51 results about "Neural development" patented technology

The present application provides a synthetic nutritional composition comprising a milk fat globule membrane (MFGM) in the range of from about 10 [mu] g / 100 kcal to about 1500 mg / 100 kcal for use in improving neurological development in a pediatric subject. During a first year of life, a synthetic nutritional composition is administered to the pediatric subject for at least three months, and the administration of the synthetic nutritional composition improves neural development of the pediatric subject starting from at least two years old.

The invention provides application of ancient-Chinese health-preserving essence in preparation of a protein regulating agent, and belongs to the technical field of biological medicines. The invention provides application of an ancient-Chinese health-preserving essence or an ancient-Chinese health-preserving essence extract in preparation of a reagent for regulating protein functions. Protein comprises at least one of NCAM2, NCAM1, MAP2, VGLUT1, CDK5, DCLK1, TUBB3 and apolipoprotein E. The invention also provides an application of the ancient-Chinese health-preserving essence or the ancient-Chinese health-preserving essence extract in preparation of a reagent for regulating protein functions. In ancient and Chinese health preserving essence positive feedback regulation proteins, an important nerve synaptic function network exists and comprises proteins such as NCAM2, NCAM1, MAP2 and the like, and the proteins play an important role in biological processes such as neural development, synaptic shaping, neural signal transmission and the like. In addition, the ancient-Chinese health-preserving essence can regulate the expression of APOE. The application of the invention not only helps to deepen the scientific understanding of the pharmacodynamic effect of the ancient-Chinese health-preserving essence, but also provides a theoretical basis for the modern and precise application of traditional Chinese medicine compounds.

The invention discloses a nutritional composition for promoting neurodevelopment and application, and provides a nutritional composition for promoting neurodevelopment, which comprises the following necessary components: a sialylated substance component comprising one or more of N-acetylneuraminic acid, sialylated oligosaccharide, sialylated protein and sialylated lipid; the whey protein component comprises alpha-lactalbumin; and a peptide component from casein, including a hydrolysate of casein; the nutritional composition comprises a sialylated substance component, a whey protein component and a casein-derived peptide component, and the mass ratio of the sialylated substance component, the whey protein component and the casein-derived peptide component in the nutritional composition is (0.5-10): (300-1): (100-0.5). The nutritional composition provided by the invention can promote brain development and cognitive functions, and can significantly promote neurodevelopment by scientifically matching the sialylated substance component, the whey protein component and the peptide component from casein.

The invention provides a neural developmental disorder prediction model construction method, system and device and a medium, and the method comprises the steps: obtaining the clinical information of a child patient, the clinical information comprises severity of developmental retardation / dyspepsia, complexity of syndromic neurodevelopmental disorder, autism spectrum disorder, epilepsy, attention deficit hyperactivity disorder, head circumference deformity, brain development deformity, hearing / visual function impairment and related ear-eye development deformity; applying logistic regression analysis to screen out predictive factors significantly related to the positive diagnosis rate of third-generation whole exon genome sequencing in the clinical information; constructing a neural developmental disorder prediction model based on binary logistic regression according to the prediction factor; and verifying the neurodevelopmental disorder prediction model by applying data of the internal verification group and the external verification group so as to evaluate the prediction efficiency of the neurodevelopmental disorder prediction model, so that the probability of obtaining positive diagnosis after the child patient receives trio-WES detection can be accurately evaluated, and the prediction efficiency is remarkably improved.

The invention discloses an euphausia superba oligopeptide nutritional composition for promoting neural development and application thereof, and belongs to the technical field of functional foods.The nutritional composition is prepared from, by weight, 0.01-10 parts of docosahexaenoic acid, 0.01-20 parts of arachidonic acid, 0.01-10 parts of phosphatidylserine and 0.01-80 parts of euphausia superba oligopeptide. The antarctic krill oligopeptide is obtained by treating antarctic krill, antarctic krill powder or degreased antarctic krill powder by utilizing an enzymolysis method, and the content of a peptide fragment with the molecular weight of less than 1000Da in the antarctic krill oligopeptide is more than 90%. The raw materials of the composition are easy to obtain, the safety is high, and the composition can be used for preparing products with the function of promoting neurodevelopment and can be taken as common food, health care products or medicines for a long time.

The application discloses a mental health evaluation method and system based on brain area electric stimulation, relates to the technical field of medical and health information science, and creatively integrates brain area electric stimulation into mental health evaluation. The basic cognitive level and neural plasticity potential of a measured person are objectively quantified through comprehensive scores before and after brain area electric stimulation, so that corresponding suitable mental health evaluation test questions are selected based on the basic cognitive level and neural plasticity potential, and the precision, sensitivity of corresponding mental tests and the mental comfort of the measured person are significantly improved. A decay quantization model of a stimulating current from an electrode to the brain is given, the decay quantization model is used to accurately control the electric quantity, and the maximum beneficial effect is realized under the condition of guaranteeing health and safety. Historical data accumulated in the application process can be effectively used to solve medical problems, such as the influence of brain area electric stimulation on child neural development evaluation, early warning of mental illness and brain function reinforcement.

The present application provides the use of betaine in preventing the occurrence of autism spectrum disorder (ASD). Specifically, the present application provides the use of betaine or a pharmaceutically acceptable salt, stereoisomer, tautomer, nitroxide, solvate, metabolite or prodrug thereof in the preparation of a medicament for preventing the occurrence of ASD, optimizing fetal neural development or reducing the risk of fetal neural development disorder. By using betaine or a pharmaceutically acceptable salt, stereoisomer, tautomer, nitroxide, solvate, metabolite or prodrug thereof as an active ingredient, the occurrence of ASD can be effectively prevented, fetal neural development can be optimized, or the risk of fetal neural development disorder can be reduced.

The embodiment of the invention discloses an autism spectrum disorder subtype division method and device, a medium and a program product. The method comprises the following steps: constructing a connection brain map based on neuroimaging data and a functional brain region division template of an ASD individual; constructing a brain age regression model, predicting the social brain age of the ASD individual based on the connection brain map and the brain age regression model, and obtaining the brain age difference of the ASD individual in combination with the actual brain age of the ASD individual; obtaining an ADOS social score of the ASD individual, and carrying out clustering analysis on the ADOS social score and the brain age difference to obtain a clustering subtype; and carrying out behavioral verification and neural dimension verification on the clustering subtypes, and constructing a combined portrait among the subtypes, the behavior features and the neural features based on a verification result. According to the method, the social brain age can be predicted by constructing the connection brain map, the clustering subtypes are divided, the combined portrait is constructed, a doctor can be accurately assisted to detect ASD subtype neural development differences, and discovery and application of subtype specific biomarkers are assisted.

The invention discloses a neural development disorder co-disease identification system based on a residual image neural network. Belongs to the technical field of neurodevelopment disorder co-disease recognition, and particularly relates to the technical field of co-disease recognition based on a neural network. The system comprises a data acquisition module for acquiring a resting-state fMRI image; the data preprocessing module is used for extracting standardized time sequences of 116 brain regions of the set resting state fMRI image; the multi-band division and feature extraction module is used for performing frequency band filtering on the standardized time sequence of each brain region to obtain a time sequence after each frequency band filtering; in each frequency band, constructing a binary topological matrix based on the PLV matrix and calculating a PLV feature vector based on the PLV matrix; the neurodevelopmental disorder co-disease recognition module is used for analyzing the brain function connection diagram through a residual image neural network model to obtain diagnostic information of neurodevelopmental disorder co-diseases; and the interpretable output module is used for outputting an abnormal brain region by taking the amplitude low-frequency fluctuation as a reference index.

The invention belongs to the technical field of food nutrition, and discloses application of an artemisia selengensis extract in preparation of a medicine for improving neurodevelopmental disorder and the medicine. The artemisia selengensis extract has the following advantages and effects: the research finds that the artemisia selengensis extract has the effect of improving neurodevelopmental disorders, which is specifically embodied in that the artemisia selengensis extract can effectively increase the activity of acetylcholin esterase, lower the content of ROS (reactive oxygen species), up-regulate antioxidant indexes (GSH (glutathione) content and sod1 and cat gene expression) and relieve oxidative stress injury of zebrafish caused by NP (natriuretic peptide); meanwhile, the artemisia selengensis extract can also up-regulate the expression of a neural development gene (alpha 1-tubulin, mbp) so as to improve the neural development disorder of the zebrafish; besides, the mechanism of improving the zebrafish neurodevelopmental disorder by the artemisia selengensis extract is mainly realized through a p38 / 5-HT / Wnt / beta-catenin signal channel, expression of p38a is down-regulated (network pharmacology finds that p38 in MAPHK is a main mechanism channel), and expression of htr1aa, maoa, wnt4a and beta-catenin is down-regulated.

The invention discloses a nutritional composition for promoting neurodevelopment. The invention provides a nutritional composition, the nutritional composition comprises the following necessary components: a grease component, a phospholipid component and a sialylated substance component, and in the nutritional composition, the molar ratio of the grease component to the phospholipid component to the sialylated substance component is (1-5): (1-10): (0.01-5). The composition provided by the invention has the advantages that the components are synergistic, the nerve development is effectively promoted, the application range is wide, and various foods or health-care products can be conveniently added or prepared.

The invention relates to the field of food science and technology, and particularly discloses a neurodevelopment food containing DHA and choline and a preparation method of the neurodevelopment food. Comprising DHA powder, a choline source, soybean peptide powder, compound amino acid, a carbohydrate source, a fat source, a vitamin mixture, a mineral mixture, prebiotics and a natural antioxidant mixture. The preparation method comprises the following steps: firstly, carrying out microencapsulation treatment on the soybean peptide powder and the DHA powder, then preparing a premix of the vitamins and the carbohydrates as well as the minerals and the fat, then mixing the microencapsulated product with other raw materials such as the compound amino acid and the choline source to obtain a primary mixture, adding the premix, carrying out high-pressure homogenization, carrying out ultrahigh-temperature instantaneous sterilization and spray drying to obtain granules, and finally, carrying out freeze-drying to obtain the feed additive. And finally performing low-humidity vacuum packaging. The product can be used for nutrition support of infant neurodevelopment and has the advantages of being high in nutrition adaptability and capable of accurately assisting healthy development of nerves. The preparation method can protect active ingredients, ensure uniform nutrition and guarantee product stability.

The invention relates to the field of neurodevelopmental disorders, and discloses an electro-oculogram signal analysis and diagnosis system based on neurodevelopmental disorders, which extracts signal features from pre-processed electro-oculogram signals, and analyzes inter-group differences between signal features of a child patient group and signal features of a healthy child group. The method comprises the following steps: preliminarily screening out signal features with significant statistical difference between two groups, then carrying out severity correlation analysis on the screened signal features, screening and forming a feature list highly related to ADHD severity, and then comparing eye movement features of a child patient group under natural behaviors with eye movement features of a healthy child group, so as to obtain a feature list related to ADHD severity. The method comprises the following steps of: identifying and forming an abnormal signal feature list, fusing the feature list highly related to the ADHD severity and the abnormal signal feature list, calculating a comprehensive abnormal score, drawing an ROC curve according to the calculated comprehensive abnormal score, and carrying out grading evaluation on the ADHD severity of a child patient, so that accurate diagnosis and severity judgment on the ADHD disease are realized.

The invention relates to the field of child neural development training, and discloses a child neural development collaborative four-dimensional dynamic training method and system, and the system comprises hardware such as a central processing unit, a multi-modal evaluation input end and an electroencephalogram signal collection device, and software modules such as a mapping analysis module and a scheme generation module. The method comprises the following steps: acquiring initial data such as age and traditional Chinese medicine syndrome characteristics of a trained object, modeling based on a four-dimensional state space vector, determining a target intervention brain region by utilizing a five-element viscera-brain region attribute mapping matrix, and constructing a training execution vector in combination with an age division control strategy; through closed-loop monitoring of electroencephalogram signals and action data, nerve relaxation and concentration indexes and action execution precision are calculated, and training parameters are dynamically adjusted through a PID (Proportion Integration Differentiation) algorithm; a multi-dimensional safety fusing mechanism is fused, and a comprehensive development index is generated and recorded after training. According to the method, traditional Chinese and western medicine theories are fused, age-based precise adaptation and nerve and movement coordinated regulation are achieved, the training pertinence and safety are improved, and the method is suitable for nerve development intervention of 12-36-month-old children.