The present invention discloses a detox and disease-proof chicken feed, which is made from the following raw material by weight: 270-290 parts of corn, 10-12 parts of banana peel, 8-10 parts of glutinous rice flour, 6-8 parts of fresh fish, 8-10 parts of eggs, 4-5 parts of cynomorium, 6-8 parts of mulberries, 5-6 parts of heartleaf houttuynia herb, 3-5 parts of crystal sugar, 4-5 parts of rhubarb, 3-4 parts of divaricate saposhnikovia, 5-6 parts of rapeseed meal, 1-2 parts of calcium hydrogen phosphate, 2-3 parts of salt, 4-7 parts of walnut kernels, 6-8 parts of sweetsop leaves, 5-6 parts of accessory ingredient and a proper amount of water. According to the present invention, the detox and disease-proof chicken feed provides water, proteins, carbohydrates, fats, minerals, trace elements, vitamins and other feed energy according to the nutritional requirement of chickens, not only ensures the healthy growth of chickens, but also enhances the digestion, detoxification, immunity and disease resistance of chickens, meanwhile improves the quality and taste of chicken, and creates good economic benefits and ecological benefits. The added sweetsop leaves have hypoglycemic and anti-oxidation effects. The added berchemia kulingensis schneid has functions of dispelling wind and eliminating dampness, activating blood circulation and removing pain.