37 results about "Nerve Impulses" patented technology

The invention provides an implant, system and method for electrically stimulating a target tissue to either activate or block neural impulses. The implant provides a conductive pathway for a portion of electrical current flowing between surface electrodes positioned on the skin and transmits that current to the target tissue. The implant has a passive electrical conductor of sufficient length to extend from subcutaneous tissue located below a surface cathodic electrode to the target tissue. The conductor has a pick-up end which forms an electrical termination having a sufficient surface area to allow a sufficient portion of the electrical current to flow through the conductor, in preference to flowing through body tissue between the surface electrodes, such that the target tissue is stimulated to either activate or block neural impulses. The conductor also has a stimulating end which forms an electrical termination for delivering the current to the target body tissue.

Systems and methods for blocking nerve impulses use an implanted electrode located on or around a nerve. A specific waveform is used that causes the nerve membrane to become incapable of transmitting an action potential. The membrane is only affected underneath the electrode, and the effect is immediately and completely reversible. The waveform has a low amplitude and can be charge balanced, with a high likelihood of being safe to the nerve for chronic conditions. It is possible to selectively block larger (motor) nerve fibers within a mixed nerve, while allowing sensory information to travel through unaffected nerve fibers.

Apparatus and methods for cooling and / or heating selected regions within a body are described herein. An implantable system is used to cool or heat nerve bodies down to about 15° C. to diminish nerve impulses. In one embodiment, the system can include an implantable unit containing a pumping mechanism and / or various control electronics. The system has a cooling element. The cooling element can be a Peltier junction or a catheter through which hot or cold fluid flows. The heated portion of the Peltier junction can be cooled by a liquid heat transfer medium which absorbs the heat from the junction and dissipates the heat elsewhere.

A method and apparatus for treating patients suffering from involuntary movement disorders (including epilepsy) by stimulating a selected cranial nerve of the patient with an electrical signal applied to induce a signal at brain by applying an electrical signal at the nerve to ameliorate the disorder and by applying a neural conduction block at the nerve selected to at least partially block nerve impulses on said nerve at a blocking site and reduce adverse effects of said signal on an organ.

At least one of a plurality of disorders of a patient are treated where the disorders are associated with a gastrointestinal tract of a patient where the disorders are characterized at least in part by hyper-tonal vagal activity innervating at least one of a plurality of alimentary tract organs of the patient at an innervation site. The treatment includes applying a neural conduction block to a vagus nerve of the patient at a blocking site proximal to the innervation site. The neural conduction block is selected to at least partially block nerve impulses on the vagus nerve at the blocking site. A treatment apparatus has an electrically controllable neural conduction electrode adapted to be placed on a vagus nerve of a patient at a blocking site proximal to an innervation site.

The invention provides an implant, system and method for electrically stimulating a target tissue to either activate or block neural impulses. The implant provides a conductive pathway for a portion of electrical current flowing between surface electrodes positioned on the skin and transmits that current to the target tissue. The implant has a passive electrical conductor of sufficient length to extend from subcutaneous tissue located below a surface cathodic electrode to the target tissue. The conductor has a pick-up end which forms an electrical termination having a sufficient surface area to allow a sufficient portion of the electrical current to flow through the conductor, in preference to flowing through body tissue between the surface electrodes, such that the target tissue is stimulated to either activate or block neural impulses. The conductor also has a stimulating end which forms an electrical termination for delivering the current to the target body tissue.

A method for treating at least one of a plurality of disorders characterized at least in part by vagal activity includes positioning an electrode around a body organ innervated by the vagus. An electrical signal is applied to the electrode to modulate vagal activity. The electrical signal is applied at a frequency selected for the signal to create a neural conduction block to the vagus with the neural conduction block selected to at least partially block nerve impulses on the vagus. The application of the electrical signal is discontinued. The application of the signal and the discontinuing of the signal are repeated with durations of the discontinuing and the application selected to treat the disorder.

A method and apparatus for treating a condition associated with impaired blood pressure and / or heart rate in a subject comprising applying an electrical treatment signal, wherein the electrical treatment signal is selected to at least partially block nerve impulses, or in some embodiments, to augment nerve impulses.

A method and apparatus for treating a condition associated with impaired blood pressure and / or heart rate in a subject comprising applying an electrical treatment signal, wherein the electrical treatment signal is selected to at least partially block nerve impulses, or in some embodiments, to augment nerve impulses. In embodiments, the apparatus provides a first therapy program to provide a downregulating signal to one or more nerves including renal artery, renal nerve, vagus nerve, celiac plexus, a splanchnic nerve, cardiac sympathetic nerves, spinal nerves originating between T10 to L5. In embodiments, the apparatus provides a third therapy program to provide an upregulating signal to one or more nerves including a glossopharyngeal nerve and / or a tissue containing baroreceptors.

A method for increasing cerebral blood flow in a patient. A electrical stimulating device is provided. The electrical stimulating device is applied to the patient at a region adjacent the cervical sympathetic chain, the brain stem, the head, or the sympathetic nervous system. The electrical stimulating device is applied by any route selected from transcutaneous, subcutaneous, and subarachnoid. The electrical stimulating device is activated to stimulate or inhibit nerve impulses of the cervical sympathetic chain, thereby producing vasodilation in the cerebral vasculature, thereby increasing cerebral blood flow. Devices for increasing cerebral blood flow in a patient are also described.

A method and apparatus for treating a condition associated with impaired blood pressure and / or heart rate in a subject comprising applying an electrical treatment signal, wherein the electrical treatment signal is selected to at least partially block nerve impulses, or in some embodiments, to augment nerve impulses.

The invention discloses an information processing method and device simulating a biological neuron information processing mechanism, which comprises a signal input circuit, an integrating circuit, a pulse generating circuit and a decoding circuit. The signal input circuit simulates and generates the nerve impulse of neuron. The integrating circuit analogous to membrane potential integrates the input signals of the signal input circuit. The pulse generating circuit compares the integrating result of the analogous membrane potential integrating circuit with a predetermined threshold potential in order to generate analogous motion potential pulse. The decoding circuit ingrates the analogous motion potential impulse in order to obtain the analogous motion potential pulse coding signals of output signals consistent with the input signals. The invention simulates the information processing mechanism of the biological neuron and realizes the biological neuron manner with a circuit method.

Techniques are provided for controlling spinal cord stimulation (SCS) or other forms of neurostimulation. In one example, SCS treatment is delivered to a patient and nerve impulse firing signals are sensed along the spinal cord following the SCS treatment. The nerve impulse signals are analyzed to determine whether the signals are associated with effective SCS and then the delivery of additional SCS is controlled to improve SCS efficacy. For example, the nerve impulse signals can be analyzed to determine whether the signals are consistent with a positive patient mood associated with pain mitigation and, if not, SCS control parameters are adjusted to improve the efficacy of the SCS in reducing pain. In other examples, heart rate variability (HRV) is also used to control SCS. Still further, adjustments may be made to SCS control parameters to improve antiarrhythmic or sympatholytic effects associated with SCS. Techniques employing baseline / target calibration procedures are also described.

The present invention discloses method and device for developing brain's potential, and belongs to the field of brain's potential developing technology. The method includes stimulating the hearing sensation, visual sensation, smell sensation and touch sensation of bright brain with music, picture, smell and massage; increasing the nerve impulse information amount transferred between two brain hemispheres; regulating the functions of the two brain hemispheres; stimulating the release of polypeptides, acetylcholine and other neurotransmitters; and regulating the brain wave to the alpha wave range of 8-13 Hz for maintaining in optimal work state. The present invention has the features of comprehensive performance and obvious effect. The present invention makes it possible for people to breed up excellent learning habit.

The invention discloses an analog-digital (time-pulse signal) conversion method and a device based on the neuron working principle. The device comprises a signal input circuit, a membrane potential integrating circuit and an action potential generating circuit. The signal input circuit is used for simulating and generating nerve impulse of neurons, the membrane potential integrating circuit is used for carrying out integration on the input signals of the signal input circuit, and the action potential generating circuit is used for comparing the integration result of the membrane potential integrating circuit with a predetermined threshold value to generate an action potential. In the invention, the analog-digital conversion device based on the neuron working principle is designed by simulating the coding mechanism of biological neurons on input information, and the information processing mode is realized by using a circuit method.

Apparatus and methods for cooling selected regions within a body are described herein. An implantable cooling system is used to cool regions of the brain, spinal cord, fibrous nerve bodies, e.g., vagus nerve, etc. down to about 30° C. to diminish nerve impulses which control seizures or chronic pain. The system includes an implantable unit containing a pumping mechanism and / or various control electronics. It also has a heat exchanger attachable to a tubular body organ, such as the superior vena cava or the inferior vena cava, through which the heat is effectively dissipated. Also included is a heat pump such as a Peltier junction configured to be placed into contact with the region of tissue to be cooled. The heated portion of the Peltier junction is cooled by a liquid heat transfer medium which absorbs the heat from the junction and dissipates it into the tubular body organ.

The invention provides novel pyridines, pharmaceutical compositions comprising such pyridines, and the use of such compositions in treating injured mammalian nerve tissue, including but not limited to an injured spinal cord. In one embodiment, the compounds, compositions, and methods of the instant invention treat a mammalian nerve tissue injury by restoring action potential or nerve impulse conduction through a nerve tissue lesion. Significantly, in vivo application of compounds of the instant invention established, on the basis of SSEP testing, that the compounds provide longer lasting effects at lower concentrations than comparable treatment with the known agent 4-aminopyridine (4 AP).

The invention belongs to the technical field of neural components, and particularly relates to a neuron circuit based on a memristor. The neuron circuit comprises an integral reset circuit, a resistance comparison circuit and a pulse output circuit, the integral reset circuit takes the current of an external circuit as the input, realizes the integration of the input current through the reset or setting operation of the memristor, and takes the monitoring voltage of the real-time resistance value of the memristor as the output. The resistance comparison circuit receives the real-time monitoring voltage, compares the real-time monitoring voltage with a voltage signal of a reference resistor, and outputs a resistance comparison result to the pulse output circuit; when the real-time monitoring voltage exceeds a threshold value, the pulse output circuit outputs a neural pulse signal to an external circuit and sends a feedback signal to the integral reset circuit, so that the memristor resistance of the integral reset circuit is reset. The method has the advantages of being low in area cost after integration, good in real-time performance and low in misoperation rate.

The invention relates to a food capable of improving functions of cerebral nerve cells and a making method of the food. The food capable of improving functions of cerebral nerve cells comprises the following raw materials in parts by weight of 50-200 parts of a fructus phyllanthi extract, 5-50 parts of phosphatidylserine, 5-50 parts of sodium hyaluronate, 1.5-15 parts of gamma-aminobutyric acid, 0.3-3 parts of calcium pantothenate and 6-30 parts of epsilon-poly-L-lysine-HCl. The food capable of improving functions of cerebral nerve cells has the effects of adjusting conduction of nerve impulse, enhancing cerebral memory functions, repairing damaged brain cells and the like; besides, the food capable of improving functions of cerebral nerve cells can be made into powder, slices, granules and liquid, so that the application crowds can be greatly widened; and besides, the making technology of the food is simple and easy to operate, and large-scale production is facilitated.

The invention discloses a neuron circuit which comprises a pulse generation circuit, an adjustment circuit, and a comparison circuit. The pulse generation circuit is configured to simulate nerve impulse oscillation through a first Tau-cell circuit structure and a second Tau-cell circuit structure, the first Tau-cell circuit structure includes a first capacitor Cv used for simulating a neuron membrane potential v, and the second Tau-cell circuit structure includes a second capacitor Cu used for simulating a neuron membrane potential adjustment variable u. The adjustment circuit is connected with the pulse generation circuit, and is used for reassigning a value to the neuron membrane potential v. The comparison circuit is connected with the pulse generation circuit, and is used for reassigning a value to the neuron membrane potential adjustment variable u. The power consumption of the neuron circuit can be lowered, and the occupied area of the neuron circuit can be reduced.

The invention discloses a repairing device and a repairing method for stimulating nerves by near infrared light. An optical fiber is connected with a laser, and near infrared laser generated by the laser is transmitted onto nervous tissue to be repaired; a microelectrode array is inserted in the nervous tissue to be repaired, and is connected with a multichannel acquisition instrument through an electrode adapter and a leading wire; the multichannel acquisition instrument is connected with a computer through a transmission cable; the multichannel acquisition instrument carries out amplification; wave filtering and digitalized treatment on induced potential acquired by the microelectrode array, and the induced potential is treated, displayed and stored through the computer; the included angle between the optical fiber long axis of the optical fiber and the axis of recording a microelectrode is 0 to 45 degrees; and the wave length of the near infrared light generated by the laser is in the range of 780-2526nm. Through the device and the method disclosed by the invention, the nervous tissue can be efficiently activated so as to induce nerve impulse and realize the repairing of neurological function, and the device is relatively short in artifact time interval, relatively high in resolution factor and is not contacted with the nervous tissue directly.

The invention provides novel pyridines, pharmaceutical compositions comprising such pyridines, and the use of such compositions in treating injured mammalian nerve tissue, including but not limited to an injured spinal cord, in one embodiment, the compounds, compositions, and methods of the instant invention treat a mammalian nerve tissue injury by restoring action potential or nerve impulse conduction through a nerve tissue lesion. Significantly, in vivo application of compounds of the instant invention established, on the basis of SSEP testing, that the compounds provide longer lasting effects at lower concentrations than comparable treatment with the known agent 4-aminopyridine (4 AP).

The invention discloses an eye and brain holographic training system. The eye and brain holographic training system comprises an external environment adjusting module, a detection module, a red and green light flickering module, a black and white bar screen drawing module, a brainwave music module and a visual function training module, wherein the external environment adjusting module is used forexternally adjusting the environment of the module in a detection chamber and externally adjusting a detection device and instrument of the detection chamber; the detection module comprises instruments and equipment for detecting the eyesight condition and an inquiry scoring system; the red and green light flickering module is used for forming benign stimulation on photoreceptor cells of retinas of human eyes so as to stimulate the activity of optic nerve cells, so that nerve impulse generated by the photoreceptor cells is transmitted to the visual center of the cerebral cortex; and the blackand white bar screen drawing module is used for arranging CAM black and white bar screens with different frequencies as visual stimulation sources. A series of benign stimuli are generated to the human brain while the eyesight is protected, controlled and improved, so that the effect of improving sleep, concentration, memory and the like can be achieved, meanwhile, the detection chamber is used for isolating the detection environment from the external environment, and a light source control system is used for adjusting the light environment in the detection chamber.

The invention provides an application of a compound FTY720 to preparation of detection markers for treating behavior abnormality and motion abnormality. The behavior abnormality and the motion abnormality are caused by nerve impulse control disorder and dyskinesia, and the amino acid sequence of ATP13A2 is shown as SEQ.No.1. The invention also provides an application of reduction of sphingomyelinin blood and rise of ceramide caused by ATPase ATP13A2 abnormality to preparation of biological detection markers for impulse control behaviors and motion abnormality diseases. The invention also provides an application of a ceramide similar compound FTY720 or a sphingomyelinase restraining compound Fluoxetine to preparation of medicines for treating impulse control behaviors and motion abnormality diseases. A new treatment medicine is provided for behavior abnormality diseases and motion abnormality diseases, and a theoretical basis is provided for clinical research of the behavior abnormality diseases and motion abnormality diseases.

The present invention provides a nerve stimulation rehabilitation system and a stimulation method based on motion intention, the system comprising: an in vitro control system, including: an EMG acquisition module, which collects surface muscle electrical signals generated by the patient's healthy side limbs; an in vitro micro-control module, which analyzes The amplitude and duration of the collected myoelectric signal waveform and the order to control the stimulator in the body; and the first wireless communication module; the implanted system in the body, including: the micro-control module in the body, which controls the stimulation order; the stimulator in the body, according to Stimulation commands are analyzed to generate stimulation waveforms; DC‑DC conversion module supplies power to each module circuit; power amplifier module amplifies the stimulation waveform generated by the internal stimulator after analyzing commands in the range of +5V to ‑5V for positive and negative charge balance waveform transmission to the stimulation electrode; the stimulation electrode generates a nerve impulse to the corresponding nerve; and the second wireless communication module. The system stimulates the nerves of the affected limb by preserving the limb on the motor side.

The invention discloses a power grid fault diagnosis method that takes into account false faults caused by measurement tampering attacks. Firstly, the suspected fault components are determined by using the connection analysis method, thereby narrowing the diagnosis range. Secondly, the present invention uses the random matrix theory and the fuzzy C-means clustering algorithm to determine whether each suspected faulty component is subjected to a measurement tampering attack, effectively solving the problem of fault diagnosis misoperation caused by a measurement tampering attack. Finally, the present invention uses the memory backtracking idea of ​​the memory nerve pulse membrane system to establish a fault diagnosis model that can comprehensively utilize telemetry and telesignaling quantities, which not only changes the original shortcoming of not being able to use telemetry modeling based on production rules, It is also possible to determine the type of fault in the event of a faulty component being diagnosed.

A method and a system for detecting the possible existence of a stroke is provided. In a first step of the method, a first measurement of a nerve impulse is obtained from the skin of a first location of a patient using a magnetometer. In a second step, the first measurement is compared with either a baseline measurement or a second measurement of a nerve impulse obtained from the skin of a second location of the patient using a magnetometer. In a third step, a signal is transmitted indicating a possible stroke if there is no symmetry between the first measurement and either the baseline measurement or the second measurement.

The present invention discloses a rapid neural response telemetry (NRT) circuit and system of a cochlear implant. The circuit comprises a stimulus generator, a signal amplifier, an analog-to-digital (A / D) converter and a calculated data memory. The stimulus generator zero charges in a nerve tissue before stimulus onset and offset, and the onset asynchrony of two continuous stimuli on the same electrode may be adjusted at will. The signal amplifier filters and amplifies nervous impulse signals that are evoked by electric stimuli and received by a collector electrode. The A / D converter can adjust the sampling frequency and start-up time, and is connected to the signal amplifier to perform A / D conversion on amplified analog signals. The calculated data memory is connected to the A / D converter to calculate and store the data undergoing A / D conversion. According to the present invention, a stimulus circuit is improved to reduce artifacts of NRT so that key parameters for NRT can be flexibly controlled, the success rate in eliciting NRT is improved, and the NRT speed is greatly improved by calculating and storing the data.