50 results about "Transudate" patented technology

Topical exposure of nitric oxide gas to wounds such as chronic non-healing wounds may be beneficial in promoting healing of the wound and in preparing the wound bed for further treatment and recovery. Nitric oxide gas may be used, for example, to reduce the microbial infection and burden on these wounds, manage exudate secretion by reducing inflammation, upregulate expression of endogenous collagenase to locally debride the wound, and regulate the formation of collagen. High concentration of nitric oxide ranging from about 160 to 400 ppm may be used without inducing toxicity in the healthy cells around a wound site. Additionally, exposure to the high concentration for a first treatment period reduces the microbial burden and inflammation at the wound site and increase collagenase expression to debride necrotic tissue at the wound site. After a first treatment period with high concentration of nitric oxide, a second treatment period at a lower concentration of nitric oxide preferably ranging from about 5-20 ppm may to provided to restore the balance of nitric oxide and induce collagen expression to aid in the closure of the wound.

A wound dressing for release of one or more therapeutic ingredients wherein the therapeutic ingredients are contained in liposomes, said liposomes may comprising releasing means being triggered by a wound constituent and thereby releasing the therapeutic ingredients of the liposomes. The dressing further comprises wound exudates handling means and is suitable for moist wound healing.

A wound dressing product, combining both a traditional dressing with a mounted absorbent material and a hydrophobic fabric attached thereto, which is to be placed towards the wound, and is capable of binding unwanted microorganisms. The wound dressing product protects the wound, absorbs exudate and reduces the number of pathogenic microorganisms, without using antimicrobial substances, and consists of three bonded layers: hydrophobic cellulose acetate fabric which binds microorganisms, an attached efficient absorbent material, and a backing (cover) which is preferably visually transparent, semi-permeable and self-adhesive.

Apparatus (130) for use in wound therapy of mammals is described, the apparatus (130) comprising: a dressing covering the wound, the dressing being substantially sealed to prevent ingress of ambient atmospheric air to the wound; aspiration means (132) operably connected to a space between the dressing and the wound by an aspiration conduit (142) sealed to the point of entry between wound and dressing against ingress of ambient atmosphere, said conduit (142) being for aspiration of said wound and for removal of fluid from said space between said wound and said dressing; a waste container (148) for receiving aspirated fluid to be discarded operably connected to said aspiration conduit; and heating means (144) for heating said fluid in order to increase the vapor pressure thereof and to cause evaporation to reduce the volume of the fluid in the waste container (148). In a preferred embodiment of the present invention the waste fluid is also provided with a sparge gas.

Disclosed herein are several embodiments of a negative pressure apparatus and methods of using the same in the treatment of wounds. Some embodiments are directed towards improved fluidic connectors configured to transmit irrigation fluid and to apply aspiration to a wound, for example using softer, kink-free conformable layers. Some embodiments may comprise a first channel for delivering irrigation fluid to the wound and a second channel for transmitting negative pressure and removing fluid comprising irrigation fluid and wound exudate from the wound, wherein the channels comprise a flexible spacer material. Some embodiments are directed toward an irrigation manifold attachable to or incorporated as part of a distal end of an irrigation and aspiration fluidic connector.

The invention provides a separation method of the geniposide, including: extracting the geniposide from the Gardenia to produce a concrete with a hydrophilic organic water solution; removing the gardenia yellow pigment of the concrete by a large-hole adsorbed resin; depressed recovery of the solvent of the transudate, and concentrating to a coarse geniposide in vacuum; fully extracting the coarse product by hot ethylhexoate, cryogenic treatment of the extract, getting the geniposide crystal; crystallizing the ethylhexoate and acetone solvent and removing the impurities in room temperature; an obtaining the geniposide crystal with a purity >=98%. The invention separates the highly purified geniposide crystal. It has a cheap material, an easy and effective preparation craft, a broad extension and a novel design.

The invention discloses a method for extracting fructus momordicae amylose. Firstly, the fructus momordicae is crushed and is leached in boiled water for three times, each leaching lasts 1.5 hours, the leaching fluid is merged and is chromatographic through a macroporous resin column to obtain the fructus momordicae flavone glycoside, the film separation is performed in the transudate to obtain the fructus momordicae amylose product; or the film separation is performed in the extracted fluid to obtain the fructus momordicae amylose product, the separating medium is chromatographic through the macroporous resin column to obtain the fructus momordicae flavone glycoside. The two extracting methods can finish the steps of separation, extraction and concentration in one step and can realize the continuous production; the high-efficiency film separation technique is adopted, the yield rate of fructus momordicae amylose is high; the used solvent only adopts water and ethanol, thereby not generating any waste water or waste residue polluting the environment; moreover, the recycling is realized, thereby saving raw materials and greatly lowering the cost; the raw materials can be the waste fluid containing amyloase wasted by an enterprise, thereby improving the utilization rate of the effective component of fructus momordicae and the benefits of the enterprise; and the device is simple and the investment is small.

A wound dressing comprising a web of gel-forming fibers or fibers soluble in wound exudates, attached to a reinforcing layer wherein the density of the web is in the range of 5-60 g / m2. The dressing may serve as a wound-contacting layer, providing moist wound healing combined with easy, non-traumatic removal from the wound site. The dressing may further comprise one or more active ingredients.

The invention provides a continuous negative-pressure drainage device capable of intermittently inflating and flushing and belongs to the technical field of medical instruments in the orthopedics department. The device is used for continuous negative-pressure drainage, that is, inflating and flushing are intermittently conducted on the surface of a wound. The device is characterized in that a negative-pressure drainage pipe is connected with an inflating pipe and a flushing water pipe, an air inlet end of the inflating pipe and an water inlet end of the flushing water pipe are connected with an oxygen delivery pipe and a flushing water pipeline respectively, the inflating pipe and the flushing water pipe are provided with electric control valves respectively, and the electric control valves are connected with a programmable controller respectively. According to the device, oxygen and physiological saline are supplied intermittently, anaerobic bacteria infection can be inhibited, exudate and contaminated tissue can be cleared away, repeated debridement is avoided, when oxygen supply and flushing are conducted, a continuous negative pressure environment can be created, exudate and necrotic tissue of the wound can be timely cleared away and drained, the local microcirculation is improved, relieving of edema of soft tissue is promoted, the growth of granulation tissue is stimulated, wound healing is accelerated, a good condition is provided for the follow-up treatment, and the treatment process is sped up.

The invention discloses a negative pressure wound treating system capable of detecting transparency of wound percolate, comprising a liquid collecting bottle, a negative wound treating device, a wound external member and a wound percolate transparency detecting module, wherein the liquid collecting bottle is used for collecting the wound percolate; the negative pressure wound treating device is composed of a negative pressure source and a controller; the wound external member is used for filling a wound and sealing the wound and is communicated with the liquid collecting bottle through a connection tube; and the wound percolate transparency detecting module comprises an emitting unit, a receiving unit and a detection control unit, wherein the emitting unit is used for emitting electromagnetic wave or sound wave signals to the liquid collecting bottle, the receiving unit is used for receiving the electromagnetic wave or sound wave signals reflected or refracted by the liquid connecting bottle and the detection control unit is arranged in the controller and is used for judging whether the transparency of the wound of the position at which the wound percolate transparency detecting module is arranged. The negative pressure wound treating system capable of detecting the transparency of the wound percolate can detect the transparency of the wound percolate, and provides convenience for management and research of the wound percolate of medical workers or other users.

The invention discloses a negative pressure wound therapeutic system capable of detecting and displaying a transudate volume, comprising a liquid collecting bottle, a negative pressure wound therapeutic apparatus, a wound kit, a transudate volume detection module, a storage unit and a display interface, wherein the liquid collecting bottle collects wound transudate, the negative pressure wound therapeutic apparatus consists of a negative pressure source and a controller, the wound kit fills and seals a wound and is communicated with the liquid collecting bottle through a connecting tube, the transudate volume detection module detects the volume of the transudate in the liquid collecting bottle, the storage unit stores the transudate volume according to time, and the display interface displays the time stored by the storage unit and transudate volume data. The negative pressure wound therapeutic system capable of detecting and displaying the transudate volume can detect and display the time and the corresponding transudate volume and provides convenience for researches of medical care personnel.

The invention provides a flushing system (1) configured to flush the pericardial cavity (PC) of a patient, wherein the system comprises: an infusion liquid outlet (4) to connect a first tube(20) having an infusion liquid lumen to guide a flow of infusion liquid from the system to the pericardial cavity, and an effusion liquid inlet (6) to connect to a second tube (21) having an effusion liquid lumen to guide the effusion liquid flow from the pericardial cavity to the system, a flow rate control system to control the flow rate of the infusion liquid flow at the infusion liquid outlet (4) on the basis of multiple sensor signals, wherein the flow rate control system comprises: a control unit (5) to provide a control signal on the basis of the sensor signals, and a pump device (3) to pump infusion liquid to the infusion liquid outlet (4) at an infusion liquid flow rate, wherein the infusion liquid flow rate is adjustable by the control signal of the control unit (5) and wherein the sensor signals registered by the control unit (5) comprise: an infusion liquid signal representative for the infusion liquid flow to the pericardial cavity, an effusion liquid signal representative for the effusion liquid flow rate from the pericardial cavity, a blood volume signal generated by a hematocrit sensor (12) representative for a blood loss flow rate in the effusion liquid from the pericardial cavity, and a pressure control signal representative for the pressure in the pericardial cavity generated by a pressure sensor positioned inside or in connection with the first tube (20), the second tube (21) or the pericardial cavity. The invention also provides a method of monitoring the blood loss volume or flow rate from the pericardium based on multiple sensor signals as well as, a method of treatment of postoperative cardiac patients in order to reduce the risk of cardiac tamponade, reduce post-operative blood loss and reduce the accumulation of blood and clots in the pericardial cavity, wherein the pericardial cavity of the patient is flushed with a flushing system according to the invention.

The invention discloses a negative pressure wound treatment system for detecting colors of percolate, which comprises a liquid collecting bottle, negative pressure wound treatment equipment, a wound kit, a color collection system and a color detection control unit, wherein the liquid collecting bottle is used for collecting wound percolate; the negative pressure wound treatment equipment consistsof a negative pressure source and a controller; the wound kit is filled in a wound and seals the wound, and is communicated with the liquid collecting bottle by a connecting pipe; the color collection system acquires color signals and / or visual signals of the percolate; and the color detection control unit is arranged in the controller, and performs operation to obtain the corresponding colors ofthe percolate according to the obtained color signals and / or visuals signals of the percolate. In the negative pressure wound treatment system, by the on-line detection of the colors of the percolate, an alarm signal can be given in time to alarm medical care personnel or patients to take measures in time before accidents, and the medical care personnel also can perform more advanced study on wound information conveniently.

The invention belongs to the field of application of biomedical materials and particularly relates to a preparation method of double-layer type water-proof, anti-bacterial and anti-cicatricial chitosan sponge dressing. The dressing is a sponge type and is of a double-layer structure, wherein the surface layer is a hydrophobic layer which is water-proof and capable of effectively preventing bacteria from invasion, a lining layer is a hydrophilic layer, has soft texture, is of a uniform three-dimensional porous structure and can rapidly absorb and remove exudate and secreta when contacted with awound and has effects of stopping bleeding and promoting healing, glucosamine is supported in the hydrophilic layer, growth of bacteria can be inhibited by positive charges, additional antibacterialdrugs are not needed, wound repair can be promoted, cicatrization can be inhibited, and therefore, the dressing can be applied to protection and wound repair of multiple types of skin wounds such as burns, trauma, diabetic foot, pressure sores and the like.

The invention discloses an intelligent gastric lavage dynamic-monitoring method. The method includes the following steps that a, a light source shines light on transudate of the stomach to be monitored; b, optical signals obtained after the transmission is performed on the transudate of the stomach are converted into digital signals; c, the digital signals in the step b are processed, and the processing result of the digital signals is compared with a preset value; d, when the comparison result in the step c is that the processing result is consistent with the preset value, it shows that the transudate of the stomach does not contain toxic substances, and the monitoring is completed; when the comparison result in the step c is that the processing result is inconsistent with the preset value, it shows that the transudate of the stomach contains toxic substances, and the step b and the step c are continued. A device used for the intelligent gastric lavage dynamic-monitoring method comprises a data processor, a display screen and a light frequency conversion device connected with the data processor. The intelligent gastric lavage dynamic-monitoring method and the device used for the method have the advantages of being high in monitoring result accuracy and convenient to operate.

The invention discloses a negative pressure wound treatment system capable of detecting the transparency of wound exudate. The negative pressure wound treatment system comprises a exudate collecting bottle, negative pressure wound treatment equipment, a wound external member, a wound exudate transparency detecting module and a detecting control unit, wherein the exudate collecting bottle is used for collecting wound exudate; the negative pressure wound treatment equipment comprises a negative pressure source and a controller; a wound external member is used for filling and sealing the wound and is communicated with the exudate collecting bottle by a connecting pipe; the wound exudate transparency detecting module is used for detecting and receiving a white light signal passing through thewound exudate and outputting a white light signal value representing the magnitude of the transparency; and the detecting control unit is arranged inside the controller and is used for obtaining the transparency of the wound exudate at the position of the wound exudate transparency detecting module according to the received white light signal value. The system is capable of detecting the transparency of the wound exudates in real time and can provide convenience for medical care personnel or other users on the management and research of the wound exudate.

The invention provides an elliptical medical drainage hole plaster with a concave-convex surface layer design. The plaster is composed of a water absorbing core, a semitransparent backing layer and an annular adhesive layer, wherein the water absorbing core is made of a strong water-absorbing material; the center of the medical drainage hole plaster is provided with a circular bulge; the outer periphery of the medical drainage hole plaster is provided with an annular leakage-preventing groove; the water absorbing core is composed of two layers; one layer, facing to skin, of the water absorbing core is arranged longitudinally, and contains drugs for promoting skin repairing and inhibiting bacterial growth; one layer, close to the backing layer, of the water absorbing core is designed transversely, and contains an ingredient which changes color under the condition of being in contact with water. The medical drainage hole plaster disclosed by the invention has the advantages that the contradiction among quick absorption, prevention of transverse diffusion and increment of water storage volume is solved, the characteristic of being suitable for radian of a human torso is obtained, the blocking effect is good, the air permeability is also good at the same time, the medical drainage hole plaster is prevented from being adhered to the skin, the advantages of promoting quick healing of a drainage hole and giving a warning on drainage hole exudate in a color developing manner are obtained at the same time, and a patient is prompted to change the plaster timely.

The invention discloses a negative pressure wound therapy system for detecting a transudate level by photoelectric total reflection. The system comprises negative pressure wound therapy equipment with a negative source and a controller, a liquid collection bottle which is used for collecting transudate, and at least one detection module; the side wall of the liquid collection bottle is protruded outward to form a protruded part; the included angle theta which is formed between planes of two opposite sides of the protruded part is more than 97.2 degrees and less than 180 degrees; and the detection module comprises a transmitting unit which is positioned on one side of the protruded part and transmits electromagnetic waves or ultrasonic signals to the liquid collection bottle, a receiving unit which is correspondingly positioned on the other side of the protruded part, and receives electromagnetic waves or ultrasonic signals which are reflected by the liquid collecting bottle, and a detection control unit which is used for judging whether transudate exists at the positions of the detection modules according to the condition that the receiving unit receives the electromagnetic waves or ultrasonic signals. The negative pressure wound therapy system can detect the level of wound transudate in the liquid collection bottle to ensure that medical workers and patients can know the transudate amount in the liquid collection bottle timely.

The invention provides an adhesive bandage using biological cellulose hydrogel, which is at least partially dehydrated, as an absorbent pad. The above biological cellulose hydrogel, which is at least partially dehydrated, has water content lower than 45%; and preferably a biological cellulose hydrogel dried to a constant weight is used as an absorbent pad. After rehydration, the absorbent pad of the adhesive bandage provided by the invention expands substantially to provide larger and more stable pressure thereby realizing better hemostatic effect. Simultaneously, the biological cellulose hydrogel, which is at least partially dehydrated, has better water-absorbing quality, and can continuously absorb diffusate of a wound for lasting usage and maintain drying of the wound for a long time. The added traditional Chinese medicine components endow the adhesive bandage with effects of sterilization, disinfection and infection prevention; and the adhesive bandage has no toxic or side effect, and has promising application prospects.

The invention provides a structure dressing with compounding of oxidized graphene and nanofiber and a preparation method. The preparation method comprises the following steps: firstly mixing and stirring nano titanium dioxide, zeolite and PVA (Polyvinyl Alcohol) solution to be uniform so as to form slurry, and coating on the surface of a supporting layer; before drying, spraying a layer of 0.2-2%sodium alginate solution, and drying at a temperature of 40-75 DEG C to form a thin layer; then covering a layer of nanofiber on the surface of the thin layer, then coating slurry prepared from the oxidized graphene, the sodium alginate, zinc hyaluronate, vitamin B2 and vitamin B12, drying, and spraying a little amount of zinc salt solution to cure. The structure dressing provided by the inventionhas the beneficial effects that on the basis of the physical sterilization mechanism of the graphene and by combination with the breathable blocking action of a nanofiber film, the structure dressingis prepared by loading effective components; by adsorption and disinfection of all layers to tissue transudate, the aseptic condition of wounds is kept, and necessary nutritional substances are provided, so that secondary infection of the wounds is avoided, the heeling is enhanced and the preparation method is simple.

The invention discloses a flushing device for a leaking liquid at the periphery of a drainage tube. The device comprises a chassis, wherein a through hole used for allowing the drainage tube to run through is formed in the middle of the chassis, a drainage box is arranged on the chassis, the side face of the drainage box is provided with a flushing hole and a draining hole, the top end of the drainage box is provided with a drainage hole used for allowing the drainage tube to run through, the drainage hole is internally provided with a valve, and the outer side of the drainage hole is providedwith a pipe clamp. When a leaking liquid occurs at the periphery of an alimentary canal fistula, the leaking liquid can be stored in the drainage box and cannot be in contact with the skin, thereby reducing the corrosion of the leaking liquid on the skin and the tissue, and greatly reducing or avoiding the infection around the drainage tube. The device is provided with a flushing tube and a draining tube, so that flushing and disinfection are convenient, and the workload of nursing is reduced. The average time in hospital is reduced, the cost in hospital is reduced, and the comfort of a patient in hospital is improved.

The invention discloses an operating towel with size-adjustable operating hole, which is composed of a left towel, a right towel and adhesive strips, wherein the center at the right side of the left towel is provided with an opening isolation groove, the adhesive strips are fixed at the front faces at the upper and lower right sides of the left towel; the right towel is corresponding to the left towel, the center at the left side of the right towel is provided with another opening isolation groove, the adhesive strips are fixed at the back faces at the upper and lower left sides of the right towel; and the left towel and the right towel are integrally lap-jointed with each other via the adhesive strips in a manner of vertical alignment. The current integral operating towel is designed in a split combined structure in which a round isolation hole is changed into a length-adjustable waist-shaped hole, as a result, the shape of the isolation hole is more suitable for the requirement of an operation, and the distance from the edge of the isolation hole to an incision is basically identical, which is better favorable for the operating towel to absorb blood and transudate generated by operation. The specification of the operating towel adopting such a structure can be unified, thereby facilitating use and production of the operating towel.

The invention discloses a quick mouth mucosa exudate detection method and belongs to the field of biotechnology. The method comprises the following steps: lightly reversing the bottom for about three times to mix the sample buffer solution in the bottle; distributing the mouth mucosa exudate in a dropper into a test tube; taking a clean swab, immediately placing the swab into the tube with the sample buffer solution; repeatedly inserting the swab into the sample buffer solution tube for 6-8 times, and rubbing two sides of the swap by leaning against the tube wall; taking out the swap from the tube; and preparing the mouth mucosa exudate for detection; transferring 200 microliters of mouth mucosa exudate to an empty test tube; taking out a determination test strip from a jar, and immediately covering the jar; avoiding touching the membrane surface at the center of the test strip by a hand; placing the determination test strip into the tube with 200 microliters of diluted sample, making the arrow on the determination test strip downward; recording the time of the determination test strip added into the sample; reading the detection result after 20 minutes; and throwing the test strip, the tube and the swap into a biological dangerous cargo container.

The invention discloses a method for measuring high and low-density lipoprotein cholesterol content of animal meat. The method comprises the following steps of: saponifying lipid in the animal meat by using potassium hydroxide and absolute ethanol, extracting cholesterol serving as an unsaponifiable substance by using absolute ethyl ether, then separating out the high-density lipoprotein cholesterol in the cholesterol by using a phosphotungstic acid-magnesium chloride precipitant, separating out the low-density lipoprotein cholesterol in the cholesterol by using a sodium citrate-heparin precipitant, finally measuring the peak areas of the high-density lipoprotein cholesterol and the low-density lipoprotein cholesterol by using a gas chromatograph, and calculating the content of the high and low-density lipoprotein cholesterol content by using the peak areas. The high and low-density lipoprotein cholesterol content of the animal meat can be accurately and quantitatively measured by adopting the method, and the content value measured by adopting a medicinal method in the animal muscular tissue transudate is not total content in the muscle. Therefore, the invention provides an accurate and reliable method for accurately evaluating the functional animal meat.

The invention discloses a sample diluent of oral mucosal transudate for detecting HIV antibody by colloidal gold method, and a preparation method thereof, belonging to the technical field of biological detection. The diluent comprises disodium hydrogen phosphate 17.3-19.2 g / L, sodium dihydrogen phosphate 2.6-2.9 g / L, sodium chloride 8.3-9.2 g / L, 10% tween 80 9.5-10.5 mL / L, serum 142.5-157.5 mL / L, streptavidin 28.5-31.5 mg / L, biotin 19-21 mL / L, EDTA-2Na 19-21 g / L, NaN3 2.9-3.2 mL / L, and the balance of purified water. The inventive sample diluent can accelerate reaction speed and enable detection to be smoother.

Disclosed herein are several embodiments of a negative pressure apparatus and methods of using the same in the treatment of wounds. Some embodiments are directed towards improved fluidic connectors configured to transmit irrigation fluid and to apply aspiration to a wound, for example using softer, kink-free conformable layers. Some embodiments may comprise a first channel for delivering irrigation fluid to the wound and a second channel for transmitting negative pressure and removing fluid comprising irrigation fluid and wound exudate from the wound, wherein the channels comprise a flexible spacer material. Some embodiments are directed toward an irrigation manifold attachable to or incorporated as part of a distal end of an irrigation and aspiration fluidic connector.

The invention provides an adhesive bandage using biological cellulose hydrogel, which is at least partially dehydrated, as an absorbent pad. The above biological cellulose hydrogel, which is at least partially dehydrated, has water content lower than 45%; and preferably a biological cellulose hydrogel dried to a constant weight is used as an absorbent pad. After rehydration, the absorbent pad of the adhesive bandage provided by the invention expands substantially to provide larger and more stable pressure thereby realizing better hemostatic effect. Simultaneously, the biological cellulose hydrogel, which is at least partially dehydrated, has better water-absorbing quality, and can continuously absorb diffusate of a wound for lasting usage and maintain drying of the wound for a long time. The added traditional Chinese medicine components endow the adhesive bandage with effects of sterilization, disinfection and infection prevention; and the adhesive bandage has no toxic or side effect, and has promising application prospects.