Applications human neuro nutriment-3 receptor gene recombination ad virus for preparing medicine treating nerve injury

A technology of recombinant adenovirus and receptor gene, applied in gene therapy, nervous system diseases, drug combination, etc., can solve the problem of weak effect of neurotrophin-3, and achieve the goal of promoting social and economic development, prolonging human lifespan, and improving the quality of life Effect

Inactive Publication Date: 2008-09-03
SUN YAT SEN UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Brain-derived neurotrophic factor, neurotrophin-4/5, and neurotrop

Method used

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  • Applications human neuro nutriment-3 receptor gene recombination ad virus for preparing medicine treating nerve injury
  • Applications human neuro nutriment-3 receptor gene recombination ad virus for preparing medicine treating nerve injury
  • Applications human neuro nutriment-3 receptor gene recombination ad virus for preparing medicine treating nerve injury

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0034] Below by specific embodiment the used main instrument experimental cell of the present invention, virus carrier, experimental animal and reagent are described in detail:

[0035] 1. Main instruments

[0036] Ultra-clean workbench (Shanghai Zhengxin Electronic Equipment Factory), ordinary centrifuge (Japan Kubota Manufacturing Co., Ltd.), constant temperature water bath box (Beijing Medical Equipment Factory), low-temperature high-speed centrifuge (Eppendorf, USA), 5% CO 2 Incubator (Queue, USA), Inverted Fluorescent Microscope (Leica, Germany), Enzyme-linked Immunoassay (Bio-Rad, USA), Microsurgical Microscope (Zhenjiang Optical Instrument Factory), Stereotaxic Instrument (Jiangwan Instrument Factory) , Biolap-410 intelligent biological signal display and processing instrument (Chengdu Taimeng Technology Co., Ltd.), cryostat slicer (Shandon, UK), fluorescence microscope (Leica, Germany) and animal crawling grid support (self-made).

[0037] 2. Experimental cells, virus...

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PUM

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Abstract

The invention relates to a biological activity of an adenovirus expression vector which is recombined by using a human neurotrophin-3 receptor gene (human TrkC gene) and an application in the nerve injury repair thereof. The human Ad-TrkC can be used for promoting the survival of the injured central neurons and the axonal regeneration, so as to promote the neural stem cells to be more divided into the neurons with the potential of synaptic formation, further to replace the injured neurons or the dead neurons. The biological activity strengthens the protection mechanism of the central nervous system after the injury on the gene treatment level, replaces the injured neurons, participates in the reconstruction of the neural network and repairs the functions of the central nervous. Thus, the application has important significances for prolonging the human life, improving the quality of lives of the wounds and the patients, reducing the social and the family burdens and promoting the development of Chinese socioeconomic development.

Description

[technical field] [0001] The invention relates to the biological activity of a recombinant adenovirus expression vector, in particular to the application of a recombinant adenovirus with human neurotrophin-3 receptor gene (human TrkC gene) in the preparation of medicine for treating nerve injury. [Background technique] [0002] Neurotrophic factors are a class of chemical factors that can support the survival of neurons in the body, promote their growth, differentiation, and maintain their functions. Before neurotrophic factors exert cytological effects on their target cells, they must first bind to receptors on the target cells. Currently known neurotrophic factors have two receptors: tyrosine protein kinase receptor (high affinity receptor) and p75 receptor (low affinity receptor). Tyrosine protein kinase receptor is a receptor encoded by the proto-oncogene Trk, so it is also called Trk receptor. Trk receptors can be divided into three types: TrkA, TrkB and TrkC. [000...

Claims

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Application Information

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IPC IPC(8): A61K48/00A61K45/00A61P25/00
Inventor 曾园山王俊梅
Owner SUN YAT SEN UNIV
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