45 results about "Antrodia" patented technology

The utility model firstly provides an air conditioning device for culturing antrodia camphorata, the air conditioning device comprises an air inlet system, a heat exchange system and an air supply system, and a carbon dioxide generator for adjusting the content of indoor carbon dioxide is arranged between the air inlet system and the heat exchange system. The utility model further provides an antrodia camphorata cultivation system which comprises a square cabin used for containing an antrodia camphorata cultivation device, and the air conditioning device is further arranged in the square cabin. According to the air conditioning device for antrodia camphorata cultivation and the antrodia camphorata cultivation system, the carbon dioxide generator is additionally arranged in a conventional air conditioner, so that the carbon dioxide concentration in the cultivation environment is adjusted, and the overall yield and the medicinal value of antrodia camphorata are improved.

The invention provides application of combination of antrodia camphorata polysaccharide and forsythin in preparation of drugs for treating metabolic diseases related to insulin resistance, and belongs to the technical field of biological medicines. The metabolic diseases related to insulin resistance include polycystic ovarian syndrome. Animal experiments find that the combination of the antrodia camphorata polysaccharide and forsythin can significantly reduce serum testosterone and luteinizing hormone levels of a rat with the polycystic ovarian syndrome, improve serum follicular hormone and estradiol levels, and achieve the effect of improving the polycystic ovarian syndrome.

The present invention discloses a fermentation method for Antrodia camphorata mycelium and an auxiliary composition for fermentation of Antrodia camphorata. The method provided by the present invention comprises the following steps: S1. subjecting an Antrodia camphorata strain to liquid fermentation for 60-120 hours; S2. adding precursors to the fermented Antrodia camphorata strain liquid fermentation broth, and continuing the fermentation for more than 120 hours to obtain Antrodia camphorata mycelium; the precursors being coenzyme Q0, p-hydroxybenzoic acid, linalool, and α-terpineol, and the fermentation broth after adding the precursors having a coenzyme Q0 content of 100-500 mg / L, a p-hydroxybenzoic acid content of 20-300 mg / L, a linalool content of 0.1-0.5 mg / L, and an α-terpineol content of 0.3-0.7 mg / L. This method adds precursor substances of specific composition and concentration to the liquid fermentation broth of Antrodia cinnamomea at a certain time and combines them with each other, which is beneficial to the secondary metabolism of Antrodia cinnamomea and promotes the synthesis of triterpenoid compounds, thereby increasing the yield. Compared with the existing technology, the yield of triterpenoid compounds produced by Antrodia cinnamomea mycelium is increased, the culture cycle is shortened, and it is more suitable for large-scale production.

The invention provides an antrodia camphorata sporocarp extract, which is prepared from the following raw materials in parts by weight: 20 to 24 parts of wild ganoderma lucidum extract, 8 to 12 parts of herba taraxaci and 8 to 12 parts of bolete. The antrodia camphorata sporocarp extract disclosed by the invention contains various physiologically active components such as triterpenoids, polysaccharides, superoxide disproportionated enzymes, adenosine, proteins (containing immune proteins), vitamins, trace elements, nucleic acid, lectin, amino acid, sterols, lignin, blood pressure stabilizing substances and the like; the traditional Chinese medicine composition can relieve various tumors such as hangover, gastrointestinal discomfort, heatstroke, hypertension, virus infection, diabetes mellitus, nephritis, liver cirrhosis and liver cancer, has the effects of resisting oxidation, resisting inflammation, inhibiting hypertension, protecting liver nerves, inhibiting tumor growth and the like, can bidirectionally regulate immunity and protect the liver, can also treat tumors at multiple targets, and has a wide application prospect. The discomfort of a patient in an anti-tumor process is reduced.

The invention discloses a component detection device for Antrodia cinnamomea fruiting bodies, comprising a base, a rotating box and a spectrophotometer are respectively fixedly installed on the top of the base, a drying box is fixedly installed on the top of the rotating box, a speed regulating motor is fixedly connected to the bottom inner wall of the rotating box, an output shaft of the speed regulating motor is fixedly connected to a first gear, the bottom inner wall of the rotating box is rotatably connected to a rotating shaft, an outer wall of the rotating shaft is fixedly sleeved with a second gear, the second gear is meshed with the first gear. The device has a simple structure and is easy to operate. The speed regulating motor can not only drive the rotating table to rotate slowly to dry the Antrodia cinnamomea fruiting bodies on the grooves in all directions, but also make the blade rotate quickly to grind the Antrodia cinnamomea fruiting bodies. The device integrates drying and grinding without separation, reduces the contamination of the Antrodia cinnamomea fruiting bodies during movement, and improves the accuracy of component detection.

The invention provides a culture method for increasing the content of Antrodin C in antrodia camphorata mycelia, and relates to the technical field of edible and medicinal fungus production processes. The culture method comprises the following steps: inoculating antrodia camphorata mycelia into a PDA liquid culture medium added with melia azedarach tender leaf homogenate, and culturing in a constant-temperature shaking table at 28 + / -2 DEG C and 150 + / -50 rpm for 15-20 days. According to the method, the defects in the prior art are overcome, the content of Antrodin C in the Gaochaigong antrodia camphorata mycelia is increased by optimizing the formula of the fermentation culture medium and improving the fermentation conditions, and the pharmacological activity of the Gaochaigong antrodia camphorata mycelia is enhanced.

This invention discloses a culture medium for Antrodia camphorata mycelium, which consists of two parts: a solid medium and a liquid medium. The liquid medium contains glucose, peptone, anhydrous magnesium sulfate, and plant hormones; the plant hormones include one or more of indolebutyric acid, lignin, gibberellin, 6-benzylaminopurine, and 24-epibrassinolide. The solid medium contains carrot powder, potato powder, glucose, and agar powder; the solid medium also contains plant hormones, including one or more of indolebutyric acid, lignin, gibberellin, 6-benzylaminopurine, and 24-epibrassinolide. During cultivation, activated mycelium is first inoculated onto the solid medium to form high-quality colonies, and then inoculated onto the liquid medium for further expansion. This method significantly increases mycelium yield and the production of crude polysaccharides and crude triterpenes, providing strong technical support for the development and utilization of Antrodia camphorata.

The object of the present disclosure is to provide a method for treating diabetes by using an Antrodia camphorata compound, wherein the Antrodia camphorata compound is shown in the following formula 1:or the pharmacologically acceptable salts of the formula 1.

To provide a novel application of compounds derived from Antrodia camphorata.SOLUTION: A compound derived from Antrodia camphorata, represented by formula (1) below, or a pharmaceutically acceptable salt thereof, reduces blood glucose levels and blood lipids in diabetic patients.SELECTED DRAWING: None

The invention provides a culture method for increasing the content of Antrocinnamomin H in antrodia camphorata mycelia, and relates to the technical field of edible and medicinal fungus production processes. The culture method comprises the following steps: inoculating antrodia camphorata mycelia into a liquid fermentation culture medium added with polygonum multiflorum powder, and culturing, the liquid fermentation culture medium is a WDF liquid fermentation culture medium, and the formula of the liquid fermentation culture medium comprises 0.5 g / 100 mL of pea meal, 0.1 g / 100 mL of monopotassium phosphate, 0.05 g / 100 mL of magnesium sulfate, 0.5 g / 100 mL of yeast powder, 0.01 g / 100 mL of VB1 and the balance of water. According to the method, the defects in the prior art are overcome, the content of Antrocinnamomin H in the Gaochaigong antrodia mycelium is increased by optimizing the formula of the fermentation culture medium and improving the fermentation conditions, and the pharmacological activity of the Gaochaigong antrodia mycelium is enhanced.

The present invention relates to a method for preventing or treating fibrotic diseases, comprising administering an effective amount of a composition to a subject in need thereof; wherein the composition comprises triterpenoid compounds extracted from Antrodia camphorata or Vernonia cinerea.

The invention relates to application of terpenoids in treating or preventing fibrotic diseases. The application comprises the step of applying an effective amount of a composition to a subject in need of the terpenoids, wherein the composition comprises a triterpenoid compound extracted from antrodia camphorata or needle herb.

The present invention relates to a use of a compound and an extract derived from natural fungus Antrodia camphorata in the preparation of an FGF21 agonist and / or an RDH10 agonist.

The invention provides application of antrodia camphorata polysaccharide in preparation of anti-hepatoma drugs, and relates to the technical field of biological medicines. The antrodia camphorata polysaccharide can regulate mononuclear cells to differentiate into macrophages, and promotes the classical activation of the macrophages through a cascade amplification effect to secrete proinflammatory factors, so that the proliferation of liver cancer cells is inhibited, and the anti-liver cancer effect is achieved. In addition, the antrodia camphorata polysaccharide is good in safety, free of toxic and side effects, capable of being used for preparing the medicine for treating the liver cancer, easy to produce, low in cost and remarkable in effect, and has great market development value and good application prospects.

The utility model discloses a humidity-controllable antrodia camphorata culture dish, which relates to the technical field of antrodia camphorata culture equipment and comprises a culture room, a through hole partition plate is arranged in the culture room, a cover is sleeved at the top end of the culture room, a cover plate is arranged in the middle of the top end of the cover, and vent holes are formed in the outer surface of the cover plate. Guide rails are fixedly installed on the front side and the rear side of the top end of the cover, limiting strips are arranged in the left sides and the right sides of the two guide rails, the two sides of a first movable cover and a second movable cover are slidably connected in the two guide rails, a gear is rotationally installed in the center of the top end of the cover, and the output end of a first motor is fixedly installed at the top end of the gear. The ventilation quantity in the culture room can be accurately controlled through the cooperation of the ventilation holes in the cover plate arranged in the middle of the top end of the cover and the first movable cover and the second movable cover, then fine adjustment of humidity is achieved, and the optimal humidity environment needed by growth of antrodia camphorata is ensured.

The invention provides application of an antrodia camphorata compound to preparation of a pharmaceutical composition for treating diabetes mellitus. The antrodia camphorata compound is shown in the following chemical formula 1: # imgabs0 # chemical formula 1, or pharmacologically acceptable salts of the chemical formula 1.

The invention relates to a preparation method of a lotus leaf biological beverage. The preparation method comprises the following steps: 1) preparing 50-60 parts by weight of lotus leaf powder; 20-30 parts of Chinese wolfberry juice; uniformly mixing 20-30 parts of grape skin to obtain a mixed raw material; 2) inoculating the mixed raw material with lotus leaf lyophyllum commune bacteria and antrodia camphorata bacteria, and fermenting for 20-30 hours to obtain fermentation liquor; 3) after the fermentation is finished, filtering the fermentation liquid, and sterilizing the filtrate; and 4) adding bioactive peptide into the sterilized filtrate, and then sequentially performing homogenization and low-temperature drying treatment to obtain the lotus leaf biological beverage. The release efficiency of active ingredients in the lotus leaves can be remarkably improved through composite strain synergistic fermentation and an ultrasonic-assisted technology, so that the overall efficacy of the product is improved; meanwhile, through compounding of multiple raw materials and addition of natural components, the bitter taste of the lotus leaves is successfully improved, the unique flower and fruit fragrance is formed, and the palatability of the product is improved.

The invention discloses a flavonoid component of Cinnamomum camphora and a preparation method and application thereof, and relates to the technical field of extraction of functional components of plants with homology of medicine and food, and the preparation method mainly comprises the following steps: analysis and definition of the flavonoid component, extraction and refining of the flavonoid component, and analysis and application of the anti-aging effect of the flavonoid component. The yield and the content of the flavonoid components of the Cinnamomum camphora Bunge prepared by the method are high; the preparation process is high in specificity, and the method has the characteristics of high preparation efficiency, high sample yield, no emission of toxic and harmful reagents and the like; the obtained flavonoid component is clear in composition and has a good anti-aging effect. The invention establishes the preparation method of the antrodia camphorata flavone component with the anti-aging effect, the antrodia camphorata flavone component is practically applied to a nematode model, the antrodia camphorata flavone component has anti-aging potential, and a technical support can be provided for deep research on the anti-aging effect of antrodia camphorata flavone compounds, development of novel functional foods and research and development of new drugs.

The present invention relates to a method of preventing or treating a fibrotic condition, comprising administering an effective amount of composition to a subject in need thereof; wherein the composition comprises triterpenes extracted from Antrodia-camphorate or Anisomeles indica.

The application provides application of a tremella fuciformis polysaccharide in preparation of an anti-liver cancer drug, and relates to the technical field of biological medicine.The tremella fuciformis polysaccharide in the application can regulate differentiation of monocytes into macrophages, promote classical activation of the macrophages through cascade amplification, and secrete proinflammatory factors, so that the proliferation of liver cancer cells is inhibited, and the effect of resisting liver cancer is achieved.In addition, the tremella fuciformis polysaccharide in the application has good safety, no toxic side effects, can guarantee that the tremella fuciformis polysaccharide is used for preparing a drug for treating liver cancer, is easy to produce, is low in cost, has remarkable effect, has great market development value and good application prospect.

The invention discloses a method for directionally converting a precursor substance in an antrodia camphorata crude extract into high-value triterpenoid antroquinonol in vitro by using recombinant yeast methylated transferase COQ5 and a mutant of the recombinant yeast methylated transferase COQ5. The method comprises the following steps: taking solid-state fermented or wild sporocarp as a raw material, and performing ethanol extraction to obtain a crude extract; in an oleic acid-adenosylmethionine-phosphoric acid buffer system, a wild type or mutant type crude enzyme solution is added, and a reaction is performed at 37 DEG C for 5-12 h, so that the content of antroquinonol can be increased by 2.0-2.6 times. Compared with a PBS blank group, the relative content of antroquinonol in the optimal mutant COQ5-V2 (H132D) catalytic group reaches 260%, and the reaction conditions are mild. The method is simple in process, low in cost and easy to amplify, and the technical bottlenecks that wild antrodia camphorata resources are deficient and the content of active ingredients is low can be solved.

This invention belongs to the field of Antrodia camphorata cultivation technology, specifically relating to a method for cultivating Antrodia camphorata that can increase the triterpenoid content, comprising the following steps: S1. Inoculating the Antrodia camphorata strain into a liquid fermentation medium for initial liquid fermentation culture to obtain initial mycelium; S2. Transferring the initial mycelium to a Cinnamomum camphora culture medium for growth culture to obtain Antrodia camphorata; during the liquid fermentation culture process, periodic ultrasonic treatment is performed, the frequency of the ultrasonic treatment is 35kHz to 60kHz, with a treatment cycle of 2min-3min followed by an interval of 1min-2min, and the treatment is performed for 4h-6h per day. This invention combines liquid fermentation culture with solid culture, which improves production efficiency. Simultaneously, during the liquid fermentation culture stage, periodic ultrasonic treatment stimulates and accelerates the metabolic process of Antrodia camphorata, thereby increasing the content of triterpenoid compounds.

The invention provides an antrodia camphorata microbial multi-effect feed additive and a preparation process thereof, and relates to the field of feed additives. A formula of the multi-effect feed additive based on the antrodia camphorata microbial flora comprises the following components in percentage by weight: 20%-30% of antrodia camphorata fermentation liquor which comprises 2%-4% of triterpenoids and 1.5%-3% of polysaccharide substances. By adopting a dynamic temperature control technology, the problem of fluctuation of active ingredients of antrodia camphorata in the fermentation process is effectively solved, the generation of triterpenoids and polysaccharides is maximized by strictly controlling the gradual increase of the fermentation temperature from 25 DEG C to 35 DEG C and keeping the fermentation time for 72 hours, and the accurately-controlled fermentation process has the advantages that the production efficiency is greatly improved, and the production cost is reduced. According to the method, the stability and uniformity of active components in fermentation liquor and fermentation residues are ensured by combining subsequent freeze drying and crushing treatment, and in addition, the component concentration is accurately detected and adjusted through a high performance liquid chromatography technology, so that the quality consistency of the product is further ensured.

The invention discloses an application of antrodia camphorata total triterpenes in treating depression. The antrodia camphorata total triterpenes are obtained by extracting antrodia camphorata sporocarp or mycelium. The antrodia camphorata total triterpenes are the main active substance in the antrodia camphorata sporocarp, and the content of the triterpenes in the antrodia camphorata is far higher than that of the ganoderma lucidum. The antrodia camphorata triterpenes in the invention can significantly improve depressive symptoms and restore neurotransmitter and inflammatory factor levels. In addition, the antrodia camphorata triterpene also has the effects of dispelling the effects of alcohol, protecting the liver, resisting hepatic fibrosis, tumor, fatigue, cancer, inflammation and virus, reducing blood pressure, regulating immunity, regulating intestinal flora and the like. The antrodia camphorata triterpene is wide in source, remarkable in effect, free of side effects and diversified in function, and has great development value and good application prospects in treating or relieving depression.

The invention discloses a traditional Chinese medicine composition and application thereof in low-deuterium small molecular group compound wine. The traditional Chinese medicine composition is prepared from the following components in parts by mass: 40 parts of an anti-tumor compound, 50-70 parts of rhizoma polygonati, 50-75 parts of fructus lycii, 45-65 parts of herba cistanche and 2-7 parts of fructus ziziphi jujubae, the anti-tumor compound is prepared from antrodia camphorata and ganoderma lucidum according to the mass ratio of (2-4): 1. The traditional Chinese medicine composition and the small-molecular-group low-deuterium compound wine prepared from the traditional Chinese medicine composition have the advantages that the negative influence of traditional Chinese liquor on human health is remarkably relieved, and the effects of nourishing the liver, tonifying the kidney, regulating both the liver and the kidney, regulating blood sugar and blood fat, improving vascular permeability, improving immunity and inhibiting tumors are achieved for a liquor product through the traditional Chinese medicine composition and the small-molecular-group low-deuterium compound wine prepared from the traditional Chinese medicine composition; and 2) experiments show that the traditional Chinese medicine composition provided by the invention obviously improves the inhibition rate of natural traditional Chinese medicines on liver cancer HepG2 cells.

The invention provides an external traditional Chinese medicine composition for treating allergic rhinitis. The external traditional Chinese medicine composition is prepared from the following raw material medicines in parts by weight: 160 to 240 parts of paniculate swallowwort root, 36 to 54 parts of cicada slough, 0.24 to 0.36 part of borneol and 0.24 to 0.36 part of antrodia camphorata. The invention further provides a preparation method and application of the external traditional Chinese medicine composition. Pharmacodynamic tests prove that the medicinal effect of the traditional Chinese medicine composition is obviously superior to that of a prescription disclosed in the application number 201010238755.7, and the traditional Chinese medicine composition is more favorable for being prepared into a gel and exerts a better medicinal effect. The prepared external nasal drop can remarkably improve clinical symptoms of allergic rhinitis and is high in safety, meanwhile, the invention further provides a method for preparing the external nasal drop, and the method is simple in process and easy to produce.

The application belongs to the technical field of traditional Chinese medicines, and particularly relates to a preparation method and application of multi-effect Antrodia camphorata composite drop granules. The preparation method comprises the following steps: (1) preparation of Antrodia camphorata extract; (2) preparation of mixed extract of Aspidistra elatior and Schisandra chinensis; (3) preparation of mixed extract of Taraxacum mongolicum, Pueraria lobata and Poria cocos; (4) mixing of the Antrodia camphorata extract, the mixed extract of Aspidistra elatior and Schisandra chinensis, the mixed extract of Taraxacum mongolicum, Pueraria lobata and Poria cocos to obtain a mixed powder; (5) heating of polyethylene glycol to be completely melted into a liquid, addition of the mixed powder, uniform mixing, injection into a spherical mold, cooling into a pill, demolding, drying, and obtaining of the multi-effect Antrodia camphorata composite drop granules. The Antrodia camphorata extract prepared in the application has a high total triterpene content, the multi-effect Antrodia camphorata composite drop granules have a quick sobering effect, and simultaneously have a liver protection effect.

The invention discloses a method for preparing hydroxytyrosol-containing extract from antrodia camphorata and hydroxytyrosol, and belongs to the technical field of research and development of natural medicines. Antrodia camphorata is used as a strain, and hydroxytyrosol is obtained through microbial fermentation, product extraction, separation and purification. The extract containing hydroxytyrosol and hydroxytyrosol prepared by the invention can be used for developing antrodia camphorata health-care food or medicine with the effects of resisting oxidation, removing wrinkles, resisting aging, resisting cancer, resisting thrombus, regulating blood fat, resisting arteriosclerosis, resisting pathogenic microorganisms and the like. The antrodia camphorata culture medium is prepared by antrodia camphorata microbial fermentation, is wide in raw material source, simple in preparation method and easy to realize industrial production.

The invention discloses a method for inducing antrodia camphorata mycelia to generate triterpenoid components by utilizing Taiwan cinnamomum kanehirae calluses, and belongs to the technical field of agricultural biology. Taiwan cinnamomum kanehirae cells are obtained through tissue culture, then the Taiwan cinnamomum kanehirae cells and antrodia camphorata strains are co-cultured, and extraction analysis or separation and purification show that the method can induce antrodia camphorata mycelia to generate triterpenoid components. According to the method, the triterpenoid component with various biological effects can be obtained without cultivating the antrodia camphorata sporocarp, and the preparation process is simple and suitable for industrial production.

This invention provides a compound traditional Chinese medicine composition, its preparation method, and its application in the preparation of drugs for treating allergic rhinitis, belonging to the field of traditional Chinese medicine technology. The compound traditional Chinese medicine composition of this invention includes: Antrodia camphorata, Paeonia suffruticosa, Cynanchum paniculatum, Cicadae periostracum, Calculus bovis, Borneol, and Mentha haplocalyx. Antrodia camphorata, the principal ingredient, fundamentally regulates immunity and reduces inflammation and swelling. Paeonia suffruticosa, Cynanchum paniculatum, and Cicadae periostracum assist in anti-allergy and clearing heat and wind. Calculus bovis and Borneol are adjuvant ingredients that resolve phlegm, open the orifices, clear heat, and relieve pain. Mentha haplocalyx guides the medicine upwards and relieves local symptoms. This invention treats allergic rhinitis using a combination of internal and external application. Internal administration exerts a systemic regulatory effect and enhances immunity, while external application to the nose quickly relieves symptoms. The comprehensive formula addresses both the root cause and symptoms, with the various drug components synergistically enhancing anti-inflammatory, anti-allergic, and immunomodulatory effects to achieve the therapeutic effect of treating allergic rhinitis.