349results about How to "High acceptability" patented technology

The invention provides a method for obtaining local anesthetics encapsulated in liposomes, such as multivesicular liposomes, with high encapsulation efficiency and slow release in vivo. When the encapsulated anesthetic is administered as a single intracutaneous dose, the duration of anesthesia and half-life of the drug at the local injection site is increased as compared to injection of unencapsulated anesthetic. The maximum tolerated dose of the encapsulated anesthetic is also markedly increased in the liposomal formulation over injection of unencapsulated anesthetic. These results show that the liposomal formulation of local anesthetic is useful for sustained local infiltration and nerve block anesthesia.

The present invention provides a lead-acid battery superior in high-efficiency charging characteristic to conventional lead-acid batteries; and a carbon material used in the lead-acid battery, having excellent charge acceptability. That is, the present invention provides a lead-acid battery which uses, as an additive to the anode active material, a simple substance and / or a compound thereof, both having a catalysis for desulfurization or a catalysis for SOx oxidation by adding to or loading on a carbon material such as active carbon, carbon black or the like and thereby has superior high-efficiency charging characteristic and improved charging acceptability. When such a lead-acid battery whose anode contains a carbon material containing or loading thereon the above simple substance and / or compound, is applied to electric cars, various hybrid cars, power storage systems, elevators, electromotive tools and power source systems such as uninterruptible power source, distributed power source and the like, all having high input and output requirements, stable control can be obtained.

A portable therapeutic field generator device (10) generates a reduced magnetic field component for a relatively large electric field by virtue that adjacent conductive tracks in a radiating element (40, 50) conduct electrical current in opposing directions. The device (10) includes a processor (12) that, in response to a control algorithm stored in memory (14), supplies a pulse wave (22) to a circuit containing the radiating element (40, 50). The pulse establishes generation of a base heartbeat reference having a frequency around a nominal heart rate. At periodic times, the base heart beat reference is supplemented by mutually exclusive periods of alpha wave, theta wave and delta wave generation (or other selected frequencies below about 200 Hz) based on selected brainwave frequencies for these waves, with the pulses having a duration generally corresponding to that ascribed to neuron depolarisation pulses. The device (10) cycles through multiple cycles (88) and, dependent upon the effect that is desired, may see delta wave frequencies follow theta wave frequencies that follow alpha wave frequencies. Delays may exist between transitions between the generated waves, with delta wave generation occurring no later than sixty minutes from commencement of alpha wave production for a mode that induces sleep. Delta waves production has, typically, a duration that is twice that of either the alpha or theta wave production. A second mode of operation sees longer pulse times for higher frequencies—between about 100 Hz and 500 Hz—associated with muscle stimulation.

A safety syringe assembly includes an elongated, generally cylindrical barrel having a hollow interior forming a hollow nozzle located at a distal end of the barrel and opening into the interior of the barrel. A plunger is slidably mounted in the barrel and has a longitudinal open channel. A needle holder mounts a needle at a distal end thereof and is slidably mounted in the longitudinal open channel of the plunger for movement between an advanced position in which the needle on the distal end of the needle holder projects from a distal end of the nozzle, and a retracted position in which the needle is retracted within the barrel. A compression spring is mounted inside of the barrel, and a spring retainer element has a spring support portion extending from the interiorly of the barrel to a portion for mounted within the barrel and supporting a distal end portion of the spring against expansion. The spring urges the needle holder toward its retracted position. A latch has a closed position in which the needle holder is latched relative to the barrel to hold the needle holder in its advanced position against the urging of the spring, and an open position in which the needle holder is unlatched relative to the barrel to allow the spring to expand in a proximal direction to move the needle holder to its retracted position.