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34 results about "Serum testosterone" patented technology

It’s also known as a serum testosterone test. Testosterone is an androgen, or a sex hormone, produced by both males and females. It plays a role in puberty and fertility. It also affects sexual desire. In males, the testes produce most of the testosterone. In females, the production of testosterone occurs mostly in...

Method of increasing testosterone and related steroid concentrations in women

The present invention relates to methods, kits, combinations, and compositions for treating, preventing or reducing the risk of developing a testosterone deficient disorder, or the symptoms associated with, or related to a testosterone deficient disorder in a subject in need thereof. The present invention also relates to a method of administering a steroid in the testosterone synthetic pathway to a subject in need thereof. In addition, the methods, kits, combinations and compositions may be used in conjunction with other pharmaceutical agents effective at treating, preventing, or reducing the risk of developing a testosterone deficient disorder. The present invention also can also be used in conjunction with a pharmacologically effective amount of an estrogenic hormone. Furthermore, the methods, kits, combinations and compositions can be used in conjunction with a pharmacologically effective amount of another steroid or pharmaceutical agent that increases serum testosterone levels in a mammal.
Owner:UNIMED PHARMA LLC

Method of increasing testosterone and related steroid concentrations in women

The present invention relates to methods, kits, combinations, and compositions for treating, preventing or reducing the risk of developing a testosterone deficient disorder, or the symptoms associated with, or related to a testosterone deficient disorder in a subject in need thereof. The present invention also relates to a method of administering a steroid in the testosterone synthetic pathway to a subject in need thereof. In addition, the methods, kits, combinations and compositions may be used in conjunction with other pharmaceutical agents effective at treating, preventing, or reducing the risk of developing a testosterone deficient disorder. The present invention also can also be used in conjunction with a pharmacologically effective amount of an estrogenic hormone. Furthermore, the methods, kits, combinations and compositions can be used in conjunction with a pharmacologically effective amount of another steroid or pharmaceutical agent that increases serum testosterone levels in a mammal.
Owner:LABORATORIES BESINS INTERNATIONAL SAS

Lipobalanced long chain testosterone esters for oral delivery

The present disclosure is drawn to oral pharmaceutical compositions and dosage forms containing select testosterone esters and related methods. In one embodiment of the present invention, an oral pharmaceutical composition for administration to subjects in need of testosterone is provided. The composition comprises a testosterone ester and a pharmaceutically acceptable carrier. The testosterone ester can have the structurewherein R is —C13H25O or —C14H27O. One or both of the esters can be present in the pharmaceutical composition. The composition is formulated such that upon single dose administration to a group of human subject, the composition provides a mean serum testosterone Cavg t12-t24 that is within about 35% to about 70% of the mean serum testosterone Cavg t0-t24.
Owner:LIPOCINE

Methods of improving screening, diagnosis and staging of prostate cancer using serum testosterone

The present invention provides methods of screening for, detecting or diagnosing prostate cancer in a subject by determining the level of prostate specific antigen (PSA), complexed PSA (cPSA), free PSA, B-PSA, PRO-PSA or HK2 in a biological sample from the subject and correcting this level for free / bioavailable serum testosterone, total testosterone or sex hormone binding globulin. The present invention further relates to identifying a subject at risk for developing prostate cancer or for determining the effectiveness of anti-cancer therapy in a subject having prostate cancer, or for detecting cancer recurrence by determining the level of prostate specific antigen (PSA), complexed PSA (cPSA), free PSA, B-PSA, PRO-PSA or HK2 in a biological sample from the subject and correcting this level for free or bioavailable serum testosterone, total testosterone or a testosterone bound protein, including but not limited to sex hormone binding globulin.
Owner:TANEJA SAMIR S

High-strength testosterone undecanoate compositions

InactiveUS20140309202A1Improve sexual symptomImproves and enhances physicalOrganic active ingredientsPowder deliverySerum igeSerum concentration
The present disclosure is drawn to pharmaceutical compositions and oral dosage capsules containing testosterone undecanoate, as well as related methods. The capsule includes a capsule shell and a capsule fill. The capsule fill can include a solubilizer and about 14 wt % to about 35 wt % testosterone undecanoate based on the total capsule fill. The oral dosage capsule is such that when a single oral administration to a male subject of one or more capsules with a total testosterone undecanoate daily dose of about 350 mg to about 650 mg it provides a ratio of serum testosterone Cmax to serum testosterone Cave of about 2.7 or less. In yet another embodiment, a method for providing a serum concentration of testosterone within a target serum testosterone concentration Cave range for a male subject is provided.
Owner:LIPOCINE

High-strength testosterone undecanoate compositions

The present disclosure is drawn to pharmaceutical compositions and oral dosage capsules containing testosterone undecanoate, as well as related methods. The capsule includes a capsule shell and a capsule fill. The capsule fill can include a solubilizer and about 14 wt % to about 35 wt % testosterone undecanoate based on the total capsule fill. The oral dosage capsule is such that when a single oral administration to a male subject of one or more capsules with a total testosterone undecanoate daily dose of about 350 mg to about 650 mg it provides a ratio of serum testosterone Cmax to serum testosterone Cave of about 2.7 or less. In yet another embodiment, a method for providing a serum concentration of testosterone within a target serum testosterone concentration Cave range for a male subject is provided.
Owner:LIPOCINE

Pharmaceutical composition with function of treating polycystic ovary syndrome

The invention discloses a pharmaceutical composition with the function of treating polycystic ovary syndrome, a preparation method and a quality detection method. The pharmaceutical composition preparation of the invention uses astragalus mongholicus, herba epimedii, rhizoma atractylodis, tuckahoe and red sage root as raw material drugs; various types of preparation can be prepared through a special preparation method. The pharmacodynamics experiment indicates that the pharmaceutical composition can reduce blood sugar and insulin, decrease the content of serum testosterone, and have importantsignificance for treating the polycystic ovary syndrome. A prescription sieving experiment indicates that, when the polycystic ovary syndrome is treated, the optimal dose level range of the pharmaceutical composition is: 50g Astragalus mongholicus, 30g rhizome, 30g tuckahoe, 30g herba epimedii, and 10g the red sage root.
Owner:侯凤祥

Traditional Chinese medicine composition for strengthening yang and tonifying kidney and preparation method thereof

The invention relates to the field of traditional Chinese medicine, in particular to a traditional Chinese medicine composition mainly used for strengthening yang and tonifying kidney and a preparation method thereof. The traditional Chinese medicine composition is mainly prepared from an oyster extracting solution, a sea cucumber extracting solution, a dendrobium officinale extracting solution, xylitol and microcrystalline cellulose. The traditional Chinese medicine composition can be used for being made into various dosage forms, such as oral liquid, tablets, capsules, pills, granules, powder, medicinal liquor and paste. The traditional Chinese medicine composition and the preparation method thereof have the advantages that a remarkable effect is achieved on the aspect of improvement of the sexual function, experimental results show that sexual vitality of mice taking the composition is improved remarkably, the content of serum testosterone of normal mice and emasculated mice taking the composition is increased obviously, and it is thus clear that the traditional Chinese medicine composition can remarkably improve sexuality. The traditional Chinese medicine composition is a pure natural traditional Chinese medicine preparation, the untoward effect and side effect caused by irritation of the stomach and intestines can be reduced, the effectiveness is achieved fast, and the composition can be made into various dosage forms for a user to take.
Owner:GUANGXI KANGSHOU BIOTECH CO LTD

Chinese medicine composition used for improving the level of serum testosterone and preparing method thereof

ActiveCN101524409AIncrease serum testosterone levelsGood testosterone metabolismEndocrine system disorderPlant ingredientsSerum igeHydrocortisone
The invention relates to a Chinese medicine composition used for improving the level of serum testosterone and a preparing method thereof. The Chinese medicine composition is a medicament which comprises raw materials with the following weight potions of: 5-50 portions of panax quinquefolium extract, 10-100 portions of cornus officinalis extract, 5-50 portions of red common stonecrop herb, 5-50 portions of herba cistanche, 10-300 portions of tribulus terrestrisl and 20-2000 portions of excipient. The Chinese medicine composition of the invention can obviously improve the level of the serum testosterone during the training of athletes, simultaneously lower the level of high blood cortisol during the intensive training effectively, provide guarantee for the athletes to keep good testosterone metabolism during the training and is very suitable for sports groups, especially for athletes who are engaged in endurance events.
Owner:BEIJING COMPETITOR SPORTS SCI & TECH

Kit for detecting serum testosterone by means of ultra-high performance liquid chromatography-tandem mass spectrometry

The invention provides a kit for detecting serum testosterone by means of ultra-high performance liquid chromatography-tandem mass spectrometry. The kit belongs to the technical field of hormone detection, and comprises a standard solution, an internal standard solution, a diluent, extracts, a dissociation agent, a stabilizer, a quality control material and a chromatographic column, wherein the extracts comprise a first extract and a second extract; the first extract is a mixed solution of ethyl acetate and normal hexane; the second extract is normal hexane; the dissociation agent is an ammonium acetate aqueous solution with a concentration of 0.4-0.6 mol / L; and the stabilizer is a sodium carbonate aqueous solution with the concentration of 0.1-0.3 mol / L. A linear range, a detection limit,a recovery rate and the precision of the testosterone content detected by adopting the kit meet the requirements, the kit is high in sensitivity, high in specificity, precise and reliable, and the kit can be applied to quantitative detection of testosterone in clinical serum samples.
Owner:天津汉科生物科技有限公司

Application of proanthocyanidin to preparation of functional food or medicine for improving sperm quality of obese men

The invention discloses application of proanthocyanidin to preparation of a functional food or medicine for improving the sperm quality of obese men and also discloses application of a pharmaceuticalcomposition taking the proanthocyanidin as an active component, and a pharmaceutically acceptable additive to preparation of the functional food or medicine for improving the sperm quality of the obese men. A research proves that the proanthocyanidin has an obvious reduction effect on a weight gain rate of rats fed by high fat diet, and has the effects of improving the level of serum testosterone,protecting the structural integrity of testicles, improving the spermatogenesis obstruction caused by obesity, reducing excessive apoptosis of spermatogenesis cells of the testicles, improving the quantity and vitality of sperms and reducing the distortion rate of the sperms, so that the provided pharmaceutical can be used for improving the sperm quality of the obese men and protecting a reproductive function of the obese men. The invention digs novel medical application of the proanthocyanidin and provides meaningful reference for solving the reproductive dysfunction of the obese men.
Owner:XINXIANG MEDICAL UNIV

Lipobalanced long chain testosterone esters for oral delivery

The present disclosure is drawn to oral pharmaceutical compositions and dosage forms containing select testosterone esters and related methods. In one embodiment of the present invention, an oral pharmaceutical composition for administration to subjects in need of testosterone is provided. The composition comprises a testosterone ester and a pharmaceutically acceptable carrier. The testosterone ester can have the structurewherein R is —C13H25O or —C14H27O. One or both of the esters can be present in the pharmaceutical composition. The composition is formulated such that upon single dose administration to a group of human subject, the composition provides a mean serum testosterone Cavg t12-t24 that is within about 35% to about 70% of the mean serum testosterone Cavg t0-t24.
Owner:LIPOCINE

Lipobalanced long chain testosterone esters for oral delivery

The present disclosure is drawn to oral pharmaceutical compositions and dosage forms containing select testosterone esters and related methods. In one embodiment of the present invention, an oral pharmaceutical composition for administration to subjects in need of testosterone is provided. The composition comprises a testosterone ester and a pharmaceutically acceptable carrier. The testosterone ester can have the structurewherein R is —C13H25O or —C14H27O. One or both of the esters can be present in the pharmaceutical composition. The composition is formulated such that upon single dose administration to a group of human subject, the composition provides a mean serum testosterone Cavg t12-t24 that is within about 35% to about 70% of the mean serum testosterone Cavg t0-424.
Owner:LIPOCINE

Fluorescence sensing method and kit for simultaneously detecting cortisol, serum testosterone and creatine kinase isoenzyme

The invention discloses a fluorescence sensing method and kit for simultaneously detecting cortisol, serum testosterone and creatine kinase isoenzyme, and belongs to the field of biomarker detection. The fluorescence sensing method comprises the following steps: (1), preparing a magnetic bead-aptamer-complementary chain compound; (2), preparing DNA tetrahedral tweezers; (3), performing competition between the target object and the complementary chain; (4), carrying out EXPAR amplification reaction; (5), carrying out complementary chain-DNA tweezers reaction; and (6), performing reading: measuring the fluorescence value of the reaction system. The EXPAR isothermal amplification technology is utilized, a complex temperature change process is not needed, stability is good, sensitivity is high, compared with other detection methods, the content of three target substances including testosterone, cortisol and creatine kinase isoenzyme in serum can be detected at the same time, the content of the target substances is detected according to the fluorescence recovery degree, cost is low. And the detection limits can respectively reach 41pM, 68pM and 8pM.
Owner:INST OF ENVIRONMENTAL MEDICINE & OCCUPATIONAL MEDICINE ACAD OF MILITARY MEDICINE ACAD OF MILITARY SCI

Application of cordycepin to preparation of related preparations for preventing and treating male sexual dysfunction

The invention discloses application of cordycepin to preparation of related preparations for preventing and treating male sexual dysfunction. Through research, it is found that the cordycepin has thetreatment effect on male sexual dysfunction caused by diabetes, the number of erection times of penises of mice can be obviously increased, the number of times of catching female mice by the male miceis increased, the inner pressure of corpora cavernosa penises of the mice is increased, the content of serum testosterone is increased, testicles of the mice are protected, a new application field isdeveloped for the cordycepin, and a new idea is provided for further development and utilization of the cordycepin. The cordycepin has the significant prevention and treatment effects on male sexualdysfunction, and also has high safety, application of the cordycepin to preparation of drugs or health food for preventing or treating male sexual dysfunction is safe and effective, and good application and popularization prospects are achieved.
Owner:江苏集萃工业生物技术研究所有限公司

High-strength testosterone undecanoate compositions

The present disclosure is drawn to pharmaceutical compositions and oral dosage capsules containing testosterone undecanoate, as well as related methods. The capsule includes a capsule shell and a capsule fill. The capsule fill can include a solubilizer and about 14 wt % to about 35 wt % testosterone undecanoate based on the total capsule fill. The oral dosage capsule is such that when a single oral administration to a male subject of one or more capsules with a total testosterone undecanoate daily dose of about 350 mg to about 650 mg it provides a ratio of serum testosterone Cmax to serum testosterone Cave of about 2.7 or less. In yet another embodiment, a method for providing a serum concentration of testosterone within a target serum testosterone concentration Cave range for a male subject is provided.
Owner:LIPOCINE

Antifatigue borojo oral liquid as well as preparation method and application thereof

The invention discloses an antifatigue borojo oral liquid as well as a preparation method and application thereof. The antifatigue borojo oral liquid comprises the following raw materials in percentage by weight: 10-30% of borojo powder, 68-88% of water and the balance of a condiment. The preparation process disclosed by the invention is simple, the raw materials are scientific in proportioning, and the borojo oral liquid is rich in nutrient component such as iridoid glycoside, triterpene and sterols, polyphenols and general flavones, multiple organic acids, superoxide dismutase and multiple trace elements essential for human bodies, and has the advantages of naturally replenishing nutrient elements of human bodies and being natural without addition; the antifatigue borojo oral liquid notonly is capable of reducing contents of serum urea and lactic acid after exercise, but also has a function of increasing storage of serum testosterone and hepatic glycogen of male animals or reducingglycogen consumption; and in the exercise process, oxygen metabolism can be effectively improved, fatigue can be rapidly eliminated, and the physical power can be rapidly recovered, so that the adaptability of the human bodies to exercise burdens and exercise capabilities of bodies can be improved, and an antifatigue effect can be achieved.
Owner:广州博罗霍生物科技有限公司 +1

Lipobalanced long chain testosterone esters for oral delivery

The present disclosure is drawn to oral pharmaceutical compositions and dosage forms containing select testosterone esters and related methods. In one embodiment of the present invention, an oral pharmaceutical composition for administration to subjects in need of testosterone is provided. The composition comprises a testosterone ester and a pharmaceutically acceptable carrier. The testosterone ester can have the structurewherein R is —C13H25O or —C14H27O. One or both of the esters can be present in the pharmaceutical composition. The composition is formulated such that upon single dose administration to a group of human subject, the composition provides a mean serum testosterone Cavg t12-t24 that is within about 35% to about 70% of the mean serum testosterone Cavg t0-t24.
Owner:LIPOCINE

Application of microorganism containing 3 beta-steroid dehydrogenase gene as marker of male depression

PendingCN113957163AImprove depression-like behaviorNervous disorderMicrobiological testing/measurementFecesPhysiology
The invention relates to application of a microorganism containing a 3 beta-steroid dehydrogenase gene as a marker of male depression. Intestinal bacteria capable of degrading testosterone are successfully separated from a feces sample of a depression patient, and are identified as mycobacterium neoaureum through sequencing. Furthermore, a behavior experiment proves that the mycobacterium neoaureum can reduce serum testosterone and induce a depression-like behavior of a rat, and the depression-like behavior of the rat is reduced after targeted antibiotic treatment. Furthermore, whole genome sequence information is obtained by performing whole genome completion graph sequencing on the mycobacterium neoaureum, and the gene for encoding 3 beta-steroid dehydrogenase is locked, thus that 3 beta-steroid dehydrogenase can degrade testosterone into androstenedione to cause the depression-like behavior is proved. Therefore, the related microorganism can be used as the marker of male depression, and a corresponding detection agent can be used for evaluating the risk of a male subject suffering from depression or judging the pathogenesis of the male depression patient.
Owner:李艳
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