154 results about "Sarcosine" patented technology

The invention discloses an oral care desensitization paste and a preparation method thereof, and mainly relates to the technical field of dental medicines. The oral care desensitization cream is prepared from the following components: bioactive glass, strontium chloride, sodium chloride, silicon dioxide, sodium carboxymethyl cellulose, polyethylene glycol 400, a xanthan gum solution, sodium lauryl sulfate, sodium lauroyl sarcosinate, titanium dioxide, beta-glucan, saccharin sodium salt, sorbitol, methylparaben, propyl hydroxybenzoate, edible essence and water. Compared with the prior art, the oral care desensitization paste disclosed by the invention can be used for sealing dentinal tubules and treating hemodia; the traditional Chinese medicine composition can also be used for treating plaque gingivitis, relieving and reducing gingival bleeding and inhibiting and reducing dental plaque; and meanwhile, the condition of mistakenly swallowing and eating in the using process is reduced.

The invention relates to the technical field of metal working fluids, in particular to a degradable environment-friendly vegetable oil-based semi-synthetic cutting fluid and a preparation method thereof. The cutting fluid comprises 20-30 parts of vegetable lubricating oil, 10-20 parts of an alkali storage agent, 2-5 parts of a corrosion inhibitor, 3-5 parts of a coupling agent, 5-8 parts of a surfactant and 6-11 parts of a composite anti-rust agent, the composite anti-rust agent comprises an anti-rust agent A and an anti-rust agent B, the anti-rust agent A comprises N-[3-(dimethylamino) propyl]-N, N-dimethylformamide, and the anti-rust agent B comprises N-[3-(dimethylamino) propyl]-N, N-dimethylformamide. The antirust agent A comprises at least one of N, N ', N'-trimethyl-1, 3-propanediamine, benzotriazole, sebacic acid and 2, 4, 6-tri (aminocaproic acid)-1, 3, 5-triazine, and the antirust agent B comprises at least one of an imidazoline compound and fatty acid sarcosine ester. The cutting fluid provided by the invention has excellent corrosion resistance, rust resistance, defoaming property, biodegradability and storage stability, and has a good application prospect.

The invention discloses a PSA electrotinning insoluble anode system and a production method of an electrotinning plate, and relates to the technical field of electrotinning. The PSA tin electroplating insoluble anode system comprises an electroplating additive which is composed of benzotriazole, N-oleoyl sarcosine, S-carboxyethyl thiosuccinic acid and sodium citrate. The problems of serious black ash and poor coating performance of an electroplated tin plate product are solved, the tin plating stability of a plating solution in an electroplating bath is improved, the black ash on the surface of the electroplated tin plate product can be effectively reduced, the requirements of low black ash and high adhesive force on the surface of an electroplated tin plate of a PSA (Pressure Swing Adsorption) electroplated tin insoluble anode system are met, and the service life of the electroplated tin plate is prolonged. The electroplated tin plate produced through the PSA electroplated tin insoluble anode system is bright and clean in plating layer surface, and after the tin layer surface with the thickness of 8.4 g / m < 2 > and below is wiped through test paper, the reduction percentage of the test paper whiteness caused by black ash is smaller than or equal to 10%.

The present invention provides synthetic peptide compounds and uses thereof for therapy and diagnostics of complement-mediated diseases, such as inflammatory diseases, autoimmune diseases, and microbial and bacterial infections; and non-complement-mediated diseases, such cystic fibrosis and various acute diseases. The invention is directed to modifications of a synthetic peptide of 15 amino acids from the Polar Assortant (PA) peptide, which is a scrambled peptide derived from human Astrovirus protein. In some embodiments, the invention is directed to peptide compounds that are peptide mimetics, peptide analogs and / or synthetic derivatives of PA (e.g., sarcosine derivatives) having, for example, internal peptide substitutions, and modifications, including PEGylation at the N-terminus and C-terminus. The invention further provides methods of selecting at least one synthetic peptide for treating various conditions.

The invention relates to the technical field of face cleansing gels, in particular to a hexagonal liquid crystal face cleansing gel and a preparation method thereof.The hexagonal liquid crystal face cleansing gel at least comprises, by mass, a phase A: 20-26% of sodium lauroyl sarcosinate and 0-1.5% of an auxiliary surfactant; a phase B: 3-8% of propylene glycol laurate; a phase C: 0.01%-4.5% of glycerol laurate; phase D: 1 to 5 percent of polyglycerol-2 laurate; 0-2% of an auxiliary agent; and deionized water: complementing the balance. By optimizing a product formula system, an amino acid cleansing product which has a transparent appearance similar to that of micelle type amino acid cleansing cream, can not depend on addition of a large number of polymers to assist thickening and shows a non-flowing appearance texture is prepared, and the amino acid cleansing product has extremely high market application and popularization value.

The invention belongs to the technical field of sarcosine detection, and relates to an integrated sarcosine detection device as well as a preparation method, a detection method and application thereof. The device consists of a sample bottle and a double-layer paper chip, wherein the double-layer paper chip is fixed in a bottle cap of the sample bottle; the double-layer paper chip comprises a target recognition layer and a detection layer, the target recognition layer is Whatman 1 # filter paper loaded with SOx / HRP-coated MAF-7 biological composite materials, the detection layer is Whatman 1 # filter paper loaded with TMB color developing agents, and the layers are bonded through water-soluble double-faced adhesive tapes. After a sample is added into the sample bottle, the bottle is turned over, SOx can recognize and oxidize sarcosine to obtain H2O2, after the double-sided adhesive tape is fully reacted and dissolved, HRP oxidizes a substrate TMB in the presence of H2O2 to generate a bright blue product oxTMB, and RGB signals are recorded through a handheld colorimeter. The detection device can be used for quantitatively detecting the sarcosine content of the prostatic cancer marker.

This invention provides a continuous method for preparing high-purity creatine monohydrate, comprising the following steps: a) adding chloroacetic acid aqueous solution dropwise to an aqueous methylamine solution, stirring at room temperature for 2 hours after the addition is complete; b) heating to 50-60°C and holding for 1 hour to remove most of the methylamine, then heating to 95°C to evaporate the methylamine aqueous solution for 1 hour; c) adding sodium hydroxide solution dropwise to the solution from step b) at 95°C, then heating to 105°C and concentrating under reduced pressure for 1.5 hours to approximately half the original volume, obtaining a creatine solution with a concentration of 30%-40%; d) cooling the solution from step c) to 40-60°C and adding a catalyst; e) drying to obtain pure creatine monohydrate. This invention reduces the methylamine equivalent, saving costs, and eliminates the need for purifying creatine for direct use in the next reaction; it can simultaneously lower the system reaction temperature and pH value to inhibit the formation of byproducts dicyandiamide and creatinine, and eliminates the need for debittering agents for purification and debittering, thus saving production costs.

The invention belongs to the technical field of biosensors, and provides molecularly imprinted hydrogel for sarcosine detection, a micro-strain conduction sensor and a preparation method of the micro-strain conduction sensor. The hydrogel is prepared by the following steps: carrying out photo-initiation polymerization on a gel pre-polymerization solution containing a 4-vinylpyridine monomer, a 2-acrylamide-2-methylpropanesulfonic acid monomer, an acrylamide monomer, sarcosine template molecules, a cross-linking agent and a photoinitiator, and washing to remove the sarcosine template molecules. The micro strain conduction sensor is composed of a hydrogel layer and a resistance strain gauge, and the hydrogel layer is chemically bonded to one side of the resistance strain gauge and completely covers sensitive grid wires of the resistance strain gauge. The hydrogel disclosed by the invention has excellent specific recognition capability on sarcosine, and high-sensitivity and high-selectivity detection of sarcosine in a complex matrix sample can be realized through the micro strain conduction sensor disclosed by the invention.

This invention relates to the field of hair care products technology, specifically disclosing a plant-based compound fermented oil-controlling and volumizing shampoo and its preparation process. The raw materials, by weight, include: 15-25 parts sodium lauroyl sarcosinate, 8-15 parts potassium cocoyl glycinate, 10-18 parts soapberry fruit fermentation liquid, 6-12 parts arborvitae leaf fermentation extract, 5-10 parts rosemary leaf fermentation liquid, 3-6 parts hydrolyzed oat protein, 2-5 parts panthenol, 0.1-0.5 parts piroctone olamine, 0.2-0.6 parts xanthan gum, 0.4-0.8 parts phenoxyethanol, and 40-60 parts deionized water. This invention utilizes a triple plant-based low-temperature anaerobic fermentation process, combined with a mild amino acid surfactant system, to provide multiple benefits including gentle cleansing, long-lasting oil control, hair root lifting, and scalp care. It is suitable for oily scalps and fine, limp hair.

The present invention provides synthetic peptides, compositions containing synthetic peptides, and methods for modifying the complement system. [Solution] The present invention relates to the modification of a 15-amino acid synthetic peptide from polar assortant (PA) peptides, which are scrambled peptides derived from human astrovirus protein. In some embodiments, the present invention relates to peptides that are modified PAs, which are stapled and / or have D-enantiomer substitutions of certain amino acids, and which include sarcosine substitutions at certain amino acid positions. The present invention further provides a method for selecting at least one synthetic peptide to treat various conditions.

This invention provides a composition for balancing skin sebum secretion, its preparation method, and its application. The composition comprises the following components: Lactobacillus fermentation lysate, yeast / zinc fermentation product, niacinamide, zinc PCA, medicinal spore extract, *Salix friesiensis* extract, capryloyl glycine, Ceylon cinnamon bark extract, and sarcosine. The composition for balancing skin sebum secretion provided by this invention utilizes multiple oil-controlling ingredients to inhibit sebum secretion through multiple pathways, while also possessing certain moisturizing and soothing effects.

The invention provides application of an Slc36a1 agonist in preparation of a medicine for preventing and / or treating colitis, and belongs to the technical field of biology. According to the invention, 4-GBA or sarcosine is applied to a colitis model mouse, and clinical and histological phenotypes of DSS-induced colitis can be significantly improved. According to experiments of colonic organs and mice, 4-GBA enhances intestinal mucosal barrier and promotes intestinal homeostasis by up-regulating Slc36a1. According to the invention, 4-GBA or sarcosine molecules targeting Slc36a1 are taken as a core, and the limitation of an existing treatment strategy is broken through by synchronously solving a linkage mechanism of stem cell regeneration-goblet cell differentiation-mucous barrier repair.

The invention discloses a universal sample type nucleic acid releasing agent and application thereof. The nucleic acid releasing agent is prepared from the following components in molar concentration: 20 to 100 mM of Tris-HCl, 30 to 500 mM of sodium chloride, 30 to 200 mM of ammonium sulfate, 1 to 6 mM of EDTA (Ethylene Diamine Tetraacetic Acid), 1 to 8 mM of a reducing agent, 0.1 to 0.2 percent of sodium dodecyl sarcosinate, 0.1 to 3 mM of Surfactin, 5 to 30 percent of Chelex-100 and 5 to 15 percent of trehalose. According to the method, various samples can be mildly split, impurities such as impure proteins and lipids can be effectively removed, the complexity of nucleic acid samples is reduced, and the method is seamlessly jointed with subsequent PCR (Polymerase Chain Reaction); the kit has double effects of sample preservation and splitting decomposition, can strongly inhibit various nuclease, and can ensure the long-term storage stability of samples.

Provided is a cyclic peptide, which has a sequence of cyclo(X1X2X3X4X5X6), wherein X1 is asparagine; X2 is glycine or sarcosine; X3 is arginine; X4 is selected from a group consisting of threonine, tyrosine, and phenylalanine; X5 is lysine; and X6 is selected from a group consisting of tyrosine, valine, and glutamic acid. Provided is a preparation method for the cyclic peptide. Provided is a complex, comprising the cyclic peptide, a linker, and a chelating agent. Provided is a use of the complex as a radionuclide-labeled targeting molecule. Provided is a radionuclide labeling method, comprising bringing a complex that chelates a radionuclide into contact with an object to be labeled by the radionuclide.

The invention provides a whitening composition as well as a preparation method and application thereof, and belongs to the technical field of cosmetics. According to the whitening composition provided by the invention, the isopropyl lauroyl sarcosinate, the diisopropyl sebacate, the PPG-14 polyglycerol-2 ether, the bis-diethoxy diglycol cyclohexane 1, 4-dicarboxylate and the poly C10-30 alkanol acrylate are used as oil phases to wrap the whitening components (magnolol, pterostilbene, ferulic acid and dimethyl methoxy benzodihydropyranol) so as to form oil sacs, so that the whitening composition can be used for whitening the skin; and then dispersing in a polyhydric alcohol and carbomer matrix to control the composition of the oil phase and the whitening component, so that the whitening effect and the transdermal absorption effect of the whitening composition are improved.

The invention relates to the technical field of nephritis medicine, in particular to an AAGN disease metabolism marker, a kit and application of the AAGN disease metabolism marker. In the blood or urine metabolism marker, the blood metabolism marker is prepared from one or more of 6-methyl nicotinamide, hypo-sulphosarcosine, guanosine, allopurinol, 8-hydroxy-2 '-deoxyguanosine, triglyceride or lysophosphatidylcholine; the urine metabolism markers comprise one or more of D-malic acid, leucyl-alanyl-valine, N-hydroxymethyl nicotinamide, DL-tribulus terrestris alkali, isoxotrexate, 1, 3-dimethyluric acid, leucyl-leucyl-phenylalanine, alloandrosterone, enterodiphenol and p-coumarin, and the urine metabolism markers comprise one or more of D-malic acid, leucyl-alanyl-valine, N-hydroxymethyl nicotinamide, DL-tribulus terrestris alkali, isoxotrexate, 1, 3-dimethyluric acid, leucyl- The metabolic marker combination and the kit are used for evaluating the disease activity state of a patient suffering from ANCA-related glomerulonephritis (AAGN), and have good repeatability, stability and biological correlation.

The invention relates to the technical field of nucleic acid detection, in particular to a lysis buffer solution, a kit and an extraction method for extracting free DNA of peripheral blood. The lysis buffer solution for extracting the free DNA of the peripheral blood comprises a first lysis solution and a second lysis solution, the first lysis solution takes guanidine hydrochloride as a main chaotropic agent and at least one of ammonium thiocyanate and guanidine isothiocyanate as an auxiliary chaotropic agent, and is compounded with a metal ion chelating agent, trehalose, dithiothreitol, digestive enzyme, sodium dodecyl sarcosinate, borate and ascorbic acid; the second lysis solution takes guanidine hydrochloride as a main chaotropic agent and urea as an auxiliary chaotropic agent, and is compounded with a metal ion chelating agent, trehalose, dithiothreitol, digestive enzyme, sodium dodecyl sarcosinate, borate, ascorbic acid and polyethylene glycol. The buffer solution of the lysate does not contain SDS (sodium dodecyl sulfate), so that the residue of SDS in an extracted product can be avoided, and the amount of extracted free DNA (deoxyribonucleic acid) is more.

To provide a novel skin cleansing agent, particularly one that leaves the skin feeling smooth after washing. [Solution] (A) Oleoyl sarcosine or its salt (B) Polyglycerol fatty acid esters in which two or more fatty acids are bonded together. A skin cleansing agent containing at least [a certain ingredient].

The present invention relates to a novel liposome composition and its application in cosmetics, and the liposome composition comprises an active ingredient, sodium stearoyl glutamate and isopropyl lauroyl sarcosinate.

The present invention aims to provide a liquid oral composition that can suppress the reduction in flavor expression caused by glycyrrhizic acid or its salts by incorporating acyl amino acids or their salts. [Solution] A liquid oral composition comprising: (A) component: at least one selected from the group consisting of glycyrrhizic acid and its salts; (B) component: at least one selected from the group consisting of acyl amino acids and their salts; and (C) component: a fragrance, wherein the ratio of the content of component (A) to the content of component (B) is 0.625 to less than 2.2 when component (B) contains acyl sarcosine and its salts, and 0.03 to less than 5 when component (B) does not contain acyl sarcosine and its salts, and substantially free of ethyl alcohol.

The invention discloses a biosynthesis process of creatine monohydrate, and belongs to the technical field of bioengineering. The invention discloses a creatine monohydrate biosynthesis method, which is characterized in that sarcosine invertase is utilized to catalyze chloroacetic acid and monomethylamine to generate N-alkylation reaction so as to prepare sarcosine, and then creatine monohydrate is generated under the catalysis of the creatine invertase, the process is mild in reaction condition, the temperature is 25-37 DEG C, the pH is 6.0-8.0, the energy consumption is lower, the conversion efficiency is high, the environment is protected, and the economical efficiency is high. The invention provides a new synthesis method for sustainable synthesis of creatine monohydrate, and provides a new idea for industrial production of creatine monohydrate.

It is an object of the present invention to provide a primer composition for surface-printed flexible packaging, an ink set, a surface-printed matter, and an inkjet printing method, which can impart excellent solid uniformity, bleeding resistance, abrasion resistance, alcohol resistance, and heat resistance to a coating film when an inkjet image is formed after applying the primer composition. Provided is a primer composition for surface-printed flexible packaging comprising an acryl-based resin emulsion emulsified with a polymer, N-oleoyl sarcosine, a hydrazine-based compound having at least two or more hydrazine residues in a molecule, and wax, wherein a content of the acryl-based resin emulsion is 3 to 40% by mass in terms of solid content, and wherein a glass transition temperature of the acryl-based resin emulsion is-40 to 30° C.

The invention discloses long-acting anti-dandruff shampoo based on microbial balance regulation and a preparation method of the long-acting anti-dandruff shampoo. The shampoo comprises a cleaning system composed of sodium lauroyl sarcosinate, cocamidopropyl betaine and decyl glucoside, a micro-ecological regulation system composed of piroctone olamine, inulin and a lactobacillus fermentation product, and skin barrier repairing lipids such as ceramide and squalane. According to the preparation method, all the components are effectively integrated through a step-by-step temperature control and homogeneous emulsification process. Through the synergistic effect of the components, malassezia is efficiently inhibited, effective microbial communities on scalp are selectively maintained, and a skin barrier is repaired, so that scalp micro-ecological balance is regulated and controlled, long-acting dandruff removal is realized, the scalp health level is improved, and the scalp care effect is improved. The problems that a traditional anti-dandruff product is likely to cause dysbacteriosis, the effect is not lasting, and relapse is caused after the traditional anti-dandruff product is stopped are solved.

Methods and dispersing agents for dispersing a polymeric low dose hydrate inhibitor are disclosed. More specifically, the method comprises contacting an aqueous fluid containing a polymeric low dose hydrate inhibitor with a dispersing agent. The dispersing agent can be selected from the group consisting of a C1-C20 alkyl sulfate, a C10-C20 alkyl ether sulfate, a C10-C20 carbonyl sarcosinate, a C10-C20 alkylbenezene sulfonate, a quaternary-ammonium based corrosion inhibitor, a glycol ether, and a combination thereof.

The invention discloses a whitening facial cleanser and a preparation method thereof, and relates to the field of skin care products. The whitening facial cleanser is prepared from 35 to 42 weight percent of a cleaning agent, 1 to 2 weight percent of a whitening and freckle-removing agent, 0.8 to 1.2 weight percent of a skin conditioner, 4 to 8 weight percent of an emollient, 4 to 6 weight percent of a humectant, 0.3 to 0.5 weight percent of a preservative, 0.05 to 0.1 weight percent of a chelating agent, 4 to 4.5 weight percent of a thickening agent, 0.2 to 0.5 weight percent of an aromatic, 0.8 to 1.0 weight percent of a pH regulator and the balance of a solvent. The cleaning agent is prepared from sodium lauroyl isethionate, sodium cocoyl aminopropionate, cocamidopropyl betaine and sodium lauroyl sarcosinate according to the weight ratio of (3.5 to 4.5) to 1 to 1 to 1; the preservative comprises DMDM hydantoin and methylparaben in a weight ratio of (3-4): 1. The whitening facial cleanser provided by the invention has both cleaning power and mildness, and also has a whitening effect.

The invention discloses a sample treating fluid, a vitamin B12 detection sample pretreatment method, a detection kit, a detection method and application thereof, and particularly discloses the sample treating fluid which comprises strong base and sodium dodecyl sarcosinate. According to the sample treatment liquid, VB12 can be completely dissociated, and a relatively stable state can be kept. The invention further provides a detection sample pretreatment method of the vitamin B12. The detection sample pretreatment method comprises the step of mixing the sample treatment liquid with a to-be-detected sample for reaction. According to the sample treatment liquid provided by the invention, VB12 can still be dissociated from binding protein under the condition that highly toxic cyanide or a complex containing cyanide ions and unstable in dissociation is not adopted, and the VB12 can be kept in a relatively stable state to participate in subsequent reaction.

The invention discloses efficient deep penetration acid liquor as well as a preparation method and application thereof. The efficient deep penetration acid liquor comprises the following components in parts by mass: 20-35 parts of a main acid agent, 5-15 parts of a penetration enhancer, 2-6 parts of a corrosion inhibitor, 2-5 parts of a stabilizer and 40-70 parts of deionized water, wherein the main acid agent is a compound of main acid and auxiliary acid, and the penetration enhancer is a compound of fatty alcohol-polyoxyethylene ether and sodium lauroyl sarcosinate. Main body acid (one or two of sulfamic acid and chloroacetic acid) and auxiliary acid (one or two of formic acid and acetic acid) are compounded to serve as a main acid agent, and the main acid agent is combined with a penetration enhancer compounded by fatty alcohol-polyoxyethylene ether and sodium lauroyl sarcosinate, a corrosion inhibitor and a stabilizer. The core goals of deep penetration and low corrosion are jointly achieved, and the method can be applied to various scenes such as soil improvement, oil and gas exploitation and industrial equipment cleaning in a cross-field mode.

The present invention relates to a cyclic peptide comprising an active region comprising the amino acid sequence X1X2X3X4X5X6 or a salt, derivative, prodrug or mimetic thereof. X2 and X5 are arginine; and either:X1 is (7-methoxy-coumarin-4-yl)-Ala-OH (Dac) and X3, X4 and X6 are any amino acid; orX3 is sarcosine (Sar) and X1, X4 and X6 are any amino acid; orX4 is 5,5-dimethylproline (dmPro) or 3-amino-3-(2-naphthyl)propionic acid (Nap) and X1, X3 and X6 are any amino acid; orX6 is Nap and X1, X3 and X4 are any amino acid.The present invention further relates to a pharmaceutical composition comprising the cyclic peptide and the peptide for use in medicine, and particularly cancer.

It is an object of the present invention to provide a primer composition for surface-printed flexible packaging, an ink set, a surface-printed matter, and an inkjet printing method, which can impart excellent solid uniformity, bleeding resistance, abrasion resistance, alcohol resistance, and heat resistance to a coating film when an inkjet image is formed after applying the primer composition. Provided is a primer composition for surface-printed flexible packaging comprising an acryl-based resin emulsion emulsified with a polymer, N-oleoyl sarcosine, a hydrazine-based compound having at least two or more hydrazine residues in a molecule, and wax, wherein a content of the acryl-based resin emulsion is 3 to 40% by mass in terms of solid content, and wherein a glass transition temperature of the acryl-based resin emulsion is-40 to 30° C.

The invention discloses a device for synthesizing sodium sarcosinate through micro-channel continuous flow, and relates to the technical field of sodium sarcosinate synthesis. The device comprises a glycine methylation reaction channel unit, a catalyst recovery assembly, a sarcosine crystallization and purification channel unit, a sarcosine neutralization reaction pipeline and a sodium sarcosine concentration and crystallization one-piece tank unit, the glycine methylation reaction channel unit comprises a raw material mixing pre-reaction pipe, a catalyst adding tank, a plunger type high-pressure pump and a high-pressure micro-channel reaction pipeline combination; the sarcosine crystallization and purification channel unit comprises a hydrogen volatilization channel, a formaldehyde volatilization and concentration channel and a glycine crystallization channel; the sodium sarcosinate concentration and crystallization integrated tank unit comprises a concentration tank, a first crystallization tank, a redissolution tank and a second crystallization tank. According to the invention, the reaction is carried out through the continuous microchannel, the reaction process separation is simpler than the traditional reaction process separation, the raw material utilization rate is high, and the problems of high preparation cost, troublesome operation, incapability of continuous production and the like of the existing glycine methylation method are solved.