260 results about "Sarcosine" patented technology

The invention discloses an oral care desensitization paste and a preparation method thereof, and mainly relates to the technical field of dental medicines. The oral care desensitization cream is prepared from the following components: bioactive glass, strontium chloride, sodium chloride, silicon dioxide, sodium carboxymethyl cellulose, polyethylene glycol 400, a xanthan gum solution, sodium lauryl sulfate, sodium lauroyl sarcosinate, titanium dioxide, beta-glucan, saccharin sodium salt, sorbitol, methylparaben, propyl hydroxybenzoate, edible essence and water. Compared with the prior art, the oral care desensitization paste disclosed by the invention can be used for sealing dentinal tubules and treating hemodia; the traditional Chinese medicine composition can also be used for treating plaque gingivitis, relieving and reducing gingival bleeding and inhibiting and reducing dental plaque; and meanwhile, the condition of mistakenly swallowing and eating in the using process is reduced.

The invention relates to the technical field of metal working fluids, in particular to a degradable environment-friendly vegetable oil-based semi-synthetic cutting fluid and a preparation method thereof. The cutting fluid comprises 20-30 parts of vegetable lubricating oil, 10-20 parts of an alkali storage agent, 2-5 parts of a corrosion inhibitor, 3-5 parts of a coupling agent, 5-8 parts of a surfactant and 6-11 parts of a composite anti-rust agent, the composite anti-rust agent comprises an anti-rust agent A and an anti-rust agent B, the anti-rust agent A comprises N-[3-(dimethylamino) propyl]-N, N-dimethylformamide, and the anti-rust agent B comprises N-[3-(dimethylamino) propyl]-N, N-dimethylformamide. The antirust agent A comprises at least one of N, N ', N'-trimethyl-1, 3-propanediamine, benzotriazole, sebacic acid and 2, 4, 6-tri (aminocaproic acid)-1, 3, 5-triazine, and the antirust agent B comprises at least one of an imidazoline compound and fatty acid sarcosine ester. The cutting fluid provided by the invention has excellent corrosion resistance, rust resistance, defoaming property, biodegradability and storage stability, and has a good application prospect.

The invention discloses a diagnosis model for hepatocellular carcinoma microvascular invasion and a construction method and application thereof, and belongs to the technical field of medical examination. Metabolite in the blood of a hepatocellular carcinoma patient is taken as a cut-in, preoperative clinical tumor indexes are combined, it is found that PIVKA-II, GGT, L-Serine, Sarcosine and tumor sizes have important significance on formation of hepatocellular carcinoma MVI, a diagnosis model based on multiple omics and multiple dimensions is established based on the diagnosis indexes, the diagnosis model is used for diagnosis of the preoperative MVI of the hepatocellular carcinoma patient, and the diagnosis model is used for diagnosis of the preoperative MVI of the hepatocellular carcinoma patient. The defects of existing diagnosis means in the aspect of preoperative diagnosis are overcome, and a more timely and accurate basis is provided for clinical decision making.

The present invention provides synthetic peptide compounds and uses thereof for therapy and diagnostics of complement-mediated diseases, such as inflammatory diseases, autoimmune diseases, and microbial and bacterial infections; and non-complement-mediated diseases, such cystic fibrosis and various acute diseases. The invention is directed to modifications of a synthetic peptide of 15 amino acids from the Polar Assortant (PA) peptide, which is a scrambled peptide derived from human Astrovirus protein. In some embodiments, the invention is directed to peptide compounds that are peptide mimetics, peptide analogs and / or synthetic derivatives of PA (e.g., sarcosine derivatives) having, for example, internal peptide substitutions, and modifications, including PEGylation at the N-terminus and C-terminus. The invention further provides methods of selecting at least one synthetic peptide for treating various conditions.

The invention belongs to the field of medicine application, and particularly discloses application of sarcosine serving as a unique active component to preparation of medicine for preventing and treating obesity and / or hyperlipidemia. The test of treating old mice with sarcosine proves that the sarcosine can reduce the total body mass and fat mass and reduce the body fat rate under the condition that the absolute lean body mass is not influenced. Through tissue staining and biochemical analysis, it is determined that sarcosine can reduce the cross sectional area of visceral adipose tissue (VAT) cells, up-regulate expression of a marker UCP1 of brown adipose tissue in visceral adipose tissue and remarkably reduce the level of triglyceride in plasma. The sarcosine has practical application value in treatment of obesity and hyperlipidemia.

The invention discloses an antibacterial composition which comprises 5-8 wt% of sodium lauroyl sarcosinate, 5-8 wt% of cocamidopropyl betaine and 2-4 wt% of sodium laureth sulfate, the pH value is 4-5.5, through reasonable combination and compatibility of different surfactants, the antibacterial composition has an obvious antibacterial synergistic effect, the antibacterial rates of candida albicans, staphylococcus aureus and escherichia coli are all larger than 90%, and the antibacterial effect is good. The compound can be used for preparing various washing and nursing materials such as laundry detergents, hand sanitizers, bath foam and private part care solutions.

The invention discloses a PSA electrotinning insoluble anode system and a production method of an electrotinning plate, and relates to the technical field of electrotinning. The PSA tin electroplating insoluble anode system comprises an electroplating additive which is composed of benzotriazole, N-oleoyl sarcosine, S-carboxyethyl thiosuccinic acid and sodium citrate. The problems of serious black ash and poor coating performance of an electroplated tin plate product are solved, the tin plating stability of a plating solution in an electroplating bath is improved, the black ash on the surface of the electroplated tin plate product can be effectively reduced, the requirements of low black ash and high adhesive force on the surface of an electroplated tin plate of a PSA (Pressure Swing Adsorption) electroplated tin insoluble anode system are met, and the service life of the electroplated tin plate is prolonged. The electroplated tin plate produced through the PSA electroplated tin insoluble anode system is bright and clean in plating layer surface, and after the tin layer surface with the thickness of 8.4 g / m < 2 > and below is wiped through test paper, the reduction percentage of the test paper whiteness caused by black ash is smaller than or equal to 10%.

The invention provides an oil-based composition containing isopropyl lauroyl sarcosinate and ferulic acid, which is characterized in that the weight ratio of ferulic acid to isopropyl lauroyl sarcosinate is less than or equal to 1 / 9. The invention also relates to an application of the oil-based composition containing the isopropyl lauroyl sarcosinate and the ferulic acid in an external preparation for the skin, wherein the external preparation for the skin is selected from skincare essence oil, face cream and emulsion.

The utility model discloses an efficient crystallization device in sarcosine preparation, which comprises a constant-temperature tank, the constant-temperature tank is used for preparing crystals from sarcosine, an auxiliary blanking mechanism is fixedly arranged at the bottom end of the constant-temperature tank, and a driving mechanism is fixedly arranged at the top end of the constant-temperature tank; the auxiliary discharging mechanism comprises a temperature control base, and a slope frame is fixedly arranged at the top end of the temperature control base. The output end of the motor fixed to the top end of the fixing frame drives the positioning gear to rotate, so that the tooth surface of the positioning gear is meshed with the tooth surface of the positioning gear ring, and the telescopic end of the electric telescopic rod fixed to the bottom end of the limiting frame drives the positioning shaft to ascend and descend; the positioning shaft drives the temperature control base and the slope frame which are fixed at the bottom end to move downwards, so that the temperature control base and the slope frame move to the bottom end of the constant-temperature tank, crystals on the inner wall of the constant-temperature tank are subjected to blanking control, and the practicability of the efficient crystallization device in sarcosine preparation is improved.

A foaming cleansing composition includes at least one amphoteric surfactant, which may be selected from cocamidopropyl hydroxysultaine, cocamidopropyl betaine, cocobetaine, sodium lauroamphoacetate, disodium cocoamphodiacetate, or combinations thereof, at least one anionic surfactant comprising methyl oleoyl taurate, at least one anionic surfactant having a carboxyl group which may be selected from sarcosinates, glycinates, alaninates, glutamates, glycolipids, or combinations thereof, and water. The foaming cleansing composition may be essentially free of added PEG-type polymeric thickeners.

The invention provides a reagent and a method for enhancing the tolerance of a PCR (Polymerase Chain Reaction) inhibitor and application. The reagent comprises arginine and sodium lauroyl sarcosinate, the method comprises the step of adding arginine and sodium lauroyl sarcosinate into a reagent for PCR (Polymerase Chain Reaction) amplification. The reagent disclosed by the invention has relatively strong tolerance to interference of inhibitors such as non-target nucleic acid and the like. The method is simple to operate, low in cost and high in nucleic acid detection sensitivity. The reagent and the method have good application prospects in detection of nucleic acid extracted from samples such as whole blood, urine, sputum and the like.

The present invention provides synthetic peptide compounds and uses thereof for therapy and diagnostics of complement-mediated diseases, such as inflammatory diseases, autoimmune diseases, and microbial and bacterial infections; and non-complement-mediated diseases, such cystic fibrosis and various acute diseases. The invention is directed to modifications of a synthetic peptide of 15 amino acids from the Polar Assortant (PA) peptide, which is a scrambled peptide derived from human Astrovirus protein. In some embodiments, the invention is directed to peptide compounds that are peptide mimetics, peptide analogs and / or synthetic derivatives of PA (e.g., sarcosine derivatives) having, for example, internal peptide substitutions, and modifications, including PEGylation at the N-terminus and C-terminus. The invention further provides methods of selecting at least one synthetic peptide for treating various conditions.

The present invention is in the field of cosmetics and in particular relates to combinations of one or more alkylamidothiazoles and one or more sarcosine alkyl esters and cosmetic formulations containing such combinations. It has been found that the sarcosine alkyl esters significantly increase the solubility of alkylamidothiazoles in cosmetic formulations.

The invention discloses a preparation method of tadalafil, which comprises the following steps: S1, taking sarcosine as a raw material, and carrying out carboxyl hydroxyl chlorination reaction under the action of thionyl chloride or oxalyl chloride to generate sarcosine chloride hydrochloride; s2, taking tryptophan methyl ester hydrochloride and piperonitrile as raw materials, and carrying out nitrile-amine condensation to generate an intermediate A; s3, taking the intermediate A as a raw material, and carrying out ring closing under the action of phosphorus oxychloride to generate an intermediate B; s4, reducing the intermediate B under the action of sodium borohydride to generate an intermediate C crude product, and purifying; and S5, carrying out an amide condensation reaction on the intermediate C and sarcosine chloride, carrying out amine ester exchange to generate a tadalafil crude product, and refining to obtain the tadalafil product. The tadalafil is synthesized with high yield, high specificity and selectivity, and the process route has the advantages of cheap and easily available raw materials, specific reaction, high product yield, safety and simplicity in operation, environmental friendliness, low equipment requirement, easiness in industrialization and the like.

The invention provides a construction method and application of a mouse gastric cancer spontaneous tumor model, and the construction method comprises the following steps: reducing or inhibiting the expression quantity of a TP53 gene and / or the activity of a P53 protein in a mouse body, and then giving a drug to the mouse for chemical induction to obtain the mouse gastric cancer spontaneous tumor model. Wherein the drug contains sodium nitrite and ethyl sarcosinate, and / or the drug contains an N-nitroso compound. According to the construction method of the mouse gastric cancer spontaneous tumor model, the construction of the C57 mouse gastric cancer spontaneous tumor model by using the NESS is proposed for the first time, and the tumor formation rate can reach 75% or above; the tumor formation period is short and is about 3-4 months, and the construction cost is low.

The invention relates to the field of preparation of guanidine or derivatives thereof, and particularly discloses high-purity creatine monohydrate and a preparation method thereof. The preparation method comprises the following steps: sequentially carrying out condensation reaction, acidolysis reaction and hydrolysis reaction on dimethyl sulfate and urea, cooling, crystallizing and filtering to obtain O-methylisourea hydrogen sulfate, and then reacting a sarcosine salt aqueous solution with the O-methylisourea hydrogen sulfate under the conditions that the temperature is 45-65 DEG C and the pH value is 10-12 to obtain the sarcosine salt. And performing post-treatment to obtain the high-purity creatine monohydrate. The preparation method has the advantages of being low in raw material cost, easy to transport and store and rich in source, byproducts in the reaction process are few, danger is low, the yield and purity are high, the industrial requirement is met, and the preparation method is suitable for large-scale industrial production.

The invention belongs to the technical field of sarcosine detection, and provides a bionic electric sensor, a preparation method thereof and application of the bionic electric sensor in ultrasensitive detection of sarcosine. The method comprises the following steps: mixing a red blood cell solution and a bionic active substance, and carrying out co-incubation to obtain bionic red blood cells, and mixing the bionic red blood cells with a conductive polymer (dopamine, pyrrole, aniline or thiophene), and carrying out an in-situ polymerization reaction to obtain the bionic electric sensor. The conductive polymer is combined with natural cells, the excellent conductivity of the conductive polymer is utilized, and meanwhile, based on the high-oxygen microenvironment of the cells, the bionic active substance has better electrocatalytic property and can be used for rapid, sensitive and efficient monitoring of Sar. The bionic electric sensor has the advantages of being high in reaction speed, low in cost, easy to miniaturize, good in biocompatibility, simple in sample pretreatment and the like, and a novel, rapid, accurate and stable diagnostic tool can be provided for the morbidity and development law of prostate diseases.

The invention discloses a synthesis method of N-lauroyl sarcosine isopropyl ester, and belongs to the technical field of fine chemical engineering. The method comprises the following steps: adding N-lauroyl sarcosine, isopropanol and an activated carbon-solid acid composite catalyst into an esterification reaction kettle (the esterification reaction kettle is provided with a multiple dehydration device), carrying out esterification reaction, after the esterification reaction is completed, filtering reaction liquid to recover the composite catalyst, and distilling filtrate to recover isopropanol, so as to obtain isopropyl N-lauroyl sarcosine; according to the method, concentrated sulfuric acid is prevented from being used as a catalyst, the esterification rate is greatly increased, operation is easy, the method is suitable for industrial production, and the obtained N-lauroyl isopropyl sarcosinate is high in yield and good in color and luster.

The invention discloses a method for using an N-acylamino acid type surfactant as a hydrate generation accelerant and applying the N-acylamino acid type surfactant to preparation of a gas hydrate, the structural general formula of the N-acylamino acid type surfactant is as follows: # imgabs0 #, and R is selected from one of lauroyl, cocoyl and oleic acid group; r1 and R2 are independently selected from one of glutamic acid, glycine, alanine and sarcosine. The N-acylamino acid type surfactant is used as the hydrate generation accelerant, the generation efficiency of the gas hydrate can be effectively improved, the environmental problem that a traditional surfactant is difficult to decompose when used as the hydrate generation accelerant is solved, and the N-acylamino acid type surfactant has the advantages of being environmentally friendly, efficient, economical, safe and the like; good application prospects are realized.

The invention provides a metabonomics-based preeclampsia risk assessment prediction model construction method, a prediction model, application of metabolites, a metabolite detection kit, a prediction product, a prediction system and related application thereof. Specifically, clinical indexes and metabolite data of a pregnant woman serve as input, whether the pregnant woman suffers from preeclampsia or not serves as output, model construction is conducted through a machine learning method, and a preeclampsia risk assessment and prediction model is obtained. The metabolite is selected from at least one of 4-hydroxyphenyllactic acid, homovanillic acid, ornithine, sarcosine, adenosine monophosphate and 3-methylbutyryl carnitine. According to the invention, not only are six metabolite markers strongly associated with preeclampsia found, but also effective prediction of early preeclampsia and late preeclampsia is realized by establishing a prediction model, and the method has extremely high clinical value.

The invention relates to the technical field of face cleansing gels, in particular to a hexagonal liquid crystal face cleansing gel and a preparation method thereof.The hexagonal liquid crystal face cleansing gel at least comprises, by mass, a phase A: 20-26% of sodium lauroyl sarcosinate and 0-1.5% of an auxiliary surfactant; a phase B: 3-8% of propylene glycol laurate; a phase C: 0.01%-4.5% of glycerol laurate; phase D: 1 to 5 percent of polyglycerol-2 laurate; 0-2% of an auxiliary agent; and deionized water: complementing the balance. By optimizing a product formula system, an amino acid cleansing product which has a transparent appearance similar to that of micelle type amino acid cleansing cream, can not depend on addition of a large number of polymers to assist thickening and shows a non-flowing appearance texture is prepared, and the amino acid cleansing product has extremely high market application and popularization value.

The invention belongs to the technical field of sarcosine detection, and relates to an integrated sarcosine detection device as well as a preparation method, a detection method and application thereof. The device consists of a sample bottle and a double-layer paper chip, wherein the double-layer paper chip is fixed in a bottle cap of the sample bottle; the double-layer paper chip comprises a target recognition layer and a detection layer, the target recognition layer is Whatman 1 # filter paper loaded with SOx / HRP-coated MAF-7 biological composite materials, the detection layer is Whatman 1 # filter paper loaded with TMB color developing agents, and the layers are bonded through water-soluble double-faced adhesive tapes. After a sample is added into the sample bottle, the bottle is turned over, SOx can recognize and oxidize sarcosine to obtain H2O2, after the double-sided adhesive tape is fully reacted and dissolved, HRP oxidizes a substrate TMB in the presence of H2O2 to generate a bright blue product oxTMB, and RGB signals are recorded through a handheld colorimeter. The detection device can be used for quantitatively detecting the sarcosine content of the prostatic cancer marker.

The invention relates to the technical field of sodium sarcosine, in particular to slow-release sodium sarcosine and a preparation method thereof. The slow-release sodium sarcosine is prepared from the following raw materials in parts by weight: 70 to 80 parts of sodium sarcosine aqueous solution, 5 to 10 parts of acrylic acid, 5 to 10 parts of acrylamide, 3 to 5 parts of hydrotropy monomer A, 0.5 to 1 part of hydrotropy monomer B, 0.05 to 0.15 part of cross-linking agent and 0.05 to 0.15 part of initiator, and the hydrotropy monomer B is a mixture of diallyl dimethyl ammonium chloride and methacryloyloxyethyl trimethyl ammonium chloride. The sustained-release sodium sarcosinate disclosed by the invention has relatively high drug loading capacity and encapsulation efficiency, does not generate a burst release phenomenon, and can act for a relatively long time in vivo, so that the benefits of the sustained-release sodium sarcosinate are better exerted, the intake frequency is reduced, and the sustained-release sodium sarcosinate has a wide application prospect.

The invention discloses a quercetin anti-wrinkle composition with high content and high stability and application. The composition is prepared from the quercetin, the 4-tert-butyl cyclohexanol and the isopropyl lauroyl sarcosinate. Compared with the prior art, the oily composition of 4-tert-butyl cyclohexanol, isopropyl lauroyl sarcosinate and quercetin is constructed, the problem that quercetin is difficult to dissolve can be effectively solved, and the application convenience of quercetin is greatly improved; the content of quercetin in the composition is high, and the composition has a certain anti-wrinkle effect; the 4-tert-butyl cyclohexanol and the isopropyl lauroyl sarcosinate have a synergistic effect on the dissolution of the quercetin; the composition can be used for preparing quercetin microemulsion after being compounded with other grease, and has extremely high stability. Therefore, the method has important application value in the field of cosmetics.

The invention relates to a preparation method and application of a cascade reactor based on 2D MOF. According to the method, a regular layered MOFs material is prepared by adjusting the molar ratio and concentration of different metal salts to ligands, then the material is soaked in an ethanol and isopropanol solvent, the material is activated through ultrasonic waves in an ice-water bath, layered separation is achieved through intermolecular force, a 2D MOFs material with the micron-scale size and the nano-scale thickness is obtained, finally, SOX is added, and the 2D MOFs material with the micron-scale size and the nano-scale thickness is obtained. The method comprises the following steps: carrying out a two-dimensional (2D) MOF / SOX cascade reactor to obtain a two-dimensional (2D) MOF / SOX cascade reactor capable of constructing a colorimetric sensor with TMB (3, 3 ', 5, 5'-tetramethyl benzidine). The reactor can perform 1-400 [mu] M linear quantification on sarcosine, and LOD is 0.324 [mu] M. According to the invention, high-efficiency, simple and cheap Pca capable of being rapidly detected can be synthesized without complex synthesis processes, instruments and expensive precious metals.

This invention provides a continuous method for preparing high-purity creatine monohydrate, comprising the following steps: a) adding chloroacetic acid aqueous solution dropwise to an aqueous methylamine solution, stirring at room temperature for 2 hours after the addition is complete; b) heating to 50-60°C and holding for 1 hour to remove most of the methylamine, then heating to 95°C to evaporate the methylamine aqueous solution for 1 hour; c) adding sodium hydroxide solution dropwise to the solution from step b) at 95°C, then heating to 105°C and concentrating under reduced pressure for 1.5 hours to approximately half the original volume, obtaining a creatine solution with a concentration of 30%-40%; d) cooling the solution from step c) to 40-60°C and adding a catalyst; e) drying to obtain pure creatine monohydrate. This invention reduces the methylamine equivalent, saving costs, and eliminates the need for purifying creatine for direct use in the next reaction; it can simultaneously lower the system reaction temperature and pH value to inhibit the formation of byproducts dicyandiamide and creatinine, and eliminates the need for debittering agents for purification and debittering, thus saving production costs.

The invention belongs to the technical field of biosensors, and provides molecularly imprinted hydrogel for sarcosine detection, a micro-strain conduction sensor and a preparation method of the micro-strain conduction sensor. The hydrogel is prepared by the following steps: carrying out photo-initiation polymerization on a gel pre-polymerization solution containing a 4-vinylpyridine monomer, a 2-acrylamide-2-methylpropanesulfonic acid monomer, an acrylamide monomer, sarcosine template molecules, a cross-linking agent and a photoinitiator, and washing to remove the sarcosine template molecules. The micro strain conduction sensor is composed of a hydrogel layer and a resistance strain gauge, and the hydrogel layer is chemically bonded to one side of the resistance strain gauge and completely covers sensitive grid wires of the resistance strain gauge. The hydrogel disclosed by the invention has excellent specific recognition capability on sarcosine, and high-sensitivity and high-selectivity detection of sarcosine in a complex matrix sample can be realized through the micro strain conduction sensor disclosed by the invention.

The invention relates to a creatine monohydrate preparation method, which comprises: S1, carrying out a first reaction on a methylaminoacetonitrile aqueous solution and a first sodium hydroxide aqueous solution to obtain a sodium sarcosinate-containing aqueous solution; s2, carrying out separation treatment on the aqueous solution containing sodium sarcosine in the step S1 by adopting a bipolar membrane electrodialysis device to obtain an aqueous solution containing sarcosine and a second sodium hydroxide solution; and S3, carrying out a second reaction on the aqueous solution containing sarcosine in the step S2 and cyanamide to obtain a crude product containing sarcosine monohydrate. The creatine monohydrate prepared by the preparation method provided by the invention is high in purity and does not contain dicyandiamide and creatinine impurities, and the total yield of the creatine monohydrate is 90% or above.

This invention relates to the field of hair care products technology, specifically disclosing a plant-based compound fermented oil-controlling and volumizing shampoo and its preparation process. The raw materials, by weight, include: 15-25 parts sodium lauroyl sarcosinate, 8-15 parts potassium cocoyl glycinate, 10-18 parts soapberry fruit fermentation liquid, 6-12 parts arborvitae leaf fermentation extract, 5-10 parts rosemary leaf fermentation liquid, 3-6 parts hydrolyzed oat protein, 2-5 parts panthenol, 0.1-0.5 parts piroctone olamine, 0.2-0.6 parts xanthan gum, 0.4-0.8 parts phenoxyethanol, and 40-60 parts deionized water. This invention utilizes a triple plant-based low-temperature anaerobic fermentation process, combined with a mild amino acid surfactant system, to provide multiple benefits including gentle cleansing, long-lasting oil control, hair root lifting, and scalp care. It is suitable for oily scalps and fine, limp hair.

The utility model relates to the field of crystallization kettles, in particular to a sarcosine crystallization kettle. Comprising an adjusting device, the adjusting device comprises a fixing rod, the fixing rod is fixedly connected with a crystallization kettle body, the end, away from the crystallization kettle body, of the fixing rod is fixedly connected with a connecting frame, the inner wall of the connecting frame is fixedly connected with a supporting plate, and the side, away from a discharging port, of the supporting plate is fixedly connected with a motor; the output end of the motor is fixedly connected with a rotating rod, the arc surface of the rotating rod is in threaded connection with a fixing ring, and one end of the arc surface of the fixing ring is fixedly connected with an adjusting plate. The sarcosine crystallization kettle provided by the utility model has the advantages that when the crystallization kettle is used for crystallizing amino acid, stirring can be carried out on the discharge hole of the crystallization kettle through the adjusting device, and good flowability of materials can be kept and the particle discharge speed can be accelerated through stirring, so that the discharge time can be shortened, and the overall production efficiency can be improved.