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143 results about "Amino acid synthesis" patented technology
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Amino acid synthesis is the set of biochemical processes (metabolic pathways) by which the amino acids are produced. The substrates for these processes are various compounds in the organism's diet or growth media. Not all organisms are able to synthesize all amino acids. For example, humans can only synthesize 11 of the 20 standard amino acids (a.k.a. non-essential amino acid), and in time of accelerated growth, histidine, can be considered an essential amino acid.
Method for synthesizing liraglutide
ActiveCN104004083AReduce carrier usageAvoid couplingPeptide preparation methodsBulk chemical productionAmino acid synthesisCoupling
The invention relates to the field of medicine synthesis, and discloses a method for synthesizing liraglutide. The method includes the steps that three polypeptide fragments of the first to the fourth amino acid, the fifteenth to the sixteenth amino acid and the seventeenth to thirty-first amino acid are synthesized at first according to the amino acid sequence from N end to C end of a main chain of liraglutide, and then the three polypeptide fragments and the other amino acid are connected according to the sequence from the C end to the N end in a coupling mode to synthesize the liraglutide. According to the method, the three fragments can be synthesized simultaneously, coupling and acidolysis with much carrier resin are avoided, the use quantity of resin carriers is greatly reduced, the synthesis cycle is shortened, and the complexity level of synthetic process is simplified on the premise that high total recovery and purity are guaranteed.
Owner:CHENGDU SHENGNUO BIOTEC CO LTD
Method for detecting free amino acids in tea by using reversed-phase high-performance liquid chromatography
InactiveCN104678044AEasy to handleLow costComponent separationChromatographic separationAmino acid synthesis
The invention relates to a method for detecting free amino acids in tea by using the reversed-phase high-performance liquid chromatography. The method comprises the following steps: drying and grinding fresh tea, and adding boiling water for digestion; after supernatant liquor is collected, repeatedly extracting and merging the supernatant liquor; after the supernatant liquor is sucked and filtered, carrying out precolumn derivatization for a tea soup sample with an AccQ.Tag derivatization reagent; optimizing chromatographic separation and detection conditions with HPLC and AccQ.Tag C18 special amino acid analysis columns, and finally separating and detecting 19 kinds of free amino acids such as glutamine. The method can simultaneously determine the contents of 19 kinds of free amino acids such as glutamine in the tea, makes up the vacancy that glutamine in the tea cannot be quickly and accurately analyzed based on the high-performance liquid chromatography qualitatively and quantitatively at present, and provides a new idea for researching the synthesis path of amino acids in the tea.
Owner:ANHUI AGRICULTURAL UNIVERSITY
Method for synthesizing laurel acyl amino acid sodium
ActiveCN105152957AHigh catalytic activityReduce solubilityOrganic compound preparationCarboxylic acid amides preparationAmino acid synthesisFatty amine
The invention discloses a method for synthesizing laurel acyl amino acid sodium. The method comprises the steps that lauric acid and phosgene react by being catalyzed by organic aryl amide, and lauroyl chloride is prepared; lauroyl chloride and amino acid react in an alkaline solution, and lauroyl amino acid salt is prepared; extraction separation is carried out, a catalyst is recycled from an organic phase, a water phase is sequentially subjected to acidification, filter separation, sodium hydroxide neutralizing and cooling crystallization, and laurel acyl amino acid sodium is obtained. According to the method, organic aryl amide is mainly adopted as the catalyst for the reaction of lauric acid and phosgene, the lauric acid acylation reaction is thorough, no residue exists, acyl chloride products do not need layering, distilling and other purifying processes can be directly used for synthesizing laurel acyl amino acid sodium, and especially the catalyst can be recycled and cyclically utilized through a simple method. Compared with use of existing DMF and other fatty amine catalysts, the process steps are greatly simplified, the yield and quality of the product are improved, production cost is reduced, environmental protection is facilitated, and the requirements of industrial production are met.
Owner:CHANGSHA PUJI BIOTECH
Production process for amino acids of the aspartate family using microorganisms
Owner:PAIK KWANG IND
Preparation method of lithocarpus polystachyus rehd fermented health drink
ActiveCN101869339AAnti-agingPrevent arteriosclerosisFood preparationBiotechnologyAmino acid synthesis
The invention discloses a preparation method of a lithocarpus polystachyus rehd fermented health drink, which comprises the following steps that: (1) adding lithocarpus polystachyus rehd sweet tea leaves into water, heating, boiling, maintaining boiling for 10 to 20min, staying still so that the lithocarpus polystachyus rehd sweet tea leaves are precipitated, and taking the supernatant as sweet tea solution; (2) selecting yeast fermentation fluid, acetic acid bacteria fermentation fluid and lactobacillus fermentation fluid as fermentation broth; and (3) switching the fermentation fluid into the sweet tea solution, adding sugar, staying still and culturing for 48 to 72h at 30DEG C, and taking filtrate as the lithocarpus polystachyus rehd fermented health drink. The method takes the lithocarpus polystachyus rehd sweet tea as a culture medium to be fermented with lactobacillus, acetic acid bacteria and yeast, and the prepared lithocarpus polystachyus rehd fermented health drink has a plurality of health care functions and natural flavor. The lactobacillus, acetic acid bacteria and yeast that the method adopts can promote human development, improve the immunity and delay the body aging; and the lactobacillus has the effect of antibacterium, intestinal peristalsis promotion, digestion assistance, pathogenicbacteria killing, vitamin and amino acid synthesis in the intestinal tract and the like.
Owner:杭州美澳生物技术有限公司
Preparation method for selenium-enriched glutathione beer yeast biological product by utilizing waste beer yeast
InactiveCN103932198AEasy to synthesizeIncrease productionFungiAnimal feeding stuffAmino acid synthesisHigh pressure
A selenium-enriched glutathione beer yeast biological product is characterized in that waste beer yeast is used for transforming inorganic selenium into organic selenium, and glutathione precursor amino acids are used for synthetizing glutathione, and thus the selenium-enriched glutathione yeast is obtained. The beer yeast biological product provided by the invention not only realizes the recycling of industrial waste of beer, but the glutathione also can promote the activity of the yeast selenium, which makes up deficiency of single selenium enriching in the existing products. The selenium-enriched glutathione beer yeast biological product not only has the effects of oxidation resistance, enhancement of human immunity and so on; at the same time, the selenium-enriched glutathione beer yeast biological product is a high efficient nutrient enhancer and supplement by providing a plurality of amino acids and vitamins to the human body. A preparation method for the selenium-enriched glutathione beer yeast biological product is characterized in that the yeast liquid biotransformed by the organic selenium and the glutathione is subjected to centrifuging, cleaning, heavy suspending, high-pressure homogenizing, colloidal milling, cold drying, pelletizing and tablet compressing to obtain the swallowable or chewable selenium-enriched glutathione yeast tablets. The selenium-enriched glutathione yeast tablets have the advantages of being convenient to eat, stable in components and easy to preserve.
Owner:UNIV OF JINAN
Ginkgo leaf freckle removing whitening cream and preparation method thereof
ActiveCN102988264AStrong free radical scavengerImprove antioxidant capacityCosmetic preparationsToilet preparationsAmino acid synthesisSalvia miltiorrhiza
The invention provides ginkgo leaf freckle removing whitening cream. Raw materials of the ginkgo leaf freckle removing whitening cream comprise, by weight, 10-30 parts of ginkgo leaf, 10-20 parts of leonurus, 10-20 parts of radix angelicae, 10-20 parts of angelica sinensis, 10-20 parts of rhizoma bletillae, 10-20 parts of salvia miltiorrhiza, 10-20 parts of peach blossom, 10-20 parts of rhizome atractylodis, 10-20 parts of myrrh, 10-20 parts of calendula, 10-20 parts of Chinese trumpet creeper, 10-20 parts of scutellaria baicalensis, 10-20 parts of radix paeoniae alba, 10-20 parts of honey suckle, 10-20 parts of albizia flower, 10-20 parts of propollis, 10-20 parts of caulis spatholobi, 10-20 parts of mint and 10-20 parts of pearl. Ginkgol biloba extract has a good effect of removing radical and an antioxidation effect. Yellow glycoside, amino acid and amino acid synthesis collagen in ginkgo leaves have a large effect on beautifying, restraining melanin and maintaining skin gloss and elasticity, and the cream is suitable for long-term use and suitable for use at night.
Owner:SANJIU JUNDA BIOTECH CO LTD GUANGDONG PROVINCE
Novel antibacterial peptide and preparation method and use thereof
InactiveCN101418039AHigh antibacterial activityGrowth inhibitionFungiPeptide/protein ingredientsAmino acid synthesisErythrocyte production
The invention relates to a new antibiosis peptide and a preparation method and application thereof, which belongs to the field of antibiosis peptide and preparation. According to the invention, the temporin-1CEa gene of the new antibiosis peptide is cloned from the total RNA of the skin of rana temporaria chensinensis; and all the DNA sequences are shown in a sequence list. The No.144 to No.192 nucleotides in the gene are encoded as temporin-1CEa; the total sequence is Phe Val Asp Leu Lys Lys Ile Ala Asn Ile Ile Asn Ser Ile Phe-AMIDATION; and the molecular weight is 1733 Daltons. The antibiosis peptide temporin-1CEa which can be prepared through an amino acid synthesizer or a genetic engineering method has remarkable antibiosis and anticancer activity and no haematolysis on the erythrocytes of a mammal, and can be used for preparing antibiosis and anticancer medicines.
Owner:LIAONING NORMAL UNIVERSITY
Membrane modification method for controlling membrane pollution
ActiveCN106943885ANot easy to loseEffective control of biological contaminationSemi-permeable membranesBiological water/sewage treatmentUltrafiltrationBiochemistry
The invention relates to a method for controlling membrane pollution by virtue of D-amino acid. The method comprises the steps of coating the surface of a natural nano-material, namely halloysite with dopamine, binding D-amino acid to halloysite so as to synthesize a nano-composite material capable of maintaining activity of D-amino acid, and adding the nano-composite material into a membrane casting liquid of an ultrafiltration membrane so as to prepare a D-amino acid modified anti-pollution ultrafiltration membrane. By efficiently utilizing the potential of D-amino acid for controlling the membrane pollution and the hydrophily of the composite material, the anti-pollution capacity of the membrane is remarkably improved, an effective and long-acting strategy is provided for controlling the membrane pollution by virtue of D-amino acid, and therefore, the wide application of membrane techniques in the water treatment field is promoted.
Owner:NANKAI UNIV
Solid-phase synthesis method of antibacterial peptide Iseganan
InactiveCN103012563AOvercome deficienciesOvercome defectsPeptide preparation methodsBulk chemical productionAmino acid synthesisDisulfide bonding
The invention relates to a solid-phase synthesis method of an antibacterial peptide Iseganan containing two pairs of disulfide bonds, which comprises the following steps: (1) according to a solid-phase synthesis method, sequentially coupling an amino resin used as a raw material with amino acids to synthesize a protected 17 peptide resin; (2) removing weak acid sensitive protecting groups, and then oxidizing to generate a first pair of disulfide bonds; (3) using iodine to remove Acm protecting groups, and cyclizing to generate a second pair of disulfide bonds; and (4) finally cracking from the resin, removing the protecting groups, and purifying to obtain the Iseganan antibacterial peptide. The route provided by the invention has the advantages of short operation steps, simple post treatment, fewer byproducts, high yield and low pollution, and is suitable for large-scale industrial production.
Owner:NANJING UNIV OF TECH +1
Large-scale preparation and purification method and application of mu-conopeptide
ActiveCN110894225AHigh synthesis efficiencyEasy to operateCosmetic preparationsToilet preparationsAmino acid synthesisCombinatorial chemistry
The invention discloses a large-scale preparation and purification method and application of mu- conopeptide. The large-scale preparation and purification method of the mu-conopeptide comprises the steps of preparation of linear peptide amino resin, cracking, linear peptide folding and crude peptide purification. Amino resin with the substitution degree of 0.6-0.8 is adopted, and the synthesis efficiency is improved; the amino acid is sequentially coupled through solid-phase synthesis to synthesize protected 22-peptide amino resin, and cracking and concentration are carried out; three pairs ofdisulfide bonds are formed by one-step folding through air oxidation, no extra oxidizing agent needs to be added in the folding process, and the method is simple to operate, low in cost and suitablefor industrial mass production; crude peptide is prepared and purified through HPLC, and the mu- conopeptide with the purity larger than 97% is obtained. The invention further provides the applicationof the mu- conopeptide in preparing wrinkle-removing cosmetics. An effect of injecting botulinum toxin can be achieved through simple smearing, and side effects such as pain and facial paralysis caused by botulinum toxin injection can be avoided.
Owner:珠海市维琪科技有限公司
Production process for amino acids of the aspartate family using microorganisms
The present invention is directed to a method utilizing a recombinant microorganism for the production of aspartate derived amino acids and precursors thereof, in particular for the production of L-lysine. Furthermore, the present invention relates to a recombinant microorganism having improved aspartate-derived amino acid synthesis activity in comparison to the initial microorganism and the use of such microorganisms in producing said amino acids and precursors and derivatives, in particular in the synthesis of L-lysine.
Owner:DAESANG
Hair treatment composition with naturally - derived peptide identical to human hair
ActiveUS20120052034A1Improve rigidityHigh strengthCosmetic preparationsHair cosmeticsAmino acid synthesisMedicine
A hair treatment composition containing at least one peptide identical to human hair, where preferably the peptide is synthesized from naturally-derived amino acids and can serve as a natural alternative to the commonly used human or animal derived (wool) keratin peptides.
Owner:HENKEL KGAA
Microbe additive for improving beach saline alkali soil structure and its preparation method and use
ActiveCN104762087AAchieve bondingRaise the ratioOrganic fertilisersSoil conditioning compositionsAmino acid synthesisAlkali soil
The invention discloses a microbe additive for improving a beach saline alkali soil structure and its preparation method and use. The microbe additive is prepared by combined fermentation of bacillus amyloliquefaciens IAE with an extracellular polypeptide gamma-polyglutamic acid secretion function and brevibacterium flavum IAE with an amino acid synthesis function. A fermentation substrate used for fermentation comprises, by weight, 900-930 parts of vinegar residue, 50-60 parts of (NH4)2SO4, 5-8 parts of K2HPO4, 5-8 parts of MnSO4 and 5-8 parts of MgSO4. The invention discloses a microbe matrix containing the microbe additive. The microbe matrix has an active bacterial strain amount of more than 1.0*10<8> cfu.g<-1>, effective improved substance gamma-polyglutamic acid content of greater than or equal to 20g.kg<-1> by dry weight, water content of less than or equal to 30% and organic matter content less than or equal to 45%. The microbe matrix can effectively improve beach saline alkali soil, has high efficiency and environmental friendliness and is conducive to sustainable development of beach soil.
Owner:江苏农丰宝生物科技有限公司
Alkyl tetramine synthesis method, alkyl tetramine product and shale inhibitor thereof
ActiveCN106350036AReliable technologyLow priceOrganic compound preparationCarboxylic acid amides preparationAmino acid synthesisEnvironmental resistance
The invention relates to an alkyl tetramine synthesis method, an alkyl tetramine product and a shale inhibitor thereof. The synthesis method comprises the following steps of S1, amino acid synthesis; S2, esterification reaction; S3, ammonia transesterification; S4, Hofmann degradation reaction; S5, BOC removal protection. The alkyl tetramine product prepared by the method has the molecular structural formula shown as the accompanying drawing; the alkyl tetramine product and clear water are prepared into the shale inhibitor according to the proportion of 1 to 3 percent. The synthesis method provided by the invention is reliable; the synthesis yield is high; the raw material price is low; the production cost is low; the product is safe, achieves the environment-friendly effects, and is suitable for large-scale industrial production. The alkyl tetramine product is nontoxic and harmless and has good water solubility; the inhibition performance is obviously improved through being compared with that of similar products; meanwhile, the temperature-resistant capability reaches 240 DEG C; the product is particularly suitable for ultra-high-temperature deep well drilling.
Owner:SOUTHWEST PETROLEUM UNIV
Recombinant strain for modifying corynebacterium glutamicum promoter, construction method of recombinant strain and application of recombinant strain in production of L-amino acid
The invention provides a method for carrying out saturated mutation on known promoters to screen a large number of promoter mutants with different starting activity intensities, and adding modified promoters in front of genes related to amino acid synthesis pathways in industrial amino acid-producing strains to screen strains with further improved amino acid yield, and a mutant promoter sequence obtained from the method and a recombinant strain obtained from the method.
Owner:SHENZHEN INST OF ADVANCED TECH CHINESE ACAD OF SCI +1
Composition with function of relieving phytotoxicity of glyphosate herbicide and application of composition
InactiveCN104430328AReduce drug damageEasy to synthesizeBiocideAnimal repellantsAmino acid synthesisBULK ACTIVE INGREDIENT
The invention relates to a composition with a function of relieving phytotoxicity of a glyphosate herbicide and application of the composition, belongs to the field of treatment and prevention of crop diseases, and aims at providing a composition with a function of relieving phytotoxicity of a glyphosate herbicide. The active components of the composition comprise algal polysaccharide, brassin and gibberellic acid according to a weight ratio of 1 to (0.02-0.2) to (0.02-20). The composition is capable of relieving phytotoxicity of the glyphosate herbicide; the amino acid synthesis in plant bodies can be accelerated; the amino acids damaged by the phytotoxicity can be supplemented; the adsorption amount of the herbicide in the plant bodies can be reduced; meanwhile, the content of chlorophyll in the plant bodies can be increased; the growth of the crops can be quickly recovered; the influence of on the final yield of the crops caused by the phytotoxicity is reduced.
Owner:CHENGDU NEWSUN CROPSCI
Concise beta2-amino acid synthesis via organocatalytic aminomethylation
ActiveUS20080058548A1High yieldGreat and easy purificationCarbamic acid derivatives preparationOrganic compound preparationAmino acid synthesisPresent method
The present invention provides a method for the synthesis of β2-amino acids. The method also provides methods yielding α-substituted β-amino aldehydes and β-substituted γ-amino alcohols. The present method according to this invention allows for increased yield and easier purification using minimal chromatography or crystallization. The methods described herein are based on an aldehyde aminomethylation which involves a Mannich reaction between an aldehyde and a formaldehyde-derived N,O-acetal (iminium precursor) and a catalyst, such as, for example, L-proline or a pyrrolidine. The invention allows for large scale, commercial preparation of β2-amino acids.
Owner:WISCONSIN ALUMNI RES FOUND
Lipoid cation function molecule synthesized from natural cholesterol and amino acid and preparation method and application thereof
InactiveCN102321140AThe synthesis method is simpleEase of implementation costTransportation and packagingMixingAmino acid synthesisCholesterol
The invention relates to a lipoid cation function molecule synthesized from natural cholesterol and amino acid and a preparation method and application thereof. The lipoid cation organic function molecule has hydrophobicity and hydrophilicity; a hydrophobic building block comes from rich natural lipoid compound cholesterol; a hydrophilic cation building block comes from natural amino acids having high biocompatibility and derivatives thereof; and a synthesis method is simple and efficient, and is easy for realizing large-scale preparation. Compared with a commercially available gene transfection reagent Bpe1-25k, the invention has the advantages that: the lipoid cation function molecule has remarkably low cell toxicity, can be taken as a gene vector for realizing efficient gene transfection in various cells, can be taken as a novel synthesis lipoid biological vector functional material for applying to loading and in-vivo transmission of genes and medicaments, and can be taken as a low-toxicity efficient cationic surfactant for applying to preparation and production of water aqua or emulsion cosmetics and personal nursing materials.
Owner:SHANGHAI INST OF ORGANIC CHEM CHINESE ACAD OF SCI
Synthetic method for teduglutide
The invention discloses a synthetic method for teduglutide and belongs to the field of polypeptide drug synthesis. The method comprises the following steps of by taking amino acids at 2-3 positions ofa teduglutide sequence as pseudo-proline-dipeptide, or amino acids at 5-6 positions of the teduglutide sequence as pseudo-proline-dipeptide, or amino acids at 22-23 positions of the teduglutide sequence as pseudo-proline-dipeptide, or amino acids at 27-28 positions of the teduglutide sequence as pseudo-proline-dipeptide or amino acids at 29-30 positions of the teduglutide sequence as pseudo-proline-dipeptide, sequentially performing solid-phase synthesis on amino acids at other positions of the teduglutide sequence according to a sequence, synthesizing full-protection teduglutide, and performing cracking precipitation to obtain the teduglutide. The method provided by the invention improves the purity of crude peptide, greatly lowers the material cost and the purification cost and is beneficial to industrial amplification production.
Owner:SINOPEP ALLSINO BIOPHARMACEUTICAL CO LTD
1'-thio-aza indirubin compound, application and preparation method thereof
InactiveCN101747339AHas antitumor activityOrganic active ingredientsOrganic chemistryAmino acid synthesisHydroxylamine
The invention discloses a 1'-thio-aza indirubin compound, application and a preparation method thereof, belonging to the field of medical technology. The preparation method of the compound comprises the steps of: respectively condensing 5-substituted, 6-substituted, 7-substituted isatin derivatives or 1-alkyl-7-azaindole-2,3-dione with thieno-(2,3-b)-pyridine-3-ketone or benzo-3(2H)-ketone to obtain a 1'-thio-aza indirubin compound in which R=O, wherein sodium carbonate is used as a catalyst; and reacting the 1'-thio-aza indirubin compound in which R=O with hydroxylamine to obtain a 1'-thio-aza indirubin compound in which R=NOH. The invention also relates to the application of the compound in the preparation of antineoplastic agents, acceptable salts in pharmacy synthesized by the compound with inorganic acid, organic acid or amino acid. The compound of the invention can suppress or kill tumor cells, have the character of anti-tumor activity and can be used for preparing medicines for treating tumors.
Owner:SHANGHAI JIAO TONG UNIV
Amino acid communicating with polyglycol as well as manufacturing method and usage thereof
InactiveCN101176791AImprove pharmacokineticsDoes not affect healingPharmaceutical non-active ingredientsAmino acid synthesisAmino acid binding
The invention relates to an amino acid bound with polyethylene glycol with the following general structure: R-PEG-CO-X-amino acid or R-PEG-X-amino acid; wherein, PEG represents for polyethylene glycol chain; R represents for a hydroxyl group or an oxyl; the oxyl can be chosen from the C1 to C12 alkoxy, cycloalkoxy or aralkoxy; wherein, X represents for the heteroatom with active hydrogen removed except Alpha-carboxyl and Alpha-amino group in amino acid. Utilizing the amino acid bound with polyethylene glycol to synthesis polypeptide, the polypeptide is made from polypeptide positioned on specific position, not only improving the pharmacokinetics, but also having no effect of original treatment. The invention discloses the production method for the amino acid bound with polyethylene glycol.
Owner:CHINA PHARM UNIV
Bio-derived olefin synthesis
InactiveUS20120178961A1Better addressOrganic compound preparationCarboxylic acid esters preparationAmino acid synthesisTyrosine
Disclosed is a method for the combined synthesis of at least two vinylic monomers, at least one of which being an acrylic compound, comprising subjecting a monoconjugated alkene-1-carboxylic compound to reaction with a C2-C4 alkene under conditions of olefin cross-metathesis. The invention is particularly useful for extracting value from protein side streams. Upon protein hydrolysis, suitable amino acids (preferably phenylalanine or tyrosine) are subjected to reductive amination so as to form the corresponding alkene-1-carboxylic acid. Preferably after esterification and separation, this is used in cross-metathesis for the concomitant production of styrene resp. hydroxy styrene, and acrylates. The invention is applicable more widely, to the synthesis of olefins on the basis of carbohydrates, naturally occurring phenolic components, natural protein resources, or amino acids obtained from fermentations.
Owner:STICHTING DIENST LANBOUWKUNDIG ONDERZOEK +1
Method for treating casing processing wastewater and application of treatment product
InactiveCN103951116AReduce processing difficultySolve application limitationsMultistage water/sewage treatmentAmino acid synthesisUltrafiltration
The invention discloses a method for treating casing processing wastewater. The method comprises the following steps: (1) regulating the PH value of the casing processing wastewater to be 6.0-7.0 with hydrochloric acid with mass concentration of 10%, thus obtaining a solution I; (2) adding a chelating agent to the obtained solution I, thus obtaining a solution II; (3) adding a coagulant aid to the obtained solution II, thus obtaining a solution III; (4) adding a flocculant to the obtained solution III, thus obtaining a solution IV; (5) enabling the obtained solution IV to stand for 1-3 hours, collecting the supernatant, and then filtering the precipitate; (6) drying the filtered precipitate; (7) treating the collected supernatant with ultrafiltration and nanofiltration membranes. The method has the advantages that polypeptides and amino acids, which are not easy to extract, in the casing processing wastewater are extracted by synthesizing an amino acid chelate with the polypeptides and amino acids, so that the extraction ratio is high; the reclaimed water can be recycled, thus saving the resources; the treatment method is simple, is easy to control and simultaneously has economic and environmental benefits.
Owner:CHONGQING TIANSHI ANIMAL PROD
Amino acid connected with polyethylene glycol and preparation method and application for amino acid
InactiveCN102827365AImprove pharmacokineticsDoes not affect healingPharmaceutical non-active ingredientsCarrier-bound/immobilised peptidesAmino acid synthesisCarboxyl radical
Amino acid connected with polyethylene glycol is provided with the following structural formula of R-PEG-X-amino acid, wherein the PEG is a polyethylene glycol chain, the R is hydroxyl or alkoxy of the PEG, the alkoxy can be selected from C1-C12 alkoxy, cyclo alkoxy or aralkyl alkoxy, and the X is a heteroatom without activated hydrogen except for alpha-carboxyl and alpha-amino in the amino acid. When the amino acid connected with the polyethylene glycol is used for synthesizing polypeptides, the polypeptides of the polyethylene glycol chain in a specific position can be obtained, and the polypeptides improve pharmacokinetics and do not influence original therapeutic effects of the polypeptides. The invention further discloses a preparation method for the amino acid.
Owner:CHINA PHARM UNIV
L-phenylalanine schiff-base metal copper complex monocrystalline and preparation method thereof
InactiveCN107043390AClear structureGood crystal formGroup 1/11 organic compounds without C-metal linkagesOrganic chemistry methodsAmino acid synthesisSpace group
The invention discloses L-phenylalanine schiff-base metal copper complex monocrystalline and a preparation method thereof. A molecular formula of the complex monocrystalline is C32H30 Cl2Cu2N4O4, a space group is P21 / c, the cell parameter alpha is 12.4595(8) angstrom, b is 8.8566(6) angstrom, c is 14.5085(9) angstrom, alpha is 90 DEG, beta is 101.982(2) DEG C, gamma is 90 DEG, the crystal cell volume V is 1566.11(18) A<3>, and F(000) is 748. The method comprises the following steps: L-phenylalanine and 2-acetylpyridine are subjected to 2-acetylpyridine L-phenylalanine schiff-base ligand, and the ligand and bivalent copper salt are used for preparing the L-phenylalanine schiff-base metal copper complex monocrystalline by a one-step solvothermal method. According to the invention, the solvothermal method is employed for reactive synthesis of the ligand and the divalent metal copper ion copper ions to obtain the L-phenylalanine schiff-base metal copper complex under condition that high temperature for schiff base decomposition and high pressure due to boiling of methanol are not generated, the blue monocrystalline with good crystal form is obtained; the synthesis technology is simple, the prepared complex has a clear structure, the metal complex has amino acid synthesized schiff base ligand, so that the metal complex has latent important application prospect under antineoplastic aspect.
Owner:QINGDAO AGRI UNIV
Synthetic method for beta-amino acids and beta-amino acids synthesized by adopting method
ActiveCN107793351ADetermine structural diversityMild process conditionsCarbamic acid derivatives preparationOrganic compound preparationStructural formulaAmination
The invention relates to a novel synthetic method for beta-amino acids and the beta-amino acids synthesized by adopting the method. The method comprises the following steps: an amide and an azo diacidester are taken as raw materials, an intermediate compound I is synthesized through direct carbon-hydrogen bond amination under the action of a catalyst, the intermediate compound I reacts with methyl bromoacetate to synthesize an intermediate compound II, an amide protecting group is removed under acidic conditions, and therefore the beta-amino acid is obtained; and the chemical structural formula of the beta-amino acid obtained by synthesis is shown in the description, wherein in a formula, R1 and R2 are separately one selected from the group consisting of hydrogen, alkyl, branched alkyl, cycloalkyl, aryl, aryl with various substituents, a heterocyclic group and a heterocyclic group with various substituents; and R3 is an ester group. Compared with the prior art, the method provided bythe invention synthesizes the intermediate compound I through the direct carbon-hydrogen bond amination process, so that substrates can be broadened in a wide range, the synthesized beta-amino acids with substituents in alpha and beta positions have structural diversity, and therefore the method provides a novel method for the industrialized production of the beta-amino acids with the substituentsin the alpha and beta positions.
Owner:SHANGHAI JIAO TONG UNIV
Amino acid gold nanoparticle and preparation method and application thereof
InactiveCN107098823AOrganic chemistry methodsColor/spectral properties measurementsAmino acid synthesisBiological body
The embodiment of the invention discloses an amino acid gold nanoparticle and a preparation method and application thereof. The amino acid gold nanoparticle is synthesized by a gold nanoparticle and amino acid. The embodiment of the invention further discloses a corresponding preparation method and application of the amino acid gold nanoparticle. The amino acid gold nanoparticle is beneficial to achievement of detection of the concentration of heavy metal ions in a living body.
Owner:SHENZHEN INST OF ADVANCED TECH CHINESE ACAD OF SCI
SpyTag/SpyCatcher-cyclized L-beta-hydroxy-alpha-amino acid synthetase and application thereof
The invention relates to SpyTag / SpyCatcher-cyclized L-beta-hydroxy-alpha-amino acid synthetase and an application thereof.
Owner:UNIV OF SCI & TECH BEIJING
Compound amino acid synthesis equipment
PendingCN113750924AIncrease the quality and safety of processed productsExtended service lifeRotary stirring mixersMixer accessoriesAmino acid synthesisChemical synthesis
Owner:刘焕英
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