306results about How to "Less weight gain" patented technology

Disclosed herein are methods for treating a vascular leak disorder, hypotension, or a procoagulant state using angiopoietin-2 (Ang-2) antagonist compounds. Also disclosed are methods for treating a vascular leak disorder associated with high dose IL-2 therapy using angiopoietin-2 antagonist compounds. Methods for diagnosing and monitoring vascular leak disorders, hypotension, or a procoagulant state that include the measurement of Ang-2 polypeptide or nucleic acid levels are also disclosed. Methods for inducing a vascular leak using an Ang-2 agonist are also disclosed.

The present invention relates to characterizing changes in mammalian bacterial gastrointestinal, cutaneous and nasal microbiota associated with antibiotic treatment and various disease conditions (such as asthma, allergy, obesity, metabolic syndrome, gastrointestinal reflux disease (GERD), eosinophilic esophagitis, gastro-esophageal junction adenocarcinomas (GEJAC), infections due to bacteria that are resistant to antibiotics, including Methicillin-resistant Staphylococcus aureus (MRSA), Clostridium difficile, vancomycin-resistant enterococci, etc.) and related diagnostic and therapeutic methods. Therapeutic methods of the invention involve the use of live bacterial inoculants that are capable of restoring healthy mammalian bacterial gastrointestinal, skin, and nasal microbiota.

The present invention relates to certain substituted pyridinyl and pyrimidinyl derivatives of Fomula (Ia) that are modulators of metabolism.

Accordingly, compounds of the present invention are useful in the treatment of metabolic-related disorders and complications thereof, such as, diabetes and obesity.

The present invention relates to certain substituted aryl and heteroaryl derivative of Formula (I) that are modulators of metabolism. Accordingly, compounds of the present invention are useful in the treatment of metabolic-related disorders and complications thereof, such as, diabetes and obesity.

Compositions for treating psychotic disorders comprise a first ingredient and a second ingredient, wherein the first ingredient comprises at least one antipsychotic agent selected from the group consisting of ziprasidone, olanzapine and risperidone and the second ingredient comprises at least one anticonvulsant selected from the group consisting of zonisamide and topiramate. Methods of treating psychotic disorders, symptoms associated with psychotic disorders, and side effects associated with antipsychotic agents, comprise administering a first ingredient and a second ingredient, wherein the first ingredient comprises at least one antipsychotic agent selected from the group consisting of ziprasidone, olanzapine and risperidone and the second ingredient comprises at least one anticonvulsant selected from the group consisting of zonisamide and topiramate. The second ingredient of the compositions and methods may further comprise an antidepressant. In various embodiments, the antipsychotic agent and the anticonvulsant act synergistically to alleviate symptoms and/or side effects associated with psychotic disorders and their treatment.

The invention relates to an unmanned helicopter three-dimensional positioning and mapping method based on laser detection and image recognition, which belongs to the technical field of application of unmanned aerial vehicles. A distance measurement sensor based on laser detection and image recognition, an altimetric sensor and a flight control computer are comprised, wherein the distance measurement sensor consists of a vehicle-mounted camera and a laser emitter and used for detecting the distance from the unmanned helicopter to obstacles around. The distance measurement sensor is used for detecting and measuring distance for the around environment of the unmanned helicopter by means of changing the angle of pitch and the angle of yaw. The altimetric sensor is used for measuring the flight altitude from the unmanned helicopter to the ground. The distance measurement data obtained from the measurement under different angles of altitude, angles of yaw and flight altitudes can realize three-dimensional synchronous positioning and mapping of unknown environment by the unmanned helicopter. In the invention, the around environment can be rapidly, simply and reliably detected during the flying by carrying the distance measurement sensor based on laser detection and image recognition on the unmanned helicopter.

This invention provides methods for alleviating seizure disorders in an animal, particularly epilepsy, by regulating the flux through the gluconeogenic enzyme PEPCK in brain cells.

The present invention relates to certain substituted aryl and heteroaryl derivatives as shown in Formula (Ia) that are modulators of metabolism. Accordingly, compounds of the present invention are useful in the prophylaxis or treatment of metabolic disorders and complications thereof, such as, diabetes and obesity.

The present invention relates to certain trisubstituted aryl and heteroaryl derivatives of Formula (I) that are modulators of metabolism.

Accordingly, compounds of the present invention are useful in the prophylaxis or treatment of metabolic disorders and complications thereof, such as, diabetes and obesity.

This invention provides methods for alleviating paroxysmal disorders in an animal, particularly epilepsy, by modulating glycolysis in brain cells.

The present invention relates to microorganisms for the treatment or the prevention of obesity or diabetes mellitus, which reduce the amount of monosaccharide or disaccharide which may be absorbed into human body by converting monosaccharides such as glucose, fructose, galactose et al. and disaccharides into polymeric materials which cannot be absorbed by the intestine, and relates to a pharmaceutical composition containing the said microorganisms.

Nutritive proteins are provided herein. Also provided are various other embodiments including nucleic acids encoding the proteins, recombinant microorganisms that make the proteins, vectors for expressing the proteins, methods of making the proteins using recombinant microorganisms, compositions that comprise the proteins, and methods of using the proteins. Nutritive proteins include engineered proteins, wherein the engineered proteins comprise a sequence of at least 20 amino acids that comprise an altered amino acid sequence compared to the amino acid sequence of a reference secreted protein and a ratio of essential amino acids to total amino acids present in the engineered protein higher than the ratio of essential amino acids to total amino acids present in the reference secreted protein. In some embodiments, the engineered protein comprises at least one essential amino acid residue substitution of a non-essential amino acid residue in the reference secreted protein.

The invention discloses a non-splash, low-deformation, high-quality and high-efficiency welding method for a T-shaped joint of an aluminum alloy sheet, which belongs to the technical field of low-deformation, high-quality and high-efficiency welding of a light metal sheet. The method mainly comprises the following steps of: controlling a short-circuited transferred arc composite heat source to perform double side welding from both sides of a rib plate 1 by using two relatively independent laser-precision waveforms, wherein precision waveform control electric arc ensures that welding current is mainly maintained at a very small value when a molten dropping liquid bridge is fractured by tension by controlling current and voltage waveforms during molten drop short circuiting transfer so as to prevent welding splash when short circuiting transfer occurs; and controlling the distance between two laser beams 4 and 11 and a welding wire filling speed within certain ranges and reasonably matching included angles between arc welding guns 5 and 10 and a substrate 2 and included angles between the laser beams 4 and 11 and the substrate 2 so as to obtain the non-splash, low-deformation and low-weight gain T-shaped joint. The welding method of the invention is suitable for high-quality welding of T-shaped joints for aluminum alloy and other light metal sheets.

Compositions, methods, and kits useful for treating hyperlipidemic conditions are provided herein. Such compositions can contain synergizing amounts of nicotinic acid, nicotinamide riboside and/or nicotinic acid metabolites in combination with leucine and/or a leucine metabolite, with or without resveratrol.

A composition comprising chromium and insulin and/or a chromium-insulin complex, its method of preparation, and its use in the prevention and treatment of hypoglycemia and hypoglycemia-related conditions. This composition can be administered in numerous ways, including parenterally, intranasally, and orally. The composition stabilizes serum glucose levels and has a synergistic effect compared to chromium and insulin administered separately.

The invention discloses a novel reinforcement method for a two-way curved arch bridge comprising the following steps: (1) closing to traffic on a bridge deck, dismantling the bridge deck and auxiliary facilities of the bridge deck and removing fillings on arches; (2) cutting rectangular grooves along the two-way curved arch bridge on the top of an extrados corresponding to an original arch rib; (3) chipping the bottom of the rectangular grooves, planting anti-shear reinforcement bars, erecting a formwork on the extrados on the top of the rectangular grooves, assembling the anti-shear reinforcement bars and pouring concrete to form new arch ribs, of which the height is same relative to the extrados, protruding from the extrados; (4) repairing transverse walls, chipping the sections, which are at the outer side of the transverse walls along the two-way curved arch bridge, of the extrados and the new arch ribs, planting reinforcement bars on the extrados and the new arch ribs which are chipped, erecting the formwork and pouring the concrete; (5) chipping the top of the transverse walls, planting vertical reinforcement bars and erecting new columns for supporting the bridge deck; (6) newly building the bridge deck. The novel reinforcement method for the two-way curved arch bridge has the advantages of being small in dead weight of a bridge structure, good in unity of an old structure and a new structure, low in reinforcement cost, good in adaptability, not restricted by surroundings under the two-way curved arch bridge, unchanged about the original appearance of the two-way curved arch bridge, good in operability and good in application prospect.

The invention provides a structure suitable for a thrust augmentation type turbofan engine and capable of realizing backward radar and infrared comprehensive stealth. The structure comprises a shielding support plate, an inner cone and a trailing edge blowing flame stabilizer, and is simple in structure, high in reliability, small in weight gain and small in aerodynamic loss, and the radar and infrared stealth performance can be remarkably improved only by virtue of the self structure.