158 results about "Antioxidative stress" patented technology

The invention relates to the technical field of hippocampus extract, in particular to a hippocampus-sourced neuroprotection and anti-oxidative stress polypeptide and a preparation method thereof.The amino acid sequence of the polypeptide is shown as SEQ ID No.1. The preparation method comprises the following steps that 1, 500 g of fresh hippocampus is weighed, surface silt is removed, freeze-drying is conducted at the temperature of-60 DEG C, then the hippocampus is smashed through a smashing machine and sieved through a 20-mesh sieve, and the hippocampus extract is obtained; dialyzing with distilled water for 24 hours, and freeze-drying to obtain hippocampus powder; (2) weighing 200g of hippocampus powder, adding 1000ml of 95% ethanol, extracting for three times, removing fat-soluble substances, and extracting and freeze-drying precipitates by using a 1 mol / L NaCl solution under the condition of 4 DEG C in combination with ultrasonic assistance to obtain crude hippocampus protein; (3) the hippocampus crude protein is taken, the hippocampus polypeptide is prepared through an ultrasonic-assisted bionic digestion method, and the hippocampus polypeptide has the advantages of being specific in molecular structure, clear in action mechanism, stable in gastrointestinal tracts, capable of protecting nerves, resistant to oxidative stress and the like.

The invention discloses an edible and medicinal composition for dispelling effects of alcohol and protecting liver as well as a preparation method and application thereof, and belongs to the technical field of functional foods. The composition consists of the following raw materials in parts by weight: 1-8 parts of ampelopsis grossedentata extract freeze-dried powder, 1-8 parts of astragalus membranaceus extract freeze-dried powder, 1-5 parts of kudzu vine root extract freeze-dried powder, 1-8 parts of hawthorn extract freeze-dried powder and 1-5 parts of cassia seed extract freeze-dried powder. The composition is designed according to a multi-component synergistic interaction principle, and the functions of protecting the liver and dispelling the effects of alcohol are enhanced through targeted interaction of active ingredients such as ampelopsis grossedentata flavone, puerarin and astragaloside; the compound preparation has the compound effects of protecting the liver, dispelling the effects of alcohol, resolving dampness, resisting oxidative stress, regulating lipid metabolism and the like, can remarkably relieve the problems of acute and chronic liver injury and metabolic disorder caused by alcohol intake, and meets the food-grade safety standard and the medicinal activity requirement; the important application prospect is realized in the aspect of preparing a preparation for relieving alcoholic liver injury and improving the liver detoxification function.

The invention belongs to the technical field of biology, and particularly relates to a composition containing plant-derived exosomes as well as a preparation method and application of the composition. The invention provides a composition containing plant-derived exosomes. The composition is prepared from the following components in parts by mass: 1-60 parts of a plant-derived exosome preparation, 1-60 parts of chitosan oligosaccharide and 1-60 parts of probiotics. According to the composition provided by the invention, the plant-derived exosome, the probiotics and the chitosan oligosaccharide are compounded according to a specific proportion, so that the abundance of effective flora can be increased for a long time, the composition of intestinal flora can be improved, the structural balance of the intestinal flora can be regulated and maintained, the intestinal inflammation can be remarkably inhibited, the intestinal leakage can be improved, and the oxidative stress can be resisted; the repair of damaged intestinal mucosa and the elimination of inflammation are facilitated. The composition is safe and stable in raw materials, free of toxic and side effects and capable of being taken as daily diet.

The invention belongs to the technical field of microorganisms and fermentation engineering, and particularly relates to application of bifidobacterium longum subsp. Infantis Y46 in the aspects of enhancing cell defense and repair and regulating metabolic homeostasis of a host. The strain is isolated from infant feces. Animal experiments prove that living cell thalli of the bifidobacterium longum subsp. Infantis Y46, which are obtained by culturing an MRS liquid culture medium added with L-cysteine hydrochloride (0.05%, v / v), can significantly enhance the oxidative stress resistance of an organism and reduce the level of active oxygen in the organism compared with a control bacterium bifidobacterium longum subsp. Infantis 15697. Transcriptomics analysis shows that the bifidobacterium longum subsp. Infantis Y46 can enhance self-protection of cells and improve physiological imbalance caused by external pressure by regulating related signal channels of an organism. The action mechanism is closely related to signaling pathways related to cell defense, metabolic homeostasis and barrier functions. The invention provides a new strain resource and an application scheme for developing functional food or medicinal preparations for enhancing the health defense function of a human body.

The invention belongs to the technical field of biological medicines, and particularly relates to a wheat peptide with antioxidant stress activity and a preparation method and application thereof. The invention provides a wheat peptide with antioxidant stress activity. The amino acid sequence of the wheat peptide is as shown in SEQ ID NO: 1. The invention discloses a wheat peptide FGWPGPK for protecting oxidative stress nerve cells as well as a screening method and application of the wheat peptide FGWPGPK. A target peptide fragment is identified from wheat germs through enzymolysis and multi-dimensional screening strategies, and it is proved that the target peptide fragment can significantly improve the survival rate of PC-12 cells damaged by H2O2 (72.88%) and reduce the ROS level (125.54%). The peptide fragment has strong antioxidant activity and nerve targeting property, and is suitable for preventing and treating neurodegenerative diseases such as Alzheimer's disease.

The invention belongs to the technical field of medical gel, and particularly relates to modified hydrogel for skin wound healing and a preparation method thereof.The modified hydrogel is prepared from, by weight, 2-5 parts of drug-loaded GDVLNs, 1-2 parts of chitosan, 0.6-1.5 parts of antioxidant, 0.2 part of LAP, 1.5 parts of MA, 18 parts of gel matrix and 100 parts of buffer solution, the drug-loaded GDVLNs prepared from the traditional Chinese medicine active ingredients and the ginseng vesicles have the functions of resisting oxidative stress, promoting angiogenesis, promoting cell proliferation and the like, and the MA modified hydrogel system can realize slow release and controlled release of the drug-loaded GDVLNs and play a long-acting healing promoting role.

The invention relates to the technical field of biological medicines, and provides a self-assembled polypeptide-rhein conjugate, a preparation as well as a preparation method and application of the self-assembled polypeptide-rhein conjugate. The sequence of the MMP-9 responsive self-assembled polypeptide-rhein conjugate is Rhein-GFFPLGLAGACE, and the MMP-9 responsive self-assembled polypeptide-rhein conjugate can respond to abnormally activated MMP-9 in atherosclerotic plaque and is self-assembled into a stable nanofiber structure in situ at a diseased region; the anti-inflammatory and anti-oxidation functions of rhein in the conjugate are remarkable, but the water solubility and oral bioavailability are low, the anti-inflammatory and anti-oxidation functions are remarkably improved after being coupled with the polypeptide, targeted delivery is achieved, and the residence time is prolonged; the introduction of the tripeptide ACE simulating the function of glutathione further enhances the oxidative stress resistance of the conjugate. Furthermore, the conjugate shows excellent anti-inflammatory and anti-oxidation effects, can clear ROS, inhibit inflammation pathways, regulate macrophage phenotypes and inhibit apoptosis, and provides a new strategy for treatment of atherosclerosis.

The invention discloses a method for increasing the extraction yield of tremella polysaccharide and application, dry tremella is used as a raw material, tremella polysaccharide is effectively extracted by utilizing an ultrasonic-cellulase wall breaking coupling green solvent method, the extraction yield of tremella polysaccharide is effectively increased, the method is green and environment-friendly and is easy to control, and the obtained tremella polysaccharide has excellent biological activity and can be used for preparing the tremella polysaccharide. The water loss rate of water can be reduced, and the moisturizing and anti-wrinkle capabilities are good; the caenorhabditis elegans can effectively remove hydroxyl free radicals, DPPH free radicals and ABTS free radicals, shows strong oxidation resistance, can significantly prolong the survival rate of caenorhabditis elegans under hydrogen peroxide stress, and shows that the caenorhabditis elegans has good oxidative stress resistance.

The invention discloses application of copper-amino acid nano enzyme in preparation of anti-inflammatory drugs, and relates to the technical field of biomedical new materials, amino acids comprise glycine, arginine, histidine, threonine, phenylalanine and cysteine; the ratio of the amino acid to the copper ions is 1: (0.5-5), and the synthesis temperature of the copper-cysteine nano enzyme is 25-125 DEG C. The copper-amino acid nano-enzyme library established by the invention has efficient hydroxyl free radical, superoxide free radical and hydrogen peroxide scavenging activity; wherein the copper-cysteine nano-enzyme shows the highest enzymatic activity, and shows low toxicity and good biocompatibility in both the cell level and the animal level; meanwhile, the copper-cysteine nano-enzyme also shows anti-inflammatory activity and anti-oxidative stress activity, can remarkably improve cell inflammation and body inflammation, relieves and treats dextran sodium sulfate induced mouse ulcerative colitis, and can be further applied to preparation of drugs for treating inflammatory bowel diseases.

The invention belongs to the technical field of biological medicine and livestock breeding, and particularly relates to application of anthocyanin in improving the reproductive function of female beef cattle by adjusting intestinal flora and reducing follicular granule cell apoptosis. Specifically, the invention discovers and verifies for the first time through research that the anthocyanin added into the feed can play roles in regulating the reproductive hormone level of the cattle with the ovarian dysfunction, improving the ovarian function and improving the intestinal flora lineage, and meanwhile, the anthocyanin can resist the apoptosis of ovarian granular cells by resisting oxidative stress injury, so that the reproductive function of the cattle is improved. The invention provides a scientific basis for the application of the anthocyanin in the aspect of improving the reproductive capacity of the female beef cattle, and discloses a mechanism for improving the ovarian function by resisting oxidation and regulating intestinal flora, thereby being beneficial to improving the application prospect of the anthocyanin in animal husbandry, and having a good practical application value.

The invention discloses a catechol ether compound as well as a pharmaceutical composition and application thereof. The structure of the compound is as shown in a formula I, the compound further comprises pharmaceutically acceptable salt of the compound, the compound has PDE4 inhibition and antioxidation dual functions, has inhibition and removal effects on PDE4 and free radical DPPH at the same time at the micromolar concentration level, shows anti-inflammatory and antioxidative stress dual effects in vivo and in vitro, and can be used for preparing a medicine for preventing and treating PDE4 and free radical DPPH. Therefore, the compound has a wide application prospect in the aspect of treating diseases related to inflammation and oxidative stress. # imgabs0 #

The invention relates to a composition with bacteriostatic, anti-inflammatory and / or oral cavity repairing effects and application of the composition in toothpaste, and belongs to the technical field of daily chemicals. The composition disclosed by the invention is prepared from the following components in parts by weight: 0.04 to 0.06 part of pyrroloquinoline quinone and 0.2 to 0.3 part of carboxymethyl chitosan. Based on the anti-oxidative stress regulation and control capability of pyrroloquinoline quinone and the broad-spectrum antibacterial synergistic effect of carboxymethyl chitosan, pyrroloquinoline quinone and carboxymethyl chitosan are compounded and applied to a toothpaste formula system, so that the toothpaste has the effects of inhibiting bacteria, resisting inflammation, proliferating and repairing gingival fibroblasts and regulating the composition and diversity of oral microorganisms. According to the composition disclosed by the invention, through a multi-mechanism synergistic effect, an oral health maintenance system integrating bacteriostatic protection, inflammation regulation and control and mucous membrane repair is constructed, and the compound requirements of modern consumers on oral microenvironment regulation and control, mucous membrane barrier strengthening and long-term health management are accurately met.

The invention provides a preparation method of human collagen and an application of the human collagen in anti-aging. The amino acid sequence of the human collagen is as shown in SEQ ID NO: 1; based on a natural collagen structure, a fusion sequence structure is provided, and the proportion of individual amino acids is adjusted; the collagen can promote skin cell growth and hyaluronic acid secretion; skin aging caused by ultraviolet radiation is resisted, inflammatory factor expression is inhibited, and oxidative stress is resisted.

The application belongs to the field of microbial metabolic engineering, and discloses a Saccharomyces cerevisiae engineering strain with enhanced isopentenol tolerance and conversion capacity, and a construction method and application thereof. The Saccharomyces cerevisiae engineering strain is obtained by modifying an isopentenol utilization pathway-dependent Saccharomyces cerevisiae strain, and the energy metabolism of the Saccharomyces cerevisiae strain is enhanced to synthesize a large amount of ATP for the isopentenol utilization pathway; and the antioxidant stress resistance of the Saccharomyces cerevisiae strain is enhanced to relieve the oxidative damage caused by the isopentenol substrate. The Saccharomyces cerevisiae engineering strain is the strain with the highest efficiency in converting isopentenol into terpenes.

The invention belongs to the technical field of compound application, and particularly relates to coriaria lactone compounds, a preparation method thereof and application of the coriaria lactone compounds in oxidative stress resistance. The coriaria lactone compound can significantly inhibit oxidative stress damage of SH-SY5Y cells, and the cell survival rate of the coriaria lactone compound is increased to 79.6%. Meanwhile, the nematode anti-aging activity is achieved, generation of nematode lipofuscin is inhibited, and the highest inhibition rate is 45%. In an extreme oxidative stress experiment, the service life of the nematodes is prolonged, so that the coriaria lactone compound has an application prospect of treating and resisting aging diseases.

This invention relates to a vulnerary multifunctional composition, based on unripe coffee cherries (peel, mucilage, beans and silverskin), seed extract of Trigonella foenum-graecum, with one or more tissue-inducing molecules derived from the secondary metabolites of both plants. The unexpected and surprising ability of this new composition to solve the problems of chronic non-healing wounds addresses a long felt unmet need in the medical arts. Through a multifaceted approach, it combats microbial infections, reduces chronic inflammation, counters oxidative stress, enhances immune responses, promotes angiogenesis, regulates protease activity, stimulates collagen deposition, increases growth factor availability, facilitates cell migration, and prevents persistent infections. These novel integrated therapies represent a breakthrough in addressing macroscopic wound healing while targeting the underlying microscale mechanisms. This invention also relates to methods for preparing, using, and administering the multifunctional composition for timely healing in mammals with various skin lesions.

The invention relates to a protective liquid formula for improving the survival rate of frozen and thawed sperms of pigs. The protective liquid formula comprises the following components in percentage by mass: 14% of sodium hexadecylsulfonate, 7% of coconut oil monoethanolamide and 79% of distilled water. The preparation method comprises the following steps: 1) weighing 14g of sodium hexadecylsulfonate and 7g of coconut oil monoethanolamide, and dissolving in 79g of distilled water; and 2) uniformly stirring the solution obtained in the step 1) at 60 DEG C until the sodium hexadecyl sulfonate and the coconut oil monoethanolamide are completely dissolved in the distilled water. The protection liquid has the advantages that the protection liquid protects porcine sperm cells, provides a suitable living environment for porcine sperms, improves the oxidative stress resistance and the preservation effect of the porcine sperms, ensures the survival rate of the porcine sperms, and further improves the breeding rate and the breeding benefits of sows; the survival rate, the sperm motility and the acrosome integrity rate of the frozen and thawed sperms of the pigs are obviously improved; the feed additive is simple in proportioning, high in reliability, low in economic cost, high in biological value and convenient to popularize and apply in production, and yolk with extremely high preparation requirements is not used.

The invention relates to the technical field of cream, in particular to an antioxidant composition, antioxidant soothing cream and a preparation method thereof. The antioxidant composition comprises the following raw materials: a mangnolia officinalis bark extract and a grape seed extract. According to the present invention, the cortex magnoliae officinalis extract and the grape seed extract are adopted as the composition according to the specific ratio so as to achieve the synergistic effect, and the antioxidant stress regulation switch Nrf2 can be opened so as to open the antioxidant stress regulation signal channel of the cell, translocate the Nrf2 to the cell nucleus, activate the ARE, activate the transcription of the antioxidant gene, and improve the antioxidant activity of the antioxidant gene; and the anti-oxidative stress system of the body is started, and anti-oxidation is carried out from an internal source.

The application discloses an eggshell membrane peptide with antioxidant and improving exercise capacity of aging organism and application thereof, and belongs to the technical field of biology. The amino acid sequence of the eggshell membrane peptide is shown as SEQ ID NO. 1, and is specifically EQPWFPAG. A novel antioxidant peptide EQPWFPAG is identified from chicken eggshell membrane hydrolysate, and the eggshell membrane peptide can improve the exercise capacity and antioxidant stress capacity of an aging organism through verification. The eggshell membrane peptide provided by the application can be used for preparing an antioxidant, and can also be used for preparing functional food, health products and pharmaceutical compositions for improving the exercise function of an aging organism, and has great application value.

The invention discloses a natural functional component for preventing and improving cardiovascular diseases of pets. The natural functional component comprises an earthworm protein extract and a leech extract, the earthworm protein extract accounts for 20wt%-40wt% of the natural functional components; the ratio of the leech extract in the natural functional components is 10wt%-30wt%; the invention also comprises a feed containing the natural functional components for preventing and improving cardiovascular diseases of pets. The traditional Chinese medicine composition has the effects of resisting blood coagulation, thrombus, inflammation and oxidative stress, can prevent thrombosis, relieve inflammatory response, reduce free radical damage and protect the health of heart and cerebral vessels, and plays a role in preventing and improving cardiovascular diseases of pets; the pet feed additive can be added into feed to protect pet health.

The present invention relates to the field of molecular biology detection technology, and particularly relates to a molecular marker for detecting the oxidative stress ability of Tibetan sheep and its application. An SNP molecular marker related to the oxidative stress ability of Tibetan sheep, the SNP molecular marker is located at the 2,157,396th base on chromosome 19 of the international sheep genome version Oar_v4.0, and the mutated base is G or A. By detecting the base at the 2,157,396th nucleotide site on chromosome 19 of Tibetan sheep, the antioxidant stress indexes MDA, NO, and T-AOC contents of Tibetan sheep individuals can be judged. The present invention provides a new SNP molecular marker resource for marker-assisted selection of antioxidant stress traits of Tibetan sheep for non-diagnostic purposes.

The present application relates to the technical field of nanomaterial application, and provides a ruthenium-doped Prussian blue nanoscale enzyme and a preparation method thereof, wherein the ruthenium-doped Prussian blue nanoscale enzyme is obtained by reacting metal ruthenium with Prussian blue nanoparticles under normal temperature conditions. The present application also provides a nanoscale enzyme library containing the ruthenium-doped Prussian blue nanoscale enzyme and a construction method thereof. The present application also provides SNP-PB nanoscale enzyme obtained by loading sodium nitroprusside into the ruthenium-doped Prussian blue nanoscale enzyme. The ruthenium-doped Prussian blue nanoscale enzyme and the SNP-PB nanoscale enzyme both have good antibacterial and anti-inflammatory properties, and can better solve the problem of biofilm resistance after being endowed with the ability to release NO gas, thereby better exerting antioxidant stress and fighting periodontal bacterial infection, and providing a new treatment method for periodontal disease.

A high-oxygen adaptive anti-aging oxygen-enhanced adaptive functional beverage formulated using advanced liposomal encapsulation, plant-based microencapsulation, and microbubble oxygenation technologies to enhance bioavailability, stability, and oxygen delivery. The oxygen-enhanced adaptive functional beverage improves cellular metabolism, mitochondrial function, and oxygen utilization, leading to increased energy levels, cognitive function, and oxidative stress resistance. By promoting efficient oxygen absorption and retention, the oxygen-enhanced adaptive functional beverage supports healthy aging, athletic performance, and high-altitude adaptation. The oxygen-enhanced adaptive functional beverage incorporates bioactive compounds, antioxidants, and essential nutrients, ensuring prolonged effectiveness and enhanced physiological benefits.

The present application relates to the technical field of molecular markers, and particularly relates to a SNP molecular marker related to the anti-oxidative stress capacity of Tibetan sheep and application thereof.A SNP molecular marker related to the anti-oxidative stress capacity of Tibetan sheep, the molecular marker is located at the 196714361th base on the 3rd chromosome of the international sheep genome Oar_v4.0 version, and the mutation base is A or C.Through detecting the base of the 196714361th nucleotide site on the 3rd chromosome of the Tibetan sheep, the anti-oxidative stress index T-AOC content of the Tibetan sheep individual can be judged, and the present application provides a new SNP molecular marker resource for the marker-assisted selection of the anti-oxidative stress trait of the Tibetan sheep for non-diagnostic purposes.

The present application relates to a kind of biomimetic reticular nanofiber composite coating and its preparation method and infectious bone defect repair application, belong to biomedical material field.The present application is aimed at solving the technical problem of the poor bone integration of implant in infectious bone defect.The present application provides a kind of biomimetic reticular nanofiber composite coating, which is formed by layer-by-layer self-assembly on the surface of implant by lysozyme amyloid fiber and polyphenols (such as tannin etc.) Form reticular structure, then prepared with bioactive metal ions coordination;The number of coating layers is 4-8 layers.Preparation method includes lysozyme fiberization, alternate deposition and ion loading steps.The composite coating of the present application has broad-spectrum antibacterial, antioxidant stress and promotes osteogenesis function;In animal model, bacterial load is reduced by 80%, bone volume fraction and trabecular bone parameters are significantly improved, and can realize anti-bacterial biofilm infection-antioxidant stress-angiogenesis-promote bone regeneration synergy.

The present invention belongs to the technical field of molecular biological detection, and in particular to a SNP molecular marker for detecting the oxidative stress ability of Tibetan sheep and its application. The present invention obtains a SNP molecular marker related to the oxidative stress ability of Tibetan sheep by screening, and the SNP molecular marker is located at the 35036005th base on chromosome 20 of the international sheep genome Oar_v4.0 version, and the mutant base is G or T. The SNP molecular marker can be used to detect the content of ROS and MDA in Tibetan sheep individuals, providing a new SNP molecular marker resource for marker-assisted selection of Tibetan sheep anti-oxidative stress traits for non-diagnostic purposes, providing a basis for screening Tibetan sheep with strong anti-oxidative stress ability, and providing a new direction for assisted breeding of Tibetan sheep.

The invention discloses a nano preparation with mitochondrial targeting, a preparation method of the nano preparation and application of the nano preparation in myasthenia gravis. According to the method, a nano-carrier is prepared from PLGA and HPMC through an anti-solvent precipitation method, astragaloside and black phosphorus quantum dots are loaded in a manner of forming nanoparticles, and the surfaces of the nanoparticles are modified with mitochondrial targeting micromolecules NH2-PEG-TPP, so that the nano-preparation for mitochondrial targeting treatment of myasthenia gravis is obtained. The nano preparation has a mitochondrial targeting function, can improve the distribution of drugs in muscle cell mitochondria, avoids the too fast degradation of BPQDs in vivo, improves the bioavailability of AS-IV and BPQDs, exerts the function of resisting oxidative stress to protect mitochondria, and provides a nano preparation for effectively treating mitochondrial damage for myasthenia gravis.

The invention discloses a lignan compound and medical application thereof.The structure of the lignan compound is shown in the formula (I), the lignan compound is derived from amomum tsao-ko and has excellent anti-oxidative stress capacity, the performance of the lignan compound is better than that of edaravone, and the lignan compound is lower in toxicity and can be used for preparing medicines for preventing and treating diseases. Therefore, the compound or the pharmaceutically acceptable salt or glycoside thereof can be used for preparing drugs for treatment or adjuvant treatment or prognosis improvement or prevention of diseases related to imbalance of the antioxidant stress system. # imgabs0 #

This invention concerns a method of using mycotoxin binder in broiler chicken feed to reduce the immunotoxicity of aflatoxin B1 and ochratoxin A. This method is implemented by mixing mycotoxin binder into broiler chicken feed contaminated with aflatoxin B1 and ochratoxin A at a certain dose, then providing the feed to broiler chickens during the rearing period. The application of this method is able to reduce the toxic impact of mixed mycotoxins on the immune system of broiler chickens by improving the immune response and protection against oxidative stress. This method provides benefits in the form of improving the health and endurance of broiler chickens and reducing economic losses in the poultry industry due to decreased performance and health of livestock.

The invention belongs to the field of feed additives, and particularly relates to a nano feed additive for improving intestinal flora and a preparation method thereof.The preparation method comprises the following steps that (1) an electric arc furnace with pure copper as an anode and a graphite rod as a cathode is provided, absolute ethyl alcohol is injected into the furnace body in the vacuum state in the electric arc furnace, the arc starting current is controlled to be 40-60 A, and the temperature is controlled to be 20-30 DEG C; and purifying in an argon atmosphere for 12-48 hours to obtain the Cu-coated C nano-particles. And (2) carrying out oxidation reaction on the Cu-coated C nano-particles in an oxygen-containing atmosphere at the reaction temperature of 200-350 DEG C for 1-5 hours to obtain an oxidized product, namely the nano feed additive. The nano feed additive disclosed by the invention can be used for preventing and treating bacterial infection, enhancing the immune function and the anti-oxidative stress function of an organism, improving intestinal flora and prolonging the service life of animals, is an effective and safe functional feed additive, is simple in preparation method and low in production cost, can realize large-scale preparation, and has an important application prospect.