27 results about "Hydrazine compound" patented technology

The application belongs to the technical field of permeation membrane, and discloses a composite permeation membrane structure, a permeation tube and application for volatile hydrazine compounds. The composite permeation membrane structure has at least two layers of permeation membranes, which include: a contact permeation membrane, which is the first layer of permeation membrane contacted by hydrazine compounds along the permeation direction. The contact permeation membrane is a material resistant to corrosion of liquid hydrazine compounds and has a first permeation coefficient for hydrazine compounds. A slow-release permeation membrane is arranged on the back side of the contact permeation membrane along the permeation direction of hydrazine compounds, and at least one layer is arranged. The slow-release permeation membrane has a second permeation coefficient for hydrazine compounds, and the second permeation coefficient is smaller than the first permeation coefficient. The composite permeation membrane structure of the application can realize stable and low-speed permeation of hydrazine compounds, and the permeation tube can be prepared to be used for preparation of low-concentration hydrazine compound standard gas.

The invention belongs to an amide intermediate treatment device and method for hydrazine hydrate production. Comprising a concentration tank, the concentration tank is provided with a water-phase reaction liquid inlet pipeline and a catalyst inlet, the catalyst inlet is connected with a quartz sand catalyst preparation unit, an outlet of the concentration tank is connected with a concentrated material inlet of an intermediate recovery kettle, and the intermediate recovery kettle is further connected with an ammonia feeding pipeline. An ammoniation liquid outlet of the intermediate recovery kettle is connected with a separation and recovery unit, and a liquid phase outlet of the separation and recovery unit is connected with a hydrazine compound synthesis section; a steam discharge pipeline is arranged at the top of the concentration tank; the method has the advantages that moisture in the water-phase reaction liquid can be removed, ammonium formate is converted into formamide and recycled, meanwhile, metal ions are prevented from being contained in ammoniation liquid, and further, the treatment cost is reduced and continuous treatment is achieved on the basis of energy conservation and consumption reduction.

This application provides a self-healing polyurethane material, its preparation method, and its applications, relating to the field of polymer materials technology. The material uses a polyurethane matrix constructed from polyols and polyisocyanates, and introduces aromatic polyaldehyde compounds to form reversible dynamic bond structures with hydrazine compounds, thereby endowing the material with excellent self-healing properties. By controlling the type of chain extender and the melt blending process conditions, the material can achieve crack healing and restore mechanical properties after damage, while also possessing good flexibility, processability, and stability. The preparation process of this application is simple and the conditions are mild. The resulting material can be widely used in coatings, seals, and elastomers, significantly improving material service life and reliability.

The invention belongs to the technical field of organic compounds, and particularly discloses an indolinone compound and a synthesis method thereof. The molecular structural formula of the indolinone compound is shown as a formula (A), and the synthesis method of the indolinone compound comprises the following steps: S1, carrying out an amide condensation reaction on a compound shown as a formula (1) to generate a compound shown as a formula (2); s2, performing aminolysis reaction on the compound as shown in the formula (2) to generate a hydrazide compound as shown in a formula (3); s3, carrying out nucleophilic substitution reaction on the compound as shown in the formula (4) to generate a compound as shown in a formula (5); and S4, carrying out condensation reaction on the compound as shown in the formula (3) and a compound as shown in a formula (5) to generate the indolinone compound as shown in a formula (A). The indolinone compound provided by the invention is novel in structure, mild and simple in synthesis method and high in yield, and the indolinone compound is also found to be effective in antibiosis.

The application belongs to the technical field of organic synthesis, and particularly relates to a 1,3,5-trisubstituted pyrazole compound and a preparation method thereof. The preparation method of the 1,3,5-trisubstituted pyrazole compound provided by the application comprises the following steps: mixing a hydrazine compound, an alpha-bromoketone compound, a photocatalyst, an alkaline compound, an additive and a polar organic solvent, and performing an addition cyclization reaction under light irradiation to obtain the 1,3,5-trisubstituted pyrazole compound. The preparation method has the advantages of mild conditions, easy control, high reaction efficiency, economical steps, cheap and easily available raw materials, no use of oxidants, good functional group tolerance and the like, and the prepared 1,3,5-trisubstituted pyrazole compound has high purity, the purity is 98.5-99.9%, and has great market promotion value.

The present application belongs to the field of pharmaceutical chemistry, and relates to azacyclic hydrazine compounds and uses thereof. Specifically, the present application provides a compound of formula I or a pharmaceutically acceptable salt, stereoisomer, tautomer, polymorph, solvate, racemate, prodrug or metabolite thereof, which exhibits good antitumor activity.

The invention discloses a diaryl hydrazine compound and a preparation method thereof, and the preparation method comprises the following steps: mixing an azobenzene compound, an alkyl NHPI ester reagent, a photosensitizer, an alkaline reagent and a solvent, and reacting under the irradiation of visible light to obtain the diaryl hydrazine compound, wherein the photosensitizer is one or a mixture of two of 2, 4, 5, 6-tetrakis (carbazole-9-yl)-1, 3-dicyanobenzene, di [2-(2, 4-difluorophenyl)-5-trifluoromethylpyridine] [2-2 '-bis (4-tert-butylpyridine)] iridium hexafluorophosphate, and the solvent is one or a mixture of two of 2, 4, 5, 6-tetrakis (carbazole-9-yl)-1, 3-dicyanobenzene and di [2-(2, 4-difluorophenyl)-5-trifluoromethylpyridine] [2-2'-bis ( And the alkaline reagent is one or a mixture of more of N, N-diisopropylethylamine, potassium phosphate and 1, 8-diazabicyclo [5.4. 0] undec-7-ene. The preparation method disclosed by the invention has the advantages of easily available raw materials, simplicity in operation, mild reaction, wide substrate applicability and the like.

The application belongs to the technical field of organic synthesis, and particularly relates to a 1,5-disubstituted-4-bromopyrazole compound, a preparation method and application thereof. The preparation method of the 1,5-disubstituted-4-bromopyrazole compound comprises the following steps: mixing an enaminone compound, a hydrazine compound, a bromination reagent, a photocatalyst, an additive and a polar organic solvent to perform a ring-forming and regioselective bromination reaction, and obtaining the 1,5-disubstituted-4-bromopyrazole compound. The preparation method has the advantages of wide substrate range, good functional group tolerance, high regioselectivity, simple operation, mild conditions and the like, and the prepared 1,5-disubstituted-4-bromopyrazole compound has high purity, and the purity is 98.5-99.9%.

This application discloses an additive for lithium-ion batteries and its application. The additive has the following raw material composition by weight: 40-70 parts first solvent; 1-10 parts first polymer; 5-15 parts second polymer; 10-20 parts small molecule organic amine; and 10-20 parts stabilizer. The first polymer contains at least one nitrogen-free polar functional group; the second polymer contains at least one nitrogen-containing polar functional group; and the stabilizer is a hydrazine compound. The additive provided in this application, when used in lithium-ion batteries, can solve the problems of thick electrodes easily cracking and the difficulty in dispersing positive electrode particles.

The invention discloses a synthesis method of a cyclohexene-containing liquid crystal monomer, which comprises the following steps: step 1, hydrazone reaction: reacting an alkyl cyclohexanone compound with a hydrazine compound to generate a corresponding hydrazone compound intermediate; step 2, coupling reaction: mixing the hydrazone compound intermediate obtained in the step 1 with aryl halide, alkali and a composite catalyst, and carrying out coupling reaction to obtain a liquid crystal monomer compound containing a cyclohexene structure; wherein the composite catalyst comprises a palladium catalyst and a phosphine ligand. According to the invention, the keto group of alkyl cyclohexanone is converted into hydrazone, then the hydrazone is used as a key intermediate and is subjected to cross coupling with aryl halide through transition metal catalysis, beta-hydrogen elimination of the hydrazone is realized, cyclohexene double bonds are directly constructed from a ketone precursor, the whole reaction can be completed by a one-step method, intermediate post-treatment and purification are not needed, and the method is suitable for industrial production. The synthesis steps are reduced, and the reaction efficiency is improved while the reaction conversion rate and yield are ensured.

The invention relates to a low-temperature fast-curing toughening type anaerobic adhesive composition and a preparation method thereof. The low-temperature fast-curing toughening type anaerobic adhesive composition comprises an anaerobic adhesive solution, a low-temperature composite accelerant and a diluent according to a mass ratio, the anaerobic glue solution comprises an acrylate monomer, a free radical initiator and a toughening agent, and the low-temperature composite accelerant is a compound of organic copper salt and an organic hydrazine compound. The method has the advantages that a specific organic hydrazine compound is introduced into a traditional copper salt promoting system to serve as an efficient synergistic reducing agent, and an oxidation-reduction initiating system capable of efficiently operating at the low temperature of 0-10 DEG C is constructed.

The application belongs to the technical field of biological medicine, and particularly relates to a substituted phenoxy acetic hydrazine compound, a preparation method thereof and application of the compound as an anti-inflammatory inhibitor of STAT3. The compound has a structure as shown in formula I. It is verified through experiments that the compound is an allosteric small-molecule compound combined with a STAT3 CCD structure domain, has high affinity, high membrane permeability and high selectivity. In a cell and a mouse acute lung injury model, the inhibitor is used to inhibit an inflammatory response of acute lung injury, so as to achieve the effect of relieving acute lung injury. The application provides a theoretical basis for drug treatment of development of a new STAT3 allosteric inhibitor for relieving an inflammatory response of acute lung injury.

The invention belongs to the technical field of organic synthesis, and discloses a synthesis method of a 3-alkylpyrazole-4-carboxylic acid derivative, which comprises the following steps: by taking alpha-halogenated-beta-keto ester as shown in a general formula (I), a hydrazine compound as shown in a general formula (II) and a formaldehyde donor as reaction raw materials, carrying out a reaction under the existence of alkali, so as to obtain the 3-alkylpyrazole-4-carboxylic acid derivative. And carrying out a one-pot reaction in the presence of water and / or an alcohol solvent to generate the 3-alkylpyrazole-4-carboxylic acid derivative as shown in a formula (III). According to the synthesis method disclosed by the invention, a formaldehyde donor, hydrazine (or substituted hydrazine) and alpha-halogenated-beta-keto ester which are low in price and easy to obtain are taken as raw materials, and the target product is efficiently synthesized with high selectivity by a three-component one-pot method through innovative'fast-slow-fast 'reaction process regulation and control; the problems of many steps, poor selectivity and difficult control of direct participation of formaldehyde in the reaction in the traditional method are overcome.

This invention relates to the field of stripping fluid purification technology, specifically disclosing a method for removing newly generated organic impurities during the recycling of stripping fluid. The method involves adding additives to the waste stripping fluid, preheating it to above 60°C for at least 0.5 hours, and then sequentially performing evaporation to remove slag and distillation purification to obtain regenerated stripping fluid. The newly generated organic impurity is 4-(diethylamino)-2-butanone, and the additives include hydrazine compounds and citric acid. This invention effectively removes the newly generated impurity 4-(diethylamino)-2-butanone from waste stripping fluid without introducing impurities and has the advantages of low cost.

The application discloses a method for regulating catalytic behavior of 3'->5' exonuclease based on deoxyribose configuration adjustment and application thereof, and belongs to the technical field of nucleic acid chemistry, biological catalytic regulation and molecular engineering. In view of the problems of poor position accuracy and unpredictable effect of the existing nucleic acid enzyme regulation method, a hydrazine compound containing an NH-NH2 functional group is used to modify and reduce an AP site in DNA, so that the deoxyribose of the AP site is changed from a closed ring configuration to a stable open chain configuration. The DNA after the AP site is modified is incubated with a nucleic acid enzyme with 3'->5' exonuclease activity, so that the nucleic acid enzyme is specifically catalyzed to stop at a nucleotide downstream of the modified AP site, and the catalytic behavior of the nucleic acid enzyme is accurately and controllably regulated with single nucleotide resolution. The application does not need to rely on steric hindrance or enzyme molecular structure modification, the regulation effect is stable and predictable, and the application can be widely applied to high-resolution DNA damage positioning, controllable DNA assembly and DNA oxidative damage level detection.

The invention belongs to the field of new materials, and discloses a preparation method of a reactive toughened and reinforced high-crystallization-rate P34HB 3D printing wire rod, which comprises the following steps: step 1, uniformly mixing dried P34HB resin with a reactive toughening agent, a nucleating agent, a chain extender and an antioxidant to obtain a premix; 2, melting, extruding and granulating the premix; 3, the particles obtained in the step 2 are subjected to wire drawing and crystallization; the reactive toughening agent is a vinyl terpolymer containing an epoxy functional group; the nucleating agent is a hydrazide compound; the chain extender is a styrene-acrylate copolymer containing a plurality of epoxy functional groups. According to the preparation method, a reactive flexibilizer and a chemical chain extender are introduced, the brittleness problem of P34HB with the low 4HB content is solved by utilizing in-situ chemical reaction, and meanwhile, the processing problem is solved by matching with a specific nucleating agent and a process window. Meanwhile, the invention further provides the P34HB 3D printing wire rod prepared on the basis of the preparation method.

The invention belongs to the technical field of high polymer materials, and particularly relates to polyester resin for a container powder coating as well as a preparation method and application of the polyester resin. The polyester resin for the container powder coating is prepared from the following raw materials: fat polyol, aromatic polyol, a hydrazide compound, polyacid, an end-capping reagent, a catalyst and a curing accelerator. The aromatic polyol and the hydrazide compound are introduced into the main chain structure of the polyester resin, so that the main chain of the polyester resin can be prevented from being broken under the conditions of high temperature, fuel gas and the like and the generation of yellowing chromophoric groups can be prevented, and the obtained polyester resin can be used for preparing the powder coating with excellent fuel gas baking resistance and temperature resistance.

This invention belongs to the field of medicinal chemistry and relates to ferulate hydrazide compounds and their uses. Specifically, this invention provides compounds of formula I or pharmaceutically acceptable salts, stereoisomers, tautomers, polymorphs, solvates, racemates, prodrugs, or metabolites thereof, which exhibit good antitumor activity.

The application discloses a pancreatic cancer JAK2 and STAT3 dual-target inhibitor containing a phenoxy acetic hydrazine compound and application thereof, and the dual-target inhibitor comprises a compound containing a phenoxy acetic hydrazine structure. The dual-target inhibitor comprises a pharmaceutically acceptable salt. The pancreatic cancer JAK2 and STAT3 dual-target inhibitor containing the phenoxy acetic hydrazine compound is applied to the preparation of a drug for treating pancreatic cancer. The drug has a new use in treating pancreatic cancer by inhibiting tumor proliferation, migration and invasion, angiogenesis, epithelial mesenchymal transition, blocking a cell cycle and promoting cell apoptosis. The pharmaceutical preparation of the drug composition comprises tablets, capsules, syrup, suspensions and injections. A drug for treating pancreatic cancer comprises the pancreatic cancer JAK2 and STAT3 dual-target inhibitor containing the phenoxy acetic hydrazine compound and a pharmaceutically acceptable carrier. The application has the beneficial effect that the pancreatic cancer JAK2 and STAT3 have a better inhibiting effect, the experimental results show that the inhibiting effect is good, the application prospect is wider, and the safety is better.

An object of the present application is to provide a novel hydrazide compound. In addition, an object of the present application is to provide a curable resin composition containing the hydrazide compound and excellent in storage stability and adhesiveness, a sealant for a liquid crystal display element formed using the curable resin composition and excellent in low liquid crystal contamination, and a liquid crystal display element. The present application is a hydrazide compound having one or more structures represented by the following formula (1) and two or more hydrazide groups in one molecule. In formula (1), * is a bonding position.

The invention discloses a method for synthesizing azo compounds by catalyzing hydrazine compounds through non-coenzyme-dependent oxidase. Comprising the following steps: adding a hydrazine compound, oxidase and hydrogen peroxide into a buffer solution containing an organic solvent, and stirring and reacting at normal temperature to obtain the azo compound. The structure of the hydrazine compound is as follows: R < 1 >-NH-NH-R < 2 >, wherein R1 and R2 are any one of phenyl or substituted phenyl; the oxidase does not depend on non-nicotinoyl cofactors and is wide in source and low in production cost. The method is simple in preparation process, mild in reaction condition, high in substrate conversion rate, good in reaction selectivity and simple in downstream treatment process.

This application provides an isoxazoline benzoyl hydrazine compound, its preparation method, and its application. The structural formula of the isoxazoline benzoyl hydrazine compound is shown in Formula I: -I. The isoxazoline benzoyl hydrazine compound provided in this application has good control effects on various agricultural pests. The preparation method of the isoxazoline benzoyl hydrazine compound provided in this application is simple and easy to produce.

The invention belongs to the field of jet fuel thermal oxidation inhibition, and particularly relates to a hydrazine compound, a hydrazine composite material, a preparation method thereof and application of the hydrazine compound and the hydrazine composite material in jet fuel efficient deoxidation. The hydrazine compound and the hydrazine composite material are successfully prepared as the jet fuel deoxidant. The hydrazine compound is prepared by adopting an alkali washing method, and the hydrazine composite material is prepared by mixing and dispersing the porous carrier and a hydrazine compound solution, performing rotary evaporation to remove a solvent and drying. The hydrazine composite material can reduce the dissolved oxygen content of the jet fuel to 1 ppm or below, and the thermal oxidation deposition amount is reduced by 90%.

The invention provides a novel preparation method of a pyrazoloquinoline compound, which comprises the following step: reacting a 1, 6-eneyne compound with a hydrazine compound under the condition of normal-pressure air to generate the pyrazoloquinoline compound. The synthesis method is simple and rapid in preparation process, and does not need inert gas protection and use of a catalyst, so that the synthesis method is expected to be used for industrial production.

The application relates to the field of organic chemical synthesis, in particular to an unsymmetrical azobenzene compound, a synthesis method and application. The application discloses a C-N bond coupling of a palladium-catalyzed aryl (pseudo) halide and an aryl hydrazine compound in an air atmosphere, one-step efficient construction of a C-N=N structure, and realization of synthesis of unsymmetrical azobenzene derivatives. The aryl halide raw material and the aryl hydrazine reagent source are wide and commercially available; the reaction condition is mild, no inert gas protection is needed, the experimental operation is simple and safe, the functional group tolerance is good, and the reaction is easy to apply and expand. The substrate tolerance of the synthesis method is excellent, the site limitation of the traditional aromatic hydrocarbon diazo reaction is broken, the structural diversity of the product is greatly expanded, the synthesis method has very good application prospect in the fields of related azo dyes, drug development and photoswitching molecule synthesis, and has foreseeable market commercialization prospect.

The invention discloses a composition, a thin film and a photoelectric device, the composition comprises a first material and a second material, the first material comprises one or more P-type organic compounds, the second material comprises one or more hydrazine compounds, the problem that the P-type organic compounds are oxidized can be effectively improved, and the photoelectric device can be applied to the field of photoelectric devices. Therefore, the performance stability of the P-type organic compound is improved, the composition can be applied to a photoelectric device, and the device efficiency, the device service life and the performance stability of the photoelectric device are improved.

The invention provides a method for synthesizing a hydrazone compound from an amino compound in one step and the obtained hydrazone compound. The method comprises the following steps: 1) taking a compound a and 3, 5-di-tert-butyl o-benzoquinone, mixing, adding an organic solvent, and stirring at room temperature for 0.5-1 hour to obtain a mixture; 2) mixing the compound b with an organic acid solution with the volume concentration of 30-70%, adding the mixture into the mixture, and reacting at room temperature for 1-16 hours to obtain a head product; and 3) removing the organic solvent in the head product to obtain residues, dissolving, washing with water, separating to obtain an organic phase, concentrating, and purifying to obtain a target product c. According to the invention, the amino compound is used as a raw material, under the action of the 3, 5-di-tert-butyl-o-benzoquinone and the hydrazine compound, the hydrazone compound is synthesized in one step through a one-pot method, the operation is simple, an intermediate product does not need to be separated, the synthesis time is saved, the operation cost is reduced, the purity is high, the yield is high, the applicable substrate is wide, and the application potential is great.