48 results about "Hydrazine compound" patented technology

The invention relates to the technical field of lithium ion battery assistants, in particular to an anode slurry dispersing, compacting and anti-cracking assistant for a lithium battery and a preparation method of the anode slurry dispersing, compacting and anti-cracking assistant. The anti-cracking aid is prepared from the following raw materials in parts by mass: 20-80 parts of a special polymer, 10-30 parts of a wetting agent, 10-30 parts of a plasticizer and 10-100 parts of a solvent, wherein the preparation raw materials of the special polymer comprise a vinyl monomer, an acrylic monomer, a diene monomer and an initiator; the wetting agent comprises the following raw materials: an amine compound and a hydrazine compound; and the plasticizer is polyether phosphate. When the additive is used for preparing the lithium battery positive electrode slurry, the slurry is uniformly dispersed and low in viscosity, the use of solvents can be reduced, the production process is shortened, and the actual use effect is excellent.

The present application relates to the technical field of rubber, in particular to a kind of hydrazide compound, rubber composition and its preparation method and application.The present application provides a kind of hydrazide compound, is mono-hydrazide compound or double hydrazide compound, they have lower melting point, can be well dispersed in rubber matrix in the range of mixing temperature, further ensure its effect.And the hydrazide compound of this kind is added to rubber composition, can obtain the tire product of processing performance improvement, dynamic modulus promotion, anti-wet sliding and balanced rolling resistance.

The invention belongs to the technical field of functional coatings, and particularly relates to a super-hydrophobic coating and a preparation method thereof. The preparation method comprises the following steps: pretreating a base material, placing the base material in an aqueous solution containing a zinc source and at least one electroplating additive, and carrying out electro-deposition to form a zinc coating on the surface of the base material; electroplating it in a first solution comprising a zinc source and an electrolyte salt; transferring into a second solution containing zinc source and alkali source precursors, and growing on the zinc plating layer by a hydrothermal method to form a ZnO nano-structure array layer; the preparation method comprises the following steps: reacting a trifluoromethyl-containing acylating agent with a hydrazine compound in an organic solvent, adding phenolic hydroxyl-containing aromatic amine or a salt thereof and alkali, and reacting under a reflux condition to obtain a fluorine-containing organic ligand; sequentially putting the zeolite imidazate framework material into a first organic solvent containing a zinc source and a second organic solvent containing a fluorine-containing organic ligand and imidazole or a derivative thereof to react, and enabling the fluorine-containing zeolite imidazate framework material to grow on the surface in situ to obtain the super-hydrophobic coating.

The application belongs to the technical field of permeation membrane, and discloses a composite permeation membrane structure, a permeation tube and application for volatile hydrazine compounds. The composite permeation membrane structure has at least two layers of permeation membranes, which include: a contact permeation membrane, which is the first layer of permeation membrane contacted by hydrazine compounds along the permeation direction. The contact permeation membrane is a material resistant to corrosion of liquid hydrazine compounds and has a first permeation coefficient for hydrazine compounds. A slow-release permeation membrane is arranged on the back side of the contact permeation membrane along the permeation direction of hydrazine compounds, and at least one layer is arranged. The slow-release permeation membrane has a second permeation coefficient for hydrazine compounds, and the second permeation coefficient is smaller than the first permeation coefficient. The composite permeation membrane structure of the application can realize stable and low-speed permeation of hydrazine compounds, and the permeation tube can be prepared to be used for preparation of low-concentration hydrazine compound standard gas.

The invention belongs to an amide intermediate treatment device and method for hydrazine hydrate production. Comprising a concentration tank, the concentration tank is provided with a water-phase reaction liquid inlet pipeline and a catalyst inlet, the catalyst inlet is connected with a quartz sand catalyst preparation unit, an outlet of the concentration tank is connected with a concentrated material inlet of an intermediate recovery kettle, and the intermediate recovery kettle is further connected with an ammonia feeding pipeline. An ammoniation liquid outlet of the intermediate recovery kettle is connected with a separation and recovery unit, and a liquid phase outlet of the separation and recovery unit is connected with a hydrazine compound synthesis section; a steam discharge pipeline is arranged at the top of the concentration tank; the method has the advantages that moisture in the water-phase reaction liquid can be removed, ammonium formate is converted into formamide and recycled, meanwhile, metal ions are prevented from being contained in ammoniation liquid, and further, the treatment cost is reduced and continuous treatment is achieved on the basis of energy conservation and consumption reduction.

This application provides a self-healing polyurethane material, its preparation method, and its applications, relating to the field of polymer materials technology. The material uses a polyurethane matrix constructed from polyols and polyisocyanates, and introduces aromatic polyaldehyde compounds to form reversible dynamic bond structures with hydrazine compounds, thereby endowing the material with excellent self-healing properties. By controlling the type of chain extender and the melt blending process conditions, the material can achieve crack healing and restore mechanical properties after damage, while also possessing good flexibility, processability, and stability. The preparation process of this application is simple and the conditions are mild. The resulting material can be widely used in coatings, seals, and elastomers, significantly improving material service life and reliability.

To provide an adhesive film which exhibits low temperature quick curability and good adhesive strength and connection reliability, can be narrowly and stably slit, and has good temporary stickiness.SOLUTION: An adhesive film has a base material film subjected to release treatment, and an insulation resin layer which is provided thereon and exhibits radical polymerizability and anion polymerizability, and has a film width of 1.0 mm or less, further 0.8 mm or less, and has a length of 5 m or more. The insulation resin layer contains: a radical polymerization initiator which contains a film-formation component containing two kinds of film components having different molecular weights, a radical polymerizable component containing a first acrylic compound, an anion polymerizable component containing an epoxy-based compound, and an organic peroxide having a one-min half-life temperature of 125°C or lower; and an anion polymerization curing agent which is solid at normal temperature and contains an organic acid hydrazide compound.SELECTED DRAWING: Figure 1A

The application discloses an electrolytic synthesis method of a pyrazolone compound intermediate, and the method uses a nitroso acid ester compound as raw material to obtain an electrolyte containing a hydrazine compound through electrochemical reduction; the electrolyte containing the hydrazine compound is subjected to a cyclization reaction to obtain a pyrazolone compound; the application uses a mild and efficient electrochemical reduction mode to replace a high-risk diazotization reaction to synthesize the pyrazolone compound; the electrolyte can be recycled for multiple times, and a large amount of sulfite, acid and other reagents needed in the synthesis process are avoided, and a large amount of 'three wastes' is reduced. The method has better product purity (> 95%) and yield (> 80%), the method is more green and environmental protection, no three wastes are generated, and is suitable for industrial production.

The invention belongs to the technical field of organic compounds, and particularly discloses an indolinone compound and a synthesis method thereof. The molecular structural formula of the indolinone compound is shown as a formula (A), and the synthesis method of the indolinone compound comprises the following steps: S1, carrying out an amide condensation reaction on a compound shown as a formula (1) to generate a compound shown as a formula (2); s2, performing aminolysis reaction on the compound as shown in the formula (2) to generate a hydrazide compound as shown in a formula (3); s3, carrying out nucleophilic substitution reaction on the compound as shown in the formula (4) to generate a compound as shown in a formula (5); and S4, carrying out condensation reaction on the compound as shown in the formula (3) and a compound as shown in a formula (5) to generate the indolinone compound as shown in a formula (A). The indolinone compound provided by the invention is novel in structure, mild and simple in synthesis method and high in yield, and the indolinone compound is also found to be effective in antibiosis.

The application belongs to the technical field of organic synthesis, and particularly relates to a 1,3,5-trisubstituted pyrazole compound and a preparation method thereof. The preparation method of the 1,3,5-trisubstituted pyrazole compound provided by the application comprises the following steps: mixing a hydrazine compound, an alpha-bromoketone compound, a photocatalyst, an alkaline compound, an additive and a polar organic solvent, and performing an addition cyclization reaction under light irradiation to obtain the 1,3,5-trisubstituted pyrazole compound. The preparation method has the advantages of mild conditions, easy control, high reaction efficiency, economical steps, cheap and easily available raw materials, no use of oxidants, good functional group tolerance and the like, and the prepared 1,3,5-trisubstituted pyrazole compound has high purity, the purity is 98.5-99.9%, and has great market promotion value.

The application discloses a kind of hydrazine compounds with eugenol as lead and its preparation method and application, and the biological activity test result shows that all compounds are excellent, broad-spectrum antibacterial activity to the plant pathogenic fungi tested.The inhibition effect of most target compounds on plant pathogenic fungi is better than that of positive control rynaxapyr, and the antibacterial effect of compound 11 on rhizoctonia solani, fusarium graminearum, alternaria solani, phoma exigua var. horii and phoma sorghicola is the best, and the EC 50 Values are 0.258 μg / mL, 0.679 μg / mL, 0.424 μg / mL, 0.384 μg / mL and 0.975 μg / mL respectively; for the gossypium gossypium, the antibacterial effect of compound 12 is the best, and the EC 50 Value is 0.989 μg / mL; followed by compound 11, and the EC 50 Value is 1.248 μg / mL.The hydrazine compounds prepared with eugenol as lead have excellent, broad-spectrum and high-efficiency anti-plant pathogenic microorganism activity, and can be used for preventing and treating plant diseases caused by plant pathogenic microorganisms.

The present application belongs to the field of pharmaceutical chemistry, and relates to azacyclic hydrazine compounds and uses thereof. Specifically, the present application provides a compound of formula I or a pharmaceutically acceptable salt, stereoisomer, tautomer, polymorph, solvate, racemate, prodrug or metabolite thereof, which exhibits good antitumor activity.

The invention discloses a diaryl hydrazine compound and a preparation method thereof, and the preparation method comprises the following steps: mixing an azobenzene compound, an alkyl NHPI ester reagent, a photosensitizer, an alkaline reagent and a solvent, and reacting under the irradiation of visible light to obtain the diaryl hydrazine compound, wherein the photosensitizer is one or a mixture of two of 2, 4, 5, 6-tetrakis (carbazole-9-yl)-1, 3-dicyanobenzene, di [2-(2, 4-difluorophenyl)-5-trifluoromethylpyridine] [2-2 '-bis (4-tert-butylpyridine)] iridium hexafluorophosphate, and the solvent is one or a mixture of two of 2, 4, 5, 6-tetrakis (carbazole-9-yl)-1, 3-dicyanobenzene and di [2-(2, 4-difluorophenyl)-5-trifluoromethylpyridine] [2-2'-bis ( And the alkaline reagent is one or a mixture of more of N, N-diisopropylethylamine, potassium phosphate and 1, 8-diazabicyclo [5.4. 0] undec-7-ene. The preparation method disclosed by the invention has the advantages of easily available raw materials, simplicity in operation, mild reaction, wide substrate applicability and the like.

The application belongs to the technical field of organic synthesis, and particularly relates to a 1,5-disubstituted-4-bromopyrazole compound, a preparation method and application thereof. The preparation method of the 1,5-disubstituted-4-bromopyrazole compound comprises the following steps: mixing an enaminone compound, a hydrazine compound, a bromination reagent, a photocatalyst, an additive and a polar organic solvent to perform a ring-forming and regioselective bromination reaction, and obtaining the 1,5-disubstituted-4-bromopyrazole compound. The preparation method has the advantages of wide substrate range, good functional group tolerance, high regioselectivity, simple operation, mild conditions and the like, and the prepared 1,5-disubstituted-4-bromopyrazole compound has high purity, and the purity is 98.5-99.9%.

Disclosed in the present application are an additive for a lithium-ion battery, and the use thereof. The additive for a lithium-ion battery comprises the following raw materials in parts by weight: 40-70 parts of a first solvent, 1-10 parts of a first polymer, 5-15 parts of a second polymer, 10-20 parts of a small-molecule organic amine and 10-20 parts of a stabilizer, wherein the first polymer contains at least one nitrogen-free polar functional group; the second polymer contains at least one nitrogen-containing polar functional group; and the stabilizer is a hydrazine compound. The additive provided in the present application is used in a lithium-ion battery, and can solve the problems of a thick electrode being prone to cracking and positive electrode particles being difficult to disperse.

This application discloses an additive for lithium-ion batteries and its application. The additive has the following raw material composition by weight: 40-70 parts first solvent; 1-10 parts first polymer; 5-15 parts second polymer; 10-20 parts small molecule organic amine; and 10-20 parts stabilizer. The first polymer contains at least one nitrogen-free polar functional group; the second polymer contains at least one nitrogen-containing polar functional group; and the stabilizer is a hydrazine compound. The additive provided in this application, when used in lithium-ion batteries, can solve the problems of thick electrodes easily cracking and the difficulty in dispersing positive electrode particles.

The invention discloses a (2, 3-indoline-(thio) carbonyl) substituted sulfonyl hydrazide compound as well as a preparation method and application of the (2, 3-indoline-(thio) carbonyl) substituted sulfonyl hydrazide compound. The structural formula is shown as a formula I. The N '-(2, 3-indoline-1-(thio) carbonyl) substituted sulfonyl hydrazine compound is obtained by introducing a sulfonyl fragment into a substituted benzaldehyde semicarbazone (thio) urea skeleton containing a 2, 3-indoline-1-(thio) carbonyl fragment, and the N'-(2, 3-indoline-1-(thio) carbonyl) substituted sulfonyl hydrazine compound is novel in structure, the preparation method is simple to operate, raw materials are easy to obtain, and harmful by-products are not easy to generate; the compound disclosed by the invention shows an inhibition effect on various plant pathogenic bacteria, particularly has an obvious inhibition effect on cucumber bacterial angular leaf spot bacteria, can be used as an agricultural bactericide, and has a great application value.

The invention discloses a preparation method of 1-substituent-5-hydroxypyrazole. The method comprises the following steps: taking halogenated acrylate shown as a formula I as an initial raw material, and reacting with a hydrazine compound shown as a formula II to generate a compound shown as a formula III in one step. The synthesis route is shown in the specification, wherein X, R1 and R are defined in the specification.

The invention relates to a dynamic borate dimer micromolecule, a high self-repairing material containing the dynamic borate dimer micromolecule and a preparation method and application of the dynamic borate dimer micromolecule. The dynamic borate dimer micromolecule (BOB-X) is obtained by reacting 2-formyl phenylboronic acid and a derivative thereof with an acid hydrazine compound, and a stable boron-oxygen coordination structure is formed; due to boron-oxygen coordination, the dimer can stably exist while having high dynamic property, and the boron-oxygen coordinated dimer micromolecule has dynamic exchange capacity at room temperature; bOB-X and hydrazide with two degrees of functionality are synergistically used as a chain extender and introduced into a polyurethane prepolymer, and a polyurethane cross-linked structure with a dynamic boron-oxygen coordination bond and quadruple hydrogen bond network is constructed; according to the polyurethane material, the synergistic effect between a B-O coordinate bond and quadruple hydrogen bonds of a hydrazide structure is achieved through molecular design, the material is endowed with the excellent graded relaxation characteristic, the multi-level energy dissipation and strain recovery capacity is shown under different stress levels and time scales, and the mechanical response and self-repairing capacity of the material is remarkably enhanced.

Disclosed are an additive for a lithium-ion battery and use thereof. The raw materials of the additive for a lithium ion battery have the following parts by weight: 40-70 parts of first solvent; 1-10 parts of first polymer; 5-15 parts of second polymer; 10-20 parts of small molecule organic amine; and 10-20 parts of stabilizer. The first polymer contains at least one nitrogen-free polar functional group; the second polymer contains at least one nitrogen-containing polar functional group; and the stabilizer is a hydrazine compound. The additive provided in the present disclosure is used in lithium-ion batteries to solve the problem of easy cracking of thick electrodes and difficult dispersion of cathode particles.

The invention discloses a synthesis method of a cyclohexene-containing liquid crystal monomer, which comprises the following steps: step 1, hydrazone reaction: reacting an alkyl cyclohexanone compound with a hydrazine compound to generate a corresponding hydrazone compound intermediate; step 2, coupling reaction: mixing the hydrazone compound intermediate obtained in the step 1 with aryl halide, alkali and a composite catalyst, and carrying out coupling reaction to obtain a liquid crystal monomer compound containing a cyclohexene structure; wherein the composite catalyst comprises a palladium catalyst and a phosphine ligand. According to the invention, the keto group of alkyl cyclohexanone is converted into hydrazone, then the hydrazone is used as a key intermediate and is subjected to cross coupling with aryl halide through transition metal catalysis, beta-hydrogen elimination of the hydrazone is realized, cyclohexene double bonds are directly constructed from a ketone precursor, the whole reaction can be completed by a one-step method, intermediate post-treatment and purification are not needed, and the method is suitable for industrial production. The synthesis steps are reduced, and the reaction efficiency is improved while the reaction conversion rate and yield are ensured.

The invention relates to a low-temperature fast-curing toughening type anaerobic adhesive composition and a preparation method thereof. The low-temperature fast-curing toughening type anaerobic adhesive composition comprises an anaerobic adhesive solution, a low-temperature composite accelerant and a diluent according to a mass ratio, the anaerobic glue solution comprises an acrylate monomer, a free radical initiator and a toughening agent, and the low-temperature composite accelerant is a compound of organic copper salt and an organic hydrazine compound. The method has the advantages that a specific organic hydrazine compound is introduced into a traditional copper salt promoting system to serve as an efficient synergistic reducing agent, and an oxidation-reduction initiating system capable of efficiently operating at the low temperature of 0-10 DEG C is constructed.

Provided is a treatment liquid having excellent organic residue removal properties and excellent stability. Also provided is a method for treating an object to be treated using the treatment liquid. The treatment liquid contains water, hydroxylamine, and one or more hydrazine compounds selected from the group consisting of hydrazine, hydrazine salts, and hydrazine derivatives, and the total hydrazine compound content is 1 part by mass or less per 100 parts by mass of hydroxylamine.

An indazole hydrazide compound, as represented in formula (I); wherein, R is selected from substituted alkyl, substituted alkenyl and substituted phenyl; substituent in the substituted alkyl and substituted alkenyl includes phenyl and / or substituted phenyl; R′ is selected from H and alkyl. Compared with the prior art, the above indole hydrazide compound can be used as integrin avβ3 receptor antagonist. Besides, it has obvious anti-prostate cancer activity and has a significant inhibitory effect on enzalutamide-resistant cell lines. In addition, the above-mentioned compound has obvious anti-tumor angiogenesis activity and can be used in the preparation of anti-tumor angiogenesis drugs to inhibit tumor angiogenesis.

The application belongs to the technical field of biological medicine, and particularly relates to a substituted phenoxy acetic hydrazine compound, a preparation method thereof and application of the compound as an anti-inflammatory inhibitor of STAT3. The compound has a structure as shown in formula I. It is verified through experiments that the compound is an allosteric small-molecule compound combined with a STAT3 CCD structure domain, has high affinity, high membrane permeability and high selectivity. In a cell and a mouse acute lung injury model, the inhibitor is used to inhibit an inflammatory response of acute lung injury, so as to achieve the effect of relieving acute lung injury. The application provides a theoretical basis for drug treatment of development of a new STAT3 allosteric inhibitor for relieving an inflammatory response of acute lung injury.

An adhesive film according to the present invention exhibits rapid low-temperature curability, good adhesive strength, and good connection reliability, and can be stably slit into narrow widths and also has good temporary adhesiveness. This adhesive film has a base material film on which a release treatment has been executed, and has an insulating resin layer that is provided on the base material film and that exhibits radical polymerizability and anionic polymerizability. The adhesive film has a film width of not more than 1.0 mm or not more than 0.8 mm, and has a length of at least 5 m. The insulating resin layer contains: a film-forming component containing two types of film components having different molecular weights; a radical-polymerizable component containing a first acrylic compound; an anionic polymerizable component containing an epoxy compound; a radical polymerization initiator containing an organic peroxide having a one-minute half-life temperature of not more than 125°C; and an anionic polymerization curing agent containing an organic acid hydrazide compound that is a solid at ordinary temperatures.

The application belongs to the polyurethane chain extension technical field, and particularly relates to a kind of generally applicable polyurethane chain extender and a preparation method thereof. First, 4-aminobutyric acid derivatives are used to prepare a series of chain extender precursors containing amide groups or urea groups with a series of diacyl chlorides and diisocyanates. The chain extender precursors continue to generate hydrazine-based polyurethane chain extenders containing amide groups or urea groups by reacting with hydrazine hydrate in alcohol solvents. The bio-based chain extender belongs to hydrazine compounds, is green in source and has low toxicity. Compared with conventional amine chain extenders, the solubility is lower and the reaction rate is relatively controllable. High-density hydrogen bonds can be introduced into the polyurethane main chain to further enhance the strength and toughness of the polyurethane material. The preparation method is templated, and the required chain extender structure can be customized according to the actual application requirements, enriches the application of polyurethane products, and meets the diversified needs of people for polyurethane materials.

The invention belongs to the technical field of organic synthesis, and discloses a synthesis method of a 3-alkylpyrazole-4-carboxylic acid derivative, which comprises the following steps: by taking alpha-halogenated-beta-keto ester as shown in a general formula (I), a hydrazine compound as shown in a general formula (II) and a formaldehyde donor as reaction raw materials, carrying out a reaction under the existence of alkali, so as to obtain the 3-alkylpyrazole-4-carboxylic acid derivative. And carrying out a one-pot reaction in the presence of water and / or an alcohol solvent to generate the 3-alkylpyrazole-4-carboxylic acid derivative as shown in a formula (III). According to the synthesis method disclosed by the invention, a formaldehyde donor, hydrazine (or substituted hydrazine) and alpha-halogenated-beta-keto ester which are low in price and easy to obtain are taken as raw materials, and the target product is efficiently synthesized with high selectivity by a three-component one-pot method through innovative'fast-slow-fast 'reaction process regulation and control; the problems of many steps, poor selectivity and difficult control of direct participation of formaldehyde in the reaction in the traditional method are overcome.

This invention relates to the field of stripping fluid purification technology, specifically disclosing a method for removing newly generated organic impurities during the recycling of stripping fluid. The method involves adding additives to the waste stripping fluid, preheating it to above 60°C for at least 0.5 hours, and then sequentially performing evaporation to remove slag and distillation purification to obtain regenerated stripping fluid. The newly generated organic impurity is 4-(diethylamino)-2-butanone, and the additives include hydrazine compounds and citric acid. This invention effectively removes the newly generated impurity 4-(diethylamino)-2-butanone from waste stripping fluid without introducing impurities and has the advantages of low cost.

The application discloses a method for regulating catalytic behavior of 3'->5' exonuclease based on deoxyribose configuration adjustment and application thereof, and belongs to the technical field of nucleic acid chemistry, biological catalytic regulation and molecular engineering. In view of the problems of poor position accuracy and unpredictable effect of the existing nucleic acid enzyme regulation method, a hydrazine compound containing an NH-NH2 functional group is used to modify and reduce an AP site in DNA, so that the deoxyribose of the AP site is changed from a closed ring configuration to a stable open chain configuration. The DNA after the AP site is modified is incubated with a nucleic acid enzyme with 3'->5' exonuclease activity, so that the nucleic acid enzyme is specifically catalyzed to stop at a nucleotide downstream of the modified AP site, and the catalytic behavior of the nucleic acid enzyme is accurately and controllably regulated with single nucleotide resolution. The application does not need to rely on steric hindrance or enzyme molecular structure modification, the regulation effect is stable and predictable, and the application can be widely applied to high-resolution DNA damage positioning, controllable DNA assembly and DNA oxidative damage level detection.