The invention discloses a method for removing
organic solvent residue from a
bulk drug. The method includes: under a temperature of 35-80DEG C and a pressure of 10-40MPa, firstly performing static extraction for 0.5-2h, and then conducting dynamic extraction for 0.5-6h so as to obtain a
bulk drug finished product with the
organic solvent residue meeting the limit standard in an extraction kettle; carrying out
pressure reduction separation on the
carbon dioxide flowing out of the extraction kettle at a pressure of 4-7MPa and a temperature of 25-45DEG C, collecting the precipitate in a separation kettle, recovering the
bulk drug, and loading the bulk
drug into the extraction kettle for application. An adsorbent is employed to conduct
adsorption separation on the
carbon dioxide flowing out of the separation kettle, and the obtained
carbon dioxide is introduced into the extraction kettle for cycle use. The bulk
drug finished product obtained by the method has the
organic solvent residue meeting the limit standard, the bulk
drug yield is high, and the carbon dioxide can be recycled. The method provided by the invention has the advantages of simple process, stable operation, economical efficiency and high efficiency, and is suitable for industrial application.