Application of proanthocyanidin to preparation of functional food or medicine for improving sperm quality of obese men

A technology of male sperm quality and proanthocyanidins, which is applied in the application field of functional food or medicine, can solve problems such as no patent literature reports, and achieve the effect of enhancing immunity, having no toxic side effects, and improving sperm quality

Inactive Publication Date: 2018-11-23
XINXIANG MEDICAL UNIV
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  • Application Information

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Problems solved by technology

At present, the research on the use of proanthocyanidins is relatively in-depth, but there is no pat

Method used

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  • Application of proanthocyanidin to preparation of functional food or medicine for improving sperm quality of obese men
  • Application of proanthocyanidin to preparation of functional food or medicine for improving sperm quality of obese men
  • Application of proanthocyanidin to preparation of functional food or medicine for improving sperm quality of obese men

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Embodiment

[0029] Proanthocyanidins improve sperm quality in obese men

[0030] 1 Materials and methods

[0031] 1.1 Materials

[0032] Proanthocyanidins (Tianjin Jianfeng Natural Products Research and Development Co., Ltd., purity ≥ 95%), testosterone (T) kit were purchased from Beijing North Biotechnology Research Institute Co., Ltd., and feed was purchased from Beijing Huafukang Biotechnology Co., Ltd.

[0033] 1.2 Experimental animals and grouping

[0034] 55 4-week-old healthy male SD rats, weighing 90-120g, were purchased from Beijing Weitong Lihua Experimental Animal Technology Co., Ltd. After returning, they were fed with basal feed for one week. Only and model group (high fat) 45. The low-fat control group was given 10% low-fat diet (LFD), and the remaining high-fat model groups were given 45% high-fat diet (HFD). After 2 weeks, 15 rats in the high-fat model group that were not sensitive to the high-fat model were eliminated according to body weight, and the remaining 30 rat...

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Abstract

The invention discloses application of proanthocyanidin to preparation of a functional food or medicine for improving the sperm quality of obese men and also discloses application of a pharmaceuticalcomposition taking the proanthocyanidin as an active component, and a pharmaceutically acceptable additive to preparation of the functional food or medicine for improving the sperm quality of the obese men. A research proves that the proanthocyanidin has an obvious reduction effect on a weight gain rate of rats fed by high fat diet, and has the effects of improving the level of serum testosterone,protecting the structural integrity of testicles, improving the spermatogenesis obstruction caused by obesity, reducing excessive apoptosis of spermatogenesis cells of the testicles, improving the quantity and vitality of sperms and reducing the distortion rate of the sperms, so that the provided pharmaceutical can be used for improving the sperm quality of the obese men and protecting a reproductive function of the obese men. The invention digs novel medical application of the proanthocyanidin and provides meaningful reference for solving the reproductive dysfunction of the obese men.

Description

technical field [0001] The invention belongs to the technical field of new medical applications of proanthocyanidins, and specifically relates to the application of proanthocyanidins in the preparation of functional foods or medicines for improving sperm quality in obese men. Background technique [0002] Obesity refers to the disorder of the body's control of body fat and energy metabolism balance mechanism, which leads to excessive accumulation or abnormal distribution of body fat, resulting in increased body mass. It is a multifactorial chronic metabolic disease. In recent years, with the improvement of living standards, most countries, including my country, have the problem of unreasonable dietary structure and high fat intake, resulting in a rapid increase in the number of overweight and obese people, and a younger trend. In recent years, with the rapid changes in living environment and diet structure and the increase in the proportion of late marriage and late childbea...

Claims

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Application Information

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IPC IPC(8): A61K31/352A61P15/08A23L33/105
CPCA61K31/352A23L33/105A23V2002/00A61P15/08A23V2250/21166A23V2200/30
Inventor 王二辉姚三巧陶玲席金彦翟德胜卜勇军
Owner XINXIANG MEDICAL UNIV
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