81results about How to "Increase dissolution rate" patented technology

The invention belongs to the technical field of resource recycling, and discloses lead-zinc tailing ceramsite and a preparation method thereof. The lead-zinc tailing ceramsite is mainly prepared from the following raw materials in parts by mass: 100 parts of lead-zinc tailings; 20 to 30 parts of limestone tailings; 6-8 parts of active mullite nano powder; 1-3 parts of glass micro powder; and 8-12 parts of dry sludge powder. The invention also provides a preparation method of the lead-zinc tailing ceramsite. The lead-zinc tailings are used as main raw materials to prepare the lead-zinc tailings ceramsite, through compounding of the lead-zinc tailings and the limestone tailings, the synergistic effect of the lead-zinc tailings and the limestone tailings is achieved, resource utilization of the lead-zinc tailings and the limestone tailings is achieved, and good economic benefits and social benefits are achieved. The density grade of the ceramsite prepared by the invention is 600-900, the cylinder compressive strength is 6.8-9.8 MPa, the water absorption rate is 9.4-11.4%, and the ceramsite has relatively good strength and relatively low water absorption rate.

The doxylamine succinate pyridoxine enteric-coated tablet comprises a tablet core and a coating layer, the coating layer comprises a first isolation layer, an enteric-coated layer and a second isolation layer, the materials of the enteric-coated layer comprise a plasticizer, an anti-sticking agent, a defoaming agent and a flexible coating material, and the flexible coating material accounts for 24-28% of the mass of the tablet core. By adding the flexible coating material, the stability of the pharmaceutical preparation is improved, the difference between batches is reduced, the drug dissolution rate reaches 90% or above, and the pharmaceutical preparation can be quickly released.

The invention relates to the technical field of oil well paraffin removal and prevention, and discloses a paraffin removal and prevention agent for an oil well shaft and a preparation process. The paraffin remover and inhibitor for the oil well shaft comprises the following components in parts by weight: 10-25 parts of a compound surfactant, 15-30 parts of a mutual solvent, 5-10 parts of a stabilizer, 1-10 parts of a novel wax crystal improver, 0.2-0.5 part of a rapid penetrant, 0.5-1.5 parts of alkali and 25-70 parts of water, the novel wax crystal improver has a structure similar to that of paraffin, and wax crystals can be dissolved in the novel wax crystal improver, so that the wax crystals are not easy to gather and deposit on a pipe wall, and the dissolution rate of the wax crystals is further improved; sodium sulfonate in the structure has strong polarity and hydrophilicity, can adjust the crystallinity of paraffin inhibitor molecules, has a synergistic effect with asphalt, colloid and the like in crude oil, reduces the surface tension of water, has a good wetting effect, and improves the low-temperature fluidity of the crude oil.

The invention relates to the technical field of oral solid preparations, in particular to a high-bioavailability coenzyme Q10 tablet and a preparation method thereof. The coenzyme Q10 tablet comprises an active component coenzyme Q10, a filler, an adhesive, a disintegrating agent, a lubricant and a high polymer material, compared with the prior art, hydroxyethyl methylcellulose and hydroxypropyl methylcellulose succinate are mixed according to a certain mass ratio to serve as a high polymer carrier material, the prepared coenzyme Q10 tablet can be rapidly dissolved out in vitro, and the coenzyme Q10 tablet has the advantages that the preparation process is simple, and the cost is low. Moreover, the stability of the medicine can be improved, the medicine can be rapidly absorbed in vivo after being orally taken, the oral bioavailability of the coenzyme Q10 is greatly improved, and a preparation process of the preparation is simple to operate, good in reproducibility and suitable for industrial production.

The present invention provides a particle collision disturbance type gas lift loop reactor, the reactor comprising: a reactor body; a draft tube with a sieve plate; particles, which can be suspended inside the draft tube when the reactor is running; a gas distributor; a main liquid distributor; a gas inlet; a liquid inlet; a gas outlet; and a liquid outlet. Compared with the traditional gas lift loop reactor, due to the turbulent disturbance of particles and fluid inside the draft tube of the reactor, it helps to prevent gas phase aggregation and increase liquid phase back mixing, so that the gas and liquid phases in the reactor are fully mixed, the solubility of the gas phase in the liquid phase and the gas-liquid contact area are increased, the mass transfer rate and heat transfer rate between fluids are improved, and at the same time, the temperature distribution in the reactor is uniform, which is conducive to gas-liquid two-phase reaction or gas-liquid-solid three-phase reaction, and can be widely used in gas-liquid two-phase or gas-liquid-solid three-phase chemical reaction processes.

The invention discloses a method for preparing iron phosphate and aluminum oxide by utilizing step-by-step leaching of red mud, which comprises the following steps: (a) carrying out ore grinding treatment on the red mud to obtain red mud powder with preset fineness; (b) adding the red mud powder into mixed acid, carrying out acid leaching treatment at 30-50 DEG C, carrying out ultrasonic treatment assisted in the acid leaching process to obtain a leaching mixed solution, and carrying out solid-liquid separation on the leaching mixed solution to obtain leaching residues and a leaching solution containing iron and aluminum ions; the mixed acid is a mixed solution of hydrochloric acid, oxalic acid and phosphoric acid, the molar ratio of hydrochloric acid to oxalic acid is (2-5): (2-5), and the ratio of the amount of phosphoric acid substance to the amount of iron substance in the red mud is (0.9-1.2): 1; the molar concentration of H < + > in the mixed acid solution is 4-10 mol / L; (c) adjusting the pH value of the leachate, carrying out auxiliary stirring reaction under a set temperature condition, and then aging and filtering to obtain crude iron phosphate and filtrate; (d) calcining the crude iron phosphate, and cooling to obtain battery-grade iron phosphate; (e) adjusting the pH value of the filtrate, carrying out auxiliary stirring reaction under a preset temperature condition, and then aging and filtering to obtain aluminum hydroxide precipitate; and (f) calcining the aluminum hydroxide precipitate, and cooling to obtain the aluminum oxide.

The method comprises the following steps that the lithium slag is sequentially subjected to first magnetic separation treatment, ore grinding treatment and second magnetic separation treatment, and iron concentrate and magnetic separation treatment tailings are obtained; the magnetic separation treatment tailings are sequentially subjected to first-stage acid treatment and second-stage acid treatment, and iron-removed and desulfurized lithium slag is obtained; wherein the acids used in the first-stage acid treatment are citric acid and hydrochloric acid, and the acids used in the second-stage acid treatment are citric acid and nitric acid. According to the method, two times of high-strength magnetic separation and two times of acid treatment are combined, the removal process of iron and sulfur in the lithium slag is optimized, and the iron removal and sulfur removal efficiency is remarkably improved.

The invention belongs to the technical field of metal materials and processing, and relates to a dissoluble magnesium alloy structure, a material and a preparation method. The magnesium alloy structure comprises nano-sized magnesium alloy grains and metal elements segregated along the grain boundary. The nano-sized magnesium alloy crystal grains comprise magnesium alloy crystal grains with the size of 1-999 nm; the segregation amount of the metal elements comprises 1 to 100 atomic layers; the low-alloying material Mg < n > A E < e > alloy of the soluble magnesium alloy structure is specifically prepared from 0.001 at.%-0.5 at.% of an element A, 0.001 at.%-0.5 at.% of an element E and the balance of an element Mg, wherein the element A is selected from one or more of Al, Zn, Ca, Mn, Zr, Si, Sr and RE elements; and the E element is selected from one or more of Cu, Ni and Co elements. The preparation method of the low-alloying material comprises the processes of alloy casting, machining forming, surface nanocrystallization, heat treatment and the like. The prepared soluble magnesium alloy material has good mechanical property and dissolving property, and can meet the requirement of soluble magnesium alloy required by shale oil and gas development.

A Karl Fischer reagent production reaction kettle comprises a reaction kettle body, a reaction kettle cover, an isolation cylinder, an isolation cover, a position control supporting rod, a lifting seat, a rotating seat and a limiting sliding rod, the inner side of the reaction kettle body is connected with the isolation cylinder, the isolation cylinder is provided with a lower positioning plate, the lower positioning plate is connected with the reaction kettle body, and the reaction kettle body is provided with a plurality of lower positioning slots. The lower positioning plate is provided with a plurality of lower positioning insertion rods, the lower positioning insertion rods are matched with the lower positioning insertion grooves and connected with the lower positioning insertion grooves, a lower fixing pipe is arranged at the bottom of the reaction kettle body, a discharging pipe is arranged at the bottom of the isolation cylinder and connected with the interior of the lower fixing pipe, and the exterior of the lower fixing pipe is connected with a lower fixing cover through threads. The lower part of the reaction kettle body is connected with fixed support legs, the upper part of the reaction kettle body is connected with a reaction kettle cover, the reaction kettle cover is provided with an upper fixed plate, the reaction kettle body is provided with a lower fixed plate, and the upper fixed plate is connected with the lower fixed plate.

The invention provides a composition for treating nerve headache and a preparation method thereof, and belongs to the technical field of medicines. The preparation method comprises the following steps: carrying out steam explosion treatment on traditional Chinese medicine powder, adding the traditional Chinese medicine powder into saline water, decocting, filtering, standing filtrate to separate out a hydrochloric acid extract, adding filter residues into ethanol, adsorbing by a magnetic adsorbent, separating by a magnet, eluting, desorbing, recovering an eluent to obtain an alcohol extract, mixing and grinding the alcohol extract, the hydrochloric acid extract and flunarizine hydrochloride / nimodipine eutectic, and filling capsules with the alcohol extract and the flunarizine hydrochloride / nimodipine eutectic. The composition for treating the nerve headache is prepared. The traditional Chinese medicine composition treats neuropathic migraine through a method of combining traditional Chinese medicine and western medicine, treats both symptoms and root causes, and is good in effect and quick and lasting in effect.

The application belongs to the technical field of copper foil and particularly relates to a copper wire forming device, which comprises a spraying part provided with a liquid spraying opening, the spraying part being capable of spraying a drawing liquid to the copper wire through the liquid spraying opening; and an extrusion assembly arranged on one side of the spraying part, the extrusion assembly being capable of forming a protrusion on the surface of the copper wire sprayed with the drawing liquid. The application can relieve the drawing stress by spraying the drawing liquid before the protrusion is formed on the surface of the copper wire, so as to avoid the rupture of the copper wire and ensure the continuity of the copper wire winding disc.

The utility model relates to the technical field of gold ore analysis and test pretreatment, and discloses solid sample and reagent rapid mixing equipment which comprises a tank body, a first threaded mounting seat is arranged at the top of the tank body, a tank cover is in threaded connection in the first threaded mounting seat, a fixing pipe is fixedly connected in the tank cover, and a fixing sleeve is fixedly connected to the bottom of the fixing pipe. A fixed sleeve is arranged in the tank body, a sliding sleeve is connected to the outer wall of the fixed sleeve in a sliding manner, a lifting pipe is fixedly connected to the bottom of the sliding sleeve, and a second threaded mounting seat is arranged at the bottom of the lifting pipe. The solid sample is placed in the circulating flow channel in the tank body, so that the dissolution rate between the solid sample and the solvent is increased through rapid flowing between the solvent and the solid sample, meanwhile, uniform dissolution of the solid sample in the solvent is achieved through circulating flowing of the solvent, and the practicability of the equipment is improved.

The application discloses a method for regenerating cellulose from waste cotton based on ion solvation pretreatment and application thereof, and belongs to the technical field of high-value utilization of biomass resources. The method is characterized in that waste cotton fabric is immersed in a metal halide aqueous solution for ion solvation pretreatment, and then subjected to mild decolorization by a reduced decoloring agent, and then high-polymerization-degree cotton cellulose after decolorization is dissolved in a cellulose solvent system to obtain a high-transparency and high-activity cellulose solution. The cellulose solution can be widely applied to the fields of regenerated cellulose fiber spinning, nanocellulose preparation, functional aerogel / hydrogel construction and high-performance gel electrolyte. The application overcomes the problem that the thoroughness of decolorization and the retention of polymerization degree of regenerated waste cotton textiles are difficult to be considered simultaneously, and realizes efficient decolorization, high-polymerization-degree retention and efficient dissolution of waste colored cotton textiles in various solvent systems.

This invention relates to the field of gray cast iron material preparation technology, and particularly to a method for preparing multi-alloy synergistically strengthened gray cast iron, comprising: adding steel raw materials to a smelting apparatus and heating to form molten iron; adding a chromium alloy to the molten iron, heating and holding at that temperature to form a basic mixture; determining the degree of furnace lining peeling based on the vibration frequency of the smelting apparatus, and determining the overheating risk level of the basic mixture based on the degree of furnace lining peeling; determining a target heating temperature based on the overheating risk level; determining the eddy current risk level based on the actual rotation speed; adjusting the stirring intensity during the smelting process based on the eddy current risk level; detecting the mixing ratio of the basic mixture and adjusting the amount of steel raw materials or the chromium alloy added to form a target solution; and simultaneously adding manganese nitride, alloyed tin, and ferrous sulfide to the target solution in a specified ratio to form multi-alloy synergistically strengthened gray cast iron. This invention improves the strength, toughness, fluidity, and resistance to solidification defects of gray cast iron.

This invention relates to the field of waste salt resource utilization and industrial waste gas treatment technology, and provides a skid-mounted micro-interface enhanced dual electro-displacement device for preparing ammonium alkali from mixed salts. The invention includes a selective electrodialysis unit, a micro / nano bubble generator unit, and at least two sets of parallel multi-chamber dual electro-displacement units. The selective electrodialysis unit separates a mixed salt solution of sodium chloride and sodium sulfate into sodium chloride and sodium sulfate stock solutions. This device integrates selective electrodialysis, the micro / nano bubble generator, and the dual electro-displacement unit in a skid-mounted configuration, forming an integrated continuous flow reaction system. This device achieves efficient and synergistic resource conversion of industrial waste salt and waste gas, producing sodium carbonate and ammonium salts with high purity that meet national standards. Furthermore, the process is energy-saving, environmentally friendly, and produces no secondary pollution.

According to the method for testing the purity of the metal rubidium, an organic alcohol-nitric acid solution system is adopted to dissolve a metal rubidium sample, organic alcohol can accelerate the dissolution rate of the metal rubidium sample, on one hand, the contact time of the metal rubidium sample and air can be greatly shortened, and the spontaneous combustion risk of the metal rubidium sample in the air is reduced; therefore, the safety of the whole test process is improved; on the other hand, the dissolution efficiency is improved, so that the possibility that the metal rubidium sample is exposed in the air for a long time is reduced, impurities in the air are prevented from being mixed into a sample system to interfere a test result, and the accuracy of the test result is improved; meanwhile, the nine impurity elements are accurately tested by combining two high-sensitivity and high-precision analysis means of inductively coupled plasma atomic emission spectrometry and inductively coupled plasma mass spectrometry, and the accuracy of the test result is further guaranteed by calculating the total mass of the impurities and converting the purity of the metal rubidium.

The utility model discloses a mixer for preparing a cell culture medium, which comprises a dissolving barrel and a mixing barrel, a fixed pipe and a hopper are arranged on the dissolving barrel, a rotating pipe is rotatably arranged at the bottom of the fixed pipe, a charging barrel is arranged on the rotating pipe, a material hole is formed in the charging barrel, a rotating device is arranged on the dissolving barrel, a plug is arranged on the dissolving barrel, and a stirring frame is arranged on the mixing barrel. A driving device is arranged on the stirring frame, a stirring pipe is rotationally arranged on the stirring frame, stirring blades are arranged on the stirring pipe, a circulating pipe and a water outlet pipe are arranged on the stirring pipe, a circulating pump is arranged in the circulating pipe, a circulating disc is arranged at the bottom of the stirring pipe in a communicating mode, and circulating holes are formed in the circulating disc. The material barrel is driven to rotate through the rotating device, the stirring pipe and the stirring blades are driven to rotate through the driving device, nutrient substances in the mixing barrel are conveniently stirred, the mixing efficiency is improved, the nutrient substances are driven to circulate through the circulating pump, and the mixing effect and the mixing efficiency are further improved.

This invention belongs to the field of sanitary ware technology and discloses a low-consumption vacuum toilet pulse flushing mechanism and sewage discharge method; it includes a toilet body, a water tank fixedly mounted on the toilet body, a toilet seat rotatably hinged to the toilet body, two independently detected infrared sensors fixedly mounted on the toilet body, and five water outlets arranged in a circumferential pattern on the inner wall of the toilet body's rim, each water outlet specifically arranged at a 35-degree angle to the inner wall of the toilet body; the five 35-degree circumferential water outlets spray a vortex thin water film with a water pressure of 0.35-0.5MPa, forming a full-coverage lubricating layer on the inner wall of the toilet in advance, preventing feces from directly adhering to the ceramic glaze from the source, eliminating the need for subsequent water replenishment and achieving water-saving pre-lubrication of the wall upon sitting. The water outlets are all designed with a 35-degree inner wall angle, and the water flow is sprayed out along the tangent of the inner wall of the rim, forming a closed-loop vortex water flow. Compared with vertical water outlets, the flushing coverage area of ​​the inner wall is comprehensively improved, and no dirt in the dead corners of the rim is missed.

This application relates to the field of demetronidazole premixes, and in particular to a highly water-soluble demetronidazole premix and its preparation method. This application involves first preparing a salt from demetronidazole and an organic acid, and then coating it with a hydrophilic carrier. This significantly improves the solubility and dissolution rate of demetronidazole, while also improving the palatability and stability of the formulation, resulting in minimal sedimentation when dissolved in water.

This invention discloses a modified volcanic rock ultrafine composite admixture and its preparation method, belonging to the technical field of building materials and solid waste resource utilization. The admixture is composed of volcanic rock, S95 grade mineral powder, fluorogypsum, silica fume, lime powder, nano-alumina, triisopropanolamine, and polycarboxylate superplasticizer in a specific ratio. The invention also discloses its preparation method, including drying, weighing, and co-grinding the raw materials to a D50 of 7.0-8.0 μm. Through the synergistic activation effect among the components, especially the depolymerization of the volcanic rock vitreous network by F⁻ in the fluorogypsum, the adjustment of the calcium-silicon ratio between the mineral powder and volcanic rock, and the combined effect of nanomaterials and chemical additives, the early and late-stage activity of the volcanic rock is significantly improved, and the water demand is reduced. The obtained admixture has a 7-day activity index ≥85%, a 28-day activity index ≥88%, and a water demand ratio ≤108%, and can directly replace traditional mineral powder and fly ash in concrete, solving the problem of the scarcity of high-quality admixtures in western regions, and has significant economic and social benefits.

The invention discloses a celecoxib solid self-emulsifying nano-microsphere and a preparation method and application thereof. The celecoxib solid self-emulsifying nano-microsphere of the invention comprises an outer shell and an inner core arranged in the outer shell, wherein the raw materials for preparing the outer shell comprise: a polymer and a solvent; and the raw materials for preparing the inner core comprise: celecoxib, an oil phase, an emulsifier, an emulsifier and a precipitation inhibitor. The celecoxib solid self-emulsifying nano-microsphere has the advantages of good dispersibility, uniform particle size and large drug loading, and can be rapidly emulsified when encountering an aqueous environment of the gastrointestinal tract, significantly improving the dissolution rate and oral bioavailability of celecoxib. In addition, the preparation process of the invention is simple, there is no heating process, and the obtained product has stable quality, and is suitable for industrial production.

The utility model relates to a clothes processing device. The clothes processing device comprises a machine shell; the cylinder assembly is arranged in the machine shell, and a washing cavity is formed in the cylinder assembly. The water inlet box is arranged on the machine shell. A first water inlet is formed in the water inlet box; the first water inlet can be communicated with an external water source; the detergent box is arranged in the water inlet box in a push-pull manner; a mixing cavity is formed in the detergent box; a siphon opening is formed in the mixing cavity and is communicated with the washing cavity; wherein the impeller is rotatably arranged in the mixing cavity; the siphon ports are arranged on the peripheral side of the impeller at intervals; when the detergent box is pushed into the water inlet box, the first water inlet can be communicated with the mixing cavity and is arranged towards the impeller; an external water source can impact the impeller through the first water inlet so as to drive the impeller to rotate and stir liquid in the mixing cavity; and the stirred liquid can flow into the washing cavity through the siphon port. According to the clothes processing equipment, the dissolution rate and the dissolution rate of the detergent can be increased, and the washing effect of the clothes processing equipment is improved.

The utility model provides a kind of puerarin production extraction device, belong to puerarin production technical field, comprising: extraction mechanism, the one side of extraction mechanism is equipped with filter-pressing mechanism, the extraction mechanism includes extraction box, the surface fixedly connected with support frame in extraction box one side, the inner wall slidingly connected with sealing cover of support frame, the surface rotationally connected with rotating paddle of sealing cover, the upper surface fixedly connected with the pulverization box of sealing cover, the inner wall rotationally connected with two crushing rollers of pulverization box, the raw material is directly dropped into extraction box after being broken by crushing roller in the scheme, carry out efficient extraction under the stirring of rotating paddle, obtained mixture can be sent into filter-pressing mechanism for rapid separation by booster pump without artificial transfer, reduce the material transfer loss and time delay between production links, improve production efficiency, while effective crushing and stirring significantly increase the dissolution rate and extraction rate of puerarin.

This application discloses a sulfur-lead composite steel rod and its preparation method, as well as a steel pipe and soluble structural components, solving the technical problem that soluble bridge plugs in the prior art do not meet the high-pressure maintenance requirements of deep wells. The steel rod comprises the following chemical composition in parts by mass: Fe: 90-97.5 parts, C≤0.6 parts; S: 0.1-0.6 parts, Mn: 0.50-3.00 parts, Pb: 0.2-0.3 parts, O: 0.0010-0.0200 parts; the steel rod has composite inclusions; the composite inclusions include an inner core and a continuous or discontinuous outer shell distributed around the inner core, the inner core including manganese sulfide particles, and the outer shell including first lead particles; the steel rod includes a first region, a second region, and a third region arranged sequentially from the inside out; the average equivalent diameter of the composite inclusions in the first region is larger than that in the second region; the number of composite inclusions per square millimeter in any cross-section of the third region is greater than that in the second region. The sulfur-lead composite steel rod provided by this application has high strength and meets the high-pressure maintenance requirements of deep wells.

The present invention relates to the field of medicine, and in particular to a pretreatment method of a nimesulide bulk drug and a composition thereof. The present invention provides a nimesulide bulk drug with a special particle size distribution, and the bulk drug with the particle size distribution is used to prepare a nimesulide product, which can improve the solubility and uniform dissolution of the nimesulide product. The present invention also provides a pretreatment method of a nimesulide raw material, which uses airflow pulverization to pulverize the poorly soluble drug nimesulide, and utilizes the collision of the material's own particles to prepare micronized poorly soluble drug nimesulide of a certain particle size. By controlling airflow pulverization parameters, optimal feed amount, and discharging method, the loss is reduced; the bulk drug after airflow pulverization is properly treated to reduce the degradation of the excellent properties of the powder caused by the re-agglomeration of the material after airflow pulverization; the particle size of the bulk drug obtained under the airflow pulverization parameters is monitored, and a nimesulide composition is prepared, and the optimal particle size range is screened by the dissolution curve.

This invention discloses a method for cyclically separating waste positive electrode current collectors and positive electrode materials using NMP, comprising the following steps: adding the positive electrode sheet to an NMP solution, stirring, and sieving to obtain a positive electrode cleaning filtrate and aluminum foil; adding a flocculant to the positive electrode cleaning filtrate, stirring, and allowing it to stand for solid-liquid separation to obtain crude NMP solution and positive electrode material powder; adding a dehydrating agent to the crude NMP solution, filtering to remove solids to obtain a recovered NMP solution, which is then recycled for the separation of the positive electrode current collector and positive electrode material. This method reuses the NMP solution repeatedly, thus reducing costs and solving the problem of high costs associated with organic solvents. Furthermore, by introducing non-solvent water into the system, the thermodynamic stability of the system is altered, increasing the solubility of PVDF and accelerating the dissolution rate.

The invention provides a preparation method of a topiramate pharmaceutical composition and the topiramate pharmaceutical composition. The preparation method comprises the following steps: dissolving a flavoring agent in an organic solvent which is heated to a certain temperature, and then adding topiramate, other organic solvents and other components. According to the preparation method disclosed by the invention, the dissolution rate of the flavoring agent is improved while the quality of the medicine is ensured, the process time is shortened, and the prepared pharmaceutical composition has remarkably improved quality stability.

The invention relates to a polymer-coated self-assembled tripterine nano particle as well as a preparation method and application thereof. The nano particle comprises a nano aggregate and a polymer shell, wherein the nano aggregate is formed by self-assembling tripterine or medicinal salt of the tripterine, and the outer surface of the nano aggregate is coated with the polymer shell. According to the self-assembled tripterine nano particle disclosed by the invention, the problems of dissolution rate and solubility of the tripterine are effectively improved, and the biocompatibility of the tripterine is improved. In addition, the polymer layer coated on the surface of the nano particle enables the structure of the nano particle to be more stable, and the residence time of the tripterine in a respiratory tract system is effectively improved. Meanwhile, under the condition of using the same dosage, compared with tripterine monomer molecules or nanoparticles not coated with polymers, the product disclosed by the invention has a more excellent antibacterial effect.

The invention discloses an asenapine maleate oral adhesion film preparation as well as a preparation method and application thereof, belongs to the field of pharmaceutical preparations, and particularly relates to an asenapine maleate self-nanoemulsion oral adhesion film and an asenapine maleate nanocrystal oral adhesion film preparation. The self-nanoemulsion can improve the solubility of asenapine maleate, the lower surface tension of the self-nanoemulsion is beneficial to penetrating through a mucous membrane hydration layer and enhancing mucous membrane absorption, and the nanocrystal can improve the solubility and dissolution rate of API, increase the drug concentration gradient near the oral mucosa and promote diffusion and oral absorption of drugs. The oral cavity adhesion film can adhere to the sublingual part and rapidly release the medicine, the medicine is absorbed by rich submucosal blood vessels and directly enters systemic circulation, metabolism of the gastrointestinal tract and the liver is avoided, and then oral bioavailability is enhanced.

This invention relates to the field of traditional Chinese medicine technology, specifically to a method for preparing concentrated Astragalus membranaceus pills and its application, including the following steps: (1) preparing a clear extract by alcohol extraction; (2) making pills by plastic molding; (3) drying the pills at a constant temperature. In the pill-making process, this invention selects 100-mesh Astragalus membranaceus mixed fine powder and adopts a mass ratio of clear extract to fine powder of 1:2. Since the 100-mesh powder has a uniform particle size and a moderate specific surface area, it can fully contact and bond with the clear extract, avoiding the problem of the pills being rough and cracked due to excessive particle size and the pills being too fine due to excessive moisture dissipation. The 1:2 ratio makes the soft material suitable for its softness and hardness, so that it will not be loose and difficult to form due to excessive powder ratio, nor will it cause adhesion and blockage of the mold due to excessive clear extract ratio. Combined with the gradient humidity soft material preparation technology, 60% purified water is added first and mixed evenly, and then the remaining water is added in two batches. Low-frequency vibration is applied simultaneously for mixing, which can make the internal humidity of the soft material uniform and the bonding force stable, thereby obtaining wet pills with smooth surface, round shape and no cracks.