5 results about "Methyl butyrate" patented technology

The application discloses a preparation method of indobufen, and belongs to the technical field of drug synthesis process, wherein the preparation method is as follows: dissolving ortho-carboxyl benzamide in an organic solvent, cooling to 2-8 DEG C, adding a reducing agent, and carrying out incubation reaction, post-treatment, and obtaining compound I; mixing the organic solvent, a catalyst and the compound I, carrying out reflux water separation reaction, post-treatment, and obtaining compound II; dissolving the compound II in an organic solvent, adding an alkaline reagent, heating to 40-50 DEG C, dropwise adding 2-(4-bromophenyl) butyric acid methyl ester, then carrying out reflux reaction, post-treatment, and obtaining compound III; dissolving the compound III in an organic solvent, adjusting the pH to 10.5-11.5, stirring and reacting at 40-50 DEG C, post-treatment, and obtaining indobufen. The preparation method improves the safety of preparation, and also improves the quality and yield of the product indobufen.

This invention belongs to the field of chemical intermediate preparation technology, and particularly relates to a method for recovering N-hydroxymethyl phthalimide from the residue of a key intermediate of 4-AA. The method includes the following steps: (1) Distillation: The toluene mother liquor produced from the preparation of methyl 2-(N-phthaliminomethyl)-3-oxobutyrate, a key intermediate of 4-AA, is filtered and distilled to obtain toluene solvent and concentrated residue. The toluene solvent is recovered and reused. (2) Hydrolysis: A hydrolysis reagent is added to the concentrated residue, with a weight ratio of concentrated residue to hydrolysis reagent of 1:(1.1-4). The mixture is heated to 30-100℃ and kept at this temperature for 1-10 hours with stirring to obtain a hydrolysis product. (3) Recovery: The hydrolysis product is cooled, crystallized, filtered, and washed with water to obtain N-hydroxymethyl phthalimide. This invention can recover effective components from hazardous waste, thereby reducing the discharge of hazardous waste and lowering the cost of hazardous waste treatment.

The utility model relates to the technical field of experimental apparatus, in particular to a kind of 2-bromoisobutyric acid methyl ester preparation condensation reflux device, and it is completed to the condensation reflux processing of 2-bromoisobutyric acid methyl ester by condensing device, detachable support is provided to condensing device by supporting device, support and condensing device fixed connection, reduce the situation that condensing device itself appears during operation Process shaking, through sealing device, the cleaning of equipment is facilitated, the practicability of device is improved;Including condensing device, supporting device and sealing device, supporting device is installed on condensing device, sealing device is installed on condensing device.

The application belongs to the technical field of medicine synthesis, and particularly relates to a preparation method of Mupiravir. The method adopts a one-pot method to prepare an intermediate of Mupiravir ((3AR, 4R, 6R, 6AR)-6-(4-(hydroxyamino)-2-oxymethyl)-2,2-dimethyltetrahydrofuran[3,4-D][1,3]dioxol-4-yl) isobutyric acid methyl ester (compound 1), and then Mupiravir is obtained. The method has the advantages of simple operation, simplified reaction post-processing steps, reduced use of solvent types, low raw material cost and production cost, small amount of mother liquor, green and environment-friendly production, and is more suitable for industrial large-scale production. The liquid phase purity of the obtained Mupiravir reaches more than 99.9%, and the yield reaches 78.9%.

The application discloses a lemon essence, a preparation method and application thereof, and belongs to the field of essence preparation. The lemon essence comprises the following raw materials: lemon fruit fragrance 10-15%, green fragrance 1-2%, sweet agent 1-3%, enhancer 5-10%, stabilizer 1-3%, and the rest is an alcohol solvent. The lemon fruit fragrance comprises lemon oil, sweet orange oil and D-limonene; the green fragrance comprises orange flower alcohol, leaf alcohol, linalool, oxidized linalool, alpha-terpineol, beta-terpinene, isopinocamphone and lemon aldehyde; the sweet agent comprises ethyl maltol and vanillin propylene glycol acetal; the enhancer comprises ethyl butyrate, ethyl 2-methyl butyrate, ethyl acetoacetate, leaf alcohol acetate, linalyl acetate and geranyl acetate; and the stabilizer comprises a low-carboxylic acid, a heat-resistant agent and an antioxidant. The application can inhibit the oxidation and thermal decomposition of the easily-oxidized components from the molecular level by synergistically compounding the components, significantly improves the aroma stability of the essence under long-term storage and high-temperature processing conditions, and can be widely applied in the fields of beverages, foods and the like.