8 results about "Clobetasol" patented technology

The invention relates to equipment for preparing clobetasol propionate liniment and a preparation method of the clobetasol propionate liniment. The equipment comprises a material mixing mechanism, a barrel, a stirring shaft rotationally arranged on the barrel, stirring blades for stirring substances, a partition plate for separating the interior of the barrel, a crystallization rod for cooling materials and a drying mechanism for drying the substances. Wherein the stirring blades are fixedly arranged around the stirring shaft, and the stirring blades at the bottom are arranged around the stirring shaft in a swinging manner; the partition plate is movably arranged in the barrel around the stirring shaft; the crystallization rod is movably arranged at the bottom of the barrel; the drying mechanism communicates with the bottom of the barrel; the drying mechanism is communicated with the mixing mechanism; the partition plate is arranged between the fixed first ring frame and the rotary second ring frame; the partition plate is connected with the first ring frame and the second ring frame. The second ring frame rotates to drive the partition plate to open or separate the cylinder. The preparation method solves the problem that the preparation efficiency of clobetasol propionate is affected due to more preparation equipment caused by complex process steps in the clobetasol propionate liniment preparation process in the existing scheme.

The invention discloses clobetasol propionate liniment and a preparation method thereof, and belongs to the technical field of pharmaceutical preparations. The clobetasol propionate liniment provided by the invention consists of clobetasol propionate and dipotassium glycyrrhizinate which serve as effective components, absolute ethyl alcohol serving as a cosolvent and a novel eutectic solvent aqueous solution. The eutectic solvent aqueous solution is prepared by heating a citric acid aqueous solution and a tartaric acid aqueous solution under specific conditions. The invention also provides a method for preparing the clobetasol propionate liniment. A eutectic solvent formed by citric acid and tartaric acid is used as a main solvent, so that the use amount of absolute ethyl alcohol is reduced, and the use irritation is reduced. According to the liniment, the solubility and stability of clobetasol propionate which is extremely difficult to dissolve in water in a liniment system are improved, meanwhile, the formula system is mild, skin irritation caused by ethyl alcohol is reduced, and the liniment has good safety and application prospects.

The invention provides an immunochromatography test strip for detecting clobetasol propionate in cosmetics and a method for quantitatively detecting clobetasol propionate in cosmetics. According to the invention, a hollow gold nano-labeled material is applied to immunodetection of glucocorticoid clobetasol propionate for the first time, and an immunochromatography test strip with high sensitivity, quantitative function and strong specificity is constructed. The test strip can complete detection within 15 minutes, has high detection sensitivity, and realizes accurate quantification in a range of 0.01-25 ng / mL; meanwhile, the method is high in anti-interference capacity, the detection recovery rate of actual cosmetic samples reaches up to 89%-107%, the false positive rate and the false negative rate are both 0, reliability is good, and a powerful screening analysis tool is provided for rapid screening and quantitative detection of clobetasol propionate addition in cosmetics.

This invention belongs to the field of pharmaceutical formulation technology and relates to a clobetasol propionate ointment and its preparation process. The ointment comprises clobetasol propionate, an emulsifier, a solubilizer, a stabilizer, a secondary stabilizer, and an ointment base. The emulsifier is Tween-80, the solubilizer is propylene glycol, the stabilizer is povidone K15 or povidone K25, the secondary stabilizer is potassium chloride, and the ointment base is white petrolatum. This invention, by adding a stabilizer and a secondary stabilizer and screening their types, prepares a clobetasol propionate ointment that exhibits low impurity content and good stability during long-term storage. Furthermore, the preparation process is simple and easy to operate, facilitating industrial production.

The invention provides a method for analyzing ten glucocorticoids in cosmetics. According to the method, an ultra-high performance liquid chromatography-time-of-flight mass spectrometry method is adopted for qualitative screening and content determination. Chromatographic conditions are as follows: a chromatographic column is a C8 chromatographic column; the detector is a time-of-flight mass spectrometer; mobile phases: A-0.1% formic acid solution and B-methanol-acetonitrile (0.1% formic acid); the flow velocity is 0.2 to 0.6 mL / min; the column temperature is 25-40 DEG C; the sample size is 0.5 to 10 [mu] L; the elution procedure is as follows: 24% B is carried out in 0-1 min; 36-37 min, 31%-90% of B is obtained; 40-40.2 min, 90-24% of B is taken. The method disclosed by the invention can be used for exclusively and sensitively screening and quantifying 10 glucocorticoids such as clobetasol impurity B in cosmetics, and is mainly suitable for analyzing cosmetic dosage forms such as cream, cream, emulsion, water aqua, film agent and the like.

The invention provides application of clobetasol in neurotoxic injury treatment, and belongs to the technical field of biological medicine. The clobetasol is proved to be capable of effectively reversing or relieving demyelination, axonal injury, neuroinflammation and depression and anxiety-like behaviors caused by neurotoxic injury, a new treatment strategy is provided for neurotoxic injury occurring after cancer patients are subjected to chemotherapy, the living quality and treatment compliance of the patients can be improved, and the clobetasol can be used for treating neurotoxic injury caused by neurotoxic injury. Meanwhile, the clinical application range of clobetasol is expanded, and a new direction is provided for development of neuroprotective drugs.

The invention relates to the technical field of drug analysis and detection, in particular to a rhizoma alismatis content determination method which comprises the following steps: preparing a clobetasol propionate reference substance solution; preparing a mixed reference substance solution, namely mixing the 23-acetyl alisol C reference substance solution, the alisol B reference substance solution, the 23-acetyl alisol B reference substance solution and the clobetasol propionate reference substance solution; preparing a test solution: mixing a rhizoma alismatis sample with the clobetasol propionate reference substance solution; and quantitative determination: injecting the test solution and the mixed reference solution into a high performance liquid chromatograph, determining the nature by adopting an ultraviolet spectrogram, and determining and calculating the contents of 23-acetyl alisol C, alisol B and 23-acetyl alisol B in the test solution. According to the present invention, the chemical drug clobetasol propionate with characteristics of low price, easy obtaining and stable property is adopted as the alternative reference substance, such that the problems of transportation, storage, use and low cost of the existing determination method using 23-acetyl alisol C, 23-acetyl alisol B and alisol B as the reference substances are avoided.

A suspension formulation of clobetasol propionate nanoparticles is described. This suspension can be used therapeutically to treat burns of the skin and eyes, to promote wound healing, to prevent or reduce hypertrophic scarring / keloids, and to treat allergic rhinitis / sinusitis, asthma, inner ear disorders (including hearing loss, tinnitus, or dizziness), tenosynovitis, tendinitis, enthesitis, or arthritis.