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Preparation of lipoic acid-loaded nano material and application of lipoic acid-loaded nano material in acute myocardial infarction disease

A technology of nanomaterials and lipoic acid, applied in the field of biochemical medicine, can solve the problems of insufficient scavenging of free radicals, low concentration of myocardial tissue, and fast tissue distribution, so as to improve the level of cardiac function, improve ventricular remodeling, and improve the therapeutic effect Effect

Active Publication Date: 2022-06-24
THE THIRD AFFILIATED HOSPITAL OF SUN YAT SEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, lipoic acid is currently not clinically applicable to the treatment of myocardial infarction, one of the reasons is its fast tissue distribution, short plasma half-life (about 25min), and strong pre-systemic clearance.
At the same time, due to the rapid response and domino effect characteristics of oxidative stress after AMI, the concentration of lipoic acid enriched to the injured myocardial tissue after oral or intravenous injection is low and the duration is short, which is not enough to remove the large amount of free radicals produced
At present, there is no report on the use of PLGA to construct a lipoic acid delivery system to improve its delivery route in AMI patients

Method used

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  • Preparation of lipoic acid-loaded nano material and application of lipoic acid-loaded nano material in acute myocardial infarction disease
  • Preparation of lipoic acid-loaded nano material and application of lipoic acid-loaded nano material in acute myocardial infarction disease
  • Preparation of lipoic acid-loaded nano material and application of lipoic acid-loaded nano material in acute myocardial infarction disease

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Example 1 Preparation of lipoic acid-loaded nanomaterials (ie PLGA-LA nanofilms) by electrospinning

[0031] Nanomaterials with different drug concentrations of lipoic acid (LA) were prepared using polylactic-co-glycolic acid (PLGA) as a carrier, wherein the PLGA / LA (w / w) were 9 / 1, 8 / 2, and 7 / 3, respectively. The specific preparation method includes the following steps:

[0032] (1) Dissolve 600 mg of PLGA in 5 mL of hexafluoroisopropanol, stir to make it evenly dispersed; then according to the mass ratios of PLGA / LA (w / w) of 9 / 1, 8 / 2, and 7 / 3, LA Dissolve in 1 mL of dichloromethane, of which 9 / 1 is 67 mg, 8 / 2 is 150 mg, and 7 / 3 is 257 mg; then add 1 mL of LA in dichloromethane solution to 5 mL of PLGA in hexafluoroisopropanol, stir to make It was uniformly dispersed, and a PLGA-LA electrospinning solution with a mass fraction of 10% (the mass fraction of LA relative to PLGA) was prepared.

[0033] (2) The electrospinning solution was placed in an electrospinning mach...

experiment example 1

[0045] Experimental Example 1 Evaluation of the therapeutic effect of PLGA-LA nanomembrane on mice with acute myocardial infarction

[0046] A mouse myocardial infarction model was prepared, and the PLGA-LA nanomembrane was locally applied to the injured area of ​​myocardial infarction, and the therapeutic effect was evaluated at the functional and morphological levels.

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Abstract

The invention belongs to the technical field of biochemical medicines, and particularly relates to preparation of a lipoic acid-loaded nano-material and application of the lipoic acid-loaded nano-material in acute myocardial infarction diseases. An electrospinning technology is adopted, and a multi-layer lipoic acid-loaded PLGA nano-film material is synthesized by taking PLGA which is degraded at a controllable speed as a raw material to load lipoic acid; the nano-film material has better drug loading capacity and encapsulation efficiency, and also has a better drug release effect in a PBS (Phosphate Buffer Solution), so that the drug can be quickly and continuously released locally in a myocardial infarction area, and a good anti-oxidative stress treatment effect is achieved; when being applied to myocardial infarction treatment (namely being placed on the surface of myocardial infarction heart tissue in a pericardial cavity) as a cardiac functional patch, the medicine can improve ventricular remodeling, improve the cardiac function level, effectively relieve myocardial cell oxidative stress injury and improve the treatment effect of acute myocardial infarction.

Description

technical field [0001] The invention belongs to the technical field of biochemical medicine, and particularly relates to the preparation of lipoic acid-loaded nanomaterials and its application in acute myocardial infarction. Background technique [0002] Cardiovascular disease is an important cause of human death, and it is estimated that more than 20 million people will die from cardiovascular disease by 2030. Among them, acute myocardial infarction (AMI) is a major category in the cardiovascular disease spectrum. It is the most important cause of death and the most common cause of chronic heart failure. It has the characteristics of acute onset, high mortality, and poor prognosis. . In recent years, the incidence of myocardial infarction has shown a trend of increasing year by year and getting younger. [0003] Reperfusion therapy is an effective way to treat acute myocardial infarction, which mainly includes percutaneous coronary intervention (PCI) therapy, thrombolysis...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/70A61K31/385A61K47/34A61P9/10D01D5/00D04H1/728
CPCA61K9/7007A61K47/34A61K31/385A61K9/0024A61P9/10D01D5/003D04H1/728Y02A50/30
Inventor 彭朝权李明强谢冬梅钟庆国许晓纯
Owner THE THIRD AFFILIATED HOSPITAL OF SUN YAT SEN UNIV
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