31 results about "Central neuron" patented technology

Methods and compositions are provided for protecting or enhancing excitable tissue function in mammals by systemic administration of an erythropoietin receptor activity modulator, such as erythropoietin, which signals via an EPO-activated receptor to modulate the function of excitable tissue. Excitable tissues include central neuronal tissues, such as the brain, peripheral neuronal tissues, retina, and heart tissue. Protection of excitable tissues provides treatment of hypoxia, seizure disorders, neurodegenerative diseases, hypoglycemia, and neurotoxin poisoning. Enhancement of function is useful in learning and memory. The invention is also directed to compositions and methods for facilitating the transport of molecules across endothelial cell tight junction barriers, such as the blood-brain barrier, by association of molecules with an erythropoietin receptor activity modulator, such as an erythropoietin.

The invention discloses an automatic detection system for the traditional-Chinese-medicine quality. Traditional-Chinese-medicine original images are collected, outlines of target areas are partitioned, the images are subjected to noise removing, a neural network PCNN corresponds to the images, central neuron corresponds to pixel points of the images, multi-wavelength LED lamps are illumed respectively, several LED lamps capable of motivating remarkable fluorescence signals are selected and alternately illumed, traditional-Chinese-medicine samples with fluorescence spectrums of 300 nm-1,100 nm are collected, the one-dimensional time-series signal characteristics of all two-dimensional images are extracted, characteristic information is stored, the airspace characteristics of traditional-Chinese-medicine microscopic images are extracted, and the traditional-Chinese-medicine quality is detected. According to the automatic detection system, the traditional-Chinese-medicine external parameters are synthetically evaluated with the electronic technology, the traditional-Chinese-medicine inherent quality is automatically detected by combing traditional-Chinese-medicine chemical-component content parameters, safety detection parameters and conventional detection parameters, the detection standard is objective and uniform, and accurate medicine making can be achieved.

The invention aims at providing a contour detection method based on non-classical receptive field space summation modulation. The method comprises the steps that 1, a to-be-detected image subjected to grey-scale processing is input; 2, Gabor filtering is conducted on the to-be-detected image to obtain Gabor energy values of all pixel points in all directions; 3, a space summation modulation weight of a non-classical receptive field to a central neuron is calculated out; 4, modulation response of the non-classical receptive field to the central neuron on a distance weight is calculated out; 5, stimulating response of the central neuron to the non-classical receptive field is obtained through calculation; 6, stimulating response of the central neuron to combined modulation of a classical receptive field and the non-classical receptive field is obtained through calculation and serves as a corresponding contour value; 7, non-maximum suppression and double-threshold processing are conducted on the contour values of all the pixel points, and final contour values of all the pixel points are obtained. The contour detection method based on non-classical receptive field space summation modulation overcomes the defects that in the prior art, the simulation effect is poor, and the contour recognition rate is low and has the advantages of being good in simulation effect and high in contour recognition rate.

The present invention provides a contour detection method based on a non-classical receptive field and linear nonlinear modulation. The method comprises: A, inputting an image to be detected through gray processing; B, performing Gabor filtering of the image to be detected to obtain the Gabor energy value of each direction of each pixel point; C, constructing X-cell and Y-cell simulation models in a retina ganglion cell; D, calculating and obtaining stimulating response of each central neuron through the non-classical receptive field corresponding to the X cell; E, calculating and obtaining the stimulating response of each central neuron through the non-classical receptive field corresponding to the Y cell; F, respectively calculating the stimulating response of central neurons of the X cell and the Y cell through the combined modulation of the classical receptive field and the non-classical receptive field, and performing addition of the stimulating response of central neurons of the X cell and the Y cell to take as a corresponding contour value; and G performing processing of the contour values of each pixel point to obtain a final contour value. The contour detection method based on the non-classical receptive field and the linear nonlinear modulation overcomes the defect that the contour recognition rate is low in the prior art, and has good simulation effect and high contour recognition rate.

The present invention relates to the construction method and application of one kind of human neurenergen-3 receptor gene (human TrkC gene) recombined adenovirus expressing vector. The basic scheme of the present invention includes: designing and synthesizing primer, RT-PCR process, construction and identification of cloned shuttle vector pShuttle-TrkC, construction and identification of recombined adenovirus vector pAdeno-TrkC, 293 cell packaging, identification of recombined adenovirus, bioactivity detection of human neurenergen-3 receptor gene recombined adenovirus expressing vector and other steps. The present invention is superior in that one kind gene recombined adenovirus expressing vector is selected to promote the survival of damaged central neure and the regeneration of axone, to promote nerve stem cell to differentiate into more neures to replace damaged or dead neures.

The invention discloses an analog-digital (integrated coding information taking time as analog quantity and pulse as digital quantity) decoding method and a device based on the neuron working principle. The device comprises a pulse width adjusting circuit, a RC integrating circuit and a low-pass filter circuit. The pulse width adjusting circuit adjusts the widths of a series of pulses arranged according to the time sequence, the RC integrating circuit carries out RC integration on the series of pulses which are arranged according to the time sequence and subjected to the pulse width adjustment, and the low-pass filter circuit filters signals subjected to the RC integration so as to restore the series of pulses arranged according to the time sequence to input signals corresponding to the pulses. In the invention, the analog-digital decoding device based on the neuron working principle is designed by simulating the decoding mechanism of biological neurons on time-pulse coding signals, and the information processing mode is realized by using a circuit method.

The invention discloses applications of gendarussa vulgaris Nees extract as a neuroprotective agent. A preparation method of the gendarussa vulgaris Nees extract comprises following steps: gendarussa vulgaris Nees is subjected to solvent extraction, condensation, and drying. It is confirmed that the gendarussa vulgaris Nees extract possesses excellent nerve protection effect, and possesses curative effect on gradual denaturation and apoptosis of central neuron, so that a promising prospect of treatment of nervous centralis degenerative diseases is achieved.

The invention relates to a biological activity of an adenovirus expression vector which is recombined by using a human neurotrophin-3 receptor gene (human TrkC gene) and an application in the nerve injury repair thereof. The human Ad-TrkC can be used for promoting the survival of the injured central neurons and the axonal regeneration, so as to promote the neural stem cells to be more divided into the neurons with the potential of synaptic formation, further to replace the injured neurons or the dead neurons. The biological activity strengthens the protection mechanism of the central nervous system after the injury on the gene treatment level, replaces the injured neurons, participates in the reconstruction of the neural network and repairs the functions of the central nervous. Thus, the application has important significances for prolonging the human life, improving the quality of lives of the wounds and the patients, reducing the social and the family burdens and promoting the development of Chinese socioeconomic development.

The invention relates to a neural stem cell derived tissue engineering spinal cord tissue for simulating a spinal cord tissue structure and main cell constituents. The neural stem cell derived tissue engineering spinal cord tissue is obtained by in-vitro culture and construction through a biological tissue engineering technology and a neural stem cell induced differentiation technology, and has a white matter like structure in the peripheral part and a grey matter like structure in the central part. CNTF (ciliary neurotrophic factor) gene modified oligodendrocyte precursor cells (OPCs) are planted in the white matter like structure; and NT-3 gene and receptor thereof TrkC gene modified neural stem cells (NSCs) are planted in the grey matter like structure. When being transplanted to a spinal cord complete transection injury site, the tissue engineering spinal cord tissue has favorable cell activity and can secrete neurotrophic factors to accelerate regeneration of spinal cord injured central neuron axons; and the tissue engineering spinal cord tissue can realize corresponding functions of oligodendrocytes and neurons, and serves as a neural information transfer relay to form a synaptic connection with regenerated nerve fibers so as to repair spinal cord injured neural circuits. The tissue engineering spinal cord tissue can also be used as an in-vitro model for neural pharmacology and neural development researches.

The invention provides application of an autophagy inducer serving as a microtubule stabilizing drug to the promotion of nerve regeneration. Specifically, the invention provides a method for promotingthe enation of in vitro culture central neuron and weakening the inhibiting effect on enation by myelin, or stabilizing microtubules central nervous damaged nerve cells, or reducing retracement or formation of retracement vesicles after a central nerve axon is damaged, or promoting axon regeneration after central nervous is damaged, and the method comprises the step of ensuring that an ex vivo nerve cell is in contact with the autophagy inducer, so as to induce autophagy. The invention further provides application of the autophagy inducer to drug preparation. By adopting the method, axon retracement can be obviously reduced after medulla spinalis is damaged, and axon regeneration and the recovery of a movement function can be promoted.

The invention discloses an infrared image and visible light image fusion method based on early visual information processing. The method comprises the following steps: S1, carrying out dynamic receptive field processing of On central neurons and Off central neurons; s2, obtaining a fusion image A and a fusion image B: fusing the On central neuron response of the visible light image, the Off central neuron response of the infrared image and the original visible light image to obtain the image A; and fusing the On central neuron response of the infrared image, the Off central neuron response ofthe visible light image and the original infrared image to obtain an image B; and S3, adding the fused image A and B to obtain a final fusion result. Salient target information in the infrared image and background information in the visible light image can be effectively fused, and more effective features are provided for computer vision tasks under the night vision conditions of subsequent high-value target detection and recognition and the like.

The present invention relates to a kind of adeno-associated virus vector preparation with gene carrying neurotrophic factor, and the preparation contains mannitol in 3-7 wt% to raise the stability of the preparation. The present invention also relates to medicine composition containing the said preparation and high permeability solution, which is selected from mannitol, arabinase, urea, fructose, lactamine and glycerin. The preparation and the medicine composition are used in preventing and treating central neurodegeneration, such as Alzheimer disease, Parkinson'e disease, etc. as well as in treating cerebral ischemic injury and cerebral traumatic injury, promoting the recovery of cerebral function after surgical operation, and preventing mental retardation of infant caused by anoxia damage.

The invention discloses application of a p53 activating agent in preparation of drugs for treating nerve injuries, and belongs to the technical field of medicines. According to the application, it isdiscovered for the first time that p53 activation not only promotes axonal regeneration of peripheral sensory neurons, but also is an important regulatory factor for axonal regeneration of central neurons such as hippocampal neurons, cortical neurons and optic nerves. The discovery provides a new direction for treatment of patients with the nerve injuries such as spinal cord injuries.

Disclosed herein are therapeutic methodologies utilizing a ring substituted derivative of the indolocarbazole K252a, the derivative represented by the formula (A). The compound is useful for treating peripheral neuropathies, central neuronal degeneration and cytokine overproduction. Typical diseases related to the above are peripheral neuropathy, Alzheimer's disease, Parkinson's disease and autoimmune and allergic conditions.