10 results about "Reproductive function" patented technology

The application discloses a kind of complex fermentation inoculant for improving equol production, fermentation liquor and application thereof, belong to microbial fermentation technical field.The complex fermentation inoculant of the application, streptococcus thermophilus BLCC2-0025 and lactococcus lactis MP1001 have high β-glucosidase activity, and low activity glycoside form is converted into high activity daidzein;Salivary lactobacillus LS1101 and lactobacillus gregius 0010 have the activity of further converting daidzein into equol;Four strains of bacteria are used in combination, which can synergistically improve the content of equol.The fermentation liquor prepared by fermenting pueraria extract with the complex fermentation inoculant of the application can target regulate intestine-ovary axis, significantly improve the reproductive function of POF mice, relieve ovarian oxidative stress and accurately regulate intestinal flora balance, providing a safe and effective preparation and application scheme for non-hormone intervention of premature ovarian failure.

This invention discloses a compound moxa stick for warming yang and unblocking obstruction, its preparation method, and its application in improving reproductive system function. It belongs to the field of external preparations of traditional Chinese medicine. Addressing the problems of limited improvement effects of pure moxa sticks, lack of systematic design in compound moxa stick formulations, unclear synergistic effects between components, large fluctuations in conditioning effects, and difficulty in balancing conditioning effects and safety, this invention uses specific weight proportions of Artemisia argyi, Cyperus rotundus, Alpinia galanga, Cinnamomum cassia, Zingiber officinale, Illicium verum, Cinnamomum cassia twig, Spatholobus suberectus, Caesalpinia sappan, Smilax glabra, Euonymus fortunei, Citrus aurantium, Amomum villosum, Citrus reticulata peel, and Atractylodes lancea to prepare a compound moxa stick. The components synergistically enhance each other, and this product is used to prepare a moxibustion intervention product for improving the reproductive function of mammals. It can stably improve female ovarian reserve function and male asthenospermia, simultaneously regulate reproductive-related hormone levels, repair pathological damage to reproductive organs, and improve the quality of reproductive cells.

This application provides the use of purine nucleoside phosphorylase inhibitors in improving the reproductive function of subjects. This application provides the use of purine nucleoside phosphorylase inhibitors in the preparation of drugs for antagonizing hydrosalpinx toxicity or improving the reproductive function of subjects. This application also provides the use of purine nucleoside phosphorylase inhibitors in the preparation of reagents for embryo culture and gamete treatment. This application utilizes purine nucleoside phosphorylase inhibitors to inhibit PNP activity, antagonizing hydrosalpinx toxicity caused by purine metabolism disorders, thereby improving the reproductive function of subjects.

This invention relates to the field of biotechnology, specifically to a hippocampal exosome-like vesicle, its preparation method, and its applications. This invention discloses for the first time a hippocampal exosome-like vesicle, which is a nanoscale membrane vesicle exhibiting a typical saucer-like morphology with an average particle size of less than 150 nm. It can be effectively taken up by mouse testicular interstitial cells, promoting testicular interstitial cell proliferation and sex hormone secretion. It can be used as a beneficial dietary supplement to improve male reproductive health and enhance reproductive function.

This invention discloses the application of the compound pimozide in combination with metronidazole in the preparation of a drug for improving oocyte quality and treating endometriosis-related fertility disorders, belonging to the field of biomedical technology. The efficacy of this invention was verified by constructing mouse models of endometriosis driven by pathogenic *Prevotella bisporus* and mouse models of ovarian endometriosis. Experimental results showed that the combined administration significantly eliminated *Prevotella bisporus* colonizing ectopic lesions, reduced succinic acid content in both eutopic and ectopic lesions, decreased the succinylation level of lysine residue 195 of the ACADVL protein, reduced the fluidity of primary endometrial epithelial cell membranes, reduced the volume and weight of endometriotic lesions, and improved oocyte spermatogenesis, ovulation rate, and litter size. This invention solves the problem that existing therapies cannot simultaneously control endometriosis lesions and protect reproductive function, providing a new, safe, and effective combined treatment option for patients with endometriosis and infertility.

The application discloses a kind of complex fermentation inoculant for improving equol production, fermentation liquor and application thereof, belong to microbial fermentation technical field.The complex fermentation inoculant of the application, streptococcus thermophilus BLCC2-0025 and lactococcus lactis MP1001 have high β-glucosidase activity, and low activity glycoside form is converted into high activity daidzein;Salivary lactobacillus LS1101 and lactobacillus gregius 0010 have the activity of further converting daidzein into equol;Four strains of bacteria are used in combination, which can synergistically improve the content of equol.The fermentation liquor prepared by fermenting pueraria extract with the complex fermentation inoculant of the application can target regulate intestine-ovary axis, significantly improve the reproductive function of POF mice, relieve ovarian oxidative stress and accurately regulate intestinal flora balance, providing a safe and effective preparation and application scheme for non-hormone intervention of premature ovarian failure.

A therapeutic composition comprising: L-arginine at 40% w / w; a branched-chain amino acid complex (BCAA) at 25% w / w, wherein the BCAA complex consists of leucine, isoleucine, and valine in a 2:1:1 ratio; L-glutamine at 15% w / w; myo-inositol at 10% w / w; one or more excipients containing fructose and flavorings at 10% w / w; and one or more micronutrients containing coenzyme Q10, folic acid, and zinc, or pharmaceutically acceptable salts thereof, in a total amount of less than 1% w / w, wherein the composition is configured to support cellular metabolism and reproductive function.

This invention discloses a traditional Chinese medicine composition for tonifying the kidneys and heart and improving male reproductive function, belonging to the field of traditional Chinese medicine technology, specifically involving a compound traditional Chinese medicine technique for regulating male organ function and improving reproductive health. The composition consists of 18 traditional Chinese medicinal materials, including 40-50 parts ginseng leaves, 40-50 parts Ophiopogon japonicus, 8-12 parts vinegar-processed Schisandra chinensis, and 55-65 parts Rehmannia glutinosa, strictly formulated according to specific weight ratios. A preferred ratio is 45 parts ginseng leaves, 45 parts Ophiopogon japonicus, and 10 parts vinegar-processed Schisandra chinensis. This invention also discloses a specific preparation method for the traditional Chinese medicine composition, a traditional Chinese medicine preparation containing the composition, and its related applications. The preparation can be formulated into conventional pharmaceutical dosage forms such as granules, capsules, and tablets according to actual needs, suitable for daily conditioning and auxiliary improvement of male sub-health conditions and decreased reproductive function.

The application belongs to the field of male infertility disease treatment, and discloses application of a valens enterobacter in improving sperm quality decline. Ileibacterium valens Liu-M1, which is preserved in China Center for Type Culture Collection (CCTCC) and has a preservation number of CCTCC M 20252545. The strain of the application is obtained by using a bacterial separation and identification method to separate and identify a fresh fecal sample of a high-fat diet mouse intervened by inulin. In vivo research finds that the live valens enterobacter can improve the reproductive function of obese male mice, has the effects of improving testosterone secretion, repairing spermatogenesis function, improving sperm quality and embryo development capacity and the like. Experimental results of the application show that the valens enterobacter can significantly improve obesity-related sperm quality decline, which indicates that the valens enterobacter has the potential to become a microbial candidate drug for treating obesity male reproductive function.

This invention provides a strain of Akkermansia myxophilus ( Akkermansia muciniphila The present invention provides a probiotic preparation comprising the aforementioned Akkermansia myxophilus or its post-genetically modified organism (PGA). The Akkermansia myxophilus or its post-genetically modified organism (PGA) of the present invention can improve vascular endothelial cell function, increase testosterone secretion, and thus improve erectile dysfunction and reproductive capacity. The probiotic preparation of the present invention may comprise the aforementioned Akkermansia myxophilus or its post-genetically modified organism (PGA) and yohimbine. This preparation can improve erectile dysfunction caused by vascular endothelial dysfunction, improve reproductive function in aged mice, and the components in this preparation have a synergistic effect.