10 results about "Ethyl pyruvate" patented technology

Methods of treating or preventing conditions in a subject are disclosed, the methods including administering to the subject a therapeutically effective amount of ethyl pyruvate, or a derivative or analog thereof, or a pharmaceutical composition thereof. Methods of treating or preventing conditions in a subject including administering to the subject a therapeutically effective amount of ethyl pyruvate, or a derivative or analog thereof, or a pharmaceutical composition thereof, and one or more additional therapeutic agents, are described.

The present invention relates to a process for the preparation of highly pure enantiomer of Fezolinetant, and in particular highly pure (R)-Fezolinetant. The invention also relates to chiral resolution by acid for the preparation of highly pure R-Fezolinetant. Additionally, the invention relates to a process for preparing intermediates useful for the preparation of (R)-Fezolinetant, their uses and a process for preparing (R)-Fezolinetant. In particular, the intermediate (R)-3-methylpiperazin-2-one is prepared by reductive amination with an imine reductase from Myxococcus stipitatus and ethylene diamine and ethyl pyruvate.

The invention belongs to the technical field of chemical processes, and particularly relates to a method for continuously synthesizing pyruvic acid through catalytic oxidation of ethyl lactate and coupled reaction rectification. According to the method, ethyl lactate and hydrogen peroxide are used as raw materials, a titanium silicalite molecular sieve is used as a catalyst, pyridine-2-formic acid is added as an auxiliary agent, ethyl pyruvate is synthesized in a tubular reactor filled with the catalyst, then under the condition of reduced pressure, pyruvate is hydrolyzed through a continuous reactive distillation tower, and a pyruvic acid water solution is obtained at the tower bottom. According to the invention, a tubular reactor model is adopted, the side reaction of hydrogen peroxide caused by backmixing of kettle reaction is solved, meanwhile, pyridine-2-formic acid is added as an auxiliary agent, the invalid decomposition of hydrogen peroxide in the catalytic oxidation process is solved, and the utilization rate of hydrogen peroxide is improved. Reaction rectification is coupled in the ethyl pyruvate hydrolysis process, continuous hydrolysis of ethyl pyruvate is achieved, a reaction section is filled with styrene resin with sulfonic acid groups to catalyze hydrolysis of ester, the reaction rate is increased from the thermodynamic angle, ethyl alcohol is promoted to be moved out of a system in the decompression hydrolysis kinetics, the reaction time is greatly shortened, and the yield is increased. And high-efficiency, continuous and green synthesis of pyruvic acid is realized.

The invention relates to a green preparation method of ethyl pyruvate. According to the method, ethyl lactate is taken as a raw material and is subjected to continuous gas-liquid phase oxidation in a fixed bed in the presence of oxygen-containing gas, a Mn-Cu-Co ternary oxide is loaded on a nitrogen-containing porous carbon catalyst, air calcination and CO2 atmosphere activation are matched, and pretreatment can be carried out in ethyl lactate / carrier gas so as to regulate and control the metal valence state and the oxygen vacancy structure. Water and trace lactic acid amide, glycine and alanine are introduced into the raw material solution, and optional phytic acid / phytate is combined with choline chloride to construct a weak coordination and hydrogen bond network to adjust the interface oxidability; the fixed bed is provided with double reaction zones for segmented temperature control and oxygen supply along the material flow direction. According to the method, high conversion of ethyl lactate and high selectivity of ethyl pyruvate are realized under relatively mild conditions, byproducts are few, and the stability of the catalyst is good.

A chemoenzymatic manufacturing process for the preparation of high value chemicals includes the enzymatic oxidation of ethanol using an oxidizing biocatalyst to form an acetaldehyde intermediate. In addition, the process includes contacting of the acetaldehyde intermediate with a carboligating biocatalyst to form pyruvic acid. Further, the process includes reacting pyruvic acid with ethanol to form ethyl pyruvate. Still further, the process includes contacting the ethyl pyruvate with a metal catalyst and hydrogen to form ethyl lactate. The process also includes hydrolyzing the ethyl lactate to produce lactic acid. Moreover, the process includes contacting at least a portion of the lactic acid with a dehydrating catalyst to form acrylic acid. In addition, the process includes contacting at least a portion of the lactic acid with a metal catalyst and hydrogen to form propylene glycol and n-propanol.

The invention belongs to the technical field of preparation of high-end high-purity wet electronic chemicals, and particularly relates to a preparation method and system of electronic-grade ethyl lactate. According to the method, food-grade ethyl lactate is taken as a raw material, ethyl pyruvate which is difficult to separate is reduced into ethyl lactate through reduction reaction, ethyl lactate homologues (methyl lactate, propyl lactate and butyl lactate) and light and heavy component impurities in the ethyl lactate are removed through vacuum distillation, and finally anions and cations in the ethyl lactate are removed through resin adsorption, so that the ethyl lactate is obtained. The content of the obtained ethyl lactate is higher than 99.99%, the anion content is smaller than or equal to 10 ppb, the metal ion content is smaller than or equal to 1 ppb, the acidity is smaller than or equal to 80 ppm, the moisture content is smaller than or equal to 100 ppm, and the requirements of electronic-grade ethyl lactate are met. The method can effectively remove ethyl pyruvate and ethyl lactate homologues which are difficult to remove in ethyl lactate, and has the advantages of low cost, low energy consumption, high production efficiency, environmental protection and the like.

The invention discloses an aza-tricyclic amide compound as well as a preparation method and application thereof, and belongs to the technical field of synthesis of organic compounds. The aza-tricyclic amide compound is prepared by taking an o-aminobenzaldehyde compound, ethyl 3-bromopyruvate and the like as raw materials through a one-step reaction. The target compound is prepared through condensation, acylation, methylation, cyclization, substitution, hydrolysis and other multi-step reactions. The compounds can significantly inhibit the growth of human colon cancer HCT116 cells, the ICC of the compound B2 reaches 0.45 mu g / mL, and the compounds can effectively act on a DNA-topoisomerase system and inhibit the proliferation of tumor cells, and can be used for the development of antitumor drugs.

The utility model discloses a reaction device for an ethyl pyruvate extraction tower, which comprises an extraction tower body, the top of the extraction tower body is fixedly provided with a first feed pipe, the top of the extraction tower body is fixedly provided with a second feed pipe, and the top of the extraction tower body is provided with a driving assembly. A toothed plate is arranged at the top of the extraction tower body through a driving assembly, a gear is arranged on the front side of the toothed plate in a meshed mode, a rotating shaft is fixedly installed in the gear and rotationally connected with the extraction tower body, a stirring net plate is fixedly installed on the surface of the rotating shaft, and a vibration assembly is arranged on the right side of the extraction tower body. A complex flow field generated by reciprocating rotation and stirring has a more uniform mixing effect, substance transfer between an ethyl pyruvate solution and diethyl ether can be quicker and more sufficient, molecular movement in the ethyl pyruvate solution and the diethyl ether can be more violent through vibration, and the collision frequency and energy between molecules are increased.

The application belongs to the technical field of antibiotic application, and discloses that microplastics affect the absorption of ciprofloxacin in the intestinal tract through the TLR4 / NF-kappa B pathway regulating P-gp protein. Our research finds that microplastics can activate the expression of P-gp glycoprotein in intestinal epithelial cells through the NF-kappa B pathway in the intestinal tract, thereby reducing the absorption of ciprofloxacin hydrochloride in the intestinal tract, and further affecting the core mechanism of pharmacokinetics and pharmacodynamics of ciprofloxacin hydrochloride in animals. Pyruvate ethyl effectively inhibits the NF-kappa B pathway. The application also finds that after ivermectin inhibits the P-gp glycoprotein of Caco2 cells, the P-gp glycoprotein cannot efflux ciprofloxacin hydrochloride, so that the content of ciprofloxacin hydrochloride in Caco2 cells increases. Therefore, the application also protects the application of ivermectin in preparing a promoter of the content of ciprofloxacin hydrochloride in Caco2 cells incubated with microplastics.

The utility model discloses an ethyl pyruvate crystallization device which comprises a crystallization box, a feeding pipe is fixedly installed at the top of the crystallization box, a cooling pipe is fixedly installed on the surface of the crystallization box, a stirring assembly is arranged in the crystallization box, a scraper blade is arranged in the crystallization box through the stirring assembly, and the stirring assembly is connected with the scraper blade. A vibration assembly is arranged on the front side of the crystallization box, a connecting pipe is fixedly installed at the bottom of the crystallization box, a valve is arranged on the connecting pipe, a filtering box is fixedly installed at the bottom end of the connecting pipe, a filtering assembly is arranged in the filtering box, and a liquid outlet pipe is fixedly installed at the bottom of the filtering box. According to the ethyl pyruvate crystal cleaning device, the aim of cleaning ethyl pyruvate crystals attached to the inner wall of the crystallization box is achieved, waste of the ethyl pyruvate crystals can be reduced, automatic separation of a solution and the ethyl pyruvate crystals can be achieved, and the situation that an extra device is used for separating the solution and the ethyl pyruvate crystals is avoided.