59 results about "Ethyl pyruvate" patented technology

The present invention relates to a new process for the synthesis of racemic and optically active bicalutamide starting from ethyl pyruvate and methyl methacrylate. The present invention discloses processes of preparing bicalutamide intermediates including ethyl-[2-{4-fluorophenyl sulfone}]-2-hydroxy propionate, 1,2-epoxy-2-methyl propionate and 2-hydrox-2-methyl-3-(4-fluorophenylthio) propionic acid. The present invention further discloses micronized rac-bicalutamide and the preparation thereof. The present invention further discloses a new process for the isolation and purification of racemic and optically active bicalutamide.

The invention relates to synthesis of an organic matter, in particular to a method for preparing ethyl pyruvate. Ethyl lactate is taken as a raw material, and the ethyl lactate is oxidized into the ethyl pyruvate by a acetone solution of halogeno organic oxidant at a temperature of between 0 and 45 DEG C under catalysis of oxynitride and alkali; the amount of the oxynitride is 0.1 to 1.0 percent of the ethyl lactate; the amount of the halogen organic oxidant is 1.0 and 1.2 times of the equivalent amount of the ethyl lactate; and the amount of the alkali is 1 and 1.2 times of the equivalent amount of the ethyl lactate. The method for preparing the ethyl pyruvate has the advantages of mild reaction conditions, rapid reaction, simple process, easy operation and easy separation. In the reaction, industrial chlorinating agent and brominating agent with low cost and easy acquisition are used as oxidants to oxidize the ethyl lactate into the ethyl pyruvate.

The invention relates to a method for synthesizing an organic compound. The method for synthesizing ethyl pyruvate adopts ethyl lactate and sodium hydroxide bicarbonate as raw materials, and the raw materials of ethyl lactate and sodium bicarbonate are prepared according to certain mole ratios and are processed by synthetic reaction in an organic solvent under the existence of an oxynitride catalyst and oxidizer trichloroisocyanuric acid; and after reaction, reaction liquid is processed by filtration, solvent removal, pressure reduction and distillation and then is collected to obtain the ethyl pyruvate product. Compared with the traditional method, the method for synthesizing the ethyl pyruvate is outstandingly characterized by reasonable proportion of reaction raw materials, simple and easily operated process, nearly 100 percent of percent conversion of the raw materials by particularly adopting the novel catalyst oxynitride and the oxidizer trichloroisocyanuric acid (TCCA), capability of quantitative reaction and high purity and yield of products obtained by reaction, thereby meeting the requirement of each industry on application.

The present invention provides methods for conferring cytoprotection and treating, suppressing or reducing the incidence of ischemia. The methods make use of an ester or amide of an alpha-ketoalkanoic acid, such as ethyl pyruvate, or compositions comprising the same.

The invention discloses a 4-halogenated-2-methyl-2-ethyl crotonate preparing method which includes following steps: (1) performing a Grignard reaction to ethyl pyruvate (II) and a vinyl magnesium halide Grignard reagent (III) to obtain a condensation compound (IV) after the reaction finished, and carrying out a hydrolysis reaction to the condensation compound (IV) to obtain a hydroxyl compound (V); and (2) performing a halogenating reaction to the hydroxyl compound and a haloid acid to obtain the 4-halogenated-2-methyl-2-ethyl crotonate (I). The 4-halogenated-2-methyl-2-ethyl crotonate preparing method is simple in total technology, allows raw materials to be obtained easily, is good in reaction selectivity, is less in by-products and is high in yield. The employed raw materials are all low-toxic or toxic-free and are all corrosiveness-free so that the method is not rigorous in requirement of devices, is environmental-friendly and is suitable for industrialized production.

A catalyst for asymmetrical catalytic hydrogenation, such as the one of ethyl pyruvate to generate (R)-(+)-ethyl lactate, has a molecular formula: Pt / Al2O3. It is prepared from chloroplatinic acid and aluminium oxide through dipping, drying, calcining at different temps in muffle furnace, and reducing in the aqueous solution of sodium formate. Its advantages are high conversion rate, and high optical selectivity to product.

The invention discloses a synthetic method of substituted indol-2-formic acid. Substituted phenylhydrazine hydrochloride or phenylhydrazine is used as a raw material, hydrazone is formed through ethyl pyruvate, then substituted indol-2-ethyl formate is obtained through a Fischer indol synthetic reaction, and the substituted indol-2-formic acid is obtained after hydrolysis. The product purity is greater than 97%, and the reaction yield is 64%. The synthetic method disclosed by the invention has the characteristics of being free of severe conditions, simple to operate and environment-friendly, and has certain economic benefit. According to the synthetic method of the indol-2-formic acid, the raw materials are easily obtained, the operation is simple and convenient, three wastes are few, and the yield is high.

A process for preparing ethyl pyruvate is characterized by that the reaction of the mixture of ethyl lactate vapour and air at 250-300 deg.C in the presence of silica gel carried silver catalyst. Its advantages are high conversion (80%) and selectivity (90%), and high activity and selectivity of catalyst.

The invention relates to synthesis of an organic matter, in particular to a method for preparing ethyl pyruvate by utilizing chlorine to oxidize ethyl lactate. The ethyl lactate is taken as a raw material, and the ethyl lactate is oxidized into the ethyl pyruvate by the chlorine at a temperature of between 0 and 40 DEG C under catalysis of oxynitride and alkali; the amount of the oxynitride is 0.1 to 1.0 percent of the ethyl lactate; the amount of the chlorine is 1.0 and 1.2 times of the equivalent amount of the ethyl lactate; and the amount of the alkali is 1 and 1.2 times of the equivalent amount of the ethyl lactate. The method for preparing the ethyl pyruvate has the advantages of mild reaction conditions, rapid reaction, simple process, easy operation, easy separation, environment-friendly reaction process, and high atom economical efficiency; and the reaction oxidizes the ethyl lactate into the ethyl pyruvate by using the chlorine with low cost and easy acquisition.

The invention relates to a method for synthesizing pyrroloquinoline quinone. By the method, ethyl pyruvate is used as a starting synthesizing raw material to prepare the pyrroloquinoline quinone. In the synthesizing method, a step of synthesizing a compound 4 into a compound 5 is a key step of the synthesizing route, in the key step (5), Lewis acid ionic liquid such as hexafluoroantimonate ionic liquid, hexafluorotitanate ionic liquid and hexafluoroborate ionic liquid is creatively used, the ionic liquid has functions of a reaction medium and a catalyst, and therefore, the reaction speed and yield of the steps can be increased. In addition, [BMIm]SbF6 ionic liquid is used optimally, [BMIm]SbF6 ionic liquid and Sc(OTf)3 can form [Sc(OTf)3-x][SbF6] with high catalytic activity, the reactionefficiency can be greatly improved, the solubility of the obtained reaction product in the [BMIm]SbF6 ionic liquid is low, the reaction product precipitates out easily, and therefore, the reaction yield (which can reach 96%) is improved.

The invention belongs to the technical field of fluorescence detection, and particularly relates to a ratio type near-infrared fluorescent probe for detecting sulfur dioxide (SO2) derivatives, a preparation method and application thereof to detection of SO2 derivatives in crop leaf tissues, SO2 derivatives in atmosphere or SO2 derivatives in soil. M-diethylaminophenol, sodium nitrite, hydrazine hydrate, a palladium-carbon catalyst, ethyl pyruvate, selenium dioxide, 1-ethyl-2-methylquinoline and the like are adopted as the raw materials to prepare the ratio type near-infrared fluorescent probefor detecting the sulfur dioxide derivative, and the fluorescent probe is used for detecting SO2 derivatives in the atmosphere, SO2 derivatives in the soil or SO2 derivatives in crop leaf tissues. Thefluorescent probe is simple in synthesis method, good in SO2 derivative selectivity and high in sensitivity, and the detection environment is suitable for large-range pH. An attempted probe test paper is a simple and portable tool, and can realize rapid on-site detection of sulfur dioxide derivatives in the atmosphere without depending on large-scale instruments and equipment, so that the attempted probe test paper has innovative significance.

The invention provides a fresh keeping agent for fresh flowers, which includes 51-62 parts of ethanol, 5-12 parts of thiourea, 6-11 parts of citric acid, 3-8 parts of sodium citrate, 31-43 parts of propanoic acid, 3-9 parts of phytic acid, 6-11 parts of sucrose, 0.6-3 parts of sodium thiosulfate, 2-6 parts of trisodium isocitrate, 0.3-0.9 parts of sodium benzoate, 2-6 parts of sodium bicarbonate, 0.6-2 parts of hydroxyethyl cellulose, 2-6 parts of glycerol, 0.5-2 parts of N,N-diethyl-p-phenylenediamine, 80-110 parts of water, 41-52 parts of ethyl pyruvate, 2-6 parts of stearic acid, 1-6 parts of salicylic acid, 0.6-2 parts of potassium sulfate, and 2-6 parts of monopotassium phosphate. A flower arranging test proves that the fresh keeping agent can greatly prolong the service of the arranged flowers than that of common water-arranged flowers. The fresh keeping agent also can effectively increase the diameter of blossoms and has excellent fresh keeping effects. The fresh keeping agent also can accelerate blossom of flowers and increasing the size of the flowers.

The invention relates to a method for synthesizing resorcinol by m-hydroxybenzoic acid. A one-step synthesis reaction is used, raw materials of m-hydroxybenzoic acid and a solvent are added in a high-pressure reaction vessel for being dissolved according to a mol ratio being 1-8:10-30, a catalyst is added for catalysis, the catalyst is a mixture of ethyl pyruvate and inulase, and m-hydroxybenzoicacid is obtained through steps of extraction and distillation. The reaction reduces soda acid pollution during a traditional technical production process and reduces the usage of a lot of organic solvents, which belongs to the environment friendly chemical reaction; waste water generated by post-treatment is less, and environment pollution is reduced.

The invention discloses a method for preparing ethyl pyruvate by gas-phase catalytic oxidation of ethyl lactate, which comprises reacting the mixed gas of ethyl lactate steam and air at 250-300 DEG C in the presence of a silver catalyst supported on silica gel to generate ethyl pyruvate. The method catalyst of the invention is easy to prepare, has high activity and selectivity, and the single-pass conversion rate is as high as 80% or more, and the selectivity is as high as 90% or more.

A fresh cut flower antistaling agent and a preparing method thereof are provided. The antistaling agent comprises antistaling components and promoting components. The antistaling components comprise ethyl pyruvate, citric acid, sodium lactate, chitosan, acetic acid, sorbic acid, sucrose ester and water. The promoting components comprise polyethylene glycol, sodium bicarbonate, potassium dihydrogen phosphate, ethylene carbonate, alpha-aminoisobutyric acid and absolute ethanol. The preparing method includes separately preparing the antistaling components and the promoting components, adding the promoting components into the antistaling components, and fully mixing the materials by stirring to obtain the antistaling agent. The antistaling agent is simple in preparing method, easily available in raw materials, low in cost, nontoxic, and capable of effectively maintaining the bright-color period of the fresh cut flower and has good preservation functions especially for cut flowers requiring a long transportation period.

The invention provides a novel synthesis method of oseltamivir. The synthesis method comprises the following steps: taking a compound (E)-2-(2-nitrovinyl) isoindoline-1,3-diketone and ethyl pyruvate as initial raw materials, and carrying out Michael addition reaction under the condition of catalysis of a thiourea catalyst to obtain a corresponding Michael addition product; then, subjecting the Michael addition product and (formyl methylene) triphenyl phosphine to a Wittig reaction and a Henry reaction in a pot so as to obtain a ring closing product; and forming an etherified product from the ring closing product and a trichloroacetonitrile intermediate, and performing reduction, acetylation and de-protection to obtain oseltamivir. The reaction route comprises six steps, raw materials used in each step of reaction are easy to obtain and not expensive, the operation is easy, the yield of each step of reaction is high, no heavy metal or azide is used in the whole synthesis process, and the method is green and safe and can be applied to industrial production.

The invention provides synergistic insecticide for oriental cherry trees, and a preparation method of the insecticide. The insecticide comprises an insecticide component and a synergistic component, wherein the insecticide component comprises carbamic acid ester, octachlorodipropyl ether, clove oil, acetamiprid, deltamethrin, chlorofluorocyantraniliprole, ethyl pyruvate, acetic anhydride and ethyl acetate; the synergistic component comprises castor oil, glyceryl oleate, emulsified silicone oil, 2-amino-2-methyl-1-propyl alcohol, ethyl acetate and ethanol. The preparation method comprises the following steps: preparing the insecticide component and the synergistic component respectively; mixing the insecticide component and the synergistic component to obtain the insecticide. The synergistic insecticide for the oriental cherry trees, provided by the invention, has significant prevention and control effects on aphides, red spiders and coccids on the oriental cherry trees, and does not influence the growth of shoots of the oriental cherry trees after being sprayed on the oriental cherry tree. The leaf color, the leaf quantity and the leaf quality of the oriental cherry trees which use the insecticide are obviously superior to those of the oriental cherry trees which do not use the insecticide.

The invention relates to a heterogeneous catalyst used in an asymmetric catalytic hydrogenation reaction of Alpha-keto ester, and the preparation as well as the application thereof, and belongs to the technology field of a chemical catalyst and synthesis. The expression of the catalyst is Pt / FDU-14; when in preparation, platinic chloride or Tetrammine platinum (2) Chloride is used as an active component precursor, and FDU-14 is used as a carrier; part of catalyst precursor is vacuum-roasted in a muffle furnace after insuccation and torrefaction, and finally the catalyst precursor is deoxygenized in sodium formate water solution to prepare the heterogeneous catalyst, wherein, the dispersion degree of active component platinum on the surface of the FDU-14 is 0.14 to 0.35, the loading of metallic platinum is 5.0 percent, and the mean particle size of platinum particles ranges from 3.2 to 8.0nm. When the heterogeneous catalyst is used in the asymmetric catalytic hydrogenation reaction of ethyl pyruvate under the room temperature and the medium hydrogen pressure, high activity and optical selectivity more than 70 percent are obtained in acetic acid solution, and the heterogeneous catalyst can be repeatedly used for more than 15 times.

The present invention belongs to the field of drug preparation, and relates to a new drug use of ethyl pyruvate. According to the present invention, exogenous ethyl pyruvate is adopted; a series of whole animal experiments are performed, wherein results show that with the ethyl pyruvate, blood-brain barrier damage after brain injury can be lessened, brain tissue injury can be reduced, sensorimotor dysfunction restoration after brain injury can be promoted, and space learning and memory ability restoration can be promoted. In addition, the experimental results show that the ethyl pyruvate can be adopted as a treatment drug for treatment of blood-brain barrier damage after brain injury, and promotion of neurological function restoration after brain injury.

The invention provides an ethyl pyruvate eye drop and a preparation method thereof, and is used for solving the problems of short retention time on ocular surface, low bioavailability, high stimulation and the like of ethyl pyruvate. According to the eye drop, ethyl pyruvate can be effectively supported by using amphipathic chitosan as a micelle vector, the amphipathic chitosan is used as a drug-carrying system, the amphipathic performance of the amphipathic chitosan is utilized, and ethyl pyruvate is effectively entrapped by the lyophobic end of the amphipathic chitosan to improve the penetrability and the adhesion, so that the retention time of the drug on the ocular surface can be effectively prolonged, and the drug is promoted to penetrate into eyes; furthermore, the eye drop has a sustained-release effect, the bioavailability of the drug can be further improved, and the sustained-release duration of 20mu L of the ethyl pyruvate eye drop in one dose can be over 12 hours. Compared with a pure drug of ethyl pyruvate, the ethyl pyruvate eye drop has the advantages that the penetrating capability on cornea can be remarkably improved, the release duration after one dose can be effectively prolonged, and clinical treatment is facilitated.

The invention discloses a preparation method of pharmaceutical-grade ultra-high-purity ethyl pyruvate, which comprises the following steps: by preparing a composite metal oxide catalyst and taking air as an oxidant, carrying out catalytic oxidation on gas-phase ethyl lactate into ethyl pyruvate through the composite metal oxide catalyst under the conditions that the temperature is 180-300 DEG C and the pressure is 0.1-0.5 MPa, and the conversion rate of the whole process is gt; the selectivity is 99.9%, and the selectivity is 70-90%. The purity gt of the final product ethyl pyruvate after rectification and purification; the purity of ethyl pyruvate is 99.8%, the content of heavy metal, total sulfur and total chlorine is smaller than 1 ppm, the defects of an existing synthesis method are overcome, the purity of ethyl pyruvate reaches the medicine level, and a foundation is laid for application of ethyl pyruvate in medicine synthesis.

The invention discloses chiral ionic liquid which is shown as the structure I, wherein n is an integer. The chiral ionic liquid has dual electrostatic and steric hindrance stabilization effect in transition metal nano-catalyst and comprises multiple chiral centers, thereby being capable of serving as a stabilizer of the transition metal nano-catalyst in asymmetric hydrogenation. By a thermoregulated phase-separable chiral ionic liquid biphase catalytic system structured by the chiral ionic liquid, the transition metal nano-catalyst stabilized by the chiral ionic liquid and a mixed solvent toluene / n-heptane, separation and recycling of the transition metal nano-catalyst stabilized by the chiral ionic liquid can be realized. In asymmetric hydrogenation of catalysis of ethyl pyruvate with nano PT, 100% conversion rate and 100% enantioselectivity are obtained, the Pt nano-catalyst stabilized by the chiral ionic liquid can be recycled for nine times, catalytic activity remains unchanged, and enantioselectivity is maintained to be 80%.

The invention discloses a preparation method of a slow-release fertilizer for Brassica alboglabra. The preparation method includes: mixing organics, sodium bicarbonate, calcium carbonate, diatomite, and humic acid to obtain mixture I; adding corn meal, sucrose ester and a chemical fertilizer into the mixture I, stirring and mixing, adding ethyl pyruvate, stirring, and granulating to obtain a granulated fertilizer; drying the granulated fertilizer to obtain the slow-release fertilizer for Brassica alboglabra. The slow-release fertilizer for Brassica alboglabra prepared via the preparation method can continuously release fertility for long time and can increase the yield of Brassica alboglabra.

The invention discloses a 4-halogenated-2-methyl-2-ethyl crotonate preparing method which includes following steps: (1) performing a Grignard reaction to ethyl pyruvate (II) and a vinyl magnesium halide Grignard reagent (III) to obtain a condensation compound (IV) after the reaction finished, and carrying out a hydrolysis reaction to the condensation compound (IV) to obtain a hydroxyl compound (V); and (2) performing a halogenating reaction to the hydroxyl compound and a haloid acid to obtain the 4-halogenated-2-methyl-2-ethyl crotonate (I). The 4-halogenated-2-methyl-2-ethyl crotonate preparing method is simple in total technology, allows raw materials to be obtained easily, is good in reaction selectivity, is less in by-products and is high in yield. The employed raw materials are all low-toxic or toxic-free and are all corrosiveness-free so that the method is not rigorous in requirement of devices, is environmental-friendly and is suitable for industrialized production.

The invention relates to a solid waste treatment method of ethyl pyruvate, and the method comprises the following steps: mixing solid waste containing sodium isocyanurate for producing ethyl pyruvatewith tap water, performing dissolving, and keeping the temperature at 50-70 DEG C for 4-5 hours to obtain a first mixture; adding a sodium hypochlorite solid into the first solution, and performing stirring for 6-10 hours at 50-70 DEG C to obtain a second mixture; cooling the second mixture to room temperature, and keeping stirring for 1.5-2 hours to obtain a third mixture; carrying out centrifugal drying on the third mixture to obtain a first solid product and centrifugal mother liquor; and employing the first solid product for preparing ethyl pyruvate. According to the solid waste treatmentmethod of ethyl pyruvate, provided by the invention, the solid waste generated in the production of ethyl pyruvate is chlorinated and oxidized again to become a reaction raw material with a reaction effect again, almost no harmful effect is caused to the environment, and the solid waste can continuously participate in the circulation of synthesizing ethyl pyruvate after harmless treatment, so theproduction cost is greatly reduced.