203 results about "Methyl propionate" patented technology

A non-aqueous electrolyte for a lithium-ion cell includes a base electrolyte consisting of lithium hexafluorophosphate or lithium bis(fluorosulfonyl)imide or a combination thereof in methyl propionate; about 2 to about 15 parts by weight, preferably about 6 to about 15 parts by weight of vinylene carbonate; and about 0.5 to about 5 parts by weight, preferably about 2 to about 5 parts by weight of an additive comprising lithium difluorophosphate, lithium difluoro(oxalate)borate, lithium bis(oxalate)borate, or a combination thereof, wherein the content of the vinylene carbonate and the additive are each based on a total weight of the base electrolyte, the vinylene carbonate, and the additives.

The invention discloses a glue solution for a copper-clad plate and a preparation method of the glue solution, and relates to the technical field of copper-clad plates. According to the prepared glue solution for the copper-clad plate, the composite epoxy resin, the curing agent, the accelerant, the solvent, the flexibilizer and the inorganic filler, the composite epoxy resin comprises bisphenol A epoxy resin, epoxy phenyl polysiloxane, itaconic acid polyaryletherketone and hydroxyl-terminated fluorine-containing vinyl polysiloxane, so that the interface bonding force with the copper plate is enhanced; the dielectric constant and the dielectric loss are effectively reduced, the peel strength and the toughness of the material are also remarkably improved, and the toughening agent is modified polyether sulfone microspheres; the modified polyethersulfone microspheres are prepared by coating polyethersulfone microspheres with hexamethylenediamine tetrapropionamide diamine, the hexamethylenediamine tetrapropionamide diamine is prepared by carrying out acylation condensation reaction on hexamethylenediamine tetramethyl propionate and ethylenediamine, and the polyethersulfone microspheres are prepared by carrying out electrostatic spinning on a spinning solution of polyethersulfone and vinylpyridine, so that the peel strength of the glue solution is remarkably improved.

The invention belongs to the field of chemical synthesis, and particularly relates to a synthetic method of cyclobutyl-containing methyl propionate and propylene glycol derivatives. Specifically, dimethyl methylmalonate represented by a formula A and a quaternary tension ring substrate represented by a formula B are taken as basic raw materials, under the action of a catalyst, a quaternary ring-containing methyl propionate represented by a formula C is prepared through a nucleophilic addition reaction, and further a propylene glycol derivative represented by a formula D or a formula E: # imgabs0 # is prepared through a decarboxylation reaction or a reduction reaction.

The invention discloses a preparation method of methyl propionate, and belongs to the technical field of methyl propionate. The preparation method of methyl propionate comprises the following steps: S1, preheating methyl acetate, formaldehyde and methanol to 350-380 DEG C, then feeding into a fixed bed reactor, and reacting at 350-400 DEG C under the action of a synthetic catalyst to obtain a reaction solution; and S2, mixing the reaction liquid obtained in the step S1 with hydrogen, feeding the mixture into a hydrogenation reactor, obtaining a product under the action of a hydrogenation catalyst, and rectifying and separating the product after the hydrogenation reaction to obtain methyl propionate. Compared with the prior art, the preparation method provided by the invention is simpler and more efficient, and the yield of methyl propionate is improved.

The invention discloses a method for preparing 2-(R)-fluoromethyl propionate with optical activity, and relates to the technical field of organic synthesis.The method comprises the steps that 1, an organic solvent and amines are added into a sealing system under nitrogen protection, hexafluoropropylene is added, a heat preservation reaction is conducted, then aftertreatment is conducted, and a fluorinating agent is obtained; and step 2, adding the fluorinating agent obtained in the step 1 and L-methyl lactate into a closed system under the protection of nitrogen, and carrying out heat preservation reaction to obtain the 2-(R)-fluoromethyl propionate. The method disclosed by the invention has the advantages of simple preparation process, low raw material cost, high yield, low safety risk, less generated three wastes and low treatment cost of the three wastes.

The present invention discloses a catalyst for aldol condensation reaction, its preparation and application, specifically relating to a method for preparing a catalyst for aldol condensation reaction using biomass-based SiO2 and using the catalyst to catalyze the preparation of methyl methacrylate from a mixed solution (or mixed aqueous solution) of formaldehyde and methyl propionate; the loading amount of the active metal on the catalyst is 1-10 wt%, and the total loading amount of the promoter is 0.5-5 wt%. The catalyst provided by the present invention has excellent water resistance and stability. The catalytic reaction is carried out in a fixed-bed reactor, and the carrier gas is an oxygen-containing inert atmosphere. The raw material formaldehyde in the reaction system can be obtained from methanol, and both methanol and the carrier SiO2 can be derived from biomass. Thus, under the background of aiming at "dual carbon" and popularizing green consumption, the high-value utilization of biomass resources is realized, and further the innovation of green and low-carbon technologies is achieved.

The invention relates to the field of polyester resin materials, in particular to low-temperature curing polyester resin and powder paint.The low-temperature curing polyester resin is prepared from, by weight, 30-40 parts of neopentyl glycol, 50-60 parts of terephthalic acid, 5-10 parts of adipic acid, 0-0.1 part of organic tin catalyst, 5-10 parts of hyperbranched polyisocyanate, 5-10 parts of end-capping reagent and 0.1-1 part of auxiliaries; the hyperbranched polyisocyanate is prepared from trimethylolpropane, N, N-dihydroxyethyl-3-amino methyl propionate and alicyclic diisocyanate, the prepared powder coating can be cured at a low temperature, the coating has excellent performance, and the powder coating has wide application prospects in the fields of building material aluminum materials and engineering machinery.

The invention relates to a synthetic method of a refined dimethenamid intermediate, which comprises the following steps: adding methanol and L-alanine into a reaction flask, starting to heat, dropwise adding an esterification reagent at a certain temperature while keeping the temperature, reacting at the same temperature while keeping the temperature after dropwise adding is finished, and after the reaction is finished, carrying out post-treatment to obtain a crude product of (S)-2-amino methyl propionate; adding a solvent and a first reducing agent into the reaction flask, dropwise adding the (S)-2-methyl aminopropionate crude product and a second reducing agent at low temperature, and after dropwise adding, carrying out heat preservation reaction for a period of time at the same temperature; and raising the reaction temperature, carrying out high-temperature heat-preservation reaction for a period of time, and carrying out post-treatment to obtain the refined dimethenamid intermediate (S)-(+)-1-methoxy-2-propylamine. When the method is used for preparation, the product can be obtained only by esterifying and reducing the raw materials, the steps are simple, the raw materials are cheap and easy to obtain, and the yield is greater than 90%.

The invention discloses a preparation method of a high-temperature-resistant new energy automobile wire harness protective sleeve material. The preparation method comprises the following steps: (1) preparing filler powder; (2) preparing a primary treatment filler; (3) gamma-methacryloyloxy propyl trimethoxy silane and 9, 10-dihydro-9-oxa-10-phosphaphenanthrene-10-methyl propionate 10-oxide are used for treatment, and a modified filling material is obtained; and (4) weighing the vacuum-dried thermoplastic polyester elastomer TPEE, the modified filler, aluminum diethyl hypophosphite, an antioxidant and zinc stearate, adding the raw materials into an internal mixer, mixing for 10 minutes at the mixing temperature of 230 DEG C, extruding and granulating at the temperature of 200 DEG C after mixing is completed, carrying out mold pressing on granules for 5 minutes under the conditions of the temperature of 200 DEG C and the pressure of 10 MPa, and carrying out pressure maintaining and cooling to normal temperature, so as to obtain the wire harness protective sleeve material. The wire harness protective sleeve material prepared by the method has good heat resistance and mechanical strength, and can play a good role in protecting automobile wire harnesses in occasions with high temperature and stress requirements, so that the durability of the automobile wire harnesses is improved, and the maintenance cost is reduced.

The present invention relates to a thiobenzimidazole derivative preparation method, a novel intermediate therefor, and the like. The present invention uses an intermediate containing O-ethyl carbonodithioate or an intermediate containing methyl 3-mercaptopropionate so as to effectively synthesize a thiobenzimidazole derivative having anti-cancer activity.

The invention discloses an alkyl phenolic resin for improving the bonding performance of a GLR rubber adhesive and a preparation method thereof, and relates to the technical field of phenolic resin preparation, the alkyl phenolic resin comprises the following raw materials by weight: 60-70 parts of modified resin, 15-20 parts of modified EPDM, 2-4 parts of carbon fiber, 5-7 parts of naphthenic oil, and 0.8-1.0 part of an anti-aging agent. The modified resin is obtained by carrying out reaction grafting on methyl 3-dodecylthio-propionate, 5-amino-2-hydroxycycloheptyl-2, 4, 6-triene-1-ketone, punicic acid and the like, and then blending with alkyl phenolic resin. The modified EPDM is obtained by grafting a functional monomer and EPDM, wherein the functional monomer contains imidazole, amino, piperazine, phosphamide, hydroxyl and terminal carbon-carbon double bonds. The prepared alkyl phenolic resin has good corrosion resistance, toughness, antibacterial property, adhesion, oil resistance and flame retardance, and is worthy of popularization and application.

The invention belongs to the technical field of textile fabric preparation, and provides a negative ion antibacterial polyester fiber fabric and a preparation method thereof, wherein the preparation method comprises the following steps: adding a hyperdispersant Solsperse 32500, a dispersant DISPERS 655, and a negative ion powder to ethylene glycol, and stirring to obtain a negative ion slurry; mixing terephthalic acid, ethylene glycol, and a catalyst, and adding them to an esterification polycondensation reactor, and esterifying for 30 to 60 minutes; then adding a negative ion slurry and N, N-dihydroxyethyl-3-aminopropionic acid methyl ester at a uniform speed within 60 minutes; removing excess ethylene glycol, raising the temperature, reacting under low vacuum conditions, cooling and granulating, and obtaining polyester chips; drying the polyester chips and performing spinning treatment, and weaving the obtained fibers to obtain negative ion textile fabrics. The polyester fiber fabric obtained by the present invention has a higher amount of released negative ions and good spinning performance.

The invention provides a mesoporous nanosphere acid-base bifunctional catalyst for synthesizing methyl methacrylate and a preparation method of the mesoporous nanosphere acid-base bifunctional catalyst. The acidic metal ions are introduced into the skeleton of the mesoporous MCM-41 carrier as a modifier, the alkaline active site Cs species are loaded, and the good acid-base balance degree is achieved by regulating and controlling the proportion of the CS species and the acidic metal ions. The composition of the catalyst is Csa / Xb-MCM-41, X is selected from one or two of Zr, Ti, Al, La, Ce and Fe, and a is the mass fraction of Cs species calculated on the basis of a carrier and is 0.08-0.30 in terms of Cs2O; and b is the mass fraction of the oxide corresponding to the element X in the MCM-41 carrier, and is 0.04-0.20. When the catalyst provided by the invention is used for synthesizing methyl methacrylate through reaction of methyl propionate and formaldehyde, excellent catalytic activity and carbon deposition resistance are shown.

The synthesis method comprises the following steps: reacting a sulfonyl chloride intermediate with a red phosphorus-iodine-acetic acid reduction system to obtain an ethyl sulfate intermediate, and reacting the ethyl sulfate intermediate with 3-(2-chloropropionamido) methyl propionate in the presence of an organic alkali and an organic solvent to obtain the dithiobac-methyl. According to the synthesis method disclosed by the invention, the ethyl sulfate intermediate obtained by reducing the sulfonyl chloride intermediate directly reacts with the methyl 3-(2-chloropropionamido) propionate to obtain the dithiobac-methyl, so that the acidolysis step is reduced, the operation process is greatly simplified, the defect that disulfide impurities are easily generated by a sulfydryl intermediate is overcome, and the yield of the dithiobac-methyl is improved. And the fluopyrithiobac-methyl with relatively high purity can be obtained.

The invention relates to a method for controlling wheat septospora which is resistant to a C14-demethylase inhibitor fungicide. The present invention relates to a method for controlling wheat septospora on a cereal plant, which wheat septospora comprises at least one mutation in the CYP51 gene and is resistant to a C14-demethylase (in sterol biosynthesis) inhibitor fungicide (DMI fungicide), the method comprises applying to these plants, seeds or soil of the plants a fungicidally effective amount of (I) methyl 2-[2-chloro-4-(4-chlorophenoxy) phenyl]-2-hydroxy-3-(1, 2, 4-triazol-1-yl) propionate or (II) 2-[2-chloro-4-(4-chlorophenoxy) phenyl]-2-hydroxy-3-(1, 2, 4-triazol-1-yl) propionic acid.

The present disclosure relates to a method for preparing methyl methacrylate and methylacrolein from methyl propionate, the method comprising: contacting a first stream comprising methyl propionate and a formaldehyde source with a catalyst and performing an aldol condensation reaction to obtain a second stream comprising methyl methacrylate and methylacrolein; the catalyst comprises a molecular sieve with metal elements, the metal elements comprise skeleton metal elements and non-skeleton metal elements, and the molar ratio of the non-skeleton metal elements to the skeleton metal elements in the molecular sieve is less than 0.1; the skeleton metal element comprises Sn; on the basis of the total mole number of all metal elements in the molecular sieve, the content of framework tin is greater than 90 mol%; the molar ratio of the framework tin to the silicon element in the molecular sieve is (0.001-0.05): 1. According to the method disclosed by the invention, the conversion rate of methyl propionate can be effectively improved, and the selectivity of methyl methacrylate and methylacrolein is improved.

The present application relates to a system for preparing high-purity MMA, comprising a diethyl ketone separation unit for separating diethyl ketone from ethylene carbonylation products; a condensation reaction unit arranged downstream of the diethyl ketone separation unit, for performing condensation reaction on the product separated by the diethyl ketone separation unit to generate MMA; and a rectification separation unit arranged downstream of the condensation reaction unit, for separating the product of the condensation reaction unit to obtain high-purity MMA. After the synthesis of methyl propionate by ethylene carbonylation, the byproduct DEK is first separated and removed by the diethyl ketone separation unit, and the methyl propionate and methanol material containing the diethyl ketone after removal are subjected to condensation reaction with formaldehyde to generate MMA, effectively avoiding the problem of difficult separation of diethyl ketone DEK and MMA with very similar boiling points, and then high-purity MMA is easily obtained by separation.

The invention relates to a method for preparing a methyl propionate palladium complex through free coordination cage effect stabilization ethylene hydrogen esterification, which aims at the problem that central metal of the palladium complex for preparing methyl propionate through ethylene methyl esterification is easy to gather and inactivate, and utilizes the cage effect of a stabilizer to construct a cage network around the palladium complex; meanwhile, the free coordination effect is utilized to cooperate with a bidentate phosphine ligand, so that the formation of palladium black inactivation of an active component palladium is effectively slowed down, the stabilization time is maximally prolonged by 360 hours, the TOF value is as high as 20000 h <-1 >, and the selectivity is 100%. The hydrogen esterification reaction system comprises ethylene, CO, methanol, a stabilizer and a palladium complex catalyst; the palladium complex catalyst comprises palladium acetate, 1, 2-bis (di-tert-butylphosphinomethyl) benzene and an acid accelerant. According to the method, the stability of the palladium complex is greatly improved while high catalytic activity and selectivity of the reaction are guaranteed, the reaction condition is mild, the atom utilization rate is high, and the method has a good application prospect in the reaction for synthesizing methyl propionate through ethylene hydrogen esterification.

The utility model relates to a tail gas treatment system for a methyl propionate synthesis process. The system comprises a reaction kettle (1), a gas-liquid separator (2), an evaporator (3), a rectifying tower (4) and a washing tower (5), wherein a tail gas pipeline of the methyl propionate synthesis process is connected with the reaction kettle (1); the reaction kettle (1) is connected with the gas-liquid separator (2); a gas phase outlet is formed in the top of the gas-liquid separator (2) and is connected with the washing tower (5); a liquid phase material flow outlet is formed in the bottom of the gas-liquid separator (2) and is connected with the evaporator (3); a liquid phase outlet in the bottom of the evaporator (3) is connected with the reaction kettle (1), and a gas phase material flow outlet in the top of the evaporator (3) is connected with the rectifying tower (4). The methyl propionate recycling device can effectively recycle methyl propionate products in recycle gas and purge gas, methanol entering the reaction kettle along with the recycle gas can be used as a reaction raw material, and the methyl propionate recycling device is simple in process, economical, efficient and good in application prospect.

The invention belongs to the technical field of lithium batteries, and relates to a lithium ion battery, in particular to a phosphate battery with both battery rate capability and safety performance. The lithium ion battery comprises a positive plate, a negative plate, a diaphragm and a non-aqueous electrolyte, the positive plate comprises a positive electrode material layer containing a phosphate material; the organic solvent comprises a first solvent, and the first solvent is selected from at least one of methyl acetate, ethyl acetate and methyl propionate; the lithium salt comprises LiPF6 and LiFSI; the first additive comprises a compound as shown in a structural formula 1; the lithium ion battery satisfies 0.02 < = 10c / a + e < = 1.8, 40 < = a < = 60, 1.1 < = b < = 1.5, 0 < e < = 1.5, and 0.05 < = c < = 2. According to the lithium ion battery provided by the invention, high-concentration LiPF6, low-content LiFSI and high-content carboxylic ester are matched with one another, so that the compatibility of rate capability and safety performance of a phosphate battery is realized.

This invention discloses a method for preparing 1,3-propanediol by hydrogenation of methyl 3-hydroxypropionate. Using manganese-doped layered copper silicate prepared by deposition precipitation as a precursor, a highly dispersed and stable copper-based catalyst is obtained through reduction. The manganese doping and layered copper silicate species enhance the interaction between copper and the support, improving the dispersion of active copper species. Simultaneously, the layered copper silicate increases the difficulty of copper species reduction, thereby improving the Cu content of the catalyst. + / Cu 0 The strong metal-support interaction and the dispersing effect of manganese can effectively inhibit the migration and aggregation of active copper species during the reaction, thus improving the stability of the catalyst. The copper-based catalyst prepared in this invention exhibits high conversion and 1,3-propanediol selectivity in the hydrogenation reaction of methyl 3-hydroxypropionate, with high catalytic activity and stability, and few byproducts, showing good prospects for industrial application.

To provide a battery having an excellent charging and discharging characteristic even under a low temperature environment.SOLUTION: A battery includes a positive electrode, a negative electrode, an electrolyte, and a separator. The electrolyte and the separator are provided between the positive electrode and the negative electrode. The negative electrode includes a carbon material. The electrolyte includes a lithium salt, a potassium salt, a fluoride cyclic carbonate, a fluoride chain carbonate, and at least one type of anions. In the above, the carbon material has a graphite, the lithium salt includes a LiPF6, the potassium salt includes a KFSI, the fluoride cyclic carbonate includes a fluoroethylene carbonate, and the fluoride chain carbonate includes a trifluoro methyl propionate.SELECTED DRAWING: Figure 1

The present invention relates to a preparation method of galaxolide, comprising: preparing herb alcohol into herb alcoholate; reacting the herb alcoholate with a compound having a structural formula as shown in formula (1) to generate an intermediate having a structural formula as shown in formula (2), wherein in formula (1), R is a halogen element; and subjecting the intermediate to a transesterification reaction with methyl propionate under the action of a transesterification catalyst to obtain galaxolide. In the preparation method of galaxolide of the present invention, the raw materials and reactants are widely sourced, low in price, low in production cost, and the yield of galaxolide is high.

The application designs a method for preparing optically active methyl fluoropropionate by using diethylamine sulfur trifluoride, comprising the following steps: fluorination reaction: under the protection of nitrogen, methyl S-lactate is added to a dry reaction kettle as raw material, the kettle temperature is cooled to a first reaction temperature, diethylamine sulfur trifluoride is added dropwise into the reaction kettle, after dropping, the reaction kettle is heated to a second reaction temperature, after the reaction is completed, the reaction mixture is added dropwise into saturated sodium / potassium bicarbonate aqueous solution to obtain R-2-fluoropropionic acid methyl ester; the molar ratio of diethylamine sulfur trifluoride to methyl S-lactate is 1-1.5:1, the method is high in efficiency, low in three-waste amount, short in reaction path, suitable for industrial production, and has economic value.

The present application provides a method for preparing a captopril intermediate D-3-acetylmercapto-2-methylpropionic acid, and relates to the pharmaceutical field. The method for preparing the captopril intermediate D-3-acetylmercapto-2-methylpropionic acid comprises: reacting a chiral amine with racemic 3-acetylmercapto-2-methylpropionic acid to obtain a chiral amine salt, wherein the chiral amine salt is subjected to alkaline hydrolysis to obtain sodium D-3-acetylmercapto-2-methylpropionic acid, and then acidified to obtain D-3-acetylmercapto-2-methylpropionic acid; wherein the chiral amine comprises one or more of R(+)-alpha-methylbenzylamine, (R)-(+)-1-amphetamine, and R(+)-alpha-tert-butylbenzylamine. The method for preparing the captopril intermediate D-3-acetylmercapto-2-methylpropionic acid provided in the present application comprises splitting 3-acetylmercapto-2-methylpropionic acid with a chiral amine, and the method is controllable and suitable for large-scale production.

The application discloses a mineral tackifier special for shotcrete and a preparation method thereof, and relates to the technical field of tackifiers. The mineral tackifier is obtained through graft copolymerization reaction of 1-vinyl-2-pyrrolidone, acrylic acid, xanthan gum and hyperbranched borate under the action of an initiator; the hyperbranched borate is generated through reaction of a hyperbranched product and 1,4-benzenediboronic acid under the catalysis of anhydrous magnesium sulfate; and the hyperbranched product is prepared through esterification reaction of 3-(bis(2-hydroxyethyl)amino)propionic acid methyl ester and 2-methyl-2-propenoic acid-2,3-dihydroxypropyl ester. The mineral tackifier prepared by the application has good compressive strength and short setting time.

The application discloses a bubble column reactor for preparing methyl propionate, a reaction system and a method. The reactor comprises a bubble column body, a gas distributor and a sieve plate. The application divides the inner cavity of the reactor into multiple spaces through multiple sieve plates, and performs CO segmented feeding on the reaction of synthesizing methyl propionate from a carbonyl group through multiple gas distributors, so that the partial pressure ratio of CO and ethylene in the reactor is reduced, the gas-liquid ratio is obviously reduced, and the reaction conversion rate is obviously improved.

Fungicidal compositions comprising carboxamides The present invention relates to fungicidal compositions comprising at least one compound selected from the group consisting (I-1) N-[1,3-dimethyl-1-(phenylmethyl)butyl]-8-fluoro-3- quinolinecarboxamide, (I-2) N-[(1R)-1-benzyl-1,3-dimethyl-butyl]-8-fluoro-quinoline-3- carboxamide, (I-3) N-[(1S)-1-benzyl-1,3-dimethyl-butyl]-8-fluoro-quinoline-3-carboxamide, as active component 2) at least one compound, or an N-oxide, or an agriculturally useful salt thereof, selected from the group consisting of (II-1) methyl 2-[2-chloro-4-(4- chlorophenoxy)phenyl]-2-hydroxy-3-(1,2,4-triazol-1-yl)propanoate, (II-2) fluoxytioconazole, (II-3) flumetylsulfurim, (II-4) pyrapropoyne, wherein the weight ratio of compound I to compound II is from 10:1 to 1:10. The invention also relates to an agrochemical composition comprising the composition and a solvent of solid carrier. Further, the invention relates to a non-therapeutic use of the inventive compositions controlling phytopathogenic harmful fungi.

The application discloses a preparation method of 3-methyl mercaptopropionate, and belongs to the technical field of pesticide intermediate preparation. The application takes di-tert-butyl disulfide and methyl acrylate as raw materials, generates 3-tert-butyl mercaptopropionate under the action of lithium borohydride, then generates 3-methyl mercaptopropionate and 5-tert-butyl-1,3-dimethoxybenzene under the action of tri (pentafluorophenyl) boron while isobutene is removed and isobutene reacts with m-dimethoxybenzene, and 3-methyl mercaptopropionate is obtained after rectification. In the method, the route is good in operability, low in three wastes and cost, and provides a reference for the preparation of the compound.

The invention relates to a method for detecting isomers of a remazolam key intermediate, in particular to a method for detecting (3S)-7-bromo-2, 3-dihydro-2-oxo-5-(2-pyridyl)-1H-1, 2, 3, 4, 5-tetrahydro-2H-1, 2, 3-tetrahydro-2H-1, 2, 3-tetrahydro-2H-1, 2, 3-tetrahydro-2H-1, 2, 3-tetrahydro-2H-1, 2, 3-tetrahydro-2H-1, 2 The invention discloses a method for effectively separating the content of chiral isomers in 2, 4-benzodiazepine-3-methyl propionate and a main peak, and adopts chromatographic conditions as follows: a chromatographic column is an amylose tri (3-chloro-5-methyl phenyl carbamate) derivative chiral column Lux i-Amylose-3 chromatographic column, the column temperature is 20-45 DEG C, the detection wavelength is 230 nm, and a mobile phase A is a trifluoroacetic acid-water solution; a mobile phase B is acetonitrile, and gradient elution is carried out; the flow velocity is 0.5 to 1.5 mL / min. The analysis and detection method provided by the invention can realize the detection of the remazolam intermediate and the isomerism thereof, improves the quality of the remazolam, provides quality guarantee for the subsequent synthesis of the remazolam, and has the advantages of high accuracy, good precision, high sensitivity and the like.