1results about How to "Significant neuroprotective effect" patented technology

This invention relates to the field of biomedical technology, specifically disclosing a polypeptide and its application in the preparation of drugs for ischemic stroke. The amino acid sequence of the polypeptide is shown in SEQ ID NO. 1. This invention utilizes an in vivo tMCAO / R model and in vitro studies covering ischemic hypoxia (OGD) and neurotoxicity (MPP). + Multiple cell models of NL-PT, including those for cellular stress and hormonal stress (CORT), were used to reveal the application potential of the peptide NL-PT from multiple dimensions and levels. These results collectively demonstrate that NL-PT not only has a significant protective effect against the core pathological processes of ischemic stroke, but also exhibits broad-spectrum biological activity against various related injuries. In particular, its well-defined mechanism of anti-oxidative stress through scavenging reactive oxygen species (ROS) further highlights its multi-target intervention characteristics, providing solid and reliable experimental evidence for its development into a novel, multi-target therapeutic drug for ischemic stroke.