percentage by volume: 1 to 20 percent of composite oil phase taking clove essential oil as a main component; 60 to 78 percent of a xanthan gum solution; and 15 to 23 percent of a starch octenyl succinate solution. The invention also provides a preparation method and application of the essential oil nano emulsion emulsified by xanthan gum. The nano emulsion can play a role in preserving fresh-cut fruits and vegetables, and particularlycan solve the problems of easy rot and browning of fresh-cut apples in the prior art.

The invention discloses a staphylococcus lysozyme local sustained release preparation, a preparation method and application thereof. The preparation comprises the following components in percentage by weight: 1 to 10 percent of staphylococcus lysozyme, 1 to 10 percent of mannite, 0 to 90 percent of polylactic acid (PLA), and 5 to 95 percent of polylactide-co-glycolide (PLGA). The preparation takes the staphylococcus lysozyme as a bactericidal active component to obtain polylactide-co-glycolide (PLA-PLGA) polymer microspheres containing the staphylococcus lysozyme through supercritical fluid microparticle preparation technology. The preparation has good physical and chemical properties and strong sterilization effect, has adjustable time during the in vitro medicament release, ensures that the medicament release process can reach three days to three months, and has steady release rate.

The invention provides a pH-sensitive agricultural microbial agent. The microbial agent is prepared from a microorganism, a binder, a dopamine or a salt thereof, and a pH-sensitive high polymer molecule. The pH-sensitive high polymer molecule is a high polymer molecule polymerized by an acrylic acid by using graphene oxide as a crosslinking agent. According to the invention, the dopamine is attached to a surface of the living granulating agent, then the pH-sensitive high polymer molecule are covered on a surface of the dopamine, so as to prepare the pH-sensitive agricultural microbial agent that a release of living bacteria of the agent can be adjusted according to the pH of the environment. In the saline-alkaline soil, by applying the pH-sensitive agricultural microbial agent provided bythe invention, the living bacteria can be quickly released, so as to accelerate the improvement of soil salinization problem; while applying the pH-sensitive agricultural microbial agent provided by the invention in the acidic soil, the release rate of the live bacteria can be effectively slowed down, so as to prevent the loss of the organic fertilizer produced by the decomposition of the living bacteria in the acidic soil, and to improve the utilization efficiency of the fertilizer.

The invention belongs to the technical field of oral cavity health care, and particularly relates to a chewable composition (such as chewing gums) containing phosphosilicate glass and a preparation method of the chewable composition. The chewable composition containing phosphosilicate glass and a chewable substance are prepared, wherein after the phosphosilicate glass is in contact with oral cavity saliva, a series of chemical reactions can occur, and finally, the repairing effects of the phosphosilicate glass on the surfaces of teeth or gums can be exerted. In addition, the phosphosilicate glass in the chewable composition and the chewable substance has high dissolving-out properties and stable pH value, so that various gene expression can be promoted, and the purpose of preventing and treating oral cavity problems of oral cavity infection, oral cavity ulcer, gingivitis and the like can be achieved; and besides, through remineralization of the chewable composition on teeth, hemodia can be relieved. The preparation method disclosed by the invention is simple in technology, the raw materials are cheap and easy to obtain, and the chewable composition is suitable for industrialized mass production.

The invention relates to the field of pharmaceutic preparations, in particular to a ginkgolide K preparation and a preparation method thereof. A ginkgolide K hot-melt extruded capsule is prepared fromthe following components in parts by mass: 7.5 to 15 parts of ginkgolide K, 30 to 75 parts of a hydrophilic macromolecular carrier, 5 to 40 parts of a solubilizer and a stabilizer and 2 to 15 parts of a plasticizer. The invention further discloses a preparation method of the ginkgolide K hot-melt extruded capsule. According to the preparation method, the ginkgolide K is prepared into the hot-meltextruded capsule, so that the dissolubility of the ginkgolide K is improved, and the biological utilization degree of oral administration can be increased; the ginkgolide K preparation has the characteristics of small use amount, high product stability, increase of the drug use compliance of a patient and the like.

The invention relates to the field of pharmaceutical preparations, in particular to a rivaroxaban tablet and a preparation method thereof. According to the rivaroxaban tablet, a co-treatment substance formed by mannitol and other pharmaceutically acceptable auxiliary materials is mixed with rivaroxaban, and the mixture can be directly tableted to form a tablet, especially in a rivaroxaban micronized raw material; and by adoption of the composition provided by the invention, the problem of uneven dispersion caused by easy agglomeration of the raw material during tabletting of the conventional rivaroxaban micronized raw material can be solved. The process for preparing the tablet from the composition is few in steps, the required equipment is simple, the manpower and fixed asset cost for preparing the rivaroxaban tablet can be greatly reduced, and meanwhile after the composition is tableted, the rivaroxaban content uniformity is better, the release rate is high, and the release degree is more stable.

The invention provides pH sensitive organic bacterial manure. The bacterial manure comprises organic matters, bacteria beneficial to the growth of plants, dopamine or salt thereof, and pH sensitive polymer molecules synthesized from acrylate by adopting graphene oxide as a cross-linking agent. The dopamine is attached to the surface of the organic matter and beneficial bacteria, the surface of thedopamine is coated with the pH sensitive polymer molecules, so that the pH sensitive organic bacterial manure provided in the invention capable of adjusting the release amount of organic bacterial fertilizer wrapped therein can be prepared. By applying the pH sensitive organic bacterial manure provided in the invention in the salinization soil, the organic fertilizer and live bacteria in the organic bacterial manure can be rapidly released, so that the salinization problem of the soil can be rapidly improved; and by applying the pH sensitive organic bacterial manure in the acidified soil, therelease rate of the fertilizer can be effectively retarded, the loss of the fertilizer in the acidic soil can be prevented, and the utilization efficiency of the fertilizer can be improved.

The invention relates to a pharmaceutical composition containing idebenone and a preparation method thereof, in particular to a polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol graft copolymer and idebenone that can improve cognitive behavior A pharmaceutical composition of benzoquinone and a preparation method thereof belong to the technical field of pharmaceutical preparations. The pharmaceutical composition comprises idebenone, a stabilizer and a freeze-drying protective agent, wherein the percentage composition of each component in the composition is as follows: idebenone accounts for 20-50%, and stabilizer accounts for 2-50%. 10%, freeze-drying protective agent accounts for 40-60%, and the weight ratio of idebenone to stabilizer is 15:1-3:1. The present invention uses freeze-drying technology to freeze-dry the prepared pharmaceutical composition suspension to obtain a powdered pharmaceutical composition, and the freeze-dried powder of the pharmaceutical composition can be rapidly dispersed into Nanosuspension state.

The invention provides a curcumin carrier with temperature response. A lyotropic liquid crystal (hexagonal phase and three-dimensional phase) is built in a water medium with non-ionic surfactants (Brij97 and Tween40) and oleic acid to serve as a drug carrier of curcumin. When the temperature of the drug carrier provided by the application rises, the releasing rate of a sample increases, and the highest releasing rate is reached when the temperature of the drug carrier is approximate to the temperature of human body. The drug carrier can be released rapidly after being taken, and facilitates rapid treatment of diseases with drug. Moreover, the carrier has a better slow-releasing effect on the curcumin, and can reduce the taking times of the curcumin.