115 results about "Lactone Compound" patented technology

An object of the present invention is to provide a chemical liquid which makes it possible to form a thinner resist film having a uniform thickness on a substrate by using a small amount of resist composition and demonstrates excellent defect inhibition performance. Another object of the present invention is to provide a pattern forming method. A chemical liquid of the present invention contains a mixture of two or more kinds of organic solvents, in which the organic solvents are selected from the group consisting of compounds represented by Formulae (1) to (7), compounds represented by Formulae (9) to (11), a 3- to 5-membered cyclic ketone compound that may have a substituent, a cyclic ketone compound with 6 or more members that may have a substituent, a lactone compound, and a lactam compound, the chemical liquid contains or does not contain an ether-based compound other than the compounds represented by Formula (1), Formula (5), Formula (7), and Formulae (9) to (11), and in a case where the chemical liquid contains the ether-based compound, a content of the ether-based compound in the chemical liquid is less than 10 mass ppm with respect to a total mass of the chemical liquid.

The invention discloses a homoserine lactone compound N-(3-cyclobutyrolactone)-4-nitrobenzene butyramide which can effectively inhibit the formation of a multi-drug-resistant pseudomonas aeruginosa biofilm, and an application of the N-(3-cyclobutyrolactone)-4-nitrobenzene butyramide in the treatment of chronic infection of drug-resistant bacteria. The N-(3-cyclobutyrolactone)-4-nitrobenzene butyramide not only can inhibit QS systems of pseudomonas aeruginosa standard strains and clinical strains and enhance the inhibitory activity of antibiotics to pseudomonas aeruginosa, but also is good in safety and can be used for treating chronic infection caused by pseudomonas aeruginosa.

The application relates to the technical field of catalysts and compound preparation, in particular to a metal-modified zeolite catalyst and a method for catalyzing lactone compounds to generate terminal olefins. ‑ SiO2; wherein the metal M is selected from any one of Ti, Cr, Mn, Co, Ni, Cu, Zn, Zr, Nb, W, Ta and Hf; in the provided metal-modified zeolite catalyst, metal atoms are arranged on the skeleton end points of a zeolite molecular sieve to form a monatomic catalyst; on one hand, the obtained catalyst has Lewis metal sites, can be beneficial to catalyzing lactone compounds to realize decarboxylation, and can ensure that the lactone compounds can be directly catalyzed to generate terminal olefins, and can be widely applied.

The invention belongs to the technical field of microbial pharmacy, and discloses a polyketone macrolide compound generated by genetically engineered streptomyces as well as a preparation method and application thereof. The polyketone macrolide compound disclosed by the invention is a cinnamyl streptomycin derivative, has cell proliferation inhibition activity better than that of a natural product Cinnamomycin A-D, can exert anti-tumor activity by inhibiting activity of human exonucleotide pyrophosphatase / phosphodiesterase 1 (ENPP1) and activating an inherent immune pathway, can be prepared into a medicine or a medicinal composition, and can be used for preparing medicines or medicinal compositions. The compound is used for treating tumors and related diseases.

To provide an andrographis paniculata diterpene lactone compound as well as extraction method and application thereof.SOLUTION: The andrographis paniculata diterpene lactone compound provided by the invention has a structure as shown in any one of formulas 1-7 and is novel in structure. The andrographis paniculata diterpene lactone compound extracted and separated from andrographis paniculata has a good anti-inflammatory effect, and has a good down-regulation effect on secretion of NO, interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β) in a lipopolysaccharide (LPS) induced mouse mononuclear macrophage (RAW264.7 cell) inflammation model; the compound also has a good inhibition effect on expression of inducible nitric oxide synthase (INOS) and cyclooxygenase-2 (COX-2) proteins, and can be applied to preparation of anti-inflammatory drugs.SELECTED DRAWING: Figure 1

The invention discloses application of biphenyl lactone compounds in treatment of Alzheimer's disease, and belongs to the field of medicine. According to the present invention, in the oleic acid treatment combined APOE4 point mutation microglial cells, the benzene lactone compound Graphislactone A can improve the abnormal lipid droplet accumulation, inhibit the microglial cells from generating inflammatory factors, and further protect the neuronal function; meanwhile, in-vivo AD mouse model experiments prove that the benzolactone compound Graphislactone A can improve cognitive impairment of AD mice and reduce abnormal accumulation of lipid droplets in brain and expression of inflammatory factors, can be used as an active ingredient of medicines for treating AD, and has wide application.

The present invention relates to a novel smoking article including a flavoring agent, and more particularly, to a smoking article including a flavoring agent including, in a basic skeleton thereof, a moiety derived from a sugar compound and a moiety derived from a flavor compound, which is a novel compound decomposed into a lactone compound, a sugar compound, and a flavor compound upon thermal decomposition.

A non-aqueous electrolyte secondary battery has a negative electrode (12) having a negative electrode current collector (40) and a negative electrode compound layer (42) disposed on the surface of the negative electrode current collector (40). The negative electrode compound layer (42) contains a first negative electrode active material with a first internal porosity and a second negative electrode active material with a second internal porosity greater than the first internal porosity. The first negative electrode active material is largely contained on the surface side of the negative electrode compound layer (42). The non-aqueous electrolyte contains at least a sulfonyl lactone compound having unsaturated bonds and fluoroethylene carbonate. In the non-aqueous electrolyte, when the concentration of the sulfonyl lactone compound is set to X mass% and the concentration of fluoroethylene carbonate is set to Y mass%, the following conditions are met: 0.01≤X≤5.0, 0.01≤Y≤2.0, and X / Y>0.5.

Phthalide lactones, as an important class of benzopentolactone skeleton, are widely distributed in natural products, medicinal plants and bioactive molecules, and have significant pharmacological activities and synthetic application potential. This kind of structure not only shows various biological activities such as antibacterial, anti-inflammatory, antitumor, antioxidant, but also is an indispensable core structural unit in many drug molecules and lead compounds. At the same time, cyano is a very valuable functional group in the field of organic synthesis and medicinal chemistry, with strong electron-withdrawing properties, strong structural stability and other advantages, which can effectively improve the electronic distribution, lipid solubility and drug performance of the molecule. In view of the important significance of phthalide lactones and cyano in organic synthesis and drug research and development, the present invention develops a synthetic method for efficiently constructing cyano-containing alkyl chain substituted phthalide lactone compounds. It has important value in medicinal chemistry and organic synthesis.

The application discloses a kind of preparation method and system of butadiene-styrene latex using emulsion coagulant modification, belong to high polymer material and synthetic rubber technical field.The application includes: the solution containing lactone compound, linear polymer with upper critical solution temperature is mixed with butadiene-styrene latex, and homogeneous premix system is formed;Under preset temperature condition, the hydrolysis reaction of the lactone compound in the homogeneous premix system is carried out, and the pH value of system drops;When the pH value of the system drops to the isoelectric point of the linear polymer, the dissolution state of the linear polymer under the preset temperature changes from hydrophilic extended conformation to hydrophobic collapse conformation, so as to coalesce latex particles in the butadiene-styrene latex.The application realizes the separation of coagulation reaction and mixing process in time, effectively inhibits the problem of local concentration polarization caused by glue deposition and particle size distribution widening, and the obtained rubber particle is uniform in size and excellent in mechanical property, suitable for industrial production.

The invention belongs to the technical field of chemical analysis, and particularly relates to application of hydroxyapatite in fruit juice pretreatment, a sample pretreatment method and a method for detecting lactone compounds in fruit juice. The method for identifying whether the NFC fruit juice is adulterated with the artificial lactone essence comprises a pretreatment part and a detection part, equipment and operation steps needed by the pretreatment method are simple, and the pretreatment method has the advantages of being small in solvent usage amount, little in pollution and high in analysis speed. According to the method, a chiral GC-MS system capable of realizing chiral lactone compound isomer resolution is used, chemical / physical means for isomer resolution are not needed, and the experimental analysis process is accelerated.

The invention belongs to the technical field of medicinal chemistry, and particularly relates to an N-thioacyl homoserine lactone compound and a preparation method thereof, the compound is an analogue of a natural self-inducer N-acyl homoserine lactone AHLs, and thioamide is used as a biological isostere of amide to replace an amide group in the natural self-inducer. The compound has an obvious inhibition effect on a Vibrio fischeri Lux system and related toxic gene phenotypes regulated by the Vibrio fischeri Lux system and can be used as a Vibrio fischeri quorum sensing activity inhibitor, and thioamide is more stable in chemical structure than dithiocarbamate and has better enzyme hydrolysis stability.

The invention provides a preparation method of sulfonic modified polyurethane fiber. The preparation method comprises the following steps: S1, carrying out prepolymerization reaction and chain extension reaction on dihydric alcohol, diisocyanate and a chain extender to obtain a polyurethane stock solution; s2, the polyurethane stock solution and sultone compounds are subjected to a ring-opening reaction, and an intermediate product grafted with sulfonate ions is obtained; carrying out a neutralization reaction on the intermediate product and an organic acid-binding agent to obtain a sulfonic modified polyurethane stock solution for spinning; s3, carrying out mixing curing, solvent evaporation, drafting, oiling and winding on the sulfo-modified polyurethane stock solution and an optional functional additive to prepare sulfo-modified polyurethane fibers; according to the preparation method, the sulfonic acid group is introduced after the chain extension reaction to modify the polyurethane stock solution, so that the adverse effect on the polymerization stability caused by improper introduction time of the sulfonic acid group is avoided; the sulfo group modified polyurethane fiber prepared by the invention has excellent mechanical properties and good coloring property and color fastness.

An electrolytic capacitor according to the present invention comprises a capacitor element and a liquid component impregnated in the capacitor element. The capacitor element includes: an anode foil provided with a dielectric layer; a cathode foil; a wound body obtained by winding a separator interposed between the anode foil and the cathode foil; a first electroconductive polymer layer formed on the separator; and a winding stop tape for fixing a winding end portion of the wound body. The coating amount of the first electroconductive polymer layer on the separator is 0.04 mg / cm2 or more. A lactone compound is present in the liquid component in a proportion of 40 mass% or less.

The present invention provides an application of a two-component metal complex in catalyzing the carbonylation of epoxides to prepare beta-lactones, the two-component metal complex including a complex A and a complex B, wherein the structure of complex A is as shown in formula (I) or formula (II), and the structure of complex B is as shown in formula (III) or formula (IV): the present invention also discloses a method for preparing beta-lactones by catalyzing the carbonylation of epoxides using the above-mentioned two-component metal complex: alkylene oxide and carbon monoxide CO are subjected to a ring amplification reaction under the catalytic action of the two-component metal complex to prepare a four-membered ring beta-lactone compound. The two-component metal complex is a catalytic system with good thermal stability and high reaction activity, which can achieve efficient preparation of beta-lactones.

A cleaning agent composition and a method for removing thermoplastic polymers using the cleaning agent composition are disclosed. The cleaning agent composition comprises at least 10 to 90 wt% of a cyclic acetal compound and 10 to 90 wt% of an aprotic solvent, wherein the aprotic solvent comprises an aromatic ether compound and / or an lactone compound. This cleaning agent composition can not only clean residual materials on wafers but also clean coating equipment and pipelines.

An electrochemical capacitor includes a positive electrode, a negative electrode, and an electrolyte. The electrolyte contains a lactone compound and an additive. The additive is at least one selected from the group consisting of a siloxane compound and a silyl fluoride compound.

The invention provides a macrolide compound and a preparation method and application of an intermediate compound of the macrolide compound, and belongs to the field of organic synthesis. The macrolide compound provided by the invention has the following chemical structure. The macrolide compound prepared by the invention is a compound with a 19-membered lactone ring structure, has a [5, 6]-tetrahydroindene ring structural unit and a (Z, E, Z) conjugated triene unit, and has a chemical structure completely different from that of MRSA drug-resistant bacterium antibiotics clinically used at present, such as polypeptide drugs (vancomycin and the like) and quinolone drugs (ofloxacin and the like), and the MRSA drug-resistant bacterium antibiotics can be used in clinical application. The macrolide is proved to have new drug-resistant bacterium resisting action targets and mechanisms. The macrolide compound provided by the invention has strong anti-MRSA activity, the minimum inhibitory concentration (MIC) is 1-2mg / mL and is equivalent to the anti-MRSA activity of vancomycin, and based on the strong anti-drug-resistant bacterium activity, the macrolide provided by the invention can be developed into a novel anti-drug-resistant bacterium drug. # imgabs0 #

The invention provides oak chips for ageing high-quality beer as well as a preparation method and application of the oak chips. Every 100 g of the oak sheet is prepared from the following components by mass: 1600 to 15000 mg of vanillin, 750 to 1600 mg of whisky lactone, 4500 to 22500 mg of furfural, 25 to 80 mg of guaiacol, and 55 to 70 mg of eugenol. The preparation method of the oak chips for aging beer comprises the steps of baking treatment and ultraviolet photolysis treatment of raw oak chips, the temperature of the baking treatment is 150-240 DEG C, and the optical power density of the ultraviolet photolysis treatment is 0.6-0.8 W / m < 2 >. The oak chips disclosed by the invention are high in content of phenols and lactones, and high-quality beer which is excellent in balance degree and harmony of various fragrances can be obtained in a short time.

The invention relates to a selenolactone compound. The preparation method comprises the following steps: firstly, chemically synthesizing a chiral selenium-containing alpha-exo-methylene lactone compound 1 to improve the selectivity of the compound 1 to tumor cells; then, a hydrophilic group is adopted to attack alpha-exo-methylene lactone to obtain a selenolactone-containing compound 2, the water solubility of the selenolactone-containing compound 2 is enhanced, tumor cells are expected to preferentially uptake a selenolactone-containing prodrug 2, then methylation is carried out under the action of in-vivo SAM enzyme to generate ammonia positive ions I, and finally alpha-exo-methylene lactone warheads 1 are released; therefore, the selectivity of the anti-tumor effect is improved. The selenolactone compound provided by the invention can effectively inhibit proliferation of various cancer cells, and has good selectivity to tumor cells; meanwhile, the growth speed and volume of tumors in vivo can be remarkably inhibited, and the compound has excellent anti-tumor activity and good safety. The invention provides sufficient scientific basis and theoretical basis for exploring the development of selenium antitumor drugs, and has important social value and scientific significance.

The invention relates to a drug combination of annona squamosa lactone compounds and sorafenib (SF), which is characterized in that four common human hepatoma cell lines HepG2, HuH7, MHCC97H and HCCLM3 are used as research objects, and the drug combination effect among different components is evaluated by using an MTT (3-(4, 5-Dimethylthiazol-2-yl)-2, 3-diphenyltetrazolium bromide) method and Synergy Finder software. The combination of the compound and SF shows an obvious synergistic inhibition effect on the growth of hepatoma carcinoma cells, and meanwhile, the pharmaceutical composition can synergistically reduce the ATP level of the hepatoma carcinoma cells and induce hepatoma carcinoma cell apoptosis. Pharmacodynamic experiments show that the compounds annonacin and SF can synergistically inhibit tumor growth and induce tumor cell apoptosis, and have no obvious toxicity to normal organs of nude mice at a low dosage. In addition, transcriptome analysis predicts that the anti-liver cancer target of the annonacin is possibly related to the SLC33A1 gene. The method can be used for preparing anti-hepatoma drugs and researching related mechanisms. The annona lactone compound disclosed by the invention is derived from annona montana Macf. Which is an annona plant, namely annona montana Macf.

A kind of the present application relates to new flavor and the product including it. More specifically, it is related to a kind of flavor, the composition and product including it, the flavor includes the part derived from flavor compound represented by chemical formula 1, and is the compound that is decomposed into lactone compound and flavor compound when thermal decomposition.

The present invention provides a method for synthesizing a cyclic lactone. An alkylene oxide shown by formula I reacts with carbon monoxide under the action of a catalytic system of a tetradentate metal complex and a metal carbonyl compound to carry out a ring expansion reaction to obtain a cyclic lactone compound shown by formula II. The catalytic system of the tetradentate metal complex and the metal carbonyl compound can achieve the ring expansion carbonylation reaction of the alkylene oxide to generate a cyclic lactone under mild reaction conditions. The conversion rate of the reaction substrate is as high as over 99%, and the regioselectivity of the product is as high as over 99%. The catalyst is simple to synthesize, has good activity and high yield, and the synthesis of the catalyst avoids the synthesis of cobalt salts sensitive to air and light. The obtained catalyst is easier to store and the catalytic reaction operation is more convenient.

An electrochemical capacitor includes: a positive electrode; a negative electrode; a separator disposed between the positive electrode and the negative electrode; and an electrolytic solution. The electrolytic solution contains a lactone compound. A capacity of the positive electrode is greater than the capacity of the negative electrode and is less than or equal to 1.6 times the capacity of the negative electrode.

The invention discloses a performance-controllable polyether ester copolymer and a preparation method thereof, and belongs to the field of high polymer materials. An epoxy compound and a cyclic lactone compound are used as comonomers for ring opening polymerization, so that the polyether ester copolymer is synthesized through a one-pot method, and the performance of the copolymer can be regulated and controlled by adjusting the feeding amount of the comonomers. Meanwhile, a small amount of ester groups are introduced into the polyether structural unit to serve as ester exchange sites, so that the compatibility of the polyester structural unit and the polyether structural unit is improved, and the polyether ester copolymer with uniform and controllable performance can be prepared. The obtained polyether ester copolymer can be used as polyurethane polyol, and can also be independently used as a high polymer material.

The invention provides an electrolyte, a sodium ion battery, a battery pack and an energy storage system, the electrolyte comprises a first additive, a second additive and a third additive, the first additive is fluoroethylene carbonate, the second additive is selected from at least one of sulfate compounds and sultone compounds, and the third additive is a first sodium salt; the mass percentage content of the first additive in the electrolyte is m1, the mass percentage content of the second additive in the electrolyte is m2, the mass percentage content of the third additive in the electrolyte is m3, m1 is 0.5%-3%, m2 is 0.1%-5%, and m3 is 0.2%-10%. Therefore, under the action of the three additives, not only can the positive electrode and the negative electrode be subjected to dual protection, but also the impedance of passive films formed on the surfaces of the positive electrode and the negative electrode can be reduced, and the ion transmission performance is improved, so that the performance of the sodium ion battery is improved.

The present invention relates to a novel flavoring agent and products including the same. More specifically, it relates to a flavoring agent, a composition including the same, and a product, wherein the flavoring agent includes a moiety derived from a fragrance compound represented by Chemical Formula 1 and is a compound that decomposes into a lactone compound and a fragrance compound upon thermal decomposition.

This curable resin composition comprises an α-methylene cyclic lactone compound. The α-methylene cyclic lactone compound optionally has a 5- to 6-membered lactone structure. This curable resin composition optionally further comprises a multifunctional monomer and a (meth)acryloyl-group-containing polymer. The composition can further contain a polyfunctional monomer and a (meth) acryloyl group-containing polymer.

The invention belongs to the technical field of stem cell culture media, and relates to a culture medium for stem cells as well as preparation and application thereof. The invention provides a culture medium for stem cells. The culture medium is composed of a basic culture medium and the following components added to the basic culture medium: a nutrition additive, a growth factor and a plant-derived lactone compound, the plant-derived lactone compounds are carabrone and parthenolide, and the plant-derived lactone compounds are carabrone and parthenolide. On one hand, the technical problem that animal-derived components such as human transferrin and human serum albumin need to be added into an existing stem cell serum-free culture medium, so that the potential pollution risk caused by introduction of animal-derived and human-derived pathogenic microorganisms exists is solved; on the other hand, when the provided culture medium is used for stem cells, the technical problems that the stem cells are easy to differentiate and difficult to amplify for a long time during in-vitro culture can be effectively solved.

This invention discloses a method for synthesizing lactone compounds and cerium-catalyzed lactone compounds. The synthesis method comprises the following steps: under visible light irradiation, in an oxygen atmosphere, and in the presence of a photocatalyst and a cerium catalyst, a cyclic ketone compound containing a structural fragment as shown in Formula II is subjected to a cyclization reaction in a solvent to obtain a lactone compound containing a structural fragment as shown in Formula I. This method uses readily available raw materials to conveniently and rapidly synthesize various medium- and large-cyclic lactones, and is simple, economical, and environmentally friendly.