36 results about "Nerve impulse" patented technology

A method for treating at least one of a plurality of disorders characterized at least in part by vagal activity includes positioning an electrode around a body organ innervated by the vagus. An electrical signal is applied to the electrode to modulate vagal activity. The electrical signal is applied at a frequency selected for the signal to create a neural conduction block to the vagus with the neural conduction block selected to at least partially block nerve impulses on the vagus. The application of the electrical signal is discontinued. The application of the signal and the discontinuing of the signal are repeated with durations of the discontinuing and the application selected to treat the disorder.

A method for treating at least one of a plurality of disorders characterized at least in part by vagal activity includes positioning an electrode at a body organ innervated by the vagus. An electrical signal is applied to the electrode to modulate vagal activity. The electrical signal is applied at a frequency in excess of 3,000 Hz for the signal to create a neural conduction block to the vagus with the neural conduction block selected to at least partially block nerve impulses on the vagus.

A treatment apparatus and method have a stimulation electrode adapted for placement on a nerve of a patient at a stimulation site and a stimulation signal generator for generating a stimulation signal at the stimulation electrode and selected to electrically stimulate a nerve to induce bi-directional propagation of nervous impulses in a stimulated nerve. The apparatus includes a blocking member for placement on the nerve at a blocking site and creating localized conditions at the blocking site that at least partially diminish transmission of nerve impulses past the blocking site.

A method and apparatus for treating patients suffering from obesity or eating disorders by applying a predetermined stimulating signal to the patient's vagus nerve appropriate to alleviate the condition and by applying a neural conduction block to the vagus nerve at a blocking site with the neural conduction block selected to at least partially block nerve impulses on the vagus nerve at the blocking site.

Methods and systems for anesthetizing a portion or all of a patient's maxillary dental arch using a nasal delivered anesthetizing composition. The process generates anesthesia sufficient for facilitation of operative dentistry, endodontics, periodontics or oral surgery for teeth of the maxillary arch. The dental nasal spray process consists of inserting one or more dispensing devices through the patient's nostril and delivering metered dosages of anesthetic solution or gel into the nasal cavity. The process may utilize a single solution which is a mixture of anesthetic agents, vasoconstricting agents and other physiological inert agents or two separate solutions, wherein one solution contains the vasoconstricting agents and the other solution contains the anesthetic agents. Anesthetic diffusion through the thin walls of the nasal cavity allows for the blocking of nerve impulses originating from the maxillary dentition and surrounding tissues. Anesthesia of specific oral regions such as right versus left sides of the dental arch, anterior versus posterior teeth, and soft tissue anesthesia may be controlled through modification of the dosage volume and the selection of right or left nostril insertion and agent delivery.

Apparatus and methods for cooling selected regions within a body are described herein. An implantable cooling system is used to cool regions of the brain, spinal cord, fibrous nerve bodies, e.g., vagus nerve, etc. down to about 30° C. to diminish nerve impulses which control seizures or chronic pain. The system includes an implantable unit containing a pumping mechanism and / or various control electronics. It also has a heat exchanger attachable to a tubular body organ, such as the superior vena cava or the inferior vena cava, through which the heat is effectively dissipated. Also included is a heat pump such as a Peltier junction configured to be placed into contact with the region of tissue to be cooled. The heated portion of the Peltier junction is cooled by a liquid heat transfer medium which absorbs the heat from the junction and dissipates it into the tubular body organ.

The invention provides an implant, system and method for electrically stimulating a target tissue to either activate or block neural impulses. The implant provides a conductive pathway for a portion of electrical current flowing between surface electrodes positioned on the skin and transmits that current to the target tissue. The implant has a passive electrical conductor of sufficient length to extend from subcutaneous tissue located below a surface cathodic electrode to the target tissue. The conductor has a pick-up end which forms an electrical termination having a sufficient surface area to allow a sufficient portion of the electrical current to flow through the conductor, in preference to flowing through body tissue between the surface electrodes, such that the target tissue is stimulated to either activate or block neural impulses. The conductor also has a stimulating end which forms an electrical termination for delivering the current to the target body tissue.

A method and apparatus for treating a condition associated with impaired blood pressure and / or heart rate in a subject comprising applying an electrical treatment signal, wherein the electrical treatment signal is selected to at least partially block nerve impulses, or in some embodiments, to augment nerve impulses.

Techniques are provided for controlling spinal cord stimulation (SCS) or other forms of neurostimulation. In one example, SCS treatment is delivered to a patient and nerve impulse firing signals are sensed along the spinal cord following the SCS treatment. The nerve impulse signals are analyzed to determine whether the signals are associated with effective SCS and then the delivery of additional SCS is controlled to improve SCS efficacy. For example, the nerve impulse signals can be analyzed to determine whether the signals are consistent with a positive patient mood associated with pain mitigation and, if not, SCS control parameters are adjusted to improve the efficacy of the SCS in reducing pain. In other examples, heart rate variability (HPV) is also used to control SCS. Still further, adjustments may be made to SCS control parameters to improve antiarrhythmic or sympatholytic effects associated with SCS. Techniques employing baseline / target calibration procedures are also described.

A method and apparatus for treating a condition associated with impaired blood pressure and / or heart rate in a subject comprising applying an electrical treatment signal, wherein the electrical treatment signal is selected to at least partially block nerve impulses, or in some embodiments, to augment nerve impulses.

The invention relates to a multi-channel light stimulation-based cochlear implant device. The device comprises a multi-channel light stimulation device, a multi-channel light pulse control circuit, a voice signal acquisition deice and a voice signal processing and encoding device, wherein the device acquires a voice signal and encodes the voice signal into a light stimulation signal; and the light stimulation signal stimulates cochlear auditory nerve through a cochlea-implanted multi-channel light pulse output port to cause nerve impulse so as to form hearing in a central nervous system. The multi-channel light stimulation-based cochlear implant solves the problem of compatibility of a stimulating electrode and biological tissue in the electronic cochlear implant and also solves the problem of mutual interference between stimulating channels caused by current diffusion in the tissue.

The invention discloses an information processing method and device simulating a biological neuron information processing mechanism, which comprises a signal input circuit, an integrating circuit, a pulse generating circuit and a decoding circuit. The signal input circuit simulates and generates the nerve impulse of neuron. The integrating circuit analogous to membrane potential integrates the input signals of the signal input circuit. The pulse generating circuit compares the integrating result of the analogous membrane potential integrating circuit with a predetermined threshold potential in order to generate analogous motion potential pulse. The decoding circuit ingrates the analogous motion potential impulse in order to obtain the analogous motion potential pulse coding signals of output signals consistent with the input signals. The invention simulates the information processing mechanism of the biological neuron and realizes the biological neuron manner with a circuit method.

Certain embodiments of the present invention provide a medical workflow system including a subvocal input device, an impulse processing component, and an information management system. The subvocal input device is capable of sensing nerve impulses in a user. The impulse processing component is in communication with the subvocal input device. The impulse processing component is capable of interpreting nerve impulses as dictation data and / or a command. The information management system is in communication with the impulse processing component. The information management system is capable of processing dictation data and / or a command from the impulse processing component.

The invention discloses an analog-digital (time-pulse signal) conversion method and a device based on the neuron working principle. The device comprises a signal input circuit, a membrane potential integrating circuit and an action potential generating circuit. The signal input circuit is used for simulating and generating nerve impulse of neurons, the membrane potential integrating circuit is used for carrying out integration on the input signals of the signal input circuit, and the action potential generating circuit is used for comparing the integration result of the membrane potential integrating circuit with a predetermined threshold value to generate an action potential. In the invention, the analog-digital conversion device based on the neuron working principle is designed by simulating the coding mechanism of biological neurons on input information, and the information processing mode is realized by using a circuit method.

The invention provides a nervonic acid composition and application thereof in neuroprotection, and belongs to the field of medicines. By organically compounding nervonic acid, phosphatidylserine, DHA,celery seed oil, Chinese herb extracts and nutrient supplements according to an assistant and guide principle, the nervonic acid composition integrates a nerve cell nutrient, a nerve fiber repair agent, a neurotransmitter activator, a nerve energy security agent and other mechanisms, so that the permeability of a nerve cell membrane is improved by using multiple systems and multiple ways, the release of a neurotransmitter is promoted, the conduction of nerve impulse is accelerated, a nerve information passage is repaired and dredged, and the brain function is activated or reversed. The nervonic acid composition breaks through the limit and the defect of a certain component which is singly applied, and becomes an important product for preventing and treating encephalopathy. Experiments onmore than 3,000 volunteers by trial products prove that the nervonic acid composition has a comprehensive health-care effect on the nervous system, and particularly has a satisfactory effect of preventing and reversing physical disability, language barrier and mental disorder of patients suffering from cerebral apoplexy.

The invention discloses a heat-sensitive surface anesthesia patch and is characterized in that a emulsion layer which is anesthesia is arranged under a bottom layer and a spontaneous heat layer on the bottom layer and arranged under a surface layer, the periphery of which is sealed tighter with that of the bottom layer; wherein, the emulsion layer which is anesthesia contains anesthetics and emulsified mixture of non-active substance; the anesthetics is the emulsified mixture of oil-phase lidocaine with 75mg and teracainum with 75mg; the heat generated from the spontaneous heat layer is no higher than 50 DEG C is conducted constantly and the temperature on skin surface is elevated by 15 DEG C; with the assistant force of the heat conduction, the percutaneous force and the releasing speed of the lidocaine and the teracainum reaching subcutaneous layer and cortical layer are increased, and furtherly, the anesthesia speed of part of subcutaneous layer is also increased. With lidocaine and teracainum accumulated on the pain receptor of cortical layer and nerve endings, the ion channel which is needed when nerve impulse is generated and conducted is blocked, thereby having an anesthesia function to a body part.

The invention relates to a food capable of improving functions of cerebral nerve cells and a making method of the food. The food capable of improving functions of cerebral nerve cells comprises the following raw materials in parts by weight of 50-200 parts of a fructus phyllanthi extract, 5-50 parts of phosphatidylserine, 5-50 parts of sodium hyaluronate, 1.5-15 parts of gamma-aminobutyric acid, 0.3-3 parts of calcium pantothenate and 6-30 parts of epsilon-poly-L-lysine-HCl. The food capable of improving functions of cerebral nerve cells has the effects of adjusting conduction of nerve impulse, enhancing cerebral memory functions, repairing damaged brain cells and the like; besides, the food capable of improving functions of cerebral nerve cells can be made into powder, slices, granules and liquid, so that the application crowds can be greatly widened; and besides, the making technology of the food is simple and easy to operate, and large-scale production is facilitated.

The invention discloses an eye and brain holographic training system. The eye and brain holographic training system comprises an external environment adjusting module, a detection module, a red and green light flickering module, a black and white bar screen drawing module, a brainwave music module and a visual function training module, wherein the external environment adjusting module is used forexternally adjusting the environment of the module in a detection chamber and externally adjusting a detection device and instrument of the detection chamber; the detection module comprises instruments and equipment for detecting the eyesight condition and an inquiry scoring system; the red and green light flickering module is used for forming benign stimulation on photoreceptor cells of retinas of human eyes so as to stimulate the activity of optic nerve cells, so that nerve impulse generated by the photoreceptor cells is transmitted to the visual center of the cerebral cortex; and the blackand white bar screen drawing module is used for arranging CAM black and white bar screens with different frequencies as visual stimulation sources. A series of benign stimuli are generated to the human brain while the eyesight is protected, controlled and improved, so that the effect of improving sleep, concentration, memory and the like can be achieved, meanwhile, the detection chamber is used for isolating the detection environment from the external environment, and a light source control system is used for adjusting the light environment in the detection chamber.

In a first embodiment, a portable, battery-operated, minimally invasive small fiber neuropathy testing and diagnostic device, microcontrolled and interfacing with wireless powering to a wireless communications device is being disclosed. Said device is constructed out of an intra-epidermal thermal stimulus consisting of an electronically heated temperature-controlled polymer covered semiconductor material 101 lowered inside the skin through a probe 108 configured with three miniaturized electrodes 109 while a nerve impulse response measurement system records and identifies nerve action potential pulses through a proprietary algorithm. The invention also discloses a detection and characterization method of action potential pulses from neuron cells with respect to their timing such as pulse repetition statistics and rates from a single-point of measurement as diagnostically relevant for determining neuropathies. In an alternate embodiment, a medical device is constructed for biological tissue treatment for achieving a collagen denaturing effect or thermal tissue ablation.

A stimulator device for use in controlling waste storage for a patient, the stimulator device having a set of at least one electrode placed in proximity to a relevant portion of a pudendal nerve. The stimulator device having a pulse generator connected to the set of at least one electrode to provide stimulation input for use by the electrode to stimulate the pudendal nerve. The pulse generator adapted to provide a first type of stimulation to cause waste to be stored within the patient. The pulse generator adapted to provide a second type of stimulation different from the first type of stimulation, the second type of stimulation to allow waste to be voided from the patient by blocking nerve impulses that would produce sphincter dyssynergia. An input device to allow an end user to select to apply the first type of stimulation or the second type of stimulation. Variations of the concept are disclosed.

A nerve impulse signal stimulation device and a method for fabricating the same are provided. The nerve impulse signal stimulation device includes: a substrate having a first surface and a second surface opposite to the first surface; a first metal layer formed on the first surface of the substrate; a second metal layer formed on the first metal layer; a plurality of openings exposing a portion of the first surface of the substrate, a portion of the first metal layer and a portion of the second metal layer; and a ferromagnetic material attached to the second surface of the substrate. The openings cause the nerve impulse signal stimulation device to obtain a parallel circuit structure, thereby increasing the current load and the magnetic field intensity, reducing the size of the device, and ensuring the safety of operations.

The present invention provides a nerve stimulation rehabilitation system and a stimulation method based on motion intention, the system comprising: an in vitro control system, including: an EMG acquisition module, which collects surface muscle electrical signals generated by the patient's healthy side limbs; an in vitro micro-control module, which analyzes The amplitude and duration of the collected myoelectric signal waveform and the order to control the stimulator in the body; and the first wireless communication module; the implanted system in the body, including: the micro-control module in the body, which controls the stimulation order; the stimulator in the body, according to Stimulation commands are analyzed to generate stimulation waveforms; DC‑DC conversion module supplies power to each module circuit; power amplifier module amplifies the stimulation waveform generated by the internal stimulator after analyzing commands in the range of +5V to ‑5V for positive and negative charge balance waveform transmission to the stimulation electrode; the stimulation electrode generates a nerve impulse to the corresponding nerve; and the second wireless communication module. The system stimulates the nerves of the affected limb by preserving the limb on the motor side.

The invention belongs to the field of insecticides, and particularly relates to an insecticidal composition containing pyriminostrobin and indoxacarb. The insecticidal composition comprises effectivecomponents including pyriminostrobin and indoxacarb. The beneficial effects are that: 1, indoxacarb is a voltage-gated sodium channel blocking agent in insect nerve cells, and can block nerve impulseconduction in insect bodies; pyriminostrobin is a mitochondrial electron transfer inhibitor, can inhibit the generation of ATP in organisms, indirectly inhibit the transmembrane transport of nerve cell sodium ion channels to ions, indirectly inhibit the nerve impulse transfer of insects, and form a synergistic effect with indoxacarb; the insecticidal composition is composed of effective componentswith different action mechanisms, the number of action sites is increased, generation of insecticide resistance of pests is delayed, and the insecticidal spectrum is expanded; 2, the pesticide effectof the insecticidal composition is obviously improved, the lasting period is prolonged, the field dosage of effective components is reduced, the production and use cost is reduced, and the pollutionof pesticide residues to the environment is reduced.

The invention discloses a power grid fault diagnosis method that takes into account false faults caused by measurement tampering attacks. Firstly, the suspected fault components are determined by using the connection analysis method, thereby narrowing the diagnosis range. Secondly, the present invention uses the random matrix theory and the fuzzy C-means clustering algorithm to determine whether each suspected faulty component is subjected to a measurement tampering attack, effectively solving the problem of fault diagnosis misoperation caused by a measurement tampering attack. Finally, the present invention uses the memory backtracking idea of ​​the memory nerve pulse membrane system to establish a fault diagnosis model that can comprehensively utilize telemetry and telesignaling quantities, which not only changes the original shortcoming of not being able to use telemetry modeling based on production rules, It is also possible to determine the type of fault in the event of a faulty component being diagnosed.

A method and a system for detecting the possible existence of a stroke is provided. In a first step of the method, a first measurement of a nerve impulse is obtained from the skin of a first location of a patient using a magnetometer. In a second step, the first measurement is compared with either a baseline measurement or a second measurement of a nerve impulse obtained from the skin of a second location of the patient using a magnetometer. In a third step, a signal is transmitted indicating a possible stroke if there is no symmetry between the first measurement and either the baseline measurement or the second measurement.

In a first embodiment, a portable, battery-operated, minimally invasive small fiber neuropathy testing and diagnostic device, microcontrolled and interfacing with wireless powering to a wireless communications device is being disclosed. Said device is constructed out of an intra-epidermal thermal stimulus consisting of an electronically heated temperature-controlled polymer covered semiconductor material 101 lowered inside the skin through a probe 108 configured with three miniaturized electrodes 109 while a nerve impulse response measurement system records and identifies nerve action potential pulses through a proprietary algorithm. The invention also discloses a detection and characterization method of action potential pulses from neuron cells with respect to their timing such as pulse repetition statistics and rates from a single-point of measurement as diagnostically relevant for determining neuropathies. In an alternate embodiment, a medical device is constructed for biological tissue treatment for achieving a collagen denaturing effect or thermal tissue ablation.