The invention discloses a preparation method of
mesalazine enteric sustained-release microparticles,
mesalazine spherical microparticles with
small particle size and high
drug loading capacity prepared by a W / O / W multiple
emulsion method are used as
drug-containing
pill cores, the particle size of the microparticles is 50-150 mu m, the roundness is high, the
mechanical strength is high, and the
drug loading capacity is high. Due to the high
mechanical strength, the shape of the particles is still kept complete under the large atomization pressure in the
fluidization coating process, due to the high roundness,
coating liquid can be sprayed on the surfaces of the particles more evenly, the same slow-release effect is achieved, and the weight increment of the
coating is smaller. The invention further discloses the
mesalazine enteric-coated sustained-release particles prepared by the preparation method, the particle size is 50-200 microns, the mesalazine enteric-coated sustained-release particles are free of gravel feeling during
oral administration, the problems of enteric-coated sustained release, difficulty in
swallowing and the like can be effectively solved, and the medication compliance of patients is greatly improved. The mesalazine enteric-coated sustained-release particles prepared by the invention are used for preparing pharmaceutical preparations such as orally disintegrating tablets, granules, dry suspensions and the like.