The invention discloses a quenched and tempered X52 hydrogen sulfide corrosion resisting seamless line pipe and a preparation method thereof, and relates to the technical field of line pipe manufacturing. The quenched and tempered X52 hydrogen sulfide corrosion resisting seamless line pipe is prepared from, by weight percent, 0.11-0.14% of C, 0.15-0.35% of Si, 0.8-1.5% of Mn, 0.01-0.02% of Ti, 0.0015% or less of S, 0.01% or less of P, 0.015-0.030% of Al, 0.0015-0.0025% of Ca, 0.008% or less of N, 0.08% or less of Ni, 0.08% or less of Cu, 0.2% or less of Cr, 0.1% or less of Mo, 0.03% or less of V, 0.02% or less of Nb, 0.39% or less of CEQ, and the balance Fe and unavoidable impurities. The line pipe is simple in alloy component, low in cost, high in yield, excellent in mechanical performance and hydrogen sulfide corrosion resisting performance and capable of being widely applied to development of gas fields containing hydrogen sulfide.