Risperidone nano-suspension temperature sensitive gel and its preparation method

A temperature-sensitive gel and nano-suspension technology, which can be used in pharmaceutical formulations, aerosol delivery, and medical preparations containing active ingredients. Achieve broad application prospects, avoid the effects of less drug release and less residue
CN104288091AInactive Publication Date: 2015-01-21HENAN UNIV OF SCI & TECH
4 Cites 14 Cited by

Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
HENAN UNIV OF SCI & TECH
Publication Date
2015-01-21
Estimated Expiration
Not applicable · inactive patent

Smart Images

  • Figure 1
    Figure 1
  • Figure 2
    Figure 2
  • Figure 3
    Figure 3
Patent Text Reader

Abstract

The invention discloses a risperidone nano-suspension temperature sensitive gel and its preparation method. Each 100ml of the nanosuspension temperature sensitive gel contains 0.1-10g of risperidone, 0.1-5g of a stabilizer, 1-50g of a temperature sensitive gel material, 0-5g of an additive, and the balance of a water-based solvent. The risperidone nano-suspension temperature sensitive gel is a temperature sensitive controlled-release in situ gel. The above dosage form makes risperidone highly dispersed, so the gel has the advantages of good drug load and good stability; after the gel is administrated in a liquid form, phase transition occurs in applied sites, and the liquid becomes non-chemically-crosslinked semisolid gel, so the gel has good histocompatibility and improves the drug dissolution rate; and the administrated gel has a long retention time in the applied sites as a drug reservoir, so the gel has a slow release effect, prolongs the drug release time, improves the drug bioavailability, reduces the administration frequency and improves the drug effect and the patient compliance.
Need to check novelty before this filing date? Find Prior Art

Description

technical field

[0001] The invention belongs to the technical field of pharmaceutical preparations, in particular to a risperidone nano-suspension temperature-sensitive gel, and also relates to a preparation method of the risperidone nano-suspension temperature-sensitive gel. Background technique

[0002] Risperidone is a benzisoxazole derivative, which is a new generation of antipsychotics. It has a strong D2 antagonistic effect and is suitable for acute and chronic schizophrenia and various positive symptoms of psychosis (such as hallucinations, hallucinations, disordered thinking, Suspicion, hostility, etc.) and obvious negative symptoms (such as less speech, unresponsiveness, apathy, social apathy, etc.), can also reduce the emotional symptoms related to schizophrenia (such as depression, anxiety, guilt). Risperidone has significant curative effect, few side effects, and is widely used clinically. Currently, its commercially available preparations include oral liquid, or...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More