10results about How to "Significant neuroprotective effect" patented technology

The invention belongs to the field of biological materials, and particularly relates to a multifunctional DNA nanometer material, a preparation method and application of the multifunctional DNA nanometer material in treatment of traumatic brain injury secondary encephaledema. The multifunctional DNA nano material comprises a plurality of deoxyribozyme (DNAzyme) targeting C1q mRNA (messenger Ribonucleic Acid) and a repeating unit which is integrally connected with G-quadruplex / Hemin in series, wherein the G-quadruplex / Hemin is labeled by streptavidin SA and biotin and is used for scavenging free radicals. The DNAzyme for silencing the C1q gene of the mouse is designed on the basis of a bioinformatics method, and the C1q gene overexpressed in an inflammation model can be knocked down to an approximate normal level. The RCA technology mediated self-assembled nano material SA-B / H has excellent enzyme mimetic activity, can effectively remove free radicals such as H2O2 and O2 <.->, and has the potential of in-vivo oxidation resistance. In-vitro experiments prove that SA-B / H can effectively relieve high-level oxidative stress of cells caused by H2O2 stimulation.

The invention discloses application of a gastrodia elata active ingredient in preparation of a medicine for preventing and treating Alzheimer's disease, and relates to the technical field of medicine and biologication.The key point of the technical scheme is that the gastrodia elata active ingredient comprises specific miRNA Gas-miR04-3p and Gas-miR19-5p obtained by screening from gastrodia elata, and the miRNA can be used for preparing the medicine for preventing and treating Alzheimer's disease through a targeted JNK3 signal channel. The occurrence of Tau protein excessive phosphorylation and cell apoptosis in the Alzheimer's disease model is regulated and controlled. The invention verifies that Gastrodia elata specific miRNA (Ribonucleic Acid) of Gastrodia elata (Gastrodia elata) of Gastrodia elata (Gastrodia elata) of Gastrodia elata (Gastrodia elata) of Gastrodia elata (Gastrodia elata) of Gastrodia elata (Gastrodia elata) and Gastrodia elata (Gastrodia elata) of Gastrodia elata (Gastrodia elata) of Gastrodia elata (Gastrodia elata) of Gastrodia elata (Gastrodia elata) of Gastrodia elata (Gastrodia elata) of Gastrodia elata (Gastrodia elata) of Gastrodia elata (Gastrodia elata) of Gastrodia elata (Gastrodia elata) of Gastrodia elata (Gastrodia

The invention relates to the technical field of supramolecular chemistry, and particularly discloses a plant polyphenol supramolecular self-assembly system and a construction method and application thereof, and the plant polyphenol supramolecular self-assembly system is obtained by mixing echinacoside and ferrous gluconate in an environment with pH of 7-11 according to a molar ratio of (5-6): 4, heating and reacting at 40-45 DEG C for 20-24 hours, and dialyzing and drying. The plant polyphenol supramolecular self-assembly system provided by the invention shows an excellent drug release behavior, shows remarkable pH responsiveness in an acid environment, effectively enhances the antioxidant and neuroprotective effects of ECH, and remarkably improves the blood-brain barrier transmittance of ECH.

The invention provides a preparation method and application of a diaza-triquinolinedione derivative. Provided is the use of a compound of formula (I) or a pharmaceutically acceptable salt thereof in the preparation of a medicament for the treatment or prevention of cerebral apoplexy and / or inflammatory diseases, neuroprotection, free radical scavenging, and / or alleviation of oxidative stress. # imgabs0 #

The invention belongs to the technical field of medicines, and provides application of polypeptide in preparation of a medicine for treating cerebral apoplexy. The amino acid sequence of the polypeptide is as follows: Ala-Glu-Pro-Val-Pro-Leu. The polypeptide has different degrees of significant improvement effects on death rate, neurobehavioral scoring and cerebral infarction volume of model rats, can significantly improve rat brain tissue hippocampal CA1 region vertebral cell injury, and also has significant improvement effects on brain microcirculation after bilateral carotid artery ligation of the model rats.

This invention relates to the field of natural product pharmaceuticals, specifically to a natural product-derived acetylcholinesterase inhibitor and its application. Currently used chemically synthesized acetylcholinesterase inhibitors in clinical treatment, while achieving certain therapeutic effects, still suffer from side effects and drug resistance. Therefore, this invention provides an acetylcholinesterase inhibitor, which is a single-drug or dual-drug composition derived from a natural product. The single drug is behenin isoflavone (TI) or isoeugenol acetate (IA), and the dual-drug composition is TI and IA mixed in a specific ratio. The acetylcholinesterase inhibitor of this invention exhibits good AChE inhibitory activity, anti-Aβ aggregation efficacy, antioxidant activity, and good neuroprotective effects, indicating that TI and / or IA can be used as novel acetylcholinesterase inhibitors in the development and use of drugs for the clinical treatment and / or prevention of Alzheimer's disease and related diseases.

The present invention provides microglia-derived exosomes and a preparation method and application thereof. The present invention provides a preparation method of microglia-derived exosomes, the preparation method comprising: culturing microglia in a culture medium containing gardenia glycosides, ligustrazine and puerarin to secrete exosomes, thereby obtaining microglia-derived exosomes. The microglia-derived exosomes prepared by the present invention can reduce neuroinflammation, inhibit oxidative stress and ferroptosis, reduce cerebral infarction volume, improve ischemia-reperfusion neurological scores, and improve brain tissue pathological damage, and have a neuroprotective effect on cerebral ischemia-reperfusion injury.

This invention relates to the field of biomedical technology, specifically disclosing a polypeptide and its application in the preparation of drugs for ischemic stroke. The amino acid sequence of the polypeptide is shown in SEQ ID NO. 1. This invention utilizes an in vivo tMCAO / R model and in vitro studies covering ischemic hypoxia (OGD) and neurotoxicity (MPP). + Multiple cell models of NL-PT, including those for cellular stress and hormonal stress (CORT), were used to reveal the application potential of the peptide NL-PT from multiple dimensions and levels. These results collectively demonstrate that NL-PT not only has a significant protective effect against the core pathological processes of ischemic stroke, but also exhibits broad-spectrum biological activity against various related injuries. In particular, its well-defined mechanism of anti-oxidative stress through scavenging reactive oxygen species (ROS) further highlights its multi-target intervention characteristics, providing solid and reliable experimental evidence for its development into a novel, multi-target therapeutic drug for ischemic stroke.

The invention relates to the technical field of cornflower roots, in particular to a cornflower root extract, a preparation method of the cornflower root extract and application of the cornflower root extract in preparation of drugs for treating or preventing neurodegenerative diseases. The neuron apoptosis caused by oxidative stress can be effectively resisted, and the survival rate of HT22 cells is improved. Due to the remarkable neuroprotective activity, the cornflower root extract has a potential research and development value as a neuroprotective drug, and is expected to provide a new natural drug choice which is low in cost, safe and effective for treating neurodegenerative diseases.

The invention relates to the technical field of biological medicine, in particular to a compound preparation for treating focal brain tissue ischemia-reperfusion injury and application of the compound preparation, the mass ratio of dextroborneol to citicoline is 1: 5000-1: 15000, preferably 1: 10000, the combined medicine of the compound preparation further comprises an auxiliary agent, and the auxiliary agent is a mixture of dextroborneol and citicoline. The auxiliary agent comprises any one or a combination of at least two of a stabilizer, a diluent, a carrier, a fluidizing agent, a dissolution medium, an oxidizing agent and a PH regulator, and the focal brain tissue ischemia reperfusion related injury is at least one of encephaledema, cerebral infarction, inflammatory response, oxidative injury, brain function injury and brain tissue pathological injury. According to the invention, the dexhanol and the citicoline are quantitatively proportioned and combined, so that the pharmaceutical composition has a remarkable neuroprotective effect in relieving focal brain tissue ischemia-reperfusion injury, the effect of the pharmaceutical composition after combination is obviously superior to that of a single medicine, the use effect of the pharmaceutical composition is improved, and the pharmaceutical composition has a good clinical application prospect.