The invention provides an elliptical medical drainage hole plaster with a concave-convex surface layer design. The plaster is composed of a water absorbing core, a semitransparent backing layer and an annular adhesive layer, wherein the water absorbing core is made of a strong water-absorbing material; the center of the medical drainage hole plaster is provided with a circular bulge; the outer periphery of the medical drainage hole plaster is provided with an annular leakage-preventing groove; the water absorbing core is composed of two layers; one layer, facing to skin, of the water absorbing core is arranged longitudinally, and contains drugs for promoting skin repairing and inhibiting bacterial growth; one layer, close to the backing layer, of the water absorbing core is designed transversely, and contains an ingredient which changes color under the condition of being in contact with water. The medical drainage hole plaster disclosed by the invention has the advantages that the contradiction among quick absorption, prevention of transverse diffusion and increment of water storage volume is solved, the characteristic of being suitable for radian of a human torso is obtained, the blocking effect is good, the air permeability is also good at the same time, the medical drainage hole plaster is prevented from being adhered to the skin, the advantages of promoting quick healing of a drainage hole and giving a warning on drainage hole exudate in a color developing manner are obtained at the same time, and a patient is prompted to change the plaster timely.