15 results about "Isatin" patented technology

Method for dyeing keratin fibres starting from isatin and from powder and / or dye extract of indigo-producing plants A subject-matter of the present invention is a method for dyeing keratin fibres, comprising the application, to the hair, of isatin and of at least one powder and / or one extract of indigo-producing plant(s).

The invention relates to the technical field of water electrolysis hydrogen production of anion exchange membranes, in particular to an anion exchange membrane and a preparation method of the anion exchange membrane. The polymer comprises: a rigid main chain formed by copolymerization of an isatin structural unit, an aromatic diphenol structural unit and a polycyclic aromatic hydrocarbon structural unit; the flexible side chains are bonded on a plurality of bonding sites of the rigid main chain through quaternization reaction, and quaternary ammonium salt cation groups are arranged on the flexible side chains; wherein the plurality of bonding sites comprise a nitrogen atom on the isatin structural unit and an oxygen atom on the aromatic diphenol structural unit. The preparation process provided by the invention is high in synthesis efficiency and low in cost, and the anion exchange membrane obtained by the preparation method has high ionic conductivity and excellent chemical stability and is suitable for various electrochemical application scenes.

The invention discloses a method for detecting Fe < 2 + > and Fe < 3 + > in a zinc plating solution, which comprises the following steps: putting a zinc plating solution test solution into a conical flask, then adding hydrochloric acid and a copper sulfate solution, heating, taking down and slightly cooling to obtain a test solution; adding an isatin indicator into the test solution, uniformly shaking, then dropwise adding a titanium trichloride solution until the test solution becomes yellow from blue green, adding excessive titanium trichloride solution after the test solution is stable, adding distilled water, cooling, standing, adding sulfuric acid-phosphoric acid mixed acid after the test solution is obviously blue, then dropwise adding a sodium diphenylaminesulfonate indicator solution, and uniformly shaking; titrating with a potassium dichromate standard titration solution until the test solution is purple, and calculating to obtain the total iron content; and measuring the content of Fe < 2 + >, and calculating the concentration component of Fe < 3 + > according to the total iron content and the concentration component of Fe < 2 + >. The concentration of Fe < 2 + > and Fe < 3 + > can be monitored in real time, anode passivation is prevented, the production quality is controlled, the operation is convenient, the test time is short, and the accuracy of an analysis result is high.

The application relates to the technical field of pharmaceutical chemistry, and discloses a sulfuryl hydrazone compound, a preparation method thereof and anti-tumor application. The compound is synthesized from isatin derivatives and sulfuryl hydrazine through two-step nucleophilic substitution-elimination reaction, has a chemical structure as shown in formula (I), and is characterized by 1H NMR, 13C NMR and HRMS. The sulfuryl hydrazone compound has significant inhibitory activity on A549 (lung cancer), HepG2 (liver cancer) and Hela (cervical cancer) three human cancer cell strains, the value of some compounds is as low as 0.03 micromole / L, the compound can induce cell apoptosis by mediating ROS generation in tumor cells, inhibiting the NF-kappa B signal pathway and activating Caspase-3 activity, and can effectively inhibit cancer cell migration and colony formation. The compound has a mild synthesis process, simple operation and wide substrate applicability, can be used as a potential anti-tumor active ingredient, can be used for preparing drugs for resisting lung cancer, liver cancer, cervical cancer and other tumors, and can provide new candidate compounds and technical support for cancer treatment.

The invention relates to the technical field of 7-methylisatin synthesis, in particular to a 7-methylisatin synthesis method, which comprises the following steps of: 1, data collection and model rehearsal; step 2, activation and pretreatment of the raw materials: a, diazotization reaction; b, carrying out a Sandmeyer reaction; c, carrying out Friedel-Crafts cyclization reaction; step 4, product purification treatment; 5, resource recycling of the waste materials; the system breaks through the limitation of a traditional experience-dependent process, a prediction-optimization-regulation intelligent closed loop is formed through deep fusion of a machine learning model and real-time process control, the system not only can accurately simulate a complex reaction path and globally optimize parameters, but also can dynamically adjust the production process according to online monitoring feedback, and the production efficiency is improved. Therefore, the self-adaptive optimization of the process is fundamentally realized, and the product yield and the excellent stability between batches are remarkably improved.

An agent for oxidatively dyeing keratinous fibers, in particular human hair, containing, in a cosmetic carrier, at least one oxidation dye precursor or the developer type, isatin, and at least one oxidizing agent and related systems and methods.

The present invention describes the development of a method for the detection of psychotropic substances having an isatin or indazole core. A further purpose of the invention is a kit for the determination of these psychotropic substances.

A biomarker composition for diagnosing side effects upon radiation exposure to the lower abdomen according to an embodiment of the present invention is composed of 12 types of blood metabolites that change upon radiation exposure to a local radiation site, wherein the blood metabolites are obtained from a radiotherapy model for prostate cancer patients, diarrhea is diagnosed as a side effect of radiation upon local radiation exposure to the lower abdomen, substances that increase at least 1.5 fold among the blood metabolites are cinnamaldehyde, oleamide, guanidinosuccinic acid, or 2-tridecanone, and substances that decrease at least 2.0 fold among the blood metabolites are isatin, acetylcarnitine, 1-(1-ethyl-1H-pyrrol-2-yl)ethanone, 1-methylhistamine, ecgonine, hexanoylglycine, boschniakine, or 4-phenylpyridine.

A biosynthetic method and composition for producing indigo dyes comprising indigotin and isatin. A tryptophanase (TRP) and a flavin monooxygenase (FMO) can be produced through a transgenic organism having carrier encoded tryptophanase and flavin monooxygenase. The produced tryptophanase and flavin monooxygenase convert L-tryptophan into indigo dyes in the presence of one or more bioactive additives selected from cysteine, 2-hydroxyindole, or 2-indoxyl, and the weight ratio of indigotin to isatin in the dyes is between 1:0.1 to 1:4. The dyes have a hue of X: 0.1920 to 0.2481, Y: 0.2537 to 0.2019, Z: 0.5543 to 0.5501 in the CIE XYZ color space definition. Selectable and repeatable dyeing hues are provided.

An agent for oxidatively dyeing keratin fibers, in particular human hair, containing, in a cosmetic carrier, isatin and at least one polymer from the group consisting of xanthan gum, algin, carrageenan, cetyl hydroxyethyl cellulose, carboxymethyl cellulose, tragacanth, gum karaya, gum ghatti, agar, chitin, chitosan, gum arabic, gellan gum, guar gum, tamarind seed flour, carob gum, and the physiologically acceptable salts thereof.

The present invention provides stereogenic 3,3-disubstituted 3-aminooxindole compounds of formula (I). In addition, the present invention provides a process for preparing a stereogenic 3,3-disubstituted 3-aminooxindole compound of formula (I) using isatins and N-methoxy benzamides in presence of highly abundant iron catalyst. The stereogenic 3,3-disubstituted 3-aminooxindole compound of formula (I) is useful in the preparation of various bio-relevant C3-aminated oxindoles.

本发明公开了氯化试剂二氯胺B介导靛红衍生物的氯代反应的方法，其制备方法如下：在空气情况下，称取1‑甲基‑3‑苯基吲哚‑2‑酮、离子对1‑氟‑4‑甲基‑1,4‑二氮杂双环[2.2.2]辛烷四氟硼酸盐（(Me‑DABCO‑F)2+ 2(BF4)‑）、溶剂N,N‑二甲基甲酰胺（DMF），随后加入二氯胺B在30 ℃条件下反应9 h。用EA（3×20 mL）萃取反应体系，用无水Na2SO4干燥，并通过旋转蒸发浓缩。粗产物通过硅胶快速柱色谱纯化，得到二氯代靛红衍生物。本发明为二氯代化合物的高效合成提供一种无需催化剂，绿色、温和经济、高效的方法，该方法具有广泛的底物适用性和良好的官能团耐受性。

This invention relates to the field of indigo synthesis technology, specifically a method for synthesizing 6-chloro-7-fluoroindigo, including intermediate synthesis. 470 mL of water is added to a reaction flask, followed by the sequential addition of 5.5 mL of concentrated sulfuric acid, 28.64 g of hydroxylamine hydrochloride, 25 g of chloral hydrate, and 20 g of 3-chloro-2-fluoroaniline under stirring. After a white solid precipitates, 100-200 g of anhydrous sodium sulfate is added, and the mixture is heated to reflux for 1.5 hours. After monitoring the remaining raw material at less than 3% using online HPLC, the mixture is cooled to 0°C and filtered. The filter cake is recrystallized using an ethanol-water mixed solvent. The cyclization reaction utilizes a single or composite organic sulfonic acid catalyst, or a recyclable solid acid catalyst, to replace traditional concentrated sulfuric acid. This method has low equipment requirements, is equipped with temperature and pressure interlock devices for automatic cooling and pressure relief, and provides mild and safe reaction conditions, reducing safety risks. Through optimization of the catalyst system, reaction temperature, and time, the cyclization yield is increased from 25.4% to over 50%, significantly improving yield and production efficiency.

Compounds of general structural formula I: Where: R is -H, -CH3, -F, -CI, -Br, -I and -NO2; n is the number of -CH2-(methylene) groups; or a pharmaceutically acceptable salt thereof, for use as a drug in a therapeutically effective concentration for the treatment of disorders involving acetylcholine deficiency in the central nervous system.

The invention discloses a synthesis method of a triarylmethane compound, and belongs to the technical field of organic synthesis. According to the method, an aza-diene compound, isatoic anhydride and an alcohol compound are used as raw materials, and under the catalysis of a Lewis acid catalyst, a one-pot decarboxylation Friedel-Crafts alkylation reaction is carried out in an organic solvent, so that the triarylmethane compound with the structural general formula IV is efficiently and highly selectively synthesized. The method is simple and convenient to operate, the raw materials are easy to obtain, the preferable bismuth trifluoromethanesulfonate catalyst and the dichloromethane solvent are adopted, the yield of 97% can be achieved under the mild condition, and the reaction has excellent para-selectivity. The method is wide in substrate applicability, provides an efficient and practical new way for constructing diversified triarylmethane skeletons, and has important application value in synthesis of medicine and material intermediates.