4 results about "Clobetasol" patented technology

The invention relates to equipment for preparing clobetasol propionate liniment and a preparation method of the clobetasol propionate liniment. The equipment comprises a material mixing mechanism, a barrel, a stirring shaft rotationally arranged on the barrel, stirring blades for stirring substances, a partition plate for separating the interior of the barrel, a crystallization rod for cooling materials and a drying mechanism for drying the substances. Wherein the stirring blades are fixedly arranged around the stirring shaft, and the stirring blades at the bottom are arranged around the stirring shaft in a swinging manner; the partition plate is movably arranged in the barrel around the stirring shaft; the crystallization rod is movably arranged at the bottom of the barrel; the drying mechanism communicates with the bottom of the barrel; the drying mechanism is communicated with the mixing mechanism; the partition plate is arranged between the fixed first ring frame and the rotary second ring frame; the partition plate is connected with the first ring frame and the second ring frame. The second ring frame rotates to drive the partition plate to open or separate the cylinder. The preparation method solves the problem that the preparation efficiency of clobetasol propionate is affected due to more preparation equipment caused by complex process steps in the clobetasol propionate liniment preparation process in the existing scheme.

The invention provides an immunochromatography test strip for detecting clobetasol propionate in cosmetics and a method for quantitatively detecting clobetasol propionate in cosmetics. According to the invention, a hollow gold nano-labeled material is applied to immunodetection of glucocorticoid clobetasol propionate for the first time, and an immunochromatography test strip with high sensitivity, quantitative function and strong specificity is constructed. The test strip can complete detection within 15 minutes, has high detection sensitivity, and realizes accurate quantification in a range of 0.01-25 ng / mL; meanwhile, the method is high in anti-interference capacity, the detection recovery rate of actual cosmetic samples reaches up to 89%-107%, the false positive rate and the false negative rate are both 0, reliability is good, and a powerful screening analysis tool is provided for rapid screening and quantitative detection of clobetasol propionate addition in cosmetics.

This invention belongs to the field of pharmaceutical formulation technology and relates to a clobetasol propionate ointment and its preparation process. The ointment comprises clobetasol propionate, an emulsifier, a solubilizer, a stabilizer, a secondary stabilizer, and an ointment base. The emulsifier is Tween-80, the solubilizer is propylene glycol, the stabilizer is povidone K15 or povidone K25, the secondary stabilizer is potassium chloride, and the ointment base is white petrolatum. This invention, by adding a stabilizer and a secondary stabilizer and screening their types, prepares a clobetasol propionate ointment that exhibits low impurity content and good stability during long-term storage. Furthermore, the preparation process is simple and easy to operate, facilitating industrial production.

A suspension formulation of clobetasol propionate nanoparticles is described. This suspension can be used therapeutically to treat burns of the skin and eyes, to promote wound healing, to prevent or reduce hypertrophic scarring / keloids, and to treat allergic rhinitis / sinusitis, asthma, inner ear disorders (including hearing loss, tinnitus, or dizziness), tenosynovitis, tendinitis, enthesitis, or arthritis.