Hot-melt pressure-sensitive adhesive type matrix for medical use and its preparation
A technology of hot-melt pressure-sensitive adhesives and hot-melt adhesives, which is applied in applications, adhesives, and medical sciences. It can solve problems such as solvent pollution, weak drug efficacy, and small drug loading, and achieve good anti-aging, strong drug efficacy, and The effect of large drug loading
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[0052] In the preparation method of the hot-melt pressure-sensitive adhesive provided by the present invention, SIS synthetic rubber and liquid paraffin are mixed and swollen. This method makes the SIS synthetic rubber not soaked, lowers the temperature and melting point, and is beneficial to low-temperature rubber production.
[0053] Hot-melt pressure-sensitive adhesives do not use solvents, do not cause environmental pollution, and have high production efficiency. Such adhesives are becoming more and more important in today's society that calls for energy saving and elimination of environmental pollution.
[0054] The above-mentioned hot-melt pressure-sensitive adhesive is used in the plaster product for transdermal administration in plaster form provided by the present invention, so that volatile substances can be retained by more than 20% compared with gasoline-based ones.
[0055] Structurally, transdermal plaster products consist of a backing that is substantially imperm...
Embodiment 1-4
[0070] With above-mentioned parts by weight, carry out according to the following steps:
[0071] (1) Mix and swell SIS synthetic rubber and liquid paraffin for more than 30 minutes, stir at 160-165 ° C, and carry out nitrogen or vacuum at the same time;
[0072] (2) Diethyl phthalate, dimethyl phthalate, isopropyl myristate and microcrystalline wax and terpene polymer; drop into the mixture of step (1) gained in batches, at 140 Stir until melting at ℃, while filling with nitrogen or under vacuum;
[0073] (3) Add lanolin, polyisobutylene, propyl gallate and accelerator BZ to the mixture obtained in step (2), stir at 100°C while filling with nitrogen or under vacuum.
Embodiment 5
[0075] Preparation of musk bone strengthening paste
[0076] 1. Preparation of drug-containing hot-melt pressure-sensitive adhesive layer
[0077] (1) hot-melt pressure-sensitive adhesive is obtained by the method of embodiment 1;
[0078] (2) Add 0.03 grams of leopard bone and 3 grams of borneol to the prepared hot-melt pressure-sensitive adhesive, stir and melt at 90° C., and fill with nitrogen;
[0079] (3) Add 3 grams of camphor, 0.48 grams of chondroitin sulfate, and 0.6 grams of diphenhydramine hydrochloride to the mixture obtained in step (2), and fill with nitrogen at the same time at a temperature of 85° C.;
[0080] (4) Add 2.55 grams of methyl salicylate and 10 grams of liquid extract to the mixture obtained in step (3) and mix evenly, and fill with nitrogen at the same time at a temperature of 80 to 85° C.;
[0081] (5) Add 0.024 gram of musk mixed powder and 4 gram of menthol to the mixture obtained in step (4), and fill with nitrogen at the same time at a tempe...
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