Hot-melt pressure-sensitive adhesive type matrix for medical use and its preparation

Abstract

The invention relates to a medical used hot melt pressure-sensitive adhesive type base material and its preparing method which provides a hot melt pressure-sensitive adhesive and an adhesive used paste preparation. The main element of the hot melt pressure-sensitive adhesive is styrenic thermoplastic elastomer SIS (phenylethene -isoprene -phenylethene three block copolymers) with adhesive resin (such as petroleum resin, terpenes polymer, polyisobutylene), flexing oil (such as liquid petrolatum) and aging retarder (such as propyl gallate, BZ) and so on.

Description

technical field

[0001] The invention relates to a hot-melt pressure-sensitive adhesive, in particular to a hot-melt pressure-sensitive adhesive matrix and its preparation and medical application. Background technique

[0002] Hot-melt pressure-sensitive adhesives can produce excellent hot-tackiness at an appropriate high temperature, and in a solid state at room temperature, the bonding effect can be produced with fingers or slight pressure.

[0003] Hot-melt pressure-sensitive adhesives with high polar components can enhance the adsorption force on the object to be bonded, and at the same time improve the bonding strength. However, chemical components (elements) with higher polarity usually have higher activity and are prone to aging phenomenon due to the interaction with oxygen.

[0004] The hot-melt pressure-sensitive adhesives in the prior art have poor compatibility among colloidal components, and are prone to oxidation and impurities during the manufacturing process; ...

Examples

preparation example Construction

[0052] In the preparation method of the hot-melt pressure-sensitive adhesive provided by the present invention, SIS synthetic rubber and liquid paraffin are mixed and swollen. This method makes the SIS synthetic rubber not soaked, lowers the temperature and melting point, and is beneficial to low-temperature rubber production.

[0053] Hot-melt pressure-sensitive adhesives do not use solvents, do not cause environmental pollution, and have high production efficiency. Such adhesives are becoming more and more important in today's society that calls for energy saving and elimination of environmental pollution.

[0054] The above-mentioned hot-melt pressure-sensitive adhesive is used in the plaster product for transdermal administration in plaster form provided by the present invention, so that volatile substances can be retained by more than 20% compared with gasoline-based ones.

[0055] Structurally, transdermal plaster products consist of a backing that is substantially imperm...

Embodiment 1-4

[0070] With above-mentioned parts by weight, carry out according to the following steps:

[0071] (1) Mix and swell SIS synthetic rubber and liquid paraffin for more than 30 minutes, stir at 160-165 ° C, and carry out nitrogen or vacuum at the same time;

[0072] (2) Diethyl phthalate, dimethyl phthalate, isopropyl myristate and microcrystalline wax and terpene polymer; drop into the mixture of step (1) gained in batches, at 140 Stir until melting at ℃, while filling with nitrogen or under vacuum;

[0073] (3) Add lanolin, polyisobutylene, propyl gallate and accelerator BZ to the mixture obtained in step (2), stir at 100°C while filling with nitrogen or under vacuum.

Embodiment 5

[0075] Preparation of musk bone strengthening paste

[0076] 1. Preparation of drug-containing hot-melt pressure-sensitive adhesive layer

[0077] (1) hot-melt pressure-sensitive adhesive is obtained by the method of embodiment 1;

[0078] (2) Add 0.03 grams of leopard bone and 3 grams of borneol to the prepared hot-melt pressure-sensitive adhesive, stir and melt at 90° C., and fill with nitrogen;

[0079] (3) Add 3 grams of camphor, 0.48 grams of chondroitin sulfate, and 0.6 grams of diphenhydramine hydrochloride to the mixture obtained in step (2), and fill with nitrogen at the same time at a temperature of 85° C.;

[0080] (4) Add 2.55 grams of methyl salicylate and 10 grams of liquid extract to the mixture obtained in step (3) and mix evenly, and fill with nitrogen at the same time at a temperature of 80 to 85° C.;

[0081] (5) Add 0.024 gram of musk mixed powder and 4 gram of menthol to the mixture obtained in step (4), and fill with nitrogen at the same time at a tempe...

technical field

[0001] The invention relates to a hot-melt pressure-sensitive adhesive, in particular to a hot-melt pressure-sensitive adhesive matrix and its preparation and medical application. Background technique

[0002] Hot-melt pressure-sensitive adhesives can produce excellent hot-tackiness at an appropriate high temperature, and in a solid state at room temperature, the bonding effect can be produced with fingers or slight pressure.

[0003] Hot-melt pressure-sensitive adhesives with high polar components can enhance the adsorption force on the object to be bonded, and at the same time improve the bonding strength. However, chemical components (elements) with higher polarity usually have higher activity and are prone to aging phenomenon due to the interaction with oxygen.

[0004] The hot-melt pressure-sensitive adhesives in the prior art have poor compatibility among colloidal components, and are prone to oxidation and impurities during the manufacturing process; ...

Examples

preparation example Construction

[0052] In the preparation method of the hot-melt pressure-sensitive adhesive provided by the present invention, SIS synthetic rubber and liquid paraffin are mixed and swollen. This method makes the SIS synthetic rubber not soaked, lowers the temperature and melting point, and is beneficial to low-temperature rubber production.

[0053] Hot-melt pressure-sensitive adhesives do not use solvents, do not cause environmental pollution, and have high production efficiency. Such adhesives are becoming more and more important in today's society that calls for energy saving and elimination of environmental pollution.

[0054] The above-mentioned hot-melt pressure-sensitive adhesive is used in the plaster product for transdermal administration in plaster form provided by the present invention, so that volatile substances can be retained by more than 20% compared with gasoline-based ones.

[0055] Structurally, transdermal plaster products consist of a backing that is substantially imperm...

Embodiment 1-4

[0070] With above-mentioned parts by weight, carry out according to the following steps:

[0071] (1) Mix and swell SIS synthetic rubber and liquid paraffin for more than 30 minutes, stir at 160-165 ° C, and carry out nitrogen or vacuum at the same time;

[0072] (2) Diethyl phthalate, dimethyl phthalate, isopropyl myristate and microcrystalline wax and terpene polymer; drop into the mixture of step (1) gained in batches, at 140 Stir until melting at ℃, while filling with nitrogen or under vacuum;

[0073] (3) Add lanolin, polyisobutylene, propyl gallate and accelerator BZ to the mixture obtained in step (2), stir at 100°C while filling with nitrogen or under vacuum.

Embodiment 5

[0075] Preparation of musk bone strengthening paste

[0076] 1. Preparation of drug-containing hot-melt pressure-sensitive adhesive layer

[0077] (1) hot-melt pressure-sensitive adhesive is obtained by the method of embodiment 1;

[0078] (2) Add 0.03 grams of leopard bone and 3 grams of borneol to the prepared hot-melt pressure-sensitive adhesive, stir and melt at 90° C., and fill with nitrogen;

[0079] (3) Add 3 grams of camphor, 0.48 grams of chondroitin sulfate, and 0.6 grams of diphenhydramine hydrochloride to the mixture obtained in step (2), and fill with nitrogen at the same time at a temperature of 85° C.;

[0080] (4) Add 2.55 grams of methyl salicylate and 10 grams of liquid extract to the mixture obtained in step (3) and mix evenly, and fill with nitrogen at the same time at a temperature of 80 to 85° C.;

[0081] (5) Add 0.024 gram of musk mixed powder and 4 gram of menthol to the mixture obtained in step (4), and fill with nitrogen at the same time at a tempe...

Images