3results about How to "Significant neuroprotective effect" patented technology

This invention relates to the field of natural product pharmaceuticals, specifically to a natural product-derived acetylcholinesterase inhibitor and its application. Currently used chemically synthesized acetylcholinesterase inhibitors in clinical treatment, while achieving certain therapeutic effects, still suffer from side effects and drug resistance. Therefore, this invention provides an acetylcholinesterase inhibitor, which is a single-drug or dual-drug composition derived from a natural product. The single drug is behenin isoflavone (TI) or isoeugenol acetate (IA), and the dual-drug composition is TI and IA mixed in a specific ratio. The acetylcholinesterase inhibitor of this invention exhibits good AChE inhibitory activity, anti-Aβ aggregation efficacy, antioxidant activity, and good neuroprotective effects, indicating that TI and / or IA can be used as novel acetylcholinesterase inhibitors in the development and use of drugs for the clinical treatment and / or prevention of Alzheimer's disease and related diseases.

This invention relates to the field of biomedical technology, specifically disclosing a polypeptide and its application in the preparation of drugs for ischemic stroke. The amino acid sequence of the polypeptide is shown in SEQ ID NO. 1. This invention utilizes an in vivo tMCAO / R model and in vitro studies covering ischemic hypoxia (OGD) and neurotoxicity (MPP). + Multiple cell models of NL-PT, including those for cellular stress and hormonal stress (CORT), were used to reveal the application potential of the peptide NL-PT from multiple dimensions and levels. These results collectively demonstrate that NL-PT not only has a significant protective effect against the core pathological processes of ischemic stroke, but also exhibits broad-spectrum biological activity against various related injuries. In particular, its well-defined mechanism of anti-oxidative stress through scavenging reactive oxygen species (ROS) further highlights its multi-target intervention characteristics, providing solid and reliable experimental evidence for its development into a novel, multi-target therapeutic drug for ischemic stroke.

The invention relates to the technical field of cornflower roots, in particular to a cornflower root extract, a preparation method of the cornflower root extract and application of the cornflower root extract in preparation of drugs for treating or preventing neurodegenerative diseases. The neuron apoptosis caused by oxidative stress can be effectively resisted, and the survival rate of HT22 cells is improved. Due to the remarkable neuroprotective activity, the cornflower root extract has a potential research and development value as a neuroprotective drug, and is expected to provide a new natural drug choice which is low in cost, safe and effective for treating neurodegenerative diseases.