191results about How to "Good anti-itch effect" patented technology

A method for preventing or treating xerosis which comprises applying a prostaglandin D receptor selective agonist to a mammal.

An object of the present invention is to provide an antipruritic agent having a novel action mechanism.

The present invention provides an antipruritic agent comprising a compound represented by the following general formula (1):

wherein R¹ represents a hydrogen atom or alkyl; the ring Q represents a cyclohexylene group or a phenylene group; A¹ and A² represent a single bond or an alkylene group; E represents —NHCO—; A³ represents a single bond or a divalent saturated or unsaturated aliphatic hydrocarbon group; R³ represents a non-cyclic aliphatic hydrocarbon group; and R⁴ and R⁵ are the same or different and each represents a hydrogen atom or alkyl, or a pharmaceutically acceptable salt thereof as an active ingredient.

The invention aims to find out a novel pharmacological effect (medical use) of cannabinoid. Since cannabinoid agonists such as palmidrol and anandamide have an excellent antipruritic effect, they are useful as an agent for treating any types of pruritus such as ocular pruritus, skin pruritus and systemic pruritus.

It is intended to find out a novel pharmacological effect of a piperidine derivative (I). Because of having an excellent antipruritic effect, the piperidine derivative (1) is useful as a therapeutic agent for itching of any types such as eye itching, skin itching and systemic itching.

The invention provides a gynecological external lotion for preventing and treating vagina inflammatory diseases. The lotion comprises the following bulk drugs in parts by weight: 10-20 parts of radix stemonae, 10-20 parts of cortex phellodendri, 10-20 parts of sophora flavescens, 10-20 parts of broom cypress fruit, 10-20 parts of dittany bark, 10-20 parts of Chinese angelica, 10-20 parts of climbing groundsel herb, 10-20 parts of rhizoma smilacis glabrae, 10-20 parts of Chinese trumpet creeper, 10-20 parts of mint, 10-20 parts of lithospermum, 10-20 parts of rhizoma bletillae, 10-20 parts of motherwort, 10-20 parts of Chinese violet, 10-20 parts of spatholobus suberctu, 10-20 parts of fructus cnidii, 10-20 parts of patrinia scabiosaefolia fisch, 10-20 parts of scutellaria baicalensis, 10-20 parts of folium artemisiae argyi, 10-20 parts of dandelion, and 10-20 parts of rhizoma atractylodis. Compared with the prior art, the lotion has the advantages of quick itching relieving, complete sterilization, strong disinfection and insect eliminating effect, good effect of anti-inflammation and itching relieving, convenience in administration, low cost and the like, is safe, small in toxic and side effect, convenient to use and short in cure time, and prevents relapse after healing, and the liquid medicine is easy to prepare.

The invention discloses sterilization itch-relieving handmade soap which comprises the following materials in part by weight: 450-550 parts of fundamental vegetable oil, 61-75 parts of sodium hydroxide, 153-187 parts of distilled water, 13.5-16.5 parts of neem oil, 4.5-5.5 parts of frankincense essential oil, 4.5-5.5 parts of myrrh essential oil, 4.5-5.5 parts of lavender essential oil, 4.5-5.5 parts of cypress essential oil, and 4.5-5.5 parts of artemisia argyi essential oil. The production method of the handmade soap comprises the following steps: saponifying the fundamental vegetable oil with the temperature of 38-42 DEG C by using a sodium hydroxide aqueous solution with the temperature same as that of the fundamental vegetable oil; when a soap liquid reaches a thick state, adding the mixed oil of the five kinds of essential oils and the neem oil, uniformly stirring, pouring into a mould, and keeping the temperature of 38-42 DEG C for 48 hours; finally, demoulding and airing. According to the invention, plenty of bubbles are generated by the handmade soap, the detergency of the soap is excellent, the various essential oils can quickly permeate into skin to kill mites, restrain bacteria, relieve itch, clear heat, remove toxicity and repair skin, and the sterilization itch-relieving handmade soap is quite suitable for skin of the aged.

The invention provides a lotion for treating gynecological disease and its preparation process, wherein the medicine is prepared from the following traditional Chinese medicinal herbs (by weight portion), cnidium fruit 30-30, kuh-seng 90-110, poria cocos wolf 40-60, peppermint 20-30.

The invention aims to provide a dermatophytosis medicament having the advantages of innocuity, no taste, no sharp pain to wounded parts and good antipruritic and analgesic effect, and having the functions of relieving sole sweating and removing foot odor, shoe odor, body odor, bromhidrosis and the like and a preparation method thereof. The medicament has the obvious antipruritic effect in the process of treating dermatophytosis, the antipruritic effect can be achieved after the medicament is used for 2 to 5 minutes, the dermatophytosis can be cured after the medicament is taken for 3 days to one week, and the medicament is taken for 10 to 15 days continuously after restoration, the dermatophytosis generally does not relapse. The medicinal composition has the characteristics of recovering patients, along with quick response, good effect and no toxic or side effect.

The invention relates to a radix lithospermi ointment containing phytosterol and a preparation method thereof. The radix lithospermi ointment comprises the following raw materials, by weight: 30 to 75parts of olive fruit oil, 20 to 30 parts of low-erucic-acid rapeseed oil, 5 to 15 parts of beewax, 1 to 10 parts of hydrogenated coco-glycerides, 1 to 10 parts of paraffin, 1 to 10 parts of sweet almond seed oil, 1 to 10 parts of simmondsia chinensis seed oil, 0.01 to 1.0 part of a radix lithospermi root extract, 0.01 to 1.0 part of Chinese angelica root extract, 0.01 to 1.0 part of the extract of the root of fangfeng, 0.01 to 1.0 part of an adhesive rehmannia root extract, 0.01 to 1.0 part of 2-[3-(4-hydroxyphenyl)propanoylamino]benzoic acid, 0.1 to 1.0 part of phytosterol oleate, 0.1 to 1.0part of behenin, 0.1 to 1.0 part of polyglycerol-6 octastearate, 0.1 to 1.0 part of tocopherol (vitamin E), 0.1 to 1.0 part of lavender oil, and 0.1 to 1.0 part of peppermint leaf oil. Therefore, theradix lithospermi ointment is prepared by combining the olive fruit oil and the low-erucic-acid rapeseed oil as main grease components with the Chinese herbal medicine components such as the radix lithospermi root extract and the 2-[3-(4-hydroxyphenyl)propanoylamino]benzoic acid and phytosteryl oleate and is capable of soothing and moisturizing the uncomfortable skin and improving the itching relieving effect.

The invention discloses an aloe polysaccharide extracting method and an aloe skin moistening composition. Full aloe leaf juice is weighed out, added with absolute ethyl alcohol and subjected to microwave treatment until the temperature of the mixed liquid reaches 75-77 DEG C, the mixed liquid is cooled, ultrasonic waves are used for assisting in extracting anthraquinones in the mixed liquid continually, extraction and filtering are carried out, and an anthraquinone ingredient extract solution and filter residues are obtained; deionized water is added to the filter residues according to the material and liquid ratio of 1:20-40, extraction is carried out for 20-60 minutes with the ultrasonic waves power ranging from 400 W to 800 W, filtering is carried out, and an aloe polysaccharide extract solution is obtained. According to the extracting process, aiming at the polysaccharide ingredients in full aloe leaves, the extracting time is effectively shortened under the premise that the extraction rate is ensured, and the aloe polysaccharide extract solution has the good moistening property and has certain antioxidant activity; in addition, the anthraquinone matter with potential skin irritation is effectively removed, an aloe skin moistening formulation adopting the aloe polysaccharide extract solution achieves good moistening, itching relieving and antioxidant activity effects.

The present invention provides a Chinese medicine for curing foot and hand tinea, including the following raw materials with the weight portions: 20 of rhizoma polygonati, 30 of purple gromwell root, 30 of lightyellow sophora root, 20 of corktree bark, 20 of dittany bark, 15 of broom cypress fruit, 20 of common cnidium fruit, 10 of cortex pseudolaricis, 20 of amargosa bark, 15 of dried ginger and 10 of dried alum. The advantages of the present invention are toxic moisture dispersion, itch and perspiration alleviation, sterilization, reasonable prescription, simple production and low cost, which can be widely applied in foot washing house to prevent foot and hand tinea. The present invention is also convenient to carry and use in business trip and travelling. The present invention has the efficacy of invigorating spleen and replenishing qi, strengthening spleen and clearing toxic moisture, and sterilizing. The present invention has the advantages of obvious itch alleviating effect, rare recurrence after cure, obvious perspiration and odor elimination. The invention has no side effect and is applied for many years and well received.

The invention discloses a scurf-removing and itching-relieving liquid shampoo, and belongs to the technical field of daily chemical products. The scurf-removing and itching-relieving liquid shampoo is prepared from the following raw materials in parts by weight: 20-25 parts of tuber fleeceflower root, 10-12 parts of black sesames, 1.5-2.0 parts of a yeast, 10-12 parts of honeysuckle flower, 15-20 parts of propolis, 10-15 parts of ginger, 12-16 parts of camellia-seed oil, 1.2-1.5 parts of white vinegar, 0.8-1.0 part of grape polyphenol, 1-1.2 parts of citric acid, 0.5-0.8 part of coconut oleic monoethanol amide, 0.1-0.3 part of sodium chloride and 0.1-0.5 part of essences. According to the scurf-removing and itching-relieving liquid shampoo disclosed by the invention, active components are extracted from natural plant raw materials and are combined and matched to replace commonly-used scurf-removing and itching-relieving chemical medicines so as to ensure that the prepared shampoo has very good scurf-removing and itching-relieving effects, and also cannot cause side effects to both the hair quality and the hairs and skins.

The invention belongs to the field of cosmetics, in particular to an antidandruff and antipruritic scalp essence and a preparation method thereof. A composition includes the following components: hexamidine diisethionate and a traditional Chinese medicine extract. The traditional Chinese medicine extract includes a gentian extract. The scalp essence prepared from the composition of the invention has good solubility and also has good antidandruff and antipruritic effects.

The antifungal medicine composition is medicine prepared with the materials including snake oil 50-100 weight portions, Miconazole nitrate 25-50 weight portions, flavescent sophora root 20-50 weight portions, pearl powder 1-10 weight portions, menthol 1-5 weight portions, and borneol 1-5 weight portions. The antifungal medicine composition as one compound Chinese and Western medicine preparation contains effective antifungal components, and components for clearing away heat and toxic material, eliminating swelling, relieving pain, astringing and promoting granulation. It is used in treating tinea corporis, tinea cruris, tinea manuum, tinea pedis, etc caused by mycotic infection, and has stable treating effect and little side effect.

The invention relates to a traditional Chinese medicinal composition for treating cervix diseases. The traditional Chinese medicinal composition comprises the following components in part by weight: 35 to 45 parts of bark of tree of heaven, 25 to 35 parts of lightyellow sophora root, 25 to 35 parts of tree peony bark, 25 to 35 parts of olibanum and 0.8 to 1.2 parts of borneol, wherein the lightyellow sophora root has the same weight as the tree peony bark and the olibanum. The invention also provides a method for detecting the traditional Chinese medicinal composition and a method for preparing a gelling agent of the traditional Chinese medicinal composition. In the traditional Chinese medicinal composition, on a basis of ensuring that the lightyellow sophora root has the same content as the tree peony bark and the olibanum, the content of bark of tree of heaven and the content of borneol are adjusted, so that the traditional Chinese medicinal composition fully utilizes the effects ofvarious raw materials to achieve the effects of clearing away heat, eliminating dampness, removing blood stasis and promoting regeneration of the tissue and has more exact efficacy. In the method forpreparing the gelling agent of the traditional Chinese medicinal composition, all components are extracted respectively to prepare the gelling agent, so that the method is simple and suitable for industrial production, has high extraction rate of drug effect ingredients and low cost. In addition, the invention also provides the method for detecting the traditional Chinese medicinal composition, which can effectively identify components and content of the traditional Chinese medicinal composition and has little disturbance and high result repeatability.

The invention belongs to the field of daily chemical products and particularly relates to mosquito-repelling toilet water and a preparation method thereof. The mosquito-repelling toilet water comprises, by weight, 6-10 parts of Artemisia vulgaris, 1-3 parts of chamomile, 1-3 parts of catnip, 1-2 parts of radix glycyrrhizae, 0.5-1.5 parts of lavender, 1-3 parts of soybean oil, 1-5 parts of menthol, 1-2 parts of borneol, 0.01-0.05 part of pH regulator, 35-55 parts of anhydrous ethanol and 15.45-52.49 parts of deionized water. The mosquito-repelling toilet water has good mosquito-repelling and itching-relieving effects and is mild and nonirritant to the skin and the respiratory tract, fresh and natural in smell and widely applicable to various people.

The invention discloses an antipruritic liquid shampoo, and the antipruritic liquid shampoo is characterized in that: the antipruritic liquid shampoo is prepared from the following substances: by weight, 40-60 parts of Chinese honey locust, 100-200 parts of fresh ginger, 35-60 parts of cortex dictamni, 40-60 parts of sophora flavescens, 20-30 parts of caulis polygoni multiflori, 20-50 parts of phellodendron, 5-15 parts of rhizoma atractylodis, 5-15 parts of lithospermum, 30-50 parts of cacumen platycladi, 30-50 parts of walnut kernel, 30-50 parts of black sesame, 20-40 parts of ligusticum wallichii, 20-40 parts of mint, 10-20 parts of vanilla and 10-20 parts of chrysanthemum; and the antipruritic liquid shampoo is prepared by water decoction after uniform mixing of the substances.

The invention discloses an antipruritic and anti-allergic baby washing and protecting preparation and an application thereof. The antipruritic and anti-allergic baby washing and protecting preparations comprises a wild chrysanthemum flower extract, a dandelion extract, a milkvetch root extract, and a bitter apricot seed extract. The antipruritic and anti-allergic baby washing and protecting preparation contains mild and natural plant extracts, the addition of irritant substances is avoided from the raw materials, the irritation of the product is reduced, and the relatively good experience sense, and relatively strong anti-allergenicity and antipruritic performance are realized through the synergistic compatibility effects of the specific components. The patch test results show that the washing and protecting preparation is a negative result, and does not have irritation to the skin, the eye irritation test results show a NC value of less than or equal to 2, the washing and protecting preparation is the stress irritation, namely, is damage-free irritation, has no eye irritation, and is safe and mild. In addition, a foam volume of the product can reach 770 mL, the time of discharging50 mL of a liquid by foam can reach 11.8 s, the foaming ability is strong, the foam stability is good, and thereby the washing and protecting preparation can be widely used in the preparation of infants and young children products.

The invention discloses baby itching-relieving lotion. The baby itching-relieving lotion is prepared from, by mass, 0.32-3.6% of natural extract, 2.1-8% of surfactant, 4-20% of oil-based raw materials and 70-92% of water. The baby itching-relieving lotion has advantages that insect bites, eczema, allergy and the like all cause itching sensation which is intrinsically allergic reaction of human bodies, human bodies release histamine to result in skin or mucosa irritation which is transmitted to the brain through neural reflex to form itching sensation, the natural extract which has antibacterial, anti-inflammation and reflex reduction efficacies plays a role in itching relieving, and especially when the natural extract contains alkaloid, formic acid released by insect bites can be neutralized. Therefore, the baby itching-relieving lotion has a great itching relieving effect on itching sensation caused by insect bites, eczema, allergy and the like and has advantages of freeness of alcohol and irritation, mildness, safety in use of the natural extract, effectiveness in itching relieving and great antibacterial and anti-inflammation effects.

The invention provides a topical traditional Chinese medicine lotion for treating gynecological inflammation. The topical traditional Chinese medicine lotion is prepared from APIs (Active Pharmaceutical Ingredients) in parts by weight: 10 to 15 parts of radix stemonae, 10 to 15 parts of golden cypress, 10 to 15 parts of radix sophorae flavescentis, 10 to 15 parts of fructus kochiae, 10 to 15 parts of dittany bark, 10 to 15 parts of angelica sinensis, 10 to 15 parts of senecio scandens, 10 to 15 parts of rhizoma smilacis glabrae, 10 to 15 parts of campsis grandiflora, 10 to 20 parts of radices lithospermi, 10 to 20 parts of rhizoma bletillae, 10 to 20 parts of leonurus japonicus, 10 to 20 parts of herba violae, 10 to 20 parts of caulis spatholobi, 10 to 20 parts of fructus cnidii, 10 to 20 parts of patrinia scabiosaefolia fisch, 10 to 20 parts of scutellaria baicalensis, 10 to 20 parts of folium artemisiae argyi, 10 to 20 parts of dandelion and 10 to 20 parts of rhizoma atractylodis. Compared with the prior art, the topical traditional Chinese medicine lotion for treating gynecological inflammation, provided by the invention, has the advantages that itching relieving is rapid, sterilization is complete, inflammation diminishment and deinsectization effects are strong, the anti-inflammatory and itching relieving effects are good, dosing is convenient, a liquid medicine can be easily made, the cost is low, and the like; safety is obtained, toxic and side effects are small, the use is convenient, the healing time is short, and gynecological inflammation is difficult to recur after being healed.

The invention discloses medicinal tincture for treating vesicle tinea pedis and a preparation method thereof. The medicinal tincture is prepared from the following raw materials in part by weight: 50 parts of glabrous greenbrier rhizome, 50 parts of lightyellow sophora root, 50 parts of golden larch bark, 50 parts of phellodendron, 50 parts of densefruit pittany root-bark, 50 parts of belvedere fruit, 50 parts of knotgrass, 50 parts of common cnidium fruit, 50 parts of chinaberry bark and root-bark, 50 parts of hydnocarpus seed and 2,200 parts of 95 percent alcohol. The preparation method comprises the following steps of: grinding the glabrous greenbrier rhizome, the lightyellow sophora root, the golden larch bark, the phellodendron, the densefruit pittany root-bark, the belvedere fruit, the knotgrass, the common cnidium fruit, the chinaberry bark and root-bark and the hydnocarpus seed into coarse powder, soaking the coarse powder into the 95 percent alcohol for 10 days, filtering medicinal residues to obtain filter liquor, namely the medicinal tincture for treating the vesicle tinea pedis, and filling the medicinal tincture into plastic bottles for later use. The invention has the advantages that: the medicinal tincture has the good effect of relieving itching, does not have irritation and is easy and convenient to use; and compared with other ointments and creams, the medicinal tincture is a pure Chinese medicinal preparation and does not have the side effect of containing hormone ointments.