9 results about "Antipsychotic Agent" patented technology

The present application relates to a sustained release delivery composition of a vesicular monoamine transporter type 2 (VMAT2) inhibitor, a deuterated derivative thereof, a pharmaceutically acceptable salt thereof, an active metabolite thereof, or a prodrug thereof for treatment of hyperkinetic movement disorders including, but not limited to, tardive dyskinesia (TD), Huntington's disease (HD) chorea, tremors, dystonia, chorea, tics, myoclonus, stereotypies, restless legs syndrome, and various other disorders with abnormal involuntary movements. The present application also relates to a sustained release delivery composition of an antipsychotic agent, a pharmaceutically acceptable salt thereof, an active metabolite thereof, or a prodrug thereof for treatment of schizophrenia, bipolar disorder, and other psychiatric diseases or disorders. The method of making or using the composition is also disclosed.

The present disclosure relates to methods of treating neurological or psychiatric diseases or disorders, such as schizophrenia. Compound 1, or a pharmaceutically acceptable salt thereof, is an antipsychotic agent with a non-D2 mechanism of action. Adverse events associated with antipsychotic agents that target the D2 dopamine receptor can be reduced by treating disorders with Compound 1, or a pharmaceutically acceptable salt thereof.

Provided is a superior, novel heterocyclic compound with improved solubility in oil such as sesame oil and benzyl benzoate, which has a broader treatment spectrum, causes less side effects, and is superior in tolerability and safety, and use thereof. A heterocyclic compound represented by the formula (I) wherein each symbol is as defined in the specification, or a salt thereof.

In some embodiments, a method of treating a patient with an antipsychotic agent can include identifying the patient as an antipsychotic agent responder. The method can further include obtaining an electroencephalogram (EEG) signals from the patient. The method can further include measuring one or more EEG metrics, thereby identifying the patient as an antipsychotic agent responder. If the patient is an antipsychotic agent responder, the method can further include then administering the antipsychotic agent.

Formulations of dendrimer conjugated to one or more antidepressant or antipsychotic agents, having greater selectivity of targeting to cell types and decreased risk of side effects, and methods of use thereof, have been developed. Preferably, the dendrimer-conjugated antidepressant or antipsychotic agents selectively bind to one or more receptors on the surface or inside the target cells. The formulations are suitable for enteral or parenteral delivery for treating one or more diseases, conditions, and injuries in the central and peripheral nervous system.

The present disclosure relates to methods of treating neurological or psychiatric diseases or disorders, such as schizophrenia. Compound 1, or a pharmaceutically acceptable salt thereof, is an antipsychotic agent with a non-D2 mechanism of action. Adverse events associated with antipsychotic agents that target the D2 dopamine receptor can be reduced by treating disorders with Compound 1, or a pharmaceutically acceptable salt thereof.

The disclosure relates to the use of phosphodiesterase 1 (PDE1) inhibitors in combination with a Compound of Formula VIII or a Compound of Formula IX, as described herein, or in combination with an antiemetic agent, such as an antipsychotic agent, e.g., olanzapine, for preventing or treating nausea and / or vomiting, e.g., CINV (chemotherapy-induced nausea and vomiting). In some embodiments, the Compound of Formula VIII or the Compound of Formula IX is used as mono-therapy (i.e., without a PDE1 inhibitor).

This application relates to methods of treating neurological or psychiatric diseases or disorders such as schizophrenia. Compound 1 or a pharmaceutically acceptable salt thereof is an antipsychotic with a non-D2 mechanism of action. By treating these disorders using Compound 1 or a pharmaceutically acceptable salt thereof, adverse events associated with antipsychotics that target D2 dopamine receptors can be reduced.

The present invention relates to a pharmaceutical composition that provides long-term stability of a hydrolytically labile antipsychotic agent