37 results about "Pericardial cavity" patented technology

The present disclosure provides compositions and methods related to the delivery of therapeutic medicines to the heart for treating a cardiac injury, such as those that occur due to a myocardial infarction (MI). In particular, the present disclosure provides novel hydrogel-based compositions that safely and effectively deliver a therapeutic agent to the pericardial cavity of the heart to treat the cardiac injury.

The invention discloses a medicine for treating or relieving heart failure, the medicine comprises an estrogen compound, and the estrogen compound is preferably mestraanol. According to the invention, verapamil hydrochloride is used for inducing and establishing the chronic heart failure model of zebrafish, and direct exposure of the estrogen compound MESTRANOL is carried out on a zebrafish embryo with heart failure, so that the heart failure of zebrafish is relieved. The phenotype of zebrafish is observed and analyzed, and physiological data, gene expression quantity related to heart failure and key events causing heart failure in rat H9c2 myocardial cells, such as ROS level and cell apoptosis, are counted; the estrogen compound MESTRANOL is innovatively found and proved to be capable of relieving heart rate decline, venous sinus extravasated blood, pericardial cavity enlargement and heart cyclization abnormity caused by heart failure, and has more excellent drug effects compared with positive drugs E2 and G1, so that a foundation is laid for developing new drugs for treating heart failure.

Methods of improving a heart function in a heart of a subject having heart dysfunction are described. An exemplary embodiment includes accessing a pericardial cavity of the heart and advancing a cutting device within the pericardial cavity to a first incision point. At least a parietal layer of a pericardium of the heart is then pierced. A cutting device is placed against the parietal layer and retracted along a selected cut path so as to create a first incision having a selected length in at least the parietal layer to reduce pressure exerted on the heart by the pericardium. The above operations are repeated to create one or more additional incisions along respective additional cut paths.

Cannabidiol, or a pharmaceutically acceptable prodrug, derivative, salt, or solvate thereof, for use in treating or preventing recurrent pericarditis is disclosed. The effectiveness of cannabidiol in attenuating the levels of interleukin-1β (IL-1β) and IL-6, and the transcription of pro-IL-1β and NLRP3 mRNA in in vitro models are disclosed. Also disclosed are experiments showing cannabidiol to be effective in preventing an increase in the pericardial space (which is an indicator of pericardial effusion) and the pericardial thickness in an in vivo mouse model of pericarditis.

A method and device for modulating the autonomic nervous system adjacent a pericardial space to treat cardiac arrhythmia includes a treatment source arranged to supply a treatment medium, a catheter having an end sized for insertion into the pericardial space, a medium delivery assembly having a distal end arranged to be positioned by the catheter into the pericardium, with the distal end of the delivery assembly comprising a delivery tip arranged to extend away from the distal end of the catheter into the pericardial space. A connector operatively couples the delivery tip of the medium delivery assembly to the treatment source, and the delivery tip of the medium delivery assembly including a plurality of delivery points for delivering the treatment medium at a plurality of treatment areas within the pericardial space. The device performs modulation or ablation of the autonomic nervous system at selected treatment areas within the pericardium.

The invention relates to a system for attaching a heart valve. The function of the system (1) is to attach a heart valve (3) to a heart prosthesis (2) intended to be implanted within the pericardial cavity of a patient and to replace the natural left and right ventricles of the patient, the system (1) comprising a male ring (10) provided with nails (11) and a mating part (12) provided with an opening (13), the male ring (10) or the mating part (12) being intended to be fixed to the heart prosthesis (2), the staples (11) and the opening (13) are configured such that, in the attached position, the staples (11) pass through the flange (9) of the heart valve (3) and into the opening (13).

A medical implant for assisting contraction of a cardiac chamber includes an implant body sized for placement at least partially within a pericardial cavity of a heart. The implant body has an opening for inflation with a filling and being flexible to expand in response to inflation with the filling. The medical implant also includes a valve disposed within the opening to allow uni-directional flow into the implant body and provide an access point for injection of the filling.

The present invention relates to a system for attaching a heart valve, the function of which is to attach a heart valve to a cardiac prosthesis intended to be implanted in a patient's pericardial cavity and to replace the patient's natural left and right ventricles, the system comprising a male ring with spikes and a cooperating part with openings, the male ring or the cooperating part being intended to be fixed to the cardiac prosthesis, the spikes and the openings being configured such that the spikes pass through a collar of the heart valve and enter the openings at the attachment position.

Among other things, there is disclosed structure and methods for maintaining access to a location in the body while reducing or eliminating the potential for pulling an access device (e.g. a catheter) back through an opening. An introducer sheath includes a distal indented portion and a balloon, so that once placed in a desired location through tissue, the balloon can be inflated to anchor the sheath against retraction. In particular embodiments, structure and methods for accessing the pericardial cavity via the right atrial appendage are shown.

The utility model provides a pericardium drainage tube which comprises a drainage tube body, the drainage tube body comprises a first bent part, a second bent part and a third bent part, a first drainage hole is formed in the surface of the first bent part, a second drainage hole is formed in the surface of the second bent part, and a third drainage hole is formed in the surface of the third bent part. The drainage tube body is made of a shape memory plastic material, and the drainage tube body is transparent. The first bending part, the second bending part and the third bending part are arranged, so that the whole drainage tube is bent, the drainage tube can better adapt to the structure of the pericardial cavity, possible scars, adhesion or tissue obstruction are avoided, the smoothness of the drainage tube is ensured, and the drainage effect is optimized; friction and stimulation to skin and tissues can be reduced, and discomfort of a patient is reduced; meanwhile, the stability of the drainage tube in the body can be improved, and the falling risk caused by external force factors such as movement, cough or body position change of the patient is reduced.

A flushing system configured to flush a wound and / or a body cavity of a patient comprises: an infusion liquid outlet to connect a first tube guiding a flow of infusion liquid from the system to the wound and / or the body cavity; an effusion liquid inlet to connect to a second tube guiding the effusion liquid flow from the wound and / or the body cavity to the system; a flow rate control system to control the flow rate at the infusion liquid outlet; and a hematocrit sensor configured to optically measure the hematocrit value of the effusion liquid received via the effusion liquid inlet, to obtain a blood loss volume and / or a blood loss flow rate from the wound and / or the body cavity by means of emitting light having different wavelengths. The different wavelengths are respectively assigned to the green wavelength range and to the red or near-infrared wavelength range.

The present invention relates to an injectable hydrogel loaded with targeted engineered extracellular vesicles, as well as its preparation method and application, and belongs to biomedical engineering. The present invention provides an injectable hydrogel loaded with targeted engineered extracellular vesicles, wherein the injectable hydrogel is a GelMA hydrogel loaded with ischemia-targeted miR222-engineered extracellular vesicles; the ischemia-targeted miR222-engineered extracellular vesicles overexpress miR222 and are surface-modified with a targeting polypeptide. The injectable hydrogel loaded with targeted engineered extracellular vesicles can be minimally invasively injected into the pericardial cavity to form a cardiac patch and improve cardiac ischemia-reperfusion injury.

This invention discloses an intraperitoneal balloon-assisted pacing implant kit, comprising: a guiding component, a dilation catheter component, and an inflation / deflation component. The guiding component includes a first guidewire, a portion of which is located inside the pericardial cavity of the target heart. The dilation catheter component includes a main tube and a balloon. The main tube has parallel guiding and air intake channels. The first guidewire is slidably connected within the guiding channels, guiding the main tube into the body. The balloon is positioned on the main tube and connected to the air intake channel. The main tube has a groove along its axial direction. Guided by the first guidewire, the balloon is embedded in the pericardial cavity of the target heart. Air is introduced through the air intake channel, causing the balloon to extend along the groove and surround the outside of the ventricle. The inflation / deflation component is connected to the balloon. With the support of ECG gating technology, the balloon expands during cardiac systole and contracts during diastole within the pericardial cavity, thereby compressing the left and right ventricles during cardiac systole.

The invention discloses a percutaneous implantable intracardiac perfusion system which is characterized in that a blood vessel sheath and an injector are connected through an outer sleeve; the double-cavity micro catheter is mounted in the outer sleeve; the spiral injection inner core needle is arranged inside the double-cavity micro catheter, and one end of the spiral injection inner core needle extends into or is separated from the double-cavity micro catheter. According to the application of the percutaneous implantable intracardiac perfusion system, an access is established through the vascular sheath, the system enters the pericardial cavity through the double-cavity micro-catheter so as to select the needed position, medicine is injected through the injector, the spiral injection inner core needle is used for ventricular wall injection, the risk of ventricular wall perforation and rupture caused by ventricular wall injection is reduced, and the percutaneous implantable intracardiac perfusion system has the advantages of being simple in structure and convenient to use. And the treatment efficiency is improved.

The invention discloses an intrapericardial balloon pacemaker implantation set which comprises a guide assembly, an expansion catheter assembly and an inflation and deflation assembly, the guide assembly comprises a first guide wire, and part of the first guide wire is located in the pericardial cavity of a target heart; the dilation catheter assembly comprises a main catheter body and an air bag, the main catheter body is internally provided with a guide channel and an air inlet channel which are parallel to each other, a first guide wire is slidably connected into the guide channel and guides the main catheter body to move into the human body, the air bag is arranged on the main catheter body and connected with the air inlet channel, and the main catheter body is provided with a slot in the axial direction of the main catheter body. Under the guidance of the first guide wire, the air bag is embedded in a pericardial cavity of a target heart, air is fed through the air inlet channel so that the air bag can stretch out along the groove seam to wrap the outer side of a ventricle, the inflation and deflation assembly is connected with the air bag, and under the support of an electrocardio gating technology, the air bag can be inflated in the pericardial cavity in the systolic period or exhausted in the diastolic period to retract. Therefore, left and right ventricles are extruded during systole.

Devices used to access the pericardial space of the heart. In particular, there is described an apparatus to enable an operator to access the pericardial space of the heart, and deliver cardiac therapies to the pericardial space, under direct visualization through a single, small incision.

A cleaning system is provided for cleaning a patient's wounds and / or body cavities, particularly the pericardial cavity (PC) and / or pleural cavity. [Solution] The cleaning system includes a carrier unit configured to be movable, an inflow unit including at least one infusion fluid container for containing an infusion fluid, and a collection unit configured to collect exudate from a patient, wherein the carrier unit is configured to house the inflow unit and the collection unit, the inflow unit further includes at least one first weighing unit for measuring the weight of the infusion fluid delivered to the patient, and the carrier unit includes a second weighing unit for measuring the weight of the exudate collected in the collection device.

The present invention relates to an irrigation system (1,200, 300, 400, 500) configured to irrigate a wound and / or a body cavity, particularly a pericardial cavity (PC) and / or one or more pleural cavities, of a patient, the system (1,200, 300, 400, 500) including an infusate lumen for connecting a first tube (4) having an infusate lumen for directing the flow of infusate from the system (1,200, 300, 400, 500) to the wound and / or body cavity, particularly the pericardial cavity (PC). an outlet (2), an effluent inlet (6) for connecting to a second tube (8) having an effluent lumen for directing the flow of effluent from the wound and / or body cavity, particularly the pericardial cavity (PC), to the system (1, 200, 300, 400, 500); a buffer container (10) having a buffer volume and including a buffer inlet (12) for receiving effluent from the wound and / or body cavity, particularly the pericardial cavity (PC), and a first buffer outlet (14) for outputting the received effluent; a flow rate control system for controlling the flow rate of effluent output from a buffer container (10), the flow rate control system comprising: a control unit (16) for providing one or more control signals; and a first pump device (18) for pumping effluent from the buffer container (10) to one or more effluent containers (20) at an effluent flow rate adjustable by the control signal of the control unit (16), wherein the buffer container (10) comprises a clot trap (22) configured to prevent blood clots contained in the effluent received from the wound and / or body cavity, in particular the pericardial cavity (PC), from exiting the buffer container (10) via the first buffer outlet (14); and / or wherein the buffer container (10) is configured for gas-liquid separation and / or configured to have a safety bypass and / or provides a flushing system (1, 200, 300, 400, 500) configured to receive a liquid overflow.

The present invention discloses a puncture needle, which is composed of a needle body and a needle seat. The head end of the needle body is laterally bent, the needle opening is opened on the inner side of the bend and is perpendicular to the longitudinal axis of the needle body, and the needle tip is an arc-shaped cutting surface. Based on this, the inventor has also designed a matching guide wire ejector, and the two together constitute a safe pericardial puncture device. Among them, the puncture needle with a side opening can reduce the sharpness of the tip of the puncture needle, change the direction of the outlet, and reduce the risk of the puncture needle and the guide wire piercing the heart; the guide wire ejector is used in conjunction with the puncture needle, and the guide wire can be automatically ejected from the lateral needle opening into the pericardial cavity at the moment when the needle opening completely enters the pericardium, so as to avoid inadvertent shaking of the puncture needle so that the needle tip pierces the heart and the guide wire is directly ejected toward the heart to damage the heart, thereby playing an immediate role in protecting the heart. Therefore, the present invention can be used to conveniently and quickly implement pericardial puncture, and it is safe, stable and reliable.

To provide a device, a system, and a method for fixing a cardiac device, particularly, a device, a system, and a method for accessing a pericardial cavity for fixation.SOLUTION: Various modes of the present disclosure are directed to a device, a system, and a method for fixing a cardiac device, particularly, a device, a system, and a method for accessing a pericardial cavity for fixation.SELECTED DRAWING: Figure 53B

A method and apparatus are disclosed for a needle for gaining access to the pericardial cavity of a heart. The needle includes an elongate member (e.g. a main shaft) defining a lumen and a side-port in fluid communication with the lumen; a blunt atraumatic tip for delivering energy for puncturing tissue; and a guiding surface (e.g. a ramp) for directing a device (e.g. a guidewire) through the side-port. The method includes using the needle for tenting a pericardium and delivering energy for puncturing the pericardium, and advancing a guidewire or other device through the needle and into the pericardial cavity.

A flushing system comprises: an infusion liquid outlet to connect to a first tube arrangement having a plurality of infusion liquid lumen guiding a flow of infusion liquid from the system to a wound and / or body cavity; an effusion liquid inlet to connect to a second tube having an effusion liquid lumen guiding the effusion liquid from the wound and / or the body cavity to the system; and a flow rate control system to control the flow rate at the infusion liquid outlet. The flow rate control system comprises: a control unit, and a pump device to pump infusion liquid to the infusion liquid outlet at a flow rate adjustable by control signals of the control unit. Each infusion liquid lumen of the first tube arrangement has openings arranged along the first tube arrangement and spaced from one another for leading the infusion liquid into the wound and / or the body cavity.

A safe, reliable, reproducible system and method for entry into the pericardial sac. The method and system described generally includes penetration of the subcutaneous tissue with a guide sheath or a relatively blunt stylet contained within a sheath. The stylet is removed from the sheath and a vacuum mechanism is installed. Once in contact with the pericardium, the sheath is engaged with the pericardial tissue, allowing the vacuum mechanism to draw the pericardium away from the heart to create a greater space between the heart and pericardium allowing needle insertion onto the pericardial cavity in a much safer and controlled manner.

The present invention relates to an irrigation system (1,300, 400, 500) configured to irrigate a wound and / or body cavity, particularly a pericardial cavity (PC) and / or one or more pleural cavities, of a patient, the system (1,300, 400, 500) comprising an infusate outlet (2) for connection to a first tubing arrangement (4) having one or more infusate lumens (100, 100a, 100b, 100b) for directing an infusate flow from the system (1,300, 400, 500) to the wound and / or body cavity, particularly the pericardial cavity (PC), and an effluent inlet (6) for connection to a second tubing (8) having an effluent lumen (104) for directing an effluent flow from the wound and / or body cavity, particularly the pericardial cavity (PC), to the system (1,300, 400, 500); and a flow rate control system for controlling the flow rate of the infusate at the infusate outlet (2), the flow rate control system comprising a control unit (16) for providing one or more control signals and a pump device (62) for pumping the infusate to the infusate outlet (2) at an infusate flow rate adjustable by the control signal of the control unit (16), each infusate lumen (100, 100a, 100b, 100b) of the first tubing arrangement (4) having at least one infusate opening (102, 102a, 102b, 102b) for directing the infusate into the wound and / or body cavity, in particular the pericardial cavity (PC), the infusate openings (102, 102a, 102b, 102b) being arranged along the first tubing arrangement (4) and spaced apart from one another. The present invention further relates to a tube arrangement (4) for an irrigation system (1, 300, 400, 500) configured to irrigate a wound and / or body cavity, particularly the pericardial cavity (PC), of a patient.

The invention belongs to the technical field of pericardiocentesis, and discloses a pericardiocentesis device which comprises a drainage main pipe, a supporting inner core, a puncture needle and a puncture guide wire, the supporting inner core is arranged in the drainage main pipe in a penetrating mode, the outer diameter of the supporting inner core is matched with the inner diameter of the drainage main pipe, the puncture needle is arranged in the supporting inner core in a penetrating mode, and a hollow cavity channel is formed in the puncture needle. A puncture guide wire is arranged in the hollow cavity channel in a penetrating mode, the puncture guide wire is in a J shape in an unstressed state, the puncture guide wire comprises a pointed end section, a bent section, a supporting section and a hard section, and developing marks are arranged at the pointed end section, the puncture end of the puncture needle and the puncture end of the drainage main pipe. The drainage main pipe is supported through the supporting inner core, and the strength of the drainage main pipe is improved; the skin and subcutaneous tissue of a patient can be easily punctured through the puncture needle, the outer layer of the pericardial cavity is punctured through the puncture guide wire and enters the pericardial cavity, the bent section forms a J shape in the pericardial cavity, the contact probability of the needle tip and the non-punctured part and the myocardial is reduced, and the safety of puncture operation is improved.

The invention discloses a percutaneous implantable pericardial cavity perfusion system which is characterized in that a blood vessel sheath and an injector are communicated through a double-cavity micro catheter; the guide wire is mounted in the double-cavity micro catheter; wherein the double-cavity micro catheter comprises a direction adjusting handle, an outer catheter body and an inner catheter body, the direction adjusting handle is installed on the outer wall of the outer catheter body, the inner catheter body is installed in the outer catheter body, one end of the inner catheter body is communicated with the outer wall of the blood vessel sheath, the other end of the inner catheter body is communicated with the injector, and the direction adjusting handle is installed on the outer wall of the outer catheter body. The guide wire is installed between the inner tube body and the outer tube body. By means of the application of the percutaneous implantable pericardial cavity perfusion system, an access is established through the blood vessel sheath, the percutaneous implantable pericardial cavity perfusion system enters the pericardial cavity through the double-cavity micro catheter, the needed position is selected, medicine is injected through the injector, and the treatment efficiency is improved.

The application provides a puncture needle in the technical field of puncture and puncture technology, and the puncture needle comprises a needle tube, a side tube and a support guide wire, a blade part is arranged at the distal end of the needle tube, and a syringe interface is arranged at the proximal end of the needle tube. One end of the side tube is fixedly arranged at the proximal end of the needle tube, and the inner cavity of the side tube is in communication with the inner cavity of the needle tube. The support guide wire is arranged in the inner cavities of the side tube and the needle tube, the support guide wire is arranged from the inner cavity of the side tube to the distal end direction of the inner cavity of the needle tube, and a blunt head is arranged at the end of the support guide wire close to the distal end, wherein the blunt head is adapted to be switched between a puncture state of being retracted into the inner cavity of the needle tube and a protection state of being extended out of the inner cavity of the needle tube. When the puncture needle enters the pericardial cavity, the blunt head is controlled to be extended out of the inner cavity of the needle tube, so that the blunt head shields the blade part of the needle tube, at this time, the puncture needle is shielded by the blunt head, a protection effect is achieved, direct contact between the puncture needle and the atrium, the ventricle or the coronary artery is avoided, and the puncture needle is prevented from piercing the atrium, the ventricle or the coronary artery.

The utility model discloses a pericardiocentesis simulation training device which comprises a pericardial cavity simulation assembly, a human body silica gel model, a static pressure liquid supply pipe set and a pulsation circulation pipe set. The pericardial cavity simulation assembly is accommodated in the heart position of the human body silica gel model; the pericardial cavity simulation assembly comprises a pericardial cavity and a heart silica gel model; and the pericardial cavity is arranged on the outer side of the heart silica gel model and is communicated with the static pressure liquid supply pipe group through a pipeline. The device can be imaged through the ultrasonic probe, so that an operator can visually see whether puncture succeeds or not; liquid different from the pericardial cavity in color is introduced into the simulated heart, an obvious blood return phenomenon can be generated after puncture enters the heart silica gel model, an operator can find operation errors in time when puncture is too deep, and forward information feedback in the training process is achieved.

A medical access system can comprise an inner needle assembly including an inner needle shaft configured to be slidably disposed at least partially within a delivery lumen of an outer needle assembly, the inner needle shaft comprising a narrower distal portion and a wider portion proximal of the narrower distal portion, and a transition segment between the narrower distal portion and the wider portion. A first delivery lumen within the inner needle shaft can extend from a proximal end of the inner needle shaft to a distal end opening at a distal end of the narrower distal portion, and a second delivery lumen within the inner needle shaft can extend from the proximal end to a distal opening associated with the transition segment.

Several exemplary transection devices are disclosed, comprising an elongated member having a distal end and a proximal end along a longitudinal axis, the proximal end coupled to an end of a catheter, a plurality of extensions operably coupled to the distal end of the elongated member, a sheath having a distal end encircling the elongated member in a longitudinally slidable relation, where in a first sliding position, the elongated member and the plurality of extensions are encircled by the sheath; and a second sliding position, the plurality of extensions projects from the distal end of the sheath. Such devices are useful for deployment in the pericardial cavity and making incisions through the pericardial membrane or parietal layer of the pericardium. These examples share the characteristic that they are deployed intravascularly through the RA, RAA, IVC, SVC, CS, or via a subxiphoid approach.