31 results about "Piperidine derivative" patented technology

The invention relates to the field of medicinal chemistry, and particularly discloses a piperidine derivative as well as a pharmaceutical composition, application and a preparation method thereof. The piperidine derivative has the following general formula. The piperidine derivative can be effectively used for treating or preventing multiple sclerosis, and shows an unexpected synergistic effect in an animal model: the piperidine derivative not only can significantly improve neurological function impairment and promote recovery, but also can deeply reduce the levels of key proinflammatory cytokines IFN-gamma and IL-17 at the same time. The invention provides a novel small molecule candidate drug with central permeability, neuroprotection and comprehensive immune regulation functions for treatment of multiple sclerosis.

The invention relates to the technical field of organic synthesis, and relates to a synthesis method of an N-substituted piperidine / homopiperidine derivative and a prepared product, and the synthesis method comprises the following steps: in the presence of a catalyst and a solvent, dialdehyde, primary amine and hydrogen react to obtain the N-substituted piperidine / homopiperidine derivative; the catalyst comprises a carrier and an active component loaded on the carrier, and the active component of the catalyst is selected from at least one of Pd, Pt, Ru, Ni and Co. The method has the advantages of mild reaction conditions, high conversion rate of the raw material dialdehyde and high selectivity of the products piperidine and the homopiperidine derivative, and is a process route with important practical application value.

This application relates to the field of medicinal chemistry, specifically disclosing a piperidine derivative, a pharmaceutical composition, its uses, and a method for preparation. The piperidine derivative has the structure of general formula (I). This piperidine derivative can significantly improve the learning and memory abilities of Aβ-induced Alzheimer's disease model rats and effectively reduce acetylcholinesterase activity in brain tissue, providing a potential candidate for the development of novel Alzheimer's disease treatments.

The present invention relates to the field of pharmacy, and in particular to compounds of formula (I) as pharmaceutically active compounds. Compounds of formula (I) have been proven for the first time to be particularly useful for the treatment of depression and eating disorders related to depression, or diseases with depressive pathology as well as for the treatment of appetite related side effects of antidepressants and antipsychotics.

The invention relates to an application of pimozide in preparation of a population effect inhibitor. The invention verifies that pimozide can inhibit the population effect of bacteria through a violaceum violaceum luminescence method, and further proves that pimozide can inhibit the population effect of pseudomonas aeruginosa and the generation of virulence factors through the inhibition of biological back membrane formation and the inhibition effect of virulence factor generation. The compound is expected to be developed into a clinically available group effect inhibitor, and has an important research value for solving the problems of bacterial infection and drug resistance.

Disclosed in the present invention are a cyclohexyl-substituted piperidine derivative, a pharmaceutical composition comprising same, and a use thereof. The cyclohexyl-substituted piperidine derivative is a compound as represented by general formula (I), a stereoisomer thereof or a pharmaceutically acceptable salt thereof. The definition of substituents in general formula (I) is stated in detail in the description. The compound and the composition of the present invention can be used for treating a variety of diseases or disorders associated with an NOP receptor.

The present invention relates to a piperidine derivative compound and a use thereof. The piperidine derivative compound of the present invention exhibits excellent inhibitory activity against FLT3, and thus can be usefully employed in the treatment or prevention of FLT3-related diseases.

The present invention relates to aromatic heterocyclic cyclohexylaminoalkylpiperidine derivatives, methods for their preparation and their use. Specifically, the present invention relates to 5-HT 1A The present invention provides a compound represented by general formula (I), a stereoisomer thereof, a tautomer thereof, or a pharmaceutically acceptable salt thereof, which is used for activating receptors and dopamine D2 and D3 receptor activity, and for use in the manufacture of a medicament for Parkinson's disease, as well as a method for producing the compound. [Formula 1] JPEG2025526807000132.jpg2058

The application discloses a hindered amine polymer material and a preparation method and application thereof. The hindered amine polymer material is a modified polyester prepared through copolymerization of an oligomer polyester and a piperidine derivative, wherein the oligomer polyester is an oligomer PBT or an oligomer PET; or, the hindered amine polymer material is prepared through copolymerization of an oligomer polymer, wherein the oligomer polymer is prepared through polycondensation of terephthalic acid or dimethyl terephthalate, a diol and a piperidine derivative, wherein the diol is 1,4-butanediol or ethylene glycol; and the piperidine derivative has a structure shown in formula I or formula II. Compared with a conventional physically mixed polymer material, the weather resistance and migration resistance of the polymer material prepared through copolymerization are significantly improved.

The present invention relates to methods for treating inflammatory bowel disease (IBD). Particularly, the present invention relates to use of specific inhibitors of Voltage-Dependent Anion Channel (VDAC1), such as piperazine- and / or piperidine-derivatives, among others, e.g., peptides and oligonucleotides, for treating IBD.

The invention relates to a piperidine derivative as shown in a formula (I), and an isotope form, a stereoisomer, a tautomer, a cis-trans-isomer, pharmaceutically acceptable salt, a pharmaceutically acceptable solvate, a hydrate, a prodrug and a polymorphic substance of the piperidine derivative. The compound has a good application prospect in the aspect of preparing medicines for preventing and / or treating TXNIP activity mediated diseases.

The disclosure relates to compounds of formula I, wherein A, B, and R1 have the meaning given in the specification, and pharmaceutically acceptable salts thereof. The compounds of formula (I) exhibit GPR183 antagonistic activity and are thus useful in the treatment or prevention of disorder, condition, or disease where GRP183 antagonist is indicated to be useful.

The present invention relates to the use of METTL3 inhibitors piperidine derivatives of formula (I), for the treatment of carcinomas.

This application relates to the field of medicinal chemistry, specifically disclosing a piperidine derivative and its pharmaceutical composition, uses, and preparation method. The piperidine derivative has the following general formula: [Formula omitted]. This piperidine derivative can be effectively used to treat or prevent multiple sclerosis, exhibiting unexpected synergistic effects in animal models: it not only significantly improves neurological function impairment and promotes recovery, but also simultaneously and profoundly reduces the levels of key pro-inflammatory cytokines IFN-γ and IL-17. This invention provides a novel small molecule drug candidate for the treatment of multiple sclerosis that combines central penetration, neuroprotection, and comprehensive immunomodulation.

: Title: Antibacterial Application of Pyrrolidin-Piperdine Derivatives Containing Composition to Inhibit Helicobacter Pylori Replication, Preparation Method Thereof The present disclosure proposes a method for identification, optimizing, and preparing a therapeutic molecule (MA01027) for inhibiting cytotoxin-associated gene A (CagA) protein of Helicobacter pylori. The therapeutic molecule specifically targets and binds to a particular protein of interest, thereby enhancing the efficacy and specificity of the treatment. The therapeutic molecule is optimized for its binding affinity and selectivity for the target protein. The therapeutic molecule involves combining specific reactants under controlled conditions to achieve high yields and purity of the therapeutic molecule. The therapeutic molecule preparation includes purification steps to isolate the therapeutic molecule from the reaction mixture using standard techniques, thereby ensuring a high-quality final product. The therapeutic molecule binds to the CagA protein of H. pylori, inhibiting its replication by more than 90% and eliminating H. pylori-associated hemolysis.

The composition contains silicon nanoparticles having a hindered piperidine derivative free radical scavenger on the surface of the silicon nanoparticles. A process for making silicon nanoparticles having a hindered piperidine derivative free radical scavenger on the surface of the silicon nanoparticles, the process comprising producing silicon nanoparticles using a VHFLPP process and collecting the silicon nanoparticles in a capture fluid as they are made, wherein the hindered piperidine derivative free radical scavenger is provided in the capture fluid before, during, or after collecting the silicon nanoparticles such that the silicon nanoparticles and the hindered piperidine derivative free radical scavenger are present together in the capture fluid.

The application belongs to the technical field of medicines, and particularly relates to a 1,3-disubstituted piperidine derivative and a preparation method and application thereof. The application provides a 1,3-disubstituted piperidine derivative and a preparation method and application thereof, wherein the 1,3-disubstituted piperidine derivative is a non-adenosine DOT1L inhibitor; the use of an adenosine or adenosine-like mother nucleus is avoided in the structure, the metabolic stability is higher, the properties are stable, the 1,3-disubstituted piperidine derivative is easy to store, the preparation route is simple and easy to implement, and the 1,3-disubstituted piperidine derivative is easy to purify.

The invention provides an MWF molecular sieve as well as a preparation method and application thereof, and belongs to the technical field of molecular sieve synthesis. The preparation method comprises the following steps: mixing an aluminum source, an inorganic metal alkali source, water, a silicon source and a structure-directing agent to obtain gel; and carrying out hydrothermal crystallization on the gel to obtain the MWF molecular sieve. According to the present invention, the piperazine derivative or the piperidine derivative is adopted as the structure-directing agent, the sodium hydroxide and the potassium hydroxide are adopted as the inorganic alkali source, and the aluminosilicate MWF molecular sieve can be synthesized by using the one-step hydrothermal crystallization method, such that the cost is low, the yield is high, and the prepared MWF molecular sieve has characteristics of high crystallinity and good stability compared with the existing structure-directing agent-based MWF molecular sieve synthesis method; the MWF molecular sieve prepared by the method has a wide SiO2 / Al2O3 molar ratio window (SiO2 / Al2O3 = 5-20), the structure does not collapse after the structure-directing agent is removed by high-temperature roasting, the thermal stability is good, and the application of the MWF molecular sieve in the fields of catalysis and adsorption is expanded.

The invention provides a 4-phenylpiperidine derivative and application thereof. Specifically, a compound represented by formula I or a pharmaceutically acceptable salt thereof is provided, and functional groups are as defined in the specification.

The invention relates to the field of medicinal chemistry, and particularly discloses a piperidine derivative, a pharmaceutical composition, application of the piperidine derivative and a preparation method of the piperidine derivative. The piperidine derivative has a structure shown in a general formula (I). The piperidine derivative can significantly improve the learning and memory ability of A beta-induced Alzheimer's disease model rats and effectively reduce the activity of acetylcholin esterase in brain tissues, and provides a potential candidate for developing novel Alzheimer's disease treatment drugs.

The invention provides a tetrahydrothiophene piperidine derivative and application of the tetrahydrothiophene piperidine derivative in preparation of a medicine for treating alopecia. The tetrahydrothiophene piperidine derivative is a brand-new compound with an alopecia treatment effect. Meanwhile, the tetrahydrothiophene piperidine derivative provided by the invention is high in activity and low in toxicity, so that the tetrahydrothiophene piperidine derivative can be used as a novel compound type for preventing and treating various different types of alopecia.

The invention relates to the field of medicinal chemistry, and particularly discloses a piperidine derivative for neurodegenerative diseases, a pharmaceutical composition and application of the piperidine derivative. The piperidine derivative has a structure shown in a general formula (I). In-vivo experiments prove that the compound can effectively improve learning and memory impairment of beta-amyloid protein induced Alzheimer disease model rats, the escape latency is remarkably shortened and the ring penetration frequency is increased in a Morris water maze test, and the behavioral improvement effect of the compound is remarkably superior to that of carristine and can be compared favorably with that of a positive control drug. Meanwhile, the series of compounds can significantly inhibit abnormally increased acetylcholin esterase activity in hippocampal tissues of model rats, have an excellent regulation effect on cholinergic system functions, and show a synergistic effect of cognitive improvement and key pathological link regulation. The compound provided by the invention provides a new and potential candidate drug for treatment of Alzheimer's disease.

The application discloses a preparation method of polymer modified asphalt. The method comprises the following steps: (1) mixing matrix asphalt in a molten state with a compatibilizer, and then performing first heating; (2) mixing the material after the first heating with a polymer and a cross-linking promoter, and shearing; (3) performing second heating on the material after the shearing in the step (2), and performing development reaction under stirring; (4) after the development reaction is completed, cooling, adding a cross-linking terminator, and stirring to obtain polymer modified asphalt; wherein the cross-linking terminator is a combination of a hindered piperidine derivative and a benzotriazole compound. The application can keep the performance of the polymer modified asphalt at a required performance index, and achieves the purpose of controllable modification degree.

The invention belongs to the technical field of coatings, and particularly relates to exterior wall latex paint as well as a preparation method and application thereof. The exterior wall latex paint comprises a styrene-acrylic emulsion, a covering polymer, a modified light stabilizer and a modified antioxidant, the modified light stabilizer is a sulfonic acid group grafted piperidine derivative hindered amine light stabilizer; the modified antioxidant is sulfonic acid group grafted dihydroxy diphenyl sulfone. According to the invention, a sulfonic acid group grafted piperidine derivative hindered amine light stabilizer is adopted as a modified light stabilizer, sulfonic acid group grafted dihydroxy diphenyl sulfone is adopted as a modified antioxidant, and other components are combined, so that the exterior wall latex paint has good weather resistance and aging resistance; and the paint has good comprehensive properties such as water resistance, alkali resistance, low-temperature stability, low-temperature film-forming property and environmental protection property.

This invention provides a class of piperidine derivatives, their preparation methods, and uses, belonging to the field of chemical pharmaceutical technology. The piperidine derivatives are compounds represented by Formula I, their salts, or their optical isomers. The piperidine derivatives of this invention exhibit agonistic activity against μ-opioid receptors and inhibitory activity against σ1 receptors, thus exerting analgesic effects in vivo and reducing the incidence of side effects. These piperidine derivatives can be used to prepare analgesic drugs, which is of great significance for clinical analgesia and has promising application prospects.

The invention discloses an organic-inorganic hybrid antimony halide and a preparation method and application thereof, and relates to the field of luminescent materials, the preparation method comprises the following steps: grinding and mixing an antimony-based compound and an organic ligand to obtain the manganese-doped organic-inorganic hybrid antimony halide, a is any one of pyridine, imidazole, piperidine, pyrazine, triphenylphosphine, a pyridine derivative, an imidazole derivative, a piperidine derivative, a pyrazine derivative and a triphenylphosphine derivative; the antimony-based compound is an antimony compound, or the antimony-based compound comprises an antimony compound and a manganese compound; the chemical formula of the organic and inorganic hybrid antimony halide is AaSbXb or AaSbXb: Mn, and X is any one of Cl, Br and I. The target product can be prepared only by grinding and mixing the raw materials of the antimony-based compound and the organic ligand, the process is simple and controllable, the operation is convenient and fast, the method is suitable for large-scale preparation, and a foundation is laid for industrial application of the organic-inorganic hybrid antimony halide.

The invention discloses a cyclohexyl-substituted piperidine derivative, a pharmaceutical composition containing the cyclohexyl-substituted piperidine derivative and application of the cyclohexyl-substituted piperidine derivative. The cyclohexyl substituted piperidine derivative is a compound as shown in a general formula (I), a stereoisomer or a pharmaceutically acceptable salt thereof, wherein the definition of each substituent group in the general formula (I) is shown in the specification. The compounds and compositions of the invention are useful for the treatment of a variety of diseases or conditions associated with NOP receptors.