45 results about "Isatin" patented technology

The invention discloses a crown ether cation selective separation membrane and a preparation method thereof. The preparation method comprises the following steps: carrying out super acid catalysis on dibenzo-18-crown-6, terphenyl and isatin in dichloromethane to synthesize a precursor; carrying out affinity substitution reaction on the precursor and a flexible side chain with an ion exchange group through a pre-modification method to obtain a functional precursor; dissolving the functionalized precursor in an organic solvent to form a film casting solution, coating on a glass plate, and heating to volatilize the solvent so as to form a film through curing; and taking down the membrane from the glass plate, acidifying in an acidic aqueous solution, washing with deionized water, and extracting with deionized water to obtain the crown ether cation selective separation membrane. The crown ether cation selective separation membrane has the advantages of relatively high mechanical strength, physical and chemical stability and the like. Meanwhile, the crown ether cation selective separation membrane shows performance superior to that of a commercial membrane in the field of monovalent cation separation, and has wide application prospects in the fields of TMAH purification, salt lake lithium extraction, seawater salt extraction and the like.

The present invention relates to a narrow-distribution low-branching polyethylene wax and a preparation method thereof. A solvent, ethylene, a catalyst and a cocatalyst are added into a reaction kettle for polymerization reaction. After the polymerization reaction is completed, post-treatment is carried out to obtain a polyethylene wax product. The catalyst is a late transition metal catalyst with isatin as the skeleton, the cocatalyst includes an alkylaluminoxane, and the molar ratio of the catalyst to the cocatalyst is 1:100-600. Compared with the prior art, the present invention uses a late transition metal catalyst with high activity and high thermal stability to prepare a polyethylene wax with excellent performance. The obtained polyethylene wax has a moderate molecular weight, a narrow molecular weight distribution and a small degree of branching.

Provided in the present invention are a polyaryl isatin-based cationic polymer, a preparation method therefor, and the use thereof. The cationic polymer is a novel polyaryl isatin scaffold synthesized by a Friedel-Crafts polycondensation reaction under the catalysis of a superacid. An isatin structural unit in the cationic polymer possesses a very large molecular volume, which can improve the dimensional stability and mechanical properties of the cationic polymer after film formation; in addition, the N site of a cation grafted onto the cationic polymer is located on the para-position of the isatin structural unit, and such a remote grafting strategy can further improve the alkali resistance stability of the cation in the film. Therefore, the cationic polymer of the present invention exhibits extremely high ionic conductivity and mechanical and chemical stability, and can thus be used as an anion exchange membrane or an anion exchange polymer adhesive for alkaline water electrolysis, alkaline fuel cells, carbon dioxide reduction and flow batteries.

The invention discloses a preparation method of a dual-response fluorescent probe based on an isatin hydrazone-pyrazole Schiff base structure, the dual-response fluorescent probe is synthesized by carrying out nucleophilic addition-elimination reaction on amino-functionalized isatin hydrazone and aldehyde group modified pyrazole, and the chemical structural formula of the dual-response fluorescent probe is as follows: # imgabs0 #. The probe disclosed by the invention has high specific recognition capability on Cu < 2 + > and CN <->. The probe shows fluorescence quenching response to Cu < 2 + >, the response time is short, and the anti-interference capability is strong. The probe realizes selective recognition of CN <-> in a fluorescence'opening 'mode, and shows a dual recognition signal of CN <-> along with obvious solution color change.

Method for dyeing keratin fibres starting from isatin and from powder and / or dye extract of indigo-producing plants A subject-matter of the present invention is a method for dyeing keratin fibres, comprising the application, to the hair, of isatin and of at least one powder and / or one extract of indigo-producing plant(s).

Embodiments herein provide fused pyridine heterocycles, such as azaindoles, carboline derivatives, furo[b]pyridines or furo[b]pyridine-isatin hybrids of formula I. Embodiments also relate to a method for synthesizing various complex pyridine heterocycles. The pyridine heterocycles can be used for treating cancer (cervical, kidney, lung, breast and epidermal skin) and multi-drug resistant tuberculosis. These heterocycles are also capable of being used as anti-biofilm agents to limit pathogenic strains, thereby minimizing the risk of secondary infections.

The invention relates to the technical field of water electrolysis hydrogen production of anion exchange membranes, in particular to an anion exchange membrane and a preparation method of the anion exchange membrane. The polymer comprises: a rigid main chain formed by copolymerization of an isatin structural unit, an aromatic diphenol structural unit and a polycyclic aromatic hydrocarbon structural unit; the flexible side chains are bonded on a plurality of bonding sites of the rigid main chain through quaternization reaction, and quaternary ammonium salt cation groups are arranged on the flexible side chains; wherein the plurality of bonding sites comprise a nitrogen atom on the isatin structural unit and an oxygen atom on the aromatic diphenol structural unit. The preparation process provided by the invention is high in synthesis efficiency and low in cost, and the anion exchange membrane obtained by the preparation method has high ionic conductivity and excellent chemical stability and is suitable for various electrochemical application scenes.

The present invention belongs to the technical field of materials science, and specifically discloses a donor-acceptor type compound based on an isoindigo derivative, a preparation method, a molecular wire and a molecular electric switch. The donor-acceptor type compound based on an isoindigo derivative is shown in Formula I: [formula content not provided in the original]. The present invention also discloses a preparation method of the donor-acceptor type compound based on an isoindigo derivative. The synthesis method of the present invention is simple, the raw material cost is low, the process is easy to industrialize, and the product purification is efficient and convenient. A series of donor-acceptor type compounds prepared based on isoindigo derivatives have different energy band gaps and play an important role as molecular wires in single-molecule electron transport materials. Through bias voltage regulation, the molecular conductance of the molecular wire can be reversibly regulated, playing an important role in practical application fields such as molecular electric switches.

The invention discloses a method for detecting Fe < 2 + > and Fe < 3 + > in a zinc plating solution, which comprises the following steps: putting a zinc plating solution test solution into a conical flask, then adding hydrochloric acid and a copper sulfate solution, heating, taking down and slightly cooling to obtain a test solution; adding an isatin indicator into the test solution, uniformly shaking, then dropwise adding a titanium trichloride solution until the test solution becomes yellow from blue green, adding excessive titanium trichloride solution after the test solution is stable, adding distilled water, cooling, standing, adding sulfuric acid-phosphoric acid mixed acid after the test solution is obviously blue, then dropwise adding a sodium diphenylaminesulfonate indicator solution, and uniformly shaking; titrating with a potassium dichromate standard titration solution until the test solution is purple, and calculating to obtain the total iron content; and measuring the content of Fe < 2 + >, and calculating the concentration component of Fe < 3 + > according to the total iron content and the concentration component of Fe < 2 + >. The concentration of Fe < 2 + > and Fe < 3 + > can be monitored in real time, anode passivation is prevented, the production quality is controlled, the operation is convenient, the test time is short, and the accuracy of an analysis result is high.

The invention provides a cationic polymer based on polyaryl isatin as well as a preparation method and application of the cationic polymer. The cationic polymer is a novel polyaryl isatin skeleton synthesized through Friedel-Crafts condensation polymerization under the catalysis of superacid; the isatin structural unit in the cationic polymer has a huge molecular volume so as to improve the dimensional stability and mechanical property of the cationic polymer after film formation, and meanwhile, the N site of the grafted cation on the cationic polymer is positioned on the para-position of the isatin structural unit; the remote grafting strategy can further improve the cation alkali-resistant stability of the membrane, so that the cationic polymer disclosed by the invention shows very high ionic conductivity and mechanical and chemical stability; the polymer can be used as an anion exchange membrane or an anion exchange polymer binder for alkaline electrolyzed water, alkaline fuel cells, carbon dioxide reduction and flow batteries.

A method of treating cancer can include administering one or more of the isatin derivatives to a patient in need thereof. In an embodiment, the cancer is selected from the group consisting of breast cancer, non-small cell lung cancer, renal cancer and melanoma. The isatin derivative is selected from the group consisting of:

The application relates to the technical field of pharmaceutical chemistry, and discloses a sulfuryl hydrazone compound, a preparation method thereof and anti-tumor application. The compound is synthesized from isatin derivatives and sulfuryl hydrazine through two-step nucleophilic substitution-elimination reaction, has a chemical structure as shown in formula (I), and is characterized by 1H NMR, 13C NMR and HRMS. The sulfuryl hydrazone compound has significant inhibitory activity on A549 (lung cancer), HepG2 (liver cancer) and Hela (cervical cancer) three human cancer cell strains, the value of some compounds is as low as 0.03 micromole / L, the compound can induce cell apoptosis by mediating ROS generation in tumor cells, inhibiting the NF-kappa B signal pathway and activating Caspase-3 activity, and can effectively inhibit cancer cell migration and colony formation. The compound has a mild synthesis process, simple operation and wide substrate applicability, can be used as a potential anti-tumor active ingredient, can be used for preparing drugs for resisting lung cancer, liver cancer, cervical cancer and other tumors, and can provide new candidate compounds and technical support for cancer treatment.

The present invention relates to a compound containing a bisisatoic anhydride functional group, a polymer with dual pH and temperature stimuli-responsive properties, and a preparation method and application thereof. The compound containing the bisisatoic anhydride functional group has a structure shown in formula (1). The polymer with dual pH and temperature stimuli-responsive properties is obtained by a polymerization reaction of the compound containing the bisisatoic anhydride functional group described in the present invention with oligoethylene glycol diamine. The aqueous solution of the polymer has dual pH and temperature stimuli-responsive properties and has LCST-type phase transition characteristics. The amino groups on its main chain make it positively charged in an aqueous solution, and it can be conjugated with negatively charged siRNA through electrostatic interaction, and can be used to load siRNA and deliver siRNA drugs, so it has potential application value in the fields of intelligent responsive materials and pharmaceutical biology. #imgabs0#

The invention relates to the technical field of 7-methylisatin synthesis, in particular to a 7-methylisatin synthesis method, which comprises the following steps of: 1, data collection and model rehearsal; step 2, activation and pretreatment of the raw materials: a, diazotization reaction; b, carrying out a Sandmeyer reaction; c, carrying out Friedel-Crafts cyclization reaction; step 4, product purification treatment; 5, resource recycling of the waste materials; the system breaks through the limitation of a traditional experience-dependent process, a prediction-optimization-regulation intelligent closed loop is formed through deep fusion of a machine learning model and real-time process control, the system not only can accurately simulate a complex reaction path and globally optimize parameters, but also can dynamically adjust the production process according to online monitoring feedback, and the production efficiency is improved. Therefore, the self-adaptive optimization of the process is fundamentally realized, and the product yield and the excellent stability between batches are remarkably improved.

An electrochemical device includes a compound that is an isatin derivative. The electrochemical device may be a lithium ion battery, a sodium ion battery, or a redox flow battery, and the isatin derivative may be a bipolar redox active material.

An isatin-based indolodihydrochromene anti-tumor compound and its synthesis method. The chemical structural formula of the compound is shown in Formula 3. The synthesis method is as follows: The isatin-derived propargyl alcohol and 2-indolylphenol derivative are added to ethyl acetate as reaction raw materials, and under the catalysis of p-toluenesulfonic acid, the reaction is stirred at 25 °C for 8-12 hours. The reaction is tracked by TLC until it is complete, and then filtered, concentrated, and purified to obtain the product. The isatin-based indolodihydrochromene compounds synthesized in the present invention, through bioactivity tests, show that these derivatives have high sensitivity and strong cytotoxic activity against human nasopharyngeal carcinoma cells HONE-1. The reaction conditions of the present invention are relatively conventional, the reaction process is mild, simple, and low-cost, suitable for large-scale industrial production, and broaden the scope of application of this method; the present invention uses a relatively large variety of substrates as reactants, obtaining products with diverse structures and high yields.

The present invention provides a new synthetic method for the preparation of building block indole-3-carboxylic acid (ICA) derivatives used as a key starting material to produce several artificial drugs. An efficient, safe, operationally simple, cost-effective method for the preparation of several ICA derivatives has been introduced in a very simple way. Utilizing easily available starting material, reagent, and solvent several key starting materials of ICA derivatives have been synthesized rapidly indicates the novel method is functional group tolerable. The preparation process does not involve use of any reducing agents or transition metals in the economically viable and operationally simple condition in one pot. ICA derivatives have been generated from isatin derivative in one step and this methodology is important with a wide range of applications from the drug development and material synthesis CN point of view.

An agent for oxidatively dyeing keratinous fibers, in particular human hair, containing, in a cosmetic carrier, at least one oxidation dye precursor or the developer type, isatin, and at least one oxidizing agent and related systems and methods.

The present invention describes the development of a method for the detection of psychotropic substances having an isatin or indazole core. A further purpose of the invention is a kit for the determination of these psychotropic substances.

The application discloses an indigoid exocyclic diene compound and a preparation method. N 2' / S N 2” addition, and reaction with (E)-1-benzyl-3-(2-oxo-2-phenylene)indole-2-ketone compounds, a tandem reaction of intermolecular [4+2] / elimination occurs, and an indigoid exocyclic diene structure is obtained in a good yield and high diastereoselectivity. The application has the advantages of good diastereoselectivity, good yield, greenness, high efficiency, mild reaction conditions, convenient operation, relatively short reaction time (20-24h), and less by-products.

A biomarker composition for diagnosing side effects upon radiation exposure to the lower abdomen according to an embodiment of the present invention is composed of 12 types of blood metabolites that change upon radiation exposure to a local radiation site, wherein the blood metabolites are obtained from a radiotherapy model for prostate cancer patients, diarrhea is diagnosed as a side effect of radiation upon local radiation exposure to the lower abdomen, substances that increase at least 1.5 fold among the blood metabolites are cinnamaldehyde, oleamide, guanidinosuccinic acid, or 2-tridecanone, and substances that decrease at least 2.0 fold among the blood metabolites are isatin, acetylcarnitine, 1-(1-ethyl-1H-pyrrol-2-yl)ethanone, 1-methylhistamine, ecgonine, hexanoylglycine, boschniakine, or 4-phenylpyridine.

The invention belongs to the technical field of biological medicines, and discloses application of isatin in preparation of a medicine for treating polycystic ovarian syndrome. The medicine for treating the polycystic ovarian syndrome contains isatin or a derivative thereof. The medicine for treating the polycystic ovarian syndrome can be an oral preparation, an injection, a granule, a pill, a capsule, powder, a slow-release or controlled-release preparation, a targeted preparation and other preparations. The preparation method of the medicine for treating the polycystic ovarian syndrome comprises the following steps: S1, purifying isatin, and preparing isatin crystals with the purity greater than 99%; and S2, adding 100 mg of isatin into 10 ml of the 1% sodium carboxymethyl cellulose solution by taking the 1% sodium carboxymethyl cellulose solution as a solvent, and carrying out ultrasonic uniform mixing at 50 DEG C to prepare a 10 mg / ml isatin solution, namely the medicine for treating the polycystic ovarian syndrome. The medicine for treating the polycystic ovarian syndrome is prepared from isatin or the derivative thereof, and reference value is provided for preparing the medicine which is good in effect, small in toxicity and low in side effect.

The invention discloses a synthesis method of 3-pyrazolidone and seven-membered nitrogen heterocyclic ring derivatives, and belongs to the field of organic synthesis. According to the method, isatin-derived alpha-trifluoromethacrylate is taken as a raw material, and reacts with hydrazine or o-phenylenediamine in an organic solvent, so that two different types of nitrogen-containing heterocyclic compounds, namely 3-pyrazolidone and seven-membered nitrogen-containing heterocyclic compounds, can be obtained. The method does not need any catalyst, the reaction is green, simple, convenient and efficient, the substrate is good in universality, and a new thought is provided for synthesis of the heterocyclic compound.

A biosynthetic method and composition for producing indigo dyes comprising indigotin and isatin. A tryptophanase (TRP) and a flavin monooxygenase (FMO) can be produced through a transgenic organism having carrier encoded tryptophanase and flavin monooxygenase. The produced tryptophanase and flavin monooxygenase convert L-tryptophan into indigo dyes in the presence of one or more bioactive additives selected from cysteine, 2-hydroxyindole, or 2-indoxyl, and the weight ratio of indigotin to isatin in the dyes is between 1:0.1 to 1:4. The dyes have a hue of X: 0.1920 to 0.2481, Y: 0.2537 to 0.2019, Z: 0.5543 to 0.5501 in the CIE XYZ color space definition. Selectable and repeatable dyeing hues are provided.

The invention relates to an agent, a kit and a method for dyeing keratin-containing fibers, in particular human hair, using an indicane-containing component which, depending on its origin, was pretreated at a temperature in the range of 60°C to 200°C, a non-vegetal beta-glucosidase (E.C. 3.2.1.21) of fungal or bacterial origin, cysteine and isatin.

The invention provides a novel 7-methyl-3-oxo-2-(2-oxoindoline-3-subunit)-6-ethoxyformyl-5-aryl-2, 3-dihydro-5H-thiazolo [3, 2-a] pyrimidine derivative as shown in a formula (I), and in the formula (I), a substituent group R is H, C1-6 alkyl, F, Cl, Br, I, alkoxy, hydroxyl, nitrile group, nitro, carboxyl, amino or sulfonic acid group. The 7-methyl-3-oxo-2-(2-oxoindoline-3-subunit)-6-ethoxyformyl-5-aryl-2, 3-dihydro-5H-thiazolo [3, 2-a] pyrimidine derivative disclosed by the invention has certain inhibitory activity on tumor cells, the synthesis method of the 7-methyl-3-oxo-2-(2-oxoindoline-3-subunit)-6-ethoxyformyl-5-aryl-2, 3-dihydro-5H-thiazolo [3, 2-a] pyrimidine derivative is simple, and the materials are easy to obtain. The compound can be used for preparing anti-tumor drugs. # imgabs0 #

The invention provides a novel (Z)-8-(2-oxoindoline-3-subunit)-9-oxo-5-aryl tetrahydropyrano [3, 2-e] thiazolo [3, 2-a] pyrimidine derivative as shown in a formula (I), and in the formula (I), a substituent group R is H, C1-6 alkyl, F, Cl, Br, I, alkoxy, hydroxyl, nitrile group, nitro, amino, carboxyl or sulfonic acid group. The (Z)-8-(2-oxoindoline-3-subunit)-9-oxo-5-aryl tetrahydropyrano [3, 2-e] thiazolo [3, 2-a] pyrimidine derivative disclosed by the invention has certain inhibitory activity on tumor cells, the synthesis method of the derivative is simple, and the materials are easy to obtain. The compound can be used for preparing anti-tumor drugs. # imgabs0 #

The present invention belongs to the field of pesticide chemistry, and relates to a pyrrolidine spirobisoxindole compound containing quinazolinone. The present invention discloses the molecular formula of the compound and also discloses its preparation method: substituting isatin, benzylamine and Schizocommunin are dissolved in a reaction solvent in proportion and reacted by the "one-pot method". After the reaction of Schizocommunin is detected to be complete by thin layer chromatography, the reaction solvent is removed under reduced pressure to obtain a crude product, which is obtained after recrystallization in a solvent. The method of the present invention does not require a catalyst, is simple and efficient. The raw materials are easily available and the atomic utilization rate is high; the operation is simple and convenient; the substrate range is wide and the functional group compatibility is good, and pyrrolidine spirobisoxindole compounds containing quinazolinone with rich structures can be obtained in high yields. The compounds disclosed by the present invention exhibit good activities against plant pathogenic fungi and can be used for controlling plant pathogenic fungi, especially Physalospora piricola Nose.

An agent for oxidatively dyeing keratin fibers, in particular human hair, containing, in a cosmetic carrier, isatin and at least one polymer from the group consisting of xanthan gum, algin, carrageenan, cetyl hydroxyethyl cellulose, carboxymethyl cellulose, tragacanth, gum karaya, gum ghatti, agar, chitin, chitosan, gum arabic, gellan gum, guar gum, tamarind seed flour, carob gum, and the physiologically acceptable salts thereof.

The invention relates to an agent, a kit and a method for dyeing keratin-containing fibers, in particular human hair, using an indicane-containing component which, depending on its origin, was pretreated at a temperature in the range of 60°C to 200°C, a non-vegetal beta-glucosidase (E.C. 3.2.1.21) of fungal or bacterial origin, cysteine and isatin.