51 results about "Lactone Compound" patented technology

The invention belongs to the technical field of microbial pharmacy, and discloses a polyketone macrolide compound generated by genetically engineered streptomyces as well as a preparation method and application thereof. The polyketone macrolide compound disclosed by the invention is a cinnamyl streptomycin derivative, has cell proliferation inhibition activity better than that of a natural product Cinnamomycin A-D, can exert anti-tumor activity by inhibiting activity of human exonucleotide pyrophosphatase / phosphodiesterase 1 (ENPP1) and activating an inherent immune pathway, can be prepared into a medicine or a medicinal composition, and can be used for preparing medicines or medicinal compositions. The compound is used for treating tumors and related diseases.

The present invention relates to a novel smoking article including a flavoring agent, and more particularly, to a smoking article including a flavoring agent including, in a basic skeleton thereof, a moiety derived from a sugar compound and a moiety derived from a flavor compound, which is a novel compound decomposed into a lactone compound, a sugar compound, and a flavor compound upon thermal decomposition.

A non-aqueous electrolyte secondary battery has a negative electrode (12) having a negative electrode current collector (40) and a negative electrode compound layer (42) disposed on the surface of the negative electrode current collector (40). The negative electrode compound layer (42) contains a first negative electrode active material with a first internal porosity and a second negative electrode active material with a second internal porosity greater than the first internal porosity. The first negative electrode active material is largely contained on the surface side of the negative electrode compound layer (42). The non-aqueous electrolyte contains at least a sulfonyl lactone compound having unsaturated bonds and fluoroethylene carbonate. In the non-aqueous electrolyte, when the concentration of the sulfonyl lactone compound is set to X mass% and the concentration of fluoroethylene carbonate is set to Y mass%, the following conditions are met: 0.01≤X≤5.0, 0.01≤Y≤2.0, and X / Y>0.5.

Phthalide lactones, as an important class of benzopentolactone skeleton, are widely distributed in natural products, medicinal plants and bioactive molecules, and have significant pharmacological activities and synthetic application potential. This kind of structure not only shows various biological activities such as antibacterial, anti-inflammatory, antitumor, antioxidant, but also is an indispensable core structural unit in many drug molecules and lead compounds. At the same time, cyano is a very valuable functional group in the field of organic synthesis and medicinal chemistry, with strong electron-withdrawing properties, strong structural stability and other advantages, which can effectively improve the electronic distribution, lipid solubility and drug performance of the molecule. In view of the important significance of phthalide lactones and cyano in organic synthesis and drug research and development, the present invention develops a synthetic method for efficiently constructing cyano-containing alkyl chain substituted phthalide lactone compounds. It has important value in medicinal chemistry and organic synthesis.

The application discloses a kind of preparation method and system of butadiene-styrene latex using emulsion coagulant modification, belong to high polymer material and synthetic rubber technical field.The application includes: the solution containing lactone compound, linear polymer with upper critical solution temperature is mixed with butadiene-styrene latex, and homogeneous premix system is formed;Under preset temperature condition, the hydrolysis reaction of the lactone compound in the homogeneous premix system is carried out, and the pH value of system drops;When the pH value of the system drops to the isoelectric point of the linear polymer, the dissolution state of the linear polymer under the preset temperature changes from hydrophilic extended conformation to hydrophobic collapse conformation, so as to coalesce latex particles in the butadiene-styrene latex.The application realizes the separation of coagulation reaction and mixing process in time, effectively inhibits the problem of local concentration polarization caused by glue deposition and particle size distribution widening, and the obtained rubber particle is uniform in size and excellent in mechanical property, suitable for industrial production.

The invention provides a preparation method of sulfonic modified polyurethane fiber. The preparation method comprises the following steps: S1, carrying out prepolymerization reaction and chain extension reaction on dihydric alcohol, diisocyanate and a chain extender to obtain a polyurethane stock solution; s2, the polyurethane stock solution and sultone compounds are subjected to a ring-opening reaction, and an intermediate product grafted with sulfonate ions is obtained; carrying out a neutralization reaction on the intermediate product and an organic acid-binding agent to obtain a sulfonic modified polyurethane stock solution for spinning; s3, carrying out mixing curing, solvent evaporation, drafting, oiling and winding on the sulfo-modified polyurethane stock solution and an optional functional additive to prepare sulfo-modified polyurethane fibers; according to the preparation method, the sulfonic acid group is introduced after the chain extension reaction to modify the polyurethane stock solution, so that the adverse effect on the polymerization stability caused by improper introduction time of the sulfonic acid group is avoided; the sulfo group modified polyurethane fiber prepared by the invention has excellent mechanical properties and good coloring property and color fastness.

An electrolytic capacitor according to the present invention comprises a capacitor element and a liquid component impregnated in the capacitor element. The capacitor element includes: an anode foil provided with a dielectric layer; a cathode foil; a wound body obtained by winding a separator interposed between the anode foil and the cathode foil; a first electroconductive polymer layer formed on the separator; and a winding stop tape for fixing a winding end portion of the wound body. The coating amount of the first electroconductive polymer layer on the separator is 0.04 mg / cm2 or more. A lactone compound is present in the liquid component in a proportion of 40 mass% or less.

A cleaning agent composition and a method for removing thermoplastic polymers using the cleaning agent composition are disclosed. The cleaning agent composition comprises at least 10 to 90 wt% of a cyclic acetal compound and 10 to 90 wt% of an aprotic solvent, wherein the aprotic solvent comprises an aromatic ether compound and / or an lactone compound. This cleaning agent composition can not only clean residual materials on wafers but also clean coating equipment and pipelines.

An electrochemical capacitor includes a positive electrode, a negative electrode, and an electrolyte. The electrolyte contains a lactone compound and an additive. The additive is at least one selected from the group consisting of a siloxane compound and a silyl fluoride compound.

A kind of the present application relates to new flavor and the product including it. More specifically, it is related to a kind of flavor, the composition and product including it, the flavor includes the part derived from flavor compound represented by chemical formula 1, and is the compound that is decomposed into lactone compound and flavor compound when thermal decomposition.

This invention discloses a method for synthesizing lactone compounds and cerium-catalyzed lactone compounds. The synthesis method comprises the following steps: under visible light irradiation, in an oxygen atmosphere, and in the presence of a photocatalyst and a cerium catalyst, a cyclic ketone compound containing a structural fragment as shown in Formula II is subjected to a cyclization reaction in a solvent to obtain a lactone compound containing a structural fragment as shown in Formula I. This method uses readily available raw materials to conveniently and rapidly synthesize various medium- and large-cyclic lactones, and is simple, economical, and environmentally friendly.

The present invention relates to a lithium secondary battery having improved high-temperature cycle characteristics, and more particularly, to a lithium secondary battery including a cathode, an anode, a separator, and an electrolyte, wherein the cathode includes lithium iron phosphate and lithium nickel cobalt manganese oxide as a cathode active material, the cathode has a loading amount of 32 mg / cm 2 to 60 mg / cm 2 , and the electrolyte includes a lithium salt, a first organic solvent, a second organic solvent, a first additive, and a second additive, wherein the first organic solvent is a cyclic lactone compound, the second organic solvent is a carbonate-based organic solvent, the first additive is an oligomer including a repeating unit derived from a monomer represented by Formula 1 and a repeating unit derived from a monomer represented by Formula 2, and the second additive is an imidazole compound.

The present invention relates to a smoking article including a novel flavorant, and more particularly, to a smoking article including a flavorant including a moiety derived from a flavor compound in a basic skeleton thereof, which is a novel compound decomposed into a lactone compound, a saccharide compound, and a flavor compound upon thermal decomposition.

The present invention relates to a non-aqueous electrolyte and a lithium secondary battery comprising same, the non-aqueous electrolyte comprising a lithium salt, an organic solvent and an additive, wherein the organic solvent comprises a carbonate-based organic solvent and a cyclic lactone compound and the additive comprises a first additive and a second additive, the first additive being a fluorine-based compound, and the second additive being a compound represented by chemical formula 1.

The application discloses a benzazepine nine-membered ring lactone compound and a preparation method and application thereof, and adopts a palladium and azepine carbene catalyst synergistic catalysis reaction, so that reaction steps are simplified, reaction conditions are more moderate, an ideal yield can be obtained, a feasible reaction path is provided for preparation of the benzazepine nine-membered ring lactone compound and industrial production thereof, meanwhile, the prepared benzazepine nine-membered ring lactone compound can effectively inhibit MRSE and MSSE, has good antibacterial activity, and is expected to be applied to preparation or screening of drugs for inhibiting MRSE or MSSE.

This disclosure provides a lithium secondary battery with improved high-temperature cycling performance. Specifically, the present invention relates to a lithium secondary battery comprising a positive electrode, a negative electrode, a separator, and an electrolyte, wherein the positive electrode comprises lithium iron phosphate oxide as the positive electrode active material, and the positive electrode loading is 32 mg / cm³. 2 Up to 60 mg / cm 2 The electrolyte comprises a lithium salt, a first organic solvent, a second organic solvent, a first additive, and a second additive, wherein the first organic solvent is a cyclic lactone compound, the second organic solvent is a carbonate organic solvent, the first additive is lithium nitrate (LiNO3), and the second additive is a sulfonamide compound.

Provided herein are engineered Streptomyces bacteria, and methods of using Streptomyces bacteria to produce Concanamycin A and Concanamycin B. The engineered Streptomyces bacteria overexpress one or more homologous regulator of the Concanamycin biosynthetic gene cluster (BGC), and express one or more heterologous regulator of the Concanamycin BGC. Further provided are optimized culture conditions for inducing Concanamycin A and Concanamycin B production, which can be used to culture Streptomyces bacteria or engineered Streptomyces bacteria.

The application discloses a gentiopicroside compound and a preparation method and application thereof. The gentiopicroside compound has a structure shown in formula 1. A new gentiopicroside compound is separated from a thermal conversion product of gentiopicroside, the preparation method is simple and easy to implement, the compound can protect the liver by inhibiting the activities of glutamic-oxaloacetic transaminase and glutamic-pyruvic transaminase, and can be used as a leading compound of liver-protecting drugs.

The invention relates to a unimolecular resin non-chemical amplification type photoresist based on cascade reaction as well as a preparation method and application of the unimolecular resin non-chemical amplification type photoresist. The monomolecular resin non-chemically amplified photoresist comprises a compound as shown in a formula (I). The triphenylsulfonium cation in the compound shown in the formula (I) is subjected to photolysis reaction after being illuminated to release protonic acid, the protonic acid and carboxylate radical form carboxylic acid, and the carboxylic acid further reacts with hydroxyl on the gamma position to form lactone. An ionic compound with high polarity is changed into a lactone compound with low polarity before and after illumination, and the solubility is obviously changed before and after illumination. Due to the cascade reaction, the sensitivity of the photoresist material is improved, remarkable solubility conversion is generated, and the requirement of high-resolution photoetching can be better met.

The photosensitive resin composition according to the first mode of the present invention can suppress post-development residue under high-temperature pre-baking conditions and can suppress post-development pattern peeling. In addition, a cured film that is suitably incorporated in an organic EL display having excellent light emission characteristics that can be driven at low voltage and excellent reliability of a light emission element can be provided. The photosensitive resin composition contains (A) an alkali-soluble resin and (C) a photosensitive agent, further contains (F1) a compound having a phosphorus atom and an aliphatic group having a valence of 1 to 2 and a carbon atom number of 6 to 30, and / or (FB) a trimethylammonium lactone compound having a phosphorus atom and a trimethylammonium lactone structure. The organic EL display according to the second mode of the present invention can provide an organic EL display having excellent light emission characteristics that can be driven at low voltage when a desired current density is obtained and excellent reliability of a light emission element. The organic EL display has a transparent conductive oxide film layer containing at least indium in a top layer of a first electrode, and a detection intensity of phosphorus ions (P-) at a position 3 nm in depth from a surface of the transparent conductive oxide film layer is a specific intensity.

This invention discloses a method for synthesizing chiral γ-acyloxybutenoic acid lactones, characterized by the following steps: (1) dissolving the substrate 2-furoic acid in an organic solvent and carrying out a photocatalytic oxidation reaction under the action of a photocatalyst and under light and oxygen conditions; (2) after the substrate in step (1) is completely converted, adding an acyl donor, and carrying out an enzymatic acylation reaction in the resulting reaction solution under the action of lipase to obtain γ-acyloxybutenoic acid lactones. This invention solves the problem of solvent compatibility between photocatalysis and enzyme catalysis systems, supporting both efficient photocatalytic oxidation and excellent medium for enzyme catalytic acylation. It realizes a one-pot conversion from the substrate 2-furoic acid to the product chiral γ-acyloxybutenoic acid lactones, with advantages such as mild reaction conditions, environmental friendliness, high synthesis efficiency, excellent selectivity, easy scale-up, and no need for separation and purification of intermediate products.

The invention discloses a novel inula flower lactone compound, a medicine containing the novel inula flower lactone compound, and a preparation method and application of the novel inula flower lactone compound, and relates to the technical field of medicines. Five inula flower lactone compounds with novel structures are successfully separated and identified from inula flowers, and in-vitro anti-hepatoma activity evaluation shows that the compounds have remarkable cytotoxic activity on a human hepatoma cell line HepG2; the invention proves that the five novel inula flower lactone compounds have anti-hepatoma activity, and important drug candidates and material basis are provided for developing novel anti-hepatoma drugs.

An electrolyte for a lithium secondary battery according to exemplary embodiments may include a lithium salt; an organic solvent; and an additive including a lactone compound having an epoxy group. Accordingly, it is possible to provide an electrolyte for a lithium secondary battery having excellent high-temperature characteristics and a lithium secondary battery including the electrolyte.

The invention relates to the technical field of gas separation, and discloses a method for separating and purifying hydrogen-containing mixed gas and a reaction system.The method comprises the steps that the hydrogen-containing mixed gas is subjected to an N-stage catalytic hydrogenation reaction, product gas containing target gas is obtained, and N is larger than or equal to 1; in each stage of catalytic hydrogenation reaction, the inlet gas is contacted with hydrogen storage organic liquid and a hydrogenation catalyst for catalytic hydrogenation reaction to obtain a liquid-phase material flow and a gas-phase material flow; inlet gas of the first-stage catalytic hydrogenation reaction is hydrogen-containing mixed gas, and gas-phase material flow obtained by the Nth-stage catalytic hydrogenation reaction is product gas; the hydrogen storage organic liquid comprises a first organic liquid and a second organic liquid, the first organic liquid is a lactone compound, and the second organic liquid is a carbonyl compound; based on the total mass of the hydrogen storage organic liquid, the content of the first organic liquid is 5-95 wt%, and the content of the second organic liquid is 5-95 wt%. The method can reduce the gas separation energy consumption and the gas separation loss rate, and improve the separation and purification efficiency.

The present invention belongs to the field of pharmaceutical chemistry, and relates to a cyclic lactone compound and a medical use thereof. Specifically, disclosed are a cyclic lactone derivative, and a stereoisomer, tautomer, or pharmaceutically acceptable salt thereof; also disclosed is a preparation method for this type of compound, and a use thereof in an antitumor drug. This type of compound has good protein inhibitory activity, and has important application prospects in the field of tumor treatment.

The invention provides a preparation method of a biphenyl lactone compound, the biphenyl lactone compound is prepared from a compound 1 through cyclization reaction and coupling reaction, and the reaction formula is shown in the specification. The preparation method provided by the invention has the advantages of simple process, mild reaction conditions, low cost, easily available raw materials and the like, and is suitable for industrial production.

The invention discloses a biosynthetic gene cluster of six-membered lactone compounds and application of the biosynthetic gene cluster. The nucleotide sequence of the biosynthetic gene cluster is shown as the 1st-15840th sites of SEQ ID NO.1, and the biosynthetic gene cluster comprises six genes: a gene A responsible for synthesis of a hexabalactone skeleton structure, a gene B responsible for synthesis of a hexabalactone skeleton structure, and a gene C responsible for synthesis of a hexabalactone skeleton structure. The gene B is responsible for hydroxylation of a carbon 2 site and a carbon 6 site on a six-membered lactone ring; and the gene E is responsible for polyketone side chain C9 hydroxyl reduction. All gene information related to the biosynthesis of the six-membered lactone compounds provided by the invention can help to understand the biosynthesis mechanism of six-membered lactone family natural products, and materials and knowledge are provided for further structural modification of the compounds.

This invention discloses an electrolyte additive, an electrolyte containing the additive, and a sodium-ion battery. The electrolyte comprises a system of 2-cyanoethyltriethoxysilane and a fluorocyclic thiophosphate lactone compound additive, wherein the 2-cyanoethyltriethoxysilane can optimize the solvation structure of the electrolyte by adjusting the sodium... + Transport pathways and promote the formation of a dense CEI film rich in NaF, while simultaneously via Na + Preferential interactions between EMC molecules inhibit the decomposition of free EMC. Furthermore, additives can suppress transition metal catalytic decomposition pathways. C≡N and Si-O groups can inhibit NaPF6 hydrolysis. These effects effectively improve the structural stability of the cathode material, suppress parasitic reactions in the electrolyte, and enhance high-voltage resistance. Additionally, fluorinated cyclic thiophosphate lactones possess flame-retardant properties; adjusting the proportion of these compounds can further improve the flame-retardant capability of the electrolyte.

The invention belongs to the technical field of coatings, and discloses an improved nitro-polyurethane mixed paint and a preparation method thereof.The preparation method comprises the following steps that a silyl ether modifier reacts with hydroxyl resin, and a sultone compound reacts with hydroxyl-containing nitrocellulose; preparing modified hydroxyl resin containing a silyl ether protecting group and modified nitrocellulose containing a sulfonate group; the preparation method comprises the following steps: respectively preparing modified isocyanate containing ketimine protecting groups from ketimine and isocyanate; mixing the improved hydroxyl resin, the modified nitrocellulose and an alcohol solvent to form a component A, adding the modified isocyanate into a volatile coordination solvent to form a component B, and uniformly stirring the component A and the component B to obtain the improved nitro-polyurethane mixed paint.