84 results about "Sarcosine" patented technology

The present invention provides synthetic peptide compounds and uses thereof for therapy and diagnostics of complement-mediated diseases, such as inflammatory diseases, autoimmune diseases, and microbial and bacterial infections; and non-complement-mediated diseases, such cystic fibrosis and various acute diseases. The invention is directed to modifications of a synthetic peptide of 15 amino acids from the Polar Assortant (PA) peptide, which is a scrambled peptide derived from human Astrovirus protein. In some embodiments, the invention is directed to peptide compounds that are peptide mimetics, peptide analogs and / or synthetic derivatives of PA (e.g., sarcosine derivatives) having, for example, internal peptide substitutions, and modifications, including PEGylation at the N-terminus and C-terminus. The invention further provides methods of selecting at least one synthetic peptide for treating various conditions.

This invention provides a continuous method for preparing high-purity creatine monohydrate, comprising the following steps: a) adding chloroacetic acid aqueous solution dropwise to an aqueous methylamine solution, stirring at room temperature for 2 hours after the addition is complete; b) heating to 50-60°C and holding for 1 hour to remove most of the methylamine, then heating to 95°C to evaporate the methylamine aqueous solution for 1 hour; c) adding sodium hydroxide solution dropwise to the solution from step b) at 95°C, then heating to 105°C and concentrating under reduced pressure for 1.5 hours to approximately half the original volume, obtaining a creatine solution with a concentration of 30%-40%; d) cooling the solution from step c) to 40-60°C and adding a catalyst; e) drying to obtain pure creatine monohydrate. This invention reduces the methylamine equivalent, saving costs, and eliminates the need for purifying creatine for direct use in the next reaction; it can simultaneously lower the system reaction temperature and pH value to inhibit the formation of byproducts dicyandiamide and creatinine, and eliminates the need for debittering agents for purification and debittering, thus saving production costs.

The invention belongs to the technical field of biosensors, and provides molecularly imprinted hydrogel for sarcosine detection, a micro-strain conduction sensor and a preparation method of the micro-strain conduction sensor. The hydrogel is prepared by the following steps: carrying out photo-initiation polymerization on a gel pre-polymerization solution containing a 4-vinylpyridine monomer, a 2-acrylamide-2-methylpropanesulfonic acid monomer, an acrylamide monomer, sarcosine template molecules, a cross-linking agent and a photoinitiator, and washing to remove the sarcosine template molecules. The micro strain conduction sensor is composed of a hydrogel layer and a resistance strain gauge, and the hydrogel layer is chemically bonded to one side of the resistance strain gauge and completely covers sensitive grid wires of the resistance strain gauge. The hydrogel disclosed by the invention has excellent specific recognition capability on sarcosine, and high-sensitivity and high-selectivity detection of sarcosine in a complex matrix sample can be realized through the micro strain conduction sensor disclosed by the invention.

This invention relates to the field of hair care products technology, specifically disclosing a plant-based compound fermented oil-controlling and volumizing shampoo and its preparation process. The raw materials, by weight, include: 15-25 parts sodium lauroyl sarcosinate, 8-15 parts potassium cocoyl glycinate, 10-18 parts soapberry fruit fermentation liquid, 6-12 parts arborvitae leaf fermentation extract, 5-10 parts rosemary leaf fermentation liquid, 3-6 parts hydrolyzed oat protein, 2-5 parts panthenol, 0.1-0.5 parts piroctone olamine, 0.2-0.6 parts xanthan gum, 0.4-0.8 parts phenoxyethanol, and 40-60 parts deionized water. This invention utilizes a triple plant-based low-temperature anaerobic fermentation process, combined with a mild amino acid surfactant system, to provide multiple benefits including gentle cleansing, long-lasting oil control, hair root lifting, and scalp care. It is suitable for oily scalps and fine, limp hair.

The present invention provides synthetic peptides, compositions containing synthetic peptides, and methods for modifying the complement system. [Solution] The present invention relates to the modification of a 15-amino acid synthetic peptide from polar assortant (PA) peptides, which are scrambled peptides derived from human astrovirus protein. In some embodiments, the present invention relates to peptides that are modified PAs, which are stapled and / or have D-enantiomer substitutions of certain amino acids, and which include sarcosine substitutions at certain amino acid positions. The present invention further provides a method for selecting at least one synthetic peptide to treat various conditions.

The invention provides application of an Slc36a1 agonist in preparation of a medicine for preventing and / or treating colitis, and belongs to the technical field of biology. According to the invention, 4-GBA or sarcosine is applied to a colitis model mouse, and clinical and histological phenotypes of DSS-induced colitis can be significantly improved. According to experiments of colonic organs and mice, 4-GBA enhances intestinal mucosal barrier and promotes intestinal homeostasis by up-regulating Slc36a1. According to the invention, 4-GBA or sarcosine molecules targeting Slc36a1 are taken as a core, and the limitation of an existing treatment strategy is broken through by synchronously solving a linkage mechanism of stem cell regeneration-goblet cell differentiation-mucous barrier repair.

The invention discloses a universal sample type nucleic acid releasing agent and application thereof. The nucleic acid releasing agent is prepared from the following components in molar concentration: 20 to 100 mM of Tris-HCl, 30 to 500 mM of sodium chloride, 30 to 200 mM of ammonium sulfate, 1 to 6 mM of EDTA (Ethylene Diamine Tetraacetic Acid), 1 to 8 mM of a reducing agent, 0.1 to 0.2 percent of sodium dodecyl sarcosinate, 0.1 to 3 mM of Surfactin, 5 to 30 percent of Chelex-100 and 5 to 15 percent of trehalose. According to the method, various samples can be mildly split, impurities such as impure proteins and lipids can be effectively removed, the complexity of nucleic acid samples is reduced, and the method is seamlessly jointed with subsequent PCR (Polymerase Chain Reaction); the kit has double effects of sample preservation and splitting decomposition, can strongly inhibit various nuclease, and can ensure the long-term storage stability of samples.

Provided is a cyclic peptide, which has a sequence of cyclo(X1X2X3X4X5X6), wherein X1 is asparagine; X2 is glycine or sarcosine; X3 is arginine; X4 is selected from a group consisting of threonine, tyrosine, and phenylalanine; X5 is lysine; and X6 is selected from a group consisting of tyrosine, valine, and glutamic acid. Provided is a preparation method for the cyclic peptide. Provided is a complex, comprising the cyclic peptide, a linker, and a chelating agent. Provided is a use of the complex as a radionuclide-labeled targeting molecule. Provided is a radionuclide labeling method, comprising bringing a complex that chelates a radionuclide into contact with an object to be labeled by the radionuclide.

To provide a novel skin cleansing agent, particularly one that leaves the skin feeling smooth after washing. [Solution] (A) Oleoyl sarcosine or its salt (B) Polyglycerol fatty acid esters in which two or more fatty acids are bonded together. A skin cleansing agent containing at least [a certain ingredient].

The present invention aims to provide a liquid oral composition that can suppress the reduction in flavor expression caused by glycyrrhizic acid or its salts by incorporating acyl amino acids or their salts. [Solution] A liquid oral composition comprising: (A) component: at least one selected from the group consisting of glycyrrhizic acid and its salts; (B) component: at least one selected from the group consisting of acyl amino acids and their salts; and (C) component: a fragrance, wherein the ratio of the content of component (A) to the content of component (B) is 0.625 to less than 2.2 when component (B) contains acyl sarcosine and its salts, and 0.03 to less than 5 when component (B) does not contain acyl sarcosine and its salts, and substantially free of ethyl alcohol.

It is an object of the present invention to provide a primer composition for surface-printed flexible packaging, an ink set, a surface-printed matter, and an inkjet printing method, which can impart excellent solid uniformity, bleeding resistance, abrasion resistance, alcohol resistance, and heat resistance to a coating film when an inkjet image is formed after applying the primer composition. Provided is a primer composition for surface-printed flexible packaging comprising an acryl-based resin emulsion emulsified with a polymer, N-oleoyl sarcosine, a hydrazine-based compound having at least two or more hydrazine residues in a molecule, and wax, wherein a content of the acryl-based resin emulsion is 3 to 40% by mass in terms of solid content, and wherein a glass transition temperature of the acryl-based resin emulsion is-40 to 30° C.

The invention discloses long-acting anti-dandruff shampoo based on microbial balance regulation and a preparation method of the long-acting anti-dandruff shampoo. The shampoo comprises a cleaning system composed of sodium lauroyl sarcosinate, cocamidopropyl betaine and decyl glucoside, a micro-ecological regulation system composed of piroctone olamine, inulin and a lactobacillus fermentation product, and skin barrier repairing lipids such as ceramide and squalane. According to the preparation method, all the components are effectively integrated through a step-by-step temperature control and homogeneous emulsification process. Through the synergistic effect of the components, malassezia is efficiently inhibited, effective microbial communities on scalp are selectively maintained, and a skin barrier is repaired, so that scalp micro-ecological balance is regulated and controlled, long-acting dandruff removal is realized, the scalp health level is improved, and the scalp care effect is improved. The problems that a traditional anti-dandruff product is likely to cause dysbacteriosis, the effect is not lasting, and relapse is caused after the traditional anti-dandruff product is stopped are solved.

The invention discloses a whitening facial cleanser and a preparation method thereof, and relates to the field of skin care products. The whitening facial cleanser is prepared from 35 to 42 weight percent of a cleaning agent, 1 to 2 weight percent of a whitening and freckle-removing agent, 0.8 to 1.2 weight percent of a skin conditioner, 4 to 8 weight percent of an emollient, 4 to 6 weight percent of a humectant, 0.3 to 0.5 weight percent of a preservative, 0.05 to 0.1 weight percent of a chelating agent, 4 to 4.5 weight percent of a thickening agent, 0.2 to 0.5 weight percent of an aromatic, 0.8 to 1.0 weight percent of a pH regulator and the balance of a solvent. The cleaning agent is prepared from sodium lauroyl isethionate, sodium cocoyl aminopropionate, cocamidopropyl betaine and sodium lauroyl sarcosinate according to the weight ratio of (3.5 to 4.5) to 1 to 1 to 1; the preservative comprises DMDM hydantoin and methylparaben in a weight ratio of (3-4): 1. The whitening facial cleanser provided by the invention has both cleaning power and mildness, and also has a whitening effect.

The invention discloses a sample treating fluid, a vitamin B12 detection sample pretreatment method, a detection kit, a detection method and application thereof, and particularly discloses the sample treating fluid which comprises strong base and sodium dodecyl sarcosinate. According to the sample treatment liquid, VB12 can be completely dissociated, and a relatively stable state can be kept. The invention further provides a detection sample pretreatment method of the vitamin B12. The detection sample pretreatment method comprises the step of mixing the sample treatment liquid with a to-be-detected sample for reaction. According to the sample treatment liquid provided by the invention, VB12 can still be dissociated from binding protein under the condition that highly toxic cyanide or a complex containing cyanide ions and unstable in dissociation is not adopted, and the VB12 can be kept in a relatively stable state to participate in subsequent reaction.

The invention discloses efficient deep penetration acid liquor as well as a preparation method and application thereof. The efficient deep penetration acid liquor comprises the following components in parts by mass: 20-35 parts of a main acid agent, 5-15 parts of a penetration enhancer, 2-6 parts of a corrosion inhibitor, 2-5 parts of a stabilizer and 40-70 parts of deionized water, wherein the main acid agent is a compound of main acid and auxiliary acid, and the penetration enhancer is a compound of fatty alcohol-polyoxyethylene ether and sodium lauroyl sarcosinate. Main body acid (one or two of sulfamic acid and chloroacetic acid) and auxiliary acid (one or two of formic acid and acetic acid) are compounded to serve as a main acid agent, and the main acid agent is combined with a penetration enhancer compounded by fatty alcohol-polyoxyethylene ether and sodium lauroyl sarcosinate, a corrosion inhibitor and a stabilizer. The core goals of deep penetration and low corrosion are jointly achieved, and the method can be applied to various scenes such as soil improvement, oil and gas exploitation and industrial equipment cleaning in a cross-field mode.

The present invention relates to a cyclic peptide comprising an active region comprising the amino acid sequence X1X2X3X4X5X6 or a salt, derivative, prodrug or mimetic thereof. X2 and X5 are arginine; and either:X1 is (7-methoxy-coumarin-4-yl)-Ala-OH (Dac) and X3, X4 and X6 are any amino acid; orX3 is sarcosine (Sar) and X1, X4 and X6 are any amino acid; orX4 is 5,5-dimethylproline (dmPro) or 3-amino-3-(2-naphthyl)propionic acid (Nap) and X1, X3 and X6 are any amino acid; orX6 is Nap and X1, X3 and X4 are any amino acid.The present invention further relates to a pharmaceutical composition comprising the cyclic peptide and the peptide for use in medicine, and particularly cancer.

The invention discloses a device for synthesizing sodium sarcosinate through micro-channel continuous flow, and relates to the technical field of sodium sarcosinate synthesis. The device comprises a glycine methylation reaction channel unit, a catalyst recovery assembly, a sarcosine crystallization and purification channel unit, a sarcosine neutralization reaction pipeline and a sodium sarcosine concentration and crystallization one-piece tank unit, the glycine methylation reaction channel unit comprises a raw material mixing pre-reaction pipe, a catalyst adding tank, a plunger type high-pressure pump and a high-pressure micro-channel reaction pipeline combination; the sarcosine crystallization and purification channel unit comprises a hydrogen volatilization channel, a formaldehyde volatilization and concentration channel and a glycine crystallization channel; the sodium sarcosinate concentration and crystallization integrated tank unit comprises a concentration tank, a first crystallization tank, a redissolution tank and a second crystallization tank. According to the invention, the reaction is carried out through the continuous microchannel, the reaction process separation is simpler than the traditional reaction process separation, the raw material utilization rate is high, and the problems of high preparation cost, troublesome operation, incapability of continuous production and the like of the existing glycine methylation method are solved.

Provided is a method for improving efficiency of heat transmission that enables improving the efficiency of heat transmission by steam in a steam system at a pH of less than 7. A method for improving the efficiency of heat transmission by steam, wherein, in a step of introducing steam into a heat exchanger to heat an object to be heated or a step of contacting the steam with a cooling body to liquefy the steam, a sarcosine compound is allowed to be present in the steam system at a pH of less than 7. As the sarcosine compound, a long-chain sarcosine compound represented by the following formula (I) is preferable. R1C(═O)—N(CH3)—(CH2)n—COOR2 . . . (I) In formula (I), R1 is an unsaturated or saturated linear or branched hydrocarbon group having 7 to 24 carbon atoms, n is an integer of 0 to 2, and R2 is a hydrogen atom or a salt-forming group.

The invention discloses a crude oil pour point depressant which comprises a main agent, an auxiliary agent and a high-flash-point organic solvent, and the mass ratio of the main agent to the auxiliary agent to the high-flash-point organic solvent is (25-35): (1-3): (62-74); wherein the main agent is formed by polymerizing ethylene-vinyl acetate, polyacrylic acid octadecanamide and alkyl maleimide according to a molar ratio of (2.8 to 3.2): (1.8 to 2.2): (1.8 to 2.2); the auxiliary agent is one or any combination of oleic acid diethanolamide, N-oleoyl sarcosine and hydroxy fatty acid; the high-flash-point organic solvent is one or any combination of trimethylbenzene, tetramethylbenzene, propylene glycol butyl ether and diethylene glycol monobutyl ether. The invention also discloses a preparation method and application thereof. The crude oil pour point depressant provided by the invention can effectively reduce the condensation point of high-condensation-point crude oil of which the condensation point is greater than 40 DEG C and improve the fluidity of the high-condensation-point crude oil of which the condensation point is greater than 40 DEG C, so that normal transportation of the crude oil is ensured, and powerful support is provided for reducing the operation cost of the high-condensation-point crude oil and ensuring normal transportation of the crude oil.

The application discloses a silk protein composition for hair growth, and belongs to the technical field of hair growth silk protein compositions. The composition comprises moisturizing agents, fragrance imparting agents, cationic surfactants, acidity adjusting agents, co-emulsifiers, preservatives, antioxidants, oily ingredients, trace ingredients, lauroylsarcosine sodium, cocoyl glutamic acid TEA salt, sodium lauroamphoacetate, sodium chloride, phenoxyethanol, sodium laurate, citric acid, allantoin, cocamide propyl betaine, hydroxybenzoic acid ester, nicotinamide and a silk protein solution. The application has the beneficial effect that the product contains proteins and amino acids, can supplement the required nutrients for damaged and fragile hair, can stimulate the cell proliferation of human head hair papilla cells and hair matrix cells, can make the head of people with thinning hair or baldness regenerate hair, and can prevent hair loss for people with normal hair.

The invention discloses a silicon-free washing and care composition with glycoprotein and polyquaternium-51 synergistic color fixation and repair and a preparation method of the silicon-free washing and care composition with glycoprotein and polyquaternium-51 synergistic color fixation and repair. The composition is prepared from the following components in parts by weight: 1 to 5 parts of glycoprotein grafted and modified by epoxy butyl sulfonate, 0.5 to 3 parts of polyquaternium-51, 0.2 to 2 parts of 2, 5-dihydroxy terephthalamide, glycerol, sodium lauroyl sarcosinate, cocamidopropyl betaine, citric acid, a preservative, essence and deionized water. The glycoprotein grafted and modified by the epoxy butyl sulfonate is prepared by reacting glycoprotein, the epoxy butyl sulfonate, sodium bicarbonate, ethanol and deionized water. Through the synergistic effect of the modified glycoprotein and the polyquaternium-51, the color fixing performance and the repairing effect of hair are effectively improved, the hair surface friction coefficient is reduced, meanwhile, the system is kept stable in long-term storage, the color fixing agent is remarkably superior to a contrast sample which is not modified or lacks key components, and the color fixing agent has a good application prospect.

The invention relates to the technical field of organic synthesis, in particular to a process for synthesizing sodium sarcosinate by using micro-channel continuous flow, which comprises the following specific steps: S1, pretreating raw materials, preparing 30-50wt% of sodium chloroacetate aqueous solution, and filtering; drying the methylamine gas, and storing under a stable pressure; preparing 32wt%-48wt% of a sodium hydroxide aqueous solution; s2, continuous mixing and pre-reaction: pumping the sodium chloroacetate aqueous solution and the methylamine gas into a micro-channel mixer according to a molar ratio of 1: (1.25-1.6), and controlling the temperature to be 20-30 DEG C and the retention time to be 1-3 minutes to obtain a pre-reaction solution; s3, main reaction; s4, neutralizing and removing impurities; s5, concentration and crystallization; and S6, separation and drying: carrying out solid-liquid separation on the crystal suspension, and then carrying out vacuum drying to obtain a sodium sarcosinate finished product. According to the invention, a micro-channel continuous flow process is adopted, continuous operation of the whole process of sodium sarcosinate synthesis is realized, batch feeding and discharging are not needed, and the occupied area of equipment and the investment cost are greatly reduced.

The invention relates to cosmetic or dermatological compositions for combating dandruff which comprise water; at least 20% by weight of at least one polyol relative to the total weight of the composition; at least one anionic surfactant selected from acyl glutamic acids and their cosmetically acceptable salts, sodium lauryl sarcosinate, and disodium cocoglucoside citrate, and mixtures thereof; at least one non-ionic surfactant selected from alkyl glucosides; and at least one anti-dandruff agent which is piroctone olamine, said composition being devoid of ciclopiroxolamine and zinc pyrithione.

The invention belongs to the technical field of biology, and discloses a biosynthesis method of 2, 4-dihydroxybutyric acid. According to the biosynthesis method, L-malic acid and formaldehyde serve as substrates to synthesize 2, 4-dihydroxybutyric acid, L-malic acid is converted into oxaloacetic acid through L-malic dehydrogenase, oxaloacetic acid is decarboxylated to generate pyruvic acid, pyruvic acid and formaldehyde are condensed under the action of aldolase to generate 2-ketone-4-hydroxybutyric acid, and 2, 4-dihydroxybutyric acid is converted into 2, 4-dihydroxybutyric acid through dehydrogenase. The invention relates to 2, 4-dihydroxybutyric acid. The method can be realized through an in-vitro multi-enzyme catalysis system, and can also be completed by introducing a way into microorganisms. Furthermore, the formaldehyde can be generated from methanol, formic acid or sarcosine under the action of enzyme. Therefore, the monocarbon resources such as methanol and formaldehyde can be introduced to synthesize the 2, 4-dihydroxybutyric acid with high value, the raw materials are low in price, and the whole synthesis method has the advantages of high atom utilization rate and high conversion rate.

To provide a delivery peptide as a DDS carrier capable of efficiently transporting a cargo molecule such as mRNA into a cell.SOLUTION: The peptide compound has a E3 ligase ligand, a basic peptide having basic amino acids, and an endosomal escape moiety. The basic peptide is preferably oligoarginine Rn (n is the number of arginine residues and is a natural number of 6 to 12). ). The E3 ligase ligand is ALAPYIP. The endosomal escape moiety is GFWFG. In order to adjust the physical properties, sarcosine Sarn (n is the number of repetitions of sarcosine and is a natural number of 5 to 30) may be further added. ).SELECTED DRAWING: Figure 5

The invention relates to the technical field of cleaning agents, and discloses a pH-neutral amino acid surfactant type water cup cleaning agent which comprises the following components in percentage by weight: 10-25% of an amino acid surfactant with the purity of greater than or equal to 98%, 1-5% of a sodium citrate-citric acid buffer pair and 65-85% of deionized water. The amino acid surfactant is selected from at least one of sodium cocoyl glutamate and sodium lauroyl sarcosinate; the weight ratio of the sodium citrate-citric acid buffer pair to the amino acid surfactant is 1: (2-5); the pH value of the cleaning agent is 6.5-7.5, and the contact corrosion rate of the cleaning agent to a glass coating layer and a ceramic glaze surface is smaller than or equal to 0.01 mm / year. By selecting food-grade-sourced active matters, stubborn tea residues and coffee stains can be thoroughly disintegrated, meanwhile, a precise coating, a ceramic glaze surface or a plastic material on the inner wall of the cup is prevented from being damaged, the general cognition that a traditional mild product is insufficient in dirt-removing power is changed, the unification of deep cleaning and great maintenance is realized, and the service life of the cup is prolonged. And the use safety is ensured.

The present invention aims at the formulation and manufacture of a new natural shampoo without sulfates and without parabens based on laurel hydrosol which will purify the scalp, eliminate oils and combat the proliferation of bacteria. The shampoo composition provided by the invention contains the following components in mass percentage: 72% laurel hydrosol, 8.5% geranium hydrosol, 9% Sodium Lauroyl Sarcosinate surfactant, 8% Coco Betaine surfactant, 0.2% preservative, 0.7% thickening stabilizer Xanthan Gum, 1% laurel oil macerate and 0.5% laurel essential oil. The physicochemical analysis of the prepared shampoo shows that its pH is 6.90, its density is 0.91, and its foaming power is 210 ml. It is rheologically stable and does not cause skin irritation.

This invention belongs to the field of personal care product technology, specifically relating to a male genital mousse wash containing PHMB and its preparation method. The wash uses polyhexamethylene biguanide hydrochloride (PHMB) as the core antibacterial agent, combined with cocoylpropyl betaine and sodium lauroyl sarcosinate as the cleansing surfactant system, compounded with sodium hyaluronate, panthenol, and dipotassium glycyrrhizate, supplemented with propylene glycol, glycerin, disodium EDTA, and phenoxyethanol. The pH is adjusted to 5.0–6.0 with L-lactic acid, and the remainder is water for injection. The preparation employs a low-temperature stepwise feeding process to obtain a weakly acidic mousse foam. The product exhibits an antibacterial rate of ≥99.99% against Escherichia coli, Staphylococcus aureus, and Candida albicans, is non-irritating to the skin, produces a dense and stable foam that is easy to rinse, and has good high and low temperature stability. It combines cleansing, antibacterial, and mucosal repair effects, solving the problems of traditional feminine hygiene products such as high irritation, easy allergy, and poor dosage form experience. It is suitable for daily cleaning and care of the male genitalia.

The invention discloses a lysate as well as a preparation method and application thereof, and belongs to the technical field of molecular biology. The lysate comprises chaotropic salt, sodium lauroyl sarcosinate, TCEP and a solvent. In addition, the invention also provides a preparation method of the lysate, which comprises the following steps: adding chaotropic salt, sodium lauroyl sarcosinate, TCEP, EDTA and Tris-HCl into a solvent to obtain a solution, and then adjusting the pH value of the solution to 7.0-7.5 to obtain the lysate. In addition, the invention also provides an application of the lysate in extraction of RNA (Ribonucleic Acid). According to the lysate provided by the invention, the RNA (Ribonucleic Acid) integrity of high RNase tissues (such as pancreas and spleen) is obviously improved.