329 results about "Isatin" patented technology

Belonging to the field of preparation of polymer materials and polymer ion exchange membranes thereof, the invention relates to a Cardo structure-containing isatin aromatic hydrocarbon copolymer, a preparation method and application thereof. Specifically, by means of superacid catalyzed hydroxyalkylation polycondensation reaction, isatin, 9, 9-disubstituted fluorene and aromatic hydrocarbon are subjected to a multi-component copolymerization reaction to synthesize an isatin-aromatic hydrocarbon copolymer containing Cardo structure and ammonium cations, so that an electrolyte solution and a tough anion exchange membrane can be conveniently prepared, and the polymerization reaction is simple and practicable. A large-volume Cardo structure is introduced into the polymer, thus reducing the adsorption on a catalyst surface and improving the fuel cell performance; an isatin structure is introduced for crosslinking or functionalization so as to further improve the chemical stability and mechanical properties. The copolymer electrolyte solution and the ion exchange membrane have high ionic conductivity, excellent alkali resistance / oxidation resistance and mechanical properties, and have wide application in fuel cells, energy storage batteries, electrolysis and other electrochemical devices or membrane separation related fields.

The invention discloses coumarin-thiazole-indolone compounds, and a preparation method and application thereof. The compounds are disclosed as Formula (I). The preparation method comprises the following steps: reacting salicylaldehyde and ethyl acetoacetate to obtain 3-acetyl-2H-benzopyranyl-2-one, carrying out bromination, cyclization and hydrazinolysis reaction to obtain 4-(2-oxo-2H-benzopyranyl-3-yl)thiazolyl-2-formylhydrazine, and finally, reacting with various substituted isatin to obtain the target compounds. The compounds can be used as a raw material of antibacterial drugs. The preparation method has the advantage of simple and accessible raw materials, and is convenient to operate.

The invention discloses application of tris(bis(trimethylsilyl)amino)lanthanum to catalyzed preparation of a spiro[cyclopropane-1,3'-indole] compound. The chemical formula of tris(bis(trimethylsilyl)amino)lanthanum is [(Me3Si)2N]3Ln(Mu-Cl)Li(THF)3, and can be taken as a catalyst for catalyzing substitution of isatin, phosphite ester and olefin to prepare the spiro[cyclopropane-1,3'-indole] compound through a one-pot reaction; in the catalyst, (Me3Si)2N represents trimethylsilylamino; Ln represents positive trivalent rare earth metal ions, and is selected from one of lanthanum, samarium, gadolinium, erbium or ytterbium; Mu- represents a bridged bond; THF represents tetrahydrofuran. In the method, a catalyst synthesizing method is simple, reaction raw materials are simple and readily available, a substrate has a wide application range, the one-pot reaction has high efficiency, reaction conditions are mild, and the yields of most target products are 85 percent or more.

The invention relates to a preparative method for isatin, including the procedures as follows: compounding hydroxylamine sulphate; utilizing the hydroxylamine sulphate to synthesize oximido antifebrin; carrying out cyclization reaction and deamination reaction for the oximido antifebrin to product the coarse product of the isatin; and refining the coarse product of the isatin to obtain the isatin product, wherein, sodium nitrite, carbonate and supercarbonate of alkali metal and sulfur dioxide are adopted as the raw materials to synthesize the ydroxylamine sulphate. Te alkali metal is kalium or natrium. The isatin product produced by the method disclosed in the present invention has the advantages of high purity and good quality.

The invention relates to a novel method for preparing 3-hydroxylquinaldine-4-carboxylic acid. The 3-hydroxylquinaldine-4-carboxylic acid produced by the prior art has low purity. To solve the problem, the novel method for preparing the 3-hydroxylquinaldine-4-carboxylic acid comprises the following steps of: (1) adding 1.0 molar part of solid isatin into enough clear water, then adding 1.0 equivalent molar part of inorganic base, mixing and dissolving, filtering, and collecting filtrate; and (2) adding 1.0 equivalent molar part of inorganic base into the obtained filtrate, dropwise adding 1 to2.0 molar parts of monochloroacetone, then dropwise adding hydrochloric acid to adjust the pH value to be 7, then emptying and filtering, collecting a filter cake, and drying to obtain a finished product. BY the method, the content and purity of the 3-hydroxylquinaldine-4-carboxylic acid are improved on the premise of not increasing equipment, raw materials, processes and the like; and the purityof the 3-hydroxylquinaldine-4-carboxylic acid prepared by the method is over 97 percent, and the yield is more than or equal to 95 percent.

The invention discloses a preparation method of 2,3-indolediketone-3-oxime or isatin-3-oxime and discloses application of the 2,3-indolediketone-3-oxime in preparing cancer prevention or control drugs. The application of the 2,3-indolediketone-3-oxime in prevention and control of cancer or other malignant tumours is characterized in that the substance has obvious growth inhibition action on various tumour cells, has specific G1-phase blocking action on cell generation cycle, i.e. the substance can stop the tumour cells carrying out DNA (deoxyribonucleic acid) replication, and has obvious down regulation action on the expression of cycle proteins cyclin E, cyclin B and cyclin A, obvious up regulation action on the expression of a cell cycle inhibiting factor p21, induction action on cancer cells or precancerosis cells and sensitization action on gene toxic chemotherapeutic agents.

The invention relates to the field of chemocatalysis and discloses a pyrrolo or indolo azacycloalkane structure containing chiral spiro oxyindole compound as well as a racemate and a preparation method thereof. The method comprises the following steps of by taking N-substituted isatin or benzene ring substituted isatin (1) and N-alkylamino group substituted pyrrole or indole (2) as reaction substrates and using chiral phosphoric acid or an enantiomer or a racemate thereof as a catalyst, directly preparing the pyrrolo or indolo azacycloalkane structure containing chiral spiro oxyindole compoundby one step by a way of catalyzing [m+1] cycloaddition in the environment of a solvent and an additive. Through a method of [5+1], [6+1] or [7+1] cycloaddition, by taking the chiral phosphoric acid as the catalyst, asymmetric synthesis is realized; and by using isatin which is not modified, a 3',4'-dihydro-2'H-spiro[indoline-3,1'-pyrrolo[1,2-a]pyrazine]-2-ketone compound is obtained for the firsttime through one-step reaction only, and the reaction can be extended to the cycloaddition process of a larger ring system. By adopting the method provided by the invention, an activity test is performed on the obtained compound, and a lead compound with very good physiological activity is obtained.

The invention relates to an isatin derivative and application thereof in preparation of medicines for resisting super-drug-resistance bacteria. The isatin derivative has very strong inhibitory action on MRSA (Methicillin-resistant Staphylococcus Aureus) and can be used for preparing novel effective anti-microbial medicines. The medicines can be made into injections, tablets, pills, capsules, suspending agents or emulsions. The administration routes of the medicines can be of oral administration and percutaneous, venous or intramuscular injection. The isatin derivative is as shown in the chemical structural formula (I), wherein in the formula, R1 is H, phenyl or p-fluorophenyl; R2 is F, C1, Br, I or H; R3 is F, C1, Br, I or H; R4 is H, CH3 and o-fluorobenzyl, m-fluorobenzyl and p-fluorobenzyl.

The invention discloses a spiro-indolone ethylene oxide derivative obtained with an o-trimethylsilylphenyl triflate, an N-methyl isatin derivative and aryl thioether as raw materials, CsF as an alkali and an organic solvent as a solvent and through a one-pot method, wherein an active intermediate benzyne is obtained by allowing o-trimethylsilylphenyl triflate to generate 1,2- elimination under fluorinion induction. In the synthetic method, the whole reaction adopts the one-pot method, reaction substrates are friendly to the environment, operations are simple, conditions are mild, product structures are diverse, and the product is widely applied in natural products and clinical medicines.