The invention provides a preparation method of 
fructus phyllanthi powder. The method comprises the following specific steps: washing fresh 
fructus phyllanthi fruits, and crushing the washed fresh 
fructus phyllanthi fruits; diluting a biological 
enzyme with drinking water; adding crushed fructus phyllanthi into a container, adding the diluted biological 
enzyme liquid into the container, stirring and uniformly mixing the crushed fructus phyllanthi and the diluted biological 
enzyme liquid, heating and carrying out heat insulation; separating a fructus phyllanthi enzymolysis solution, and filtering by virtue of a filter cloth, thus obtaining a primary filtrate; filtering the primary filtrate with a 
ceramic film; adsorbing by virtue of 
macroporous resin and eluting; and 
drying so as to obtain the fructus phyllanthi 
powder. According to the invention, the 
biological activity of the biological enzyme is utilized for enzymolyzing the 
pectin, 
starch and 
cellulose contained in the crushed fresh fructus phyllanthi fruits into glycose, so that the tissues of the crushed fresh fructus phyllanthi fruits to form gaps which are beneficial to the 
dissolution of 
active components; an enzyme 
hydrolysis technology adopted in the invention can be used for improving the yield and comprehensive 
utilization rate of the fructus phyllanthi 
powder and reducing the production cost; the enzyme 
hydrolysis macroporous resin, cryoconcentration, low-temperature 
spray drying technologies are applied, so that damages or losses of thermo-sensitivity components such as natural 
vitamin C (VC) and the like are reduced, thus the contents of the VC and other main components in the product are improved, the product quality is stable, and the possibilities of 
moisture absorption and discoloration are small; and the method has the advantages that the design is reasonable, the process is advanced, the product quality is high, the product taste is good, and the 
raw material utilization ratio is high.