163 results about "Reproductive function" patented technology

The present invention is concerned with compounds of the general Formula I:

and pharmaceutically acceptable salts thereof, which are useful as melanin concentrating hormone receptor antagonists, particularly MCH-1R antagonists. As such, compounds of the present invention are useful for the treatment or prevention of obesity or eating disorders associated with excessive food intake and complications thereof, osteoarthritis, certain cancers, AIDS wasting, cachexia, frailty (particularly in elderly), mental disorders stress, cognitive disorders, sexual function, reproductive function, kidney function, locomotor disorders, attention deficit disorder (ADD), substance abuse disorders and dyskinesias, Huntington's disease, epilepsy, memory function, and spinal muscular atrophy. Compounds of formula I may therefore be used in the treatment of these conditions, and in the manufacture of a medicament useful in treating these conditions. Pharmaceutical formulations comprising one of the compounds of formula (I) as an active ingredient are disclosed, as are processes for preparing these compounds.

This invention relates to a novel polypeptide involving in the modulation of central nervous system function, circulatory function, immune function, gastrointestinal function, metabolic function, reproductive function, etc., it can be used as a drug for treating or preventing a variety of diseases, e.g. HIV infection or AIDS (acquired immune deficiency syndrome) or the like.

The invention discloses seminal plasma piRNA markers or their combination for detecting and/or predicting male reproductive dysfunction and application thereof. The piRNA markers or their combination are 61 in quantity and mainly include piR-31068, piR-31925, piR-43771, piR-43773 and piR-30198; this combination can be used to detect and/or predict asthenospermia and azoospermia. In the invention, seminal plasma is easy to obtain, no other tissues are required, and examinations are noninvasive; seminal plasma piRNA can indicate pathological and biological conditions of a whole spermatogenic stage, accuracy level of detection can be increased using the seminal plasma piRNA as auxiliary detection indexes, the pathological and biological conditions the whole spermatogenic process are indicated on molecular level, and a latent target is provided for the diagnosis and treatment of male reproductive dysfunction.

The invention provides recombinant forms of piscine follicle-stimulating hormone (FSH) with characteristic intramolecular disulfide bonds and modified glycosylation patterns in the β-subunit that enhance the stability and metabolic activity of the hormone. Also provided are recombinant materials to produce the FSH β and glycoprotein α-subunits singly or in combination to obtain complete heterodimeric hormone of regulated glycosylation pattern. The piscine FSH agonists of the invention are therapeutically useful to expedite the onset of puberty in captive fish and to alleviate reproductive dysfunctions in fish. Likewise, the piscine FSH antagonists of the invention will be therapeutically useful to halt gonadal development, thereby contributing to body weight gain of the fish,

The invention belongs to the technical field of traditional Chinese medicines and in particular relates to a traditional Chinese medicine composition for treating female infertility and a preparation method thereof. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 5-10 parts of epimediums, 10-15 parts of semen cuscutae, 10-60 parts of astragalus membranaceus, 5-15 parts of human placenta, 10-15 parts of white atractylodes rhizome, 5-15 parts of angelica, 6-12 parts of ossa sepiae, 5-10 parts of pulp of dogwood fruit, 10-15 parts of fructus lycii, 3-10 parts of scutellaria baicalensis, 6-12 parts of rhizoma cyperi and 3-10 parts of ligusticum wallichii. The traditional Chinese medicine composition has the effects of warming yang, benefiting vital energy, nourishing blood, replenishing essence, regulating vital energy and removing blood stasis; the raw materials are carefully selected, metaplasia of follicle and restoration of reproductive function and organs such as the kidney, the heart, the liver and the spleen are promoted, and a remarkable treatment effect on the female infertility is achieved.

The invention discloses a seminal plasma piRNA marker combination reflecting male sperm activity and judging reproductive dysfunction and application thereof. Four piRNA markers include DQ570956, DQ571813, DQ575659 and DQ575661. The combination can be used for detecting sperm activity and predicting reproductive dysfunction caused by low sperm activity. Seminal plasma is easy to obtain, other tissue is not needed, and noninvasive examination is realized; seminal plasma piRNA can reflect pathological and physiological conditions of the whole spermatogenesis stage, detection accuracy can be improved by taking the seminal plasma piRNA as an auxiliary detection index, the pathological and physiological conditions in the whole spermatogenesis stage are reflected on the molecular level, and a potential target is provided for diagnosis and treatment of male reproductive dysfunction; a numerical value is calculated for each testee by a danger coefficient mathematical calculation method, and sperm activity can be reflected directly and visually through the numerical values, so that interference caused by subjective factors and lack of experience is avoided.

The invention discloses a production method for selenium-enriched ganoderma mycelium. The method comprises steps of: selecting strains, performing procedures of shaker, first-stage enlargement, second-stage enlargement and a selenium salt culture fermentation process at 25-26 DEG C, and finally performing pressure filtration and drying and crushing. The invention has the beneficial effects: ganoderma is enabled to accumulate selenium elements in a submerged liquid culture by designing a culture medium formula and optimizing and improving a production process, so that an inorganic form of selenium is transformed into organic selenium, so as to form a component of a ganoderma mycelium structure; therefore, selenium content of produced selenium enriched ganoderma mycelium is as high as 75-90 ppm; furthermore, organic selenium is more conducive to human body absorption; the selenium enriched ganoderma mycelium not only has wide pharmacological effects that the ganoderma has, but also has the pharmacological effects of the selenium element, including anticancer and anti-aging function, increasing of immunity-, improving of reproductive function and adjusting of absorption and utilization of vitamins, thereby providing a way for developing the efficient medicinal value of the ganoderma. The production process is easy and controllable, and mass production can be implemented.

The invention discloses application of pyrroloquinoline quinone (PQQ) in preparing products for preventing and/or treating male reproductive dysfunction or improving male reproductive function. Research results of the invention show that the pyrroloquinoline quinone can obviously reduce Bmi1-/-mouse spermatogenic cell DNA damage and finally can improve Bmi1-/-mouse spermatogenic cell proliferation and inhibit spermatogenic cell apoptosis. According to the novel application disclosed by the invention, the pyrroloquinoline quinone is applied to treat male sterility for the first time, a more ideal treating effect is obtained, a novel preventing and treating choice is provided for treating male sterility in clinical application, and very high application valve is achieved.

The invention relates to antisense oligonucleotides, in particular to antisense oligonucleotides to receptor genes, and the use of such oligonucleotides to regulate reproductive function and as chemopreventive or as a chemotherapeutic for various cancers, especially ovarian cancers. The invention also provides a method for preventing estrogen synthesis, a function of developing ovarian follicles, a therapeutic consideration for the prevention and treatment of some cancers of the breast, endometrium, ovary and cervix and of some endometriosis. The invention also relates to pharmaceutical compositions containing antisense oligonucleotides (ODNs, having 8 to 60 nucleotides) that act by binding to intracellular molecular targets. Optionally, for efficient delivery to a target DNA, RNA or protein, the ODNs may be covalently linked to a carrier moiety, which facilitates delivery of the ODN to the cytosol.

The invention discloses a traditional Chinese preparation for tonifying kidney and Yang, of which the raw material composition and weight proportion are as follows: 0.5-1.5 parts of cartialgenous, 5-15 parts of epimedium, 1-2 parts of wolfberry fruit, 0.5-1.5 parts of cordyceps sinensis extract, 1-3 parts of Tuckahoe, 0.5-1.5 parts of sea cucumber, 0.5-1.5 parts of silkworm moth, 0.5-1.5 parts of dogberry, 2-4 parts of Chinese chive seed, 4-6 parts of Chinese yam, 0.5-1.5 parts of donkey-hide gelatin, 0.5-1.5 parts of American ginseng, 4-6 parts of semen cuscutae, 0.5-1.5 parts of the fruit of Chinese magnoliavine, 1-3 parts of pawpaw, 2-4 parts of lucid ganoderma, 0.5-1.5 parts of propolis, 0.5-1.5 parts of cistanche, 1-3 parts of walnut seed, 4-6 parts of parasitic loranthus, 1-3 parts of astragalus mongholicus, 1-3 parts of sweet potato, and 0.5-1.5 parts of sharpleaf galangal fruit. The traditional Chinese preparation has obvious efficacy for curing such symptoms as deficiency of kidney, weak waist and knees, weak masculine reproductive function, etc.

Embodiments of the invention disclose a Cordyceps-lucid ganoderma composition capable of improving immunity. The Cordyceps-lucid ganoderma composition comprises the following effective components in parts by weight: 6 to 15 parts of Cordyceps militaris powder, 8 to 20 parts of ginseng, 35 to 70 parts of Maca, 3 to 10 parts of astaxanthin, 30 to 60 parts of proanthocyanidins, 5 to 10 parts of lycopene, 35 to 70 parts of lucid ganoderma spore powder and 20 to 50 parts of vitamin E. Embodiments of the invention also disclose a preparation process for the above-mentioned Cordyceps-lucid ganodermacomposition capable of improving immunity. According to the invention, eight antioxidant substances--ginseng, Cordyceps militaris powder, Maca, astaxanthin, proanthocyanidin, lycopene, lucid ganodermaspore powder and vitamin E are combined in a certain proportion, so complementary and synergistic effects of the antioxidant substances are exerted; the effect of antioxidation is good; and a plurality of functions of preventing occurrence of a variety of tumors, preventing leukemia, exerting protection effects on eyesight and the central nervous system, preventing obesity and gout, reinforcing immunity, preventing cardiovascular diseases, preventing oxidation and aging, maintaining reproductive function and the like of a variety of substances can be simultaneously exerted.

The invention relates to application of 5-aminolevulinic acid or pharmaceutically acceptable salts thereof or a medicament composition containing the 5-aminolevulinic acid or the pharmaceutically acceptable salts thereof in preparing medicaments for treating HPV (Human Papilloma Virus) infection, which is characterized by being applied to treating patients with continuous high-risk HPV infection with viral load not less than 10. When in treatment implementation, the invention is very safe and has no haemorrhage or anesthesia in the treatment process, pathological tissues can be selectively damaged, normal cervical tissue structures a re reserved, and the invention has no influence on the reproductive function of the patient, can be used for repetitive treatment, and has fast drug metabolism, no phototoxicity and no need of being kept in the dark.

The invention provides a yak feed additive for improving yak survival rate and a preparation method thereof. The yak feed additive is prepared from a traditional Chinese medicine extract, whey proteinpowder and a compound microbial fermentation broth with a weight ratio of 15-35:45-55:10-30, the raw materials of traditional Chinese medicine extract are 20 to 35 parts of Codonopsis pilosula, 15 to30 parts of Radix Astragali, 10 to 25 parts of sea buckthorn, 10 to 15 parts of Cortex moutan, 10 to 15 parts of Chinese magnoliavine, 5 to 10 parts of Radix isatidis, and 5 to 10 parts of licorice,and the zymophyte in the composite microbial fermentation broth include saccharomycetes, lactobacillus, bacillus, and Clostridium dibutyrate. The Chinese herbal medicine is natural green, safe and non-polluting, and promotes the growth and development of poultry, enhances disease resistance and enhances reproductive function; the microorganisms can improve the nutrient composition of a feed, promotes the absorption of nutrients by yak, and improves the utilization of the feed. The microorganisms can also change the medicinal properties, improves the efficacy, and reduces toxic side effects. The feed additive of the invention has the effects of enhancing resistance, promoting growth and preventing diseases, and improves the survival rate of the yak.

The present invention relates to uses of icariside II, particularly to uses of icariside II in preparation of products for prevention or treatment of reproduction dysfunction, prevention and/or treatment of abnormal semen quality, prevention and/or treatment of sterility caused by clinical oligospermia, asthenospermia, teratozoospermia or oligospermia-asthenospermia-teratozoospermia triad, or improvement of sperm amount and/or sperm motility.

Monoclonal antibodies against gonadotropin releasing hormone (GnRH) receptor induce cellular apoptosis of various cancer cells expressing this surface receptor. The monoclonal antibodies and their humanized forms, or fragments thereof, can serve as anti-cancer agents for the treatment of cancer in humans, and can function as analogs of GnRH to affect regulation of reproductive functions or fertility in humans.

The invention discloses a feed for laying ducks and a preparation method thereof. The feed for laying ducks comprises, by weight, 90-120 parts of corn flour, 90-100 parts of soybean meal, 60-80 parts of bran, 4-8 parts of fish bone meal, 0.5-1 part of salt, 2-5 parts of lactobacillus plantarum, 1-3 parts of saccharomyces cerevisiae and 1-2 parts of a traditional Chinese medicine. By adding the traditional Chinese medicine additive, the feed can regulate reproductive function, immune function, absorption and metabolism and conversion functions to nutrients and the like of ducks from the three aspects of tonifying kidney and boosting qi, fortifying stomach to improve digestion, and clearing heat and resisting bacteria, thereby increasing egg laying rate and improving the quality of duck eggs.

The invention relates to the field of function rehabilitation physiotherapy instruments, in particular to a physiotherapy chair having healthcare functions of relaxing muscles and shaking spines. The physiotherapy chair is characterized by comprising a chair base, a backrest frame, a hip seat frame, a leg frame and a foot frame, the chair base and the leg frame are connected through an electric ejector rod, and the electric ejector rod is used for adjusting inclination angles of opposite horizontal planes of the backrest frame and the leg frame to enable form of the physiotherapy chair to realize conversion among -5-degree prone position, horizontal prone position and upright sitting position to adapt to different physiotherapy procedures. Compared with the prior art, the physiotherapy chair has the advantages that a function of shaking whole body can be realized, and metabolism can be accelerated; an airbag combing function can be realized, and uncomfortable symptoms and pain caused by muscles of cervical vertebra and lumbar vertebra can be relieved; the physiotherapy chair has unique effect on regulating physiological and reproductive functions; a muscle stretching function can be realized, and muscle length can be averagely increased by 4-6cm by performing a cycle of muscle stretching; the physiotherapy chair can strengthen body and improve human immunity if being used in a lasting manner.

The method treats or improves generative function of male animals nonpharmacologically or the method controls sexual behavior of male animals. Electrodes are exposed to said male animals in a non-contact state and a low frequency AC electric field is exposed to a whole or a part of said male animals. Said electric field is exposed for a prescribed time period of a day and the exposure is repeated every day.

The invention relates to a target protein which takes a betaB2 crystal protein to improve the spermatogensis and a novel application thereof. A betaB2 crystal protein knockout mouse model is used for analyzing the expression of the betaB2 crystal protein in mouse testis tissues to confirm the reduction of CaMKIV expression and activity, caused by betaB2 crystal protein knockout, so as to reduce a reproductive function; and a CaMKIV expression level is reduced so that the expression of Bcl-2 is reduced to enable testis germ cells to be excessively proliferated and apoptotic and damage sperms. Therefore, the target protein for improving the spermatogensis is the betaB2 crystal protein, and a novel medicine resource and a novel application preparation are provided; and the target protein has the very important value for improving the existing medical level. The target protein disclosed by the invention is safe and cheap, effective in treatment and stable in property, is suitable for large-scale production and business application of industries of medicines, reagents and the like, is easy to popularize and apply, has a very good application prospect, and has obvious social benefits and economic benefits.