117 results about "Sarcosine" patented technology

The invention relates to the technical field of metal working fluids, in particular to a degradable environment-friendly vegetable oil-based semi-synthetic cutting fluid and a preparation method thereof. The cutting fluid comprises 20-30 parts of vegetable lubricating oil, 10-20 parts of an alkali storage agent, 2-5 parts of a corrosion inhibitor, 3-5 parts of a coupling agent, 5-8 parts of a surfactant and 6-11 parts of a composite anti-rust agent, the composite anti-rust agent comprises an anti-rust agent A and an anti-rust agent B, the anti-rust agent A comprises N-[3-(dimethylamino) propyl]-N, N-dimethylformamide, and the anti-rust agent B comprises N-[3-(dimethylamino) propyl]-N, N-dimethylformamide. The antirust agent A comprises at least one of N, N ', N'-trimethyl-1, 3-propanediamine, benzotriazole, sebacic acid and 2, 4, 6-tri (aminocaproic acid)-1, 3, 5-triazine, and the antirust agent B comprises at least one of an imidazoline compound and fatty acid sarcosine ester. The cutting fluid provided by the invention has excellent corrosion resistance, rust resistance, defoaming property, biodegradability and storage stability, and has a good application prospect.

The present invention provides synthetic peptide compounds and uses thereof for therapy and diagnostics of complement-mediated diseases, such as inflammatory diseases, autoimmune diseases, and microbial and bacterial infections; and non-complement-mediated diseases, such cystic fibrosis and various acute diseases. The invention is directed to modifications of a synthetic peptide of 15 amino acids from the Polar Assortant (PA) peptide, which is a scrambled peptide derived from human Astrovirus protein. In some embodiments, the invention is directed to peptide compounds that are peptide mimetics, peptide analogs and / or synthetic derivatives of PA (e.g., sarcosine derivatives) having, for example, internal peptide substitutions, and modifications, including PEGylation at the N-terminus and C-terminus. The invention further provides methods of selecting at least one synthetic peptide for treating various conditions.

This invention provides a continuous method for preparing high-purity creatine monohydrate, comprising the following steps: a) adding chloroacetic acid aqueous solution dropwise to an aqueous methylamine solution, stirring at room temperature for 2 hours after the addition is complete; b) heating to 50-60°C and holding for 1 hour to remove most of the methylamine, then heating to 95°C to evaporate the methylamine aqueous solution for 1 hour; c) adding sodium hydroxide solution dropwise to the solution from step b) at 95°C, then heating to 105°C and concentrating under reduced pressure for 1.5 hours to approximately half the original volume, obtaining a creatine solution with a concentration of 30%-40%; d) cooling the solution from step c) to 40-60°C and adding a catalyst; e) drying to obtain pure creatine monohydrate. This invention reduces the methylamine equivalent, saving costs, and eliminates the need for purifying creatine for direct use in the next reaction; it can simultaneously lower the system reaction temperature and pH value to inhibit the formation of byproducts dicyandiamide and creatinine, and eliminates the need for debittering agents for purification and debittering, thus saving production costs.

The invention belongs to the technical field of biosensors, and provides molecularly imprinted hydrogel for sarcosine detection, a micro-strain conduction sensor and a preparation method of the micro-strain conduction sensor. The hydrogel is prepared by the following steps: carrying out photo-initiation polymerization on a gel pre-polymerization solution containing a 4-vinylpyridine monomer, a 2-acrylamide-2-methylpropanesulfonic acid monomer, an acrylamide monomer, sarcosine template molecules, a cross-linking agent and a photoinitiator, and washing to remove the sarcosine template molecules. The micro strain conduction sensor is composed of a hydrogel layer and a resistance strain gauge, and the hydrogel layer is chemically bonded to one side of the resistance strain gauge and completely covers sensitive grid wires of the resistance strain gauge. The hydrogel disclosed by the invention has excellent specific recognition capability on sarcosine, and high-sensitivity and high-selectivity detection of sarcosine in a complex matrix sample can be realized through the micro strain conduction sensor disclosed by the invention.

This invention relates to the field of hair care products technology, specifically disclosing a plant-based compound fermented oil-controlling and volumizing shampoo and its preparation process. The raw materials, by weight, include: 15-25 parts sodium lauroyl sarcosinate, 8-15 parts potassium cocoyl glycinate, 10-18 parts soapberry fruit fermentation liquid, 6-12 parts arborvitae leaf fermentation extract, 5-10 parts rosemary leaf fermentation liquid, 3-6 parts hydrolyzed oat protein, 2-5 parts panthenol, 0.1-0.5 parts piroctone olamine, 0.2-0.6 parts xanthan gum, 0.4-0.8 parts phenoxyethanol, and 40-60 parts deionized water. This invention utilizes a triple plant-based low-temperature anaerobic fermentation process, combined with a mild amino acid surfactant system, to provide multiple benefits including gentle cleansing, long-lasting oil control, hair root lifting, and scalp care. It is suitable for oily scalps and fine, limp hair.

The present invention provides synthetic peptides, compositions containing synthetic peptides, and methods for modifying the complement system. [Solution] The present invention relates to the modification of a 15-amino acid synthetic peptide from polar assortant (PA) peptides, which are scrambled peptides derived from human astrovirus protein. In some embodiments, the present invention relates to peptides that are modified PAs, which are stapled and / or have D-enantiomer substitutions of certain amino acids, and which include sarcosine substitutions at certain amino acid positions. The present invention further provides a method for selecting at least one synthetic peptide to treat various conditions.

This invention provides a composition for balancing skin sebum secretion, its preparation method, and its application. The composition comprises the following components: Lactobacillus fermentation lysate, yeast / zinc fermentation product, niacinamide, zinc PCA, medicinal spore extract, *Salix friesiensis* extract, capryloyl glycine, Ceylon cinnamon bark extract, and sarcosine. The composition for balancing skin sebum secretion provided by this invention utilizes multiple oil-controlling ingredients to inhibit sebum secretion through multiple pathways, while also possessing certain moisturizing and soothing effects.

The invention provides application of an Slc36a1 agonist in preparation of a medicine for preventing and / or treating colitis, and belongs to the technical field of biology. According to the invention, 4-GBA or sarcosine is applied to a colitis model mouse, and clinical and histological phenotypes of DSS-induced colitis can be significantly improved. According to experiments of colonic organs and mice, 4-GBA enhances intestinal mucosal barrier and promotes intestinal homeostasis by up-regulating Slc36a1. According to the invention, 4-GBA or sarcosine molecules targeting Slc36a1 are taken as a core, and the limitation of an existing treatment strategy is broken through by synchronously solving a linkage mechanism of stem cell regeneration-goblet cell differentiation-mucous barrier repair.

The invention discloses a universal sample type nucleic acid releasing agent and application thereof. The nucleic acid releasing agent is prepared from the following components in molar concentration: 20 to 100 mM of Tris-HCl, 30 to 500 mM of sodium chloride, 30 to 200 mM of ammonium sulfate, 1 to 6 mM of EDTA (Ethylene Diamine Tetraacetic Acid), 1 to 8 mM of a reducing agent, 0.1 to 0.2 percent of sodium dodecyl sarcosinate, 0.1 to 3 mM of Surfactin, 5 to 30 percent of Chelex-100 and 5 to 15 percent of trehalose. According to the method, various samples can be mildly split, impurities such as impure proteins and lipids can be effectively removed, the complexity of nucleic acid samples is reduced, and the method is seamlessly jointed with subsequent PCR (Polymerase Chain Reaction); the kit has double effects of sample preservation and splitting decomposition, can strongly inhibit various nuclease, and can ensure the long-term storage stability of samples.

Provided is a cyclic peptide, which has a sequence of cyclo(X1X2X3X4X5X6), wherein X1 is asparagine; X2 is glycine or sarcosine; X3 is arginine; X4 is selected from a group consisting of threonine, tyrosine, and phenylalanine; X5 is lysine; and X6 is selected from a group consisting of tyrosine, valine, and glutamic acid. Provided is a preparation method for the cyclic peptide. Provided is a complex, comprising the cyclic peptide, a linker, and a chelating agent. Provided is a use of the complex as a radionuclide-labeled targeting molecule. Provided is a radionuclide labeling method, comprising bringing a complex that chelates a radionuclide into contact with an object to be labeled by the radionuclide.

The invention relates to the technical field of nephritis medicine, in particular to an AAGN disease metabolism marker, a kit and application of the AAGN disease metabolism marker. In the blood or urine metabolism marker, the blood metabolism marker is prepared from one or more of 6-methyl nicotinamide, hypo-sulphosarcosine, guanosine, allopurinol, 8-hydroxy-2 '-deoxyguanosine, triglyceride or lysophosphatidylcholine; the urine metabolism markers comprise one or more of D-malic acid, leucyl-alanyl-valine, N-hydroxymethyl nicotinamide, DL-tribulus terrestris alkali, isoxotrexate, 1, 3-dimethyluric acid, leucyl-leucyl-phenylalanine, alloandrosterone, enterodiphenol and p-coumarin, and the urine metabolism markers comprise one or more of D-malic acid, leucyl-alanyl-valine, N-hydroxymethyl nicotinamide, DL-tribulus terrestris alkali, isoxotrexate, 1, 3-dimethyluric acid, leucyl- The metabolic marker combination and the kit are used for evaluating the disease activity state of a patient suffering from ANCA-related glomerulonephritis (AAGN), and have good repeatability, stability and biological correlation.

The invention relates to the technical field of nucleic acid detection, in particular to a lysis buffer solution, a kit and an extraction method for extracting free DNA of peripheral blood. The lysis buffer solution for extracting the free DNA of the peripheral blood comprises a first lysis solution and a second lysis solution, the first lysis solution takes guanidine hydrochloride as a main chaotropic agent and at least one of ammonium thiocyanate and guanidine isothiocyanate as an auxiliary chaotropic agent, and is compounded with a metal ion chelating agent, trehalose, dithiothreitol, digestive enzyme, sodium dodecyl sarcosinate, borate and ascorbic acid; the second lysis solution takes guanidine hydrochloride as a main chaotropic agent and urea as an auxiliary chaotropic agent, and is compounded with a metal ion chelating agent, trehalose, dithiothreitol, digestive enzyme, sodium dodecyl sarcosinate, borate, ascorbic acid and polyethylene glycol. The buffer solution of the lysate does not contain SDS (sodium dodecyl sulfate), so that the residue of SDS in an extracted product can be avoided, and the amount of extracted free DNA (deoxyribonucleic acid) is more.

To provide a novel skin cleansing agent, particularly one that leaves the skin feeling smooth after washing. [Solution] (A) Oleoyl sarcosine or its salt (B) Polyglycerol fatty acid esters in which two or more fatty acids are bonded together. A skin cleansing agent containing at least [a certain ingredient].

The present invention aims to provide a liquid oral composition that can suppress the reduction in flavor expression caused by glycyrrhizic acid or its salts by incorporating acyl amino acids or their salts. [Solution] A liquid oral composition comprising: (A) component: at least one selected from the group consisting of glycyrrhizic acid and its salts; (B) component: at least one selected from the group consisting of acyl amino acids and their salts; and (C) component: a fragrance, wherein the ratio of the content of component (A) to the content of component (B) is 0.625 to less than 2.2 when component (B) contains acyl sarcosine and its salts, and 0.03 to less than 5 when component (B) does not contain acyl sarcosine and its salts, and substantially free of ethyl alcohol.

The invention discloses a biosynthesis process of creatine monohydrate, and belongs to the technical field of bioengineering. The invention discloses a creatine monohydrate biosynthesis method, which is characterized in that sarcosine invertase is utilized to catalyze chloroacetic acid and monomethylamine to generate N-alkylation reaction so as to prepare sarcosine, and then creatine monohydrate is generated under the catalysis of the creatine invertase, the process is mild in reaction condition, the temperature is 25-37 DEG C, the pH is 6.0-8.0, the energy consumption is lower, the conversion efficiency is high, the environment is protected, and the economical efficiency is high. The invention provides a new synthesis method for sustainable synthesis of creatine monohydrate, and provides a new idea for industrial production of creatine monohydrate.

It is an object of the present invention to provide a primer composition for surface-printed flexible packaging, an ink set, a surface-printed matter, and an inkjet printing method, which can impart excellent solid uniformity, bleeding resistance, abrasion resistance, alcohol resistance, and heat resistance to a coating film when an inkjet image is formed after applying the primer composition. Provided is a primer composition for surface-printed flexible packaging comprising an acryl-based resin emulsion emulsified with a polymer, N-oleoyl sarcosine, a hydrazine-based compound having at least two or more hydrazine residues in a molecule, and wax, wherein a content of the acryl-based resin emulsion is 3 to 40% by mass in terms of solid content, and wherein a glass transition temperature of the acryl-based resin emulsion is-40 to 30° C.

The invention discloses long-acting anti-dandruff shampoo based on microbial balance regulation and a preparation method of the long-acting anti-dandruff shampoo. The shampoo comprises a cleaning system composed of sodium lauroyl sarcosinate, cocamidopropyl betaine and decyl glucoside, a micro-ecological regulation system composed of piroctone olamine, inulin and a lactobacillus fermentation product, and skin barrier repairing lipids such as ceramide and squalane. According to the preparation method, all the components are effectively integrated through a step-by-step temperature control and homogeneous emulsification process. Through the synergistic effect of the components, malassezia is efficiently inhibited, effective microbial communities on scalp are selectively maintained, and a skin barrier is repaired, so that scalp micro-ecological balance is regulated and controlled, long-acting dandruff removal is realized, the scalp health level is improved, and the scalp care effect is improved. The problems that a traditional anti-dandruff product is likely to cause dysbacteriosis, the effect is not lasting, and relapse is caused after the traditional anti-dandruff product is stopped are solved.

The invention discloses a whitening facial cleanser and a preparation method thereof, and relates to the field of skin care products. The whitening facial cleanser is prepared from 35 to 42 weight percent of a cleaning agent, 1 to 2 weight percent of a whitening and freckle-removing agent, 0.8 to 1.2 weight percent of a skin conditioner, 4 to 8 weight percent of an emollient, 4 to 6 weight percent of a humectant, 0.3 to 0.5 weight percent of a preservative, 0.05 to 0.1 weight percent of a chelating agent, 4 to 4.5 weight percent of a thickening agent, 0.2 to 0.5 weight percent of an aromatic, 0.8 to 1.0 weight percent of a pH regulator and the balance of a solvent. The cleaning agent is prepared from sodium lauroyl isethionate, sodium cocoyl aminopropionate, cocamidopropyl betaine and sodium lauroyl sarcosinate according to the weight ratio of (3.5 to 4.5) to 1 to 1 to 1; the preservative comprises DMDM hydantoin and methylparaben in a weight ratio of (3-4): 1. The whitening facial cleanser provided by the invention has both cleaning power and mildness, and also has a whitening effect.

The invention discloses a sample treating fluid, a vitamin B12 detection sample pretreatment method, a detection kit, a detection method and application thereof, and particularly discloses the sample treating fluid which comprises strong base and sodium dodecyl sarcosinate. According to the sample treatment liquid, VB12 can be completely dissociated, and a relatively stable state can be kept. The invention further provides a detection sample pretreatment method of the vitamin B12. The detection sample pretreatment method comprises the step of mixing the sample treatment liquid with a to-be-detected sample for reaction. According to the sample treatment liquid provided by the invention, VB12 can still be dissociated from binding protein under the condition that highly toxic cyanide or a complex containing cyanide ions and unstable in dissociation is not adopted, and the VB12 can be kept in a relatively stable state to participate in subsequent reaction.

The invention discloses efficient deep penetration acid liquor as well as a preparation method and application thereof. The efficient deep penetration acid liquor comprises the following components in parts by mass: 20-35 parts of a main acid agent, 5-15 parts of a penetration enhancer, 2-6 parts of a corrosion inhibitor, 2-5 parts of a stabilizer and 40-70 parts of deionized water, wherein the main acid agent is a compound of main acid and auxiliary acid, and the penetration enhancer is a compound of fatty alcohol-polyoxyethylene ether and sodium lauroyl sarcosinate. Main body acid (one or two of sulfamic acid and chloroacetic acid) and auxiliary acid (one or two of formic acid and acetic acid) are compounded to serve as a main acid agent, and the main acid agent is combined with a penetration enhancer compounded by fatty alcohol-polyoxyethylene ether and sodium lauroyl sarcosinate, a corrosion inhibitor and a stabilizer. The core goals of deep penetration and low corrosion are jointly achieved, and the method can be applied to various scenes such as soil improvement, oil and gas exploitation and industrial equipment cleaning in a cross-field mode.

The present invention relates to a cyclic peptide comprising an active region comprising the amino acid sequence X1X2X3X4X5X6 or a salt, derivative, prodrug or mimetic thereof. X2 and X5 are arginine; and either:X1 is (7-methoxy-coumarin-4-yl)-Ala-OH (Dac) and X3, X4 and X6 are any amino acid; orX3 is sarcosine (Sar) and X1, X4 and X6 are any amino acid; orX4 is 5,5-dimethylproline (dmPro) or 3-amino-3-(2-naphthyl)propionic acid (Nap) and X1, X3 and X6 are any amino acid; orX6 is Nap and X1, X3 and X4 are any amino acid.The present invention further relates to a pharmaceutical composition comprising the cyclic peptide and the peptide for use in medicine, and particularly cancer.

The invention discloses a device for synthesizing sodium sarcosinate through micro-channel continuous flow, and relates to the technical field of sodium sarcosinate synthesis. The device comprises a glycine methylation reaction channel unit, a catalyst recovery assembly, a sarcosine crystallization and purification channel unit, a sarcosine neutralization reaction pipeline and a sodium sarcosine concentration and crystallization one-piece tank unit, the glycine methylation reaction channel unit comprises a raw material mixing pre-reaction pipe, a catalyst adding tank, a plunger type high-pressure pump and a high-pressure micro-channel reaction pipeline combination; the sarcosine crystallization and purification channel unit comprises a hydrogen volatilization channel, a formaldehyde volatilization and concentration channel and a glycine crystallization channel; the sodium sarcosinate concentration and crystallization integrated tank unit comprises a concentration tank, a first crystallization tank, a redissolution tank and a second crystallization tank. According to the invention, the reaction is carried out through the continuous microchannel, the reaction process separation is simpler than the traditional reaction process separation, the raw material utilization rate is high, and the problems of high preparation cost, troublesome operation, incapability of continuous production and the like of the existing glycine methylation method are solved.

The invention provides a composite spray lotion of a targeted vaginal pathogenic bacterium biological membrane and an ultrasonic infiltration promotion system. The spray lotion comprises the following components in parts by weight: 0.1-5 parts of antibacterial peptide; 10 to 100 parts of bacteriophage; 30 to 80 parts of rose water; 10 to 30 parts of betaine; 20 to 50 parts of cocamidopropyl betaine; 5 to 20 parts of lauryl glucoside; 5 to 20 parts of sodium lauroyl sarcosinate; 0.2 to 1 part of chlorhexidine acetate; and 500 to 1000 parts of purified water. The antibacterial peptide of the spray-washing liquid directly acts on extracellular polymeric substances of vagina biomembranes, the compact structure of the extracellular polymeric substances is destroyed, and a permeation channel is opened for subsequent antibacterial components; meanwhile, pathogenic bacteria in vaginal biomembranes can be directly killed, the action mechanism of the antibacterial peptide is that bacterial cell membranes are physically damaged, and the pathogenic bacteria are not prone to generating drug resistance. The components such as the rose water can relieve discomfort such as pruritus, dryness and scorching hot caused by vaginal infection or improper cleaning, and are suitable for treatment scenes such as colpitis mycotica and abnormal leucorrhea, high in safety and wide in applicability.

An anionic surfactant comprises a compound or mixture of compounds having the formula: Y=head group wherein R1 comprises hydrogen or methyl or hydroxy, R2 comprises methyl, hydroxy, or hydrogen, R'2 comprises methyl, hydroxy, or hydrogen, and R3 comprises a hydrocarbon group having 1 to 18 carbon atoms, including straight-chain hydrocarbon groups, branched hydrocarbon groups, saturated hydrocarbon groups, unsaturated hydrocarbon groups, or a combination thereof; wherein if both R2 and R'2 comprise hydrogen, then R1 does not comprise hydrogen if R3 is a linear hydrocarbon group and wherein if R3 is a branched hydrocarbon, then all of R2, R2, and R1 comprise hydrogen,, wherein the hydroxy is derivatized into other functional groups; and wherein Y comprises a taurate head group, a sarcosinate head group, an aspartate head group, or a glutamate head group.

Provided is a method for improving efficiency of heat transmission that enables improving the efficiency of heat transmission by steam in a steam system at a pH of less than 7. A method for improving the efficiency of heat transmission by steam, wherein, in a step of introducing steam into a heat exchanger to heat an object to be heated or a step of contacting the steam with a cooling body to liquefy the steam, a sarcosine compound is allowed to be present in the steam system at a pH of less than 7. As the sarcosine compound, a long-chain sarcosine compound represented by the following formula (I) is preferable. R1C(═O)—N(CH3)—(CH2)n—COOR2 . . . (I) In formula (I), R1 is an unsaturated or saturated linear or branched hydrocarbon group having 7 to 24 carbon atoms, n is an integer of 0 to 2, and R2 is a hydrogen atom or a salt-forming group.

The invention discloses a crude oil pour point depressant which comprises a main agent, an auxiliary agent and a high-flash-point organic solvent, and the mass ratio of the main agent to the auxiliary agent to the high-flash-point organic solvent is (25-35): (1-3): (62-74); wherein the main agent is formed by polymerizing ethylene-vinyl acetate, polyacrylic acid octadecanamide and alkyl maleimide according to a molar ratio of (2.8 to 3.2): (1.8 to 2.2): (1.8 to 2.2); the auxiliary agent is one or any combination of oleic acid diethanolamide, N-oleoyl sarcosine and hydroxy fatty acid; the high-flash-point organic solvent is one or any combination of trimethylbenzene, tetramethylbenzene, propylene glycol butyl ether and diethylene glycol monobutyl ether. The invention also discloses a preparation method and application thereof. The crude oil pour point depressant provided by the invention can effectively reduce the condensation point of high-condensation-point crude oil of which the condensation point is greater than 40 DEG C and improve the fluidity of the high-condensation-point crude oil of which the condensation point is greater than 40 DEG C, so that normal transportation of the crude oil is ensured, and powerful support is provided for reducing the operation cost of the high-condensation-point crude oil and ensuring normal transportation of the crude oil.

The application discloses a silk protein composition for hair growth, and belongs to the technical field of hair growth silk protein compositions. The composition comprises moisturizing agents, fragrance imparting agents, cationic surfactants, acidity adjusting agents, co-emulsifiers, preservatives, antioxidants, oily ingredients, trace ingredients, lauroylsarcosine sodium, cocoyl glutamic acid TEA salt, sodium lauroamphoacetate, sodium chloride, phenoxyethanol, sodium laurate, citric acid, allantoin, cocamide propyl betaine, hydroxybenzoic acid ester, nicotinamide and a silk protein solution. The application has the beneficial effect that the product contains proteins and amino acids, can supplement the required nutrients for damaged and fragile hair, can stimulate the cell proliferation of human head hair papilla cells and hair matrix cells, can make the head of people with thinning hair or baldness regenerate hair, and can prevent hair loss for people with normal hair.

The invention discloses a silicon-free washing and care composition with glycoprotein and polyquaternium-51 synergistic color fixation and repair and a preparation method of the silicon-free washing and care composition with glycoprotein and polyquaternium-51 synergistic color fixation and repair. The composition is prepared from the following components in parts by weight: 1 to 5 parts of glycoprotein grafted and modified by epoxy butyl sulfonate, 0.5 to 3 parts of polyquaternium-51, 0.2 to 2 parts of 2, 5-dihydroxy terephthalamide, glycerol, sodium lauroyl sarcosinate, cocamidopropyl betaine, citric acid, a preservative, essence and deionized water. The glycoprotein grafted and modified by the epoxy butyl sulfonate is prepared by reacting glycoprotein, the epoxy butyl sulfonate, sodium bicarbonate, ethanol and deionized water. Through the synergistic effect of the modified glycoprotein and the polyquaternium-51, the color fixing performance and the repairing effect of hair are effectively improved, the hair surface friction coefficient is reduced, meanwhile, the system is kept stable in long-term storage, the color fixing agent is remarkably superior to a contrast sample which is not modified or lacks key components, and the color fixing agent has a good application prospect.

The invention provides a Nectin-4-targeted bicyclopeptide nuclide ligand, a probe as well as a preparation method and application of the Nectin-4-targeted bicyclopeptide nuclide ligand and the probe, the Nectin-4-targeted bicyclopeptide nuclide ligand and the probe are used for imaging diagnosis of Nectin-4 positive tumor patients, and medication guidance and real-time curative effect monitoring of the patients receiving anti-cancer targeted drug treatment can be realized; according to the present invention, the pharmacokinetic modification molecule polysarcosine is added between the chelating agent for radionuclide labeling and the Nectin-4 targeting polypeptide, such that the biocompatibility of the probe is improved, and the pharmacokinetic property, especially the non-tumor tissue removal kinetics, is optimized so as to achieve the good diagnosis and treatment effect; the bicyclic peptide nuclide ligand DOTA-Sar-bicyclic peptide provided by the invention uses DOTA as a bifunctional chelating agent, so that the bicyclic peptide nuclide ligand DOTA-Sar-bicyclic peptide has better in-vivo and in-vitro stability.

The invention belongs to the technical field of oral care, and provides toothpaste for preventing and treating oral ulcer and a preparation method thereof, and the toothpaste for preventing and treating oral ulcer comprises the following components: dipotassium glycyrrhizinate, beta-glucan, sodium hyaluronate, a honeysuckle extract, poloxamer 407, an abrasive, a humectant, a foaming agent, an adhesive, a sweetening agent, a preservative, essence and water. The core of the toothpaste is that a gel film is formed in an oral cavity by utilizing the temperature-sensitive characteristic of poloxamer 407, so that the retention and action time of active ingredients is remarkably prolonged, and long-acting nursing is realized; meanwhile, a sodium lauroyl sarcosinate SLS-free mild foaming system is adopted, so that mucous membrane stimulation is avoided. The formula can effectively prevent oral ulcer recurrence through multi-mechanism synergy of anti-inflammation, immunoregulation and physical repair, and clinically shows that the recurrence rate can be reduced by 55%, the recurrence interval can be prolonged to 28 days or above, the tooth brushing pricking occurrence rate is reduced to 5%, and use is safe and comfortable.