315 results about "Azobenzene" patented technology

The invention relates to the technical field of biodegradable materials, and discloses a full-biodegradable bamboo fiber film material and a preparation method thereof, the full-biodegradable bamboo fiber film material comprises the following raw materials by weight: 30-50 parts of modified bamboo fiber, 20-40 parts of a biodegradable polymer, 3-8 parts of a plasticizer, and 1-5 parts of a cross-linking agent. Acrylic acid grafted hydroxyethyl methylacrylate is grafted to epoxy resin containing azobenzene side chains to form a grafting product of a latticed structure, and the grafting product and hydroxyl groups on bamboo fibers form ether bonds to modify the bamboo fibers. The latticed structure can effectively improve the mechanical property of the film, and azobenzene is grafted to the side chain of bisphenol A epoxy resin, so that the epoxy resin has better degradability.

The invention relates to the technical field of flocculants, in particular to a composite flocculant containing a cationic etherifying agent and a preparation method of the composite flocculant, and the composite flocculant is prepared from the following raw materials in parts by weight: 15-20 parts of carboxymethyl guar gum, 12-15 parts of cationic konjac glucomannan, 1.2-1.5 parts of the cationic etherifying agent, 1.8-2.2 parts of a magnetic polysilicate metal salt flocculant and 0.2-0.3 part of a preservative. According to the present invention, by compounding the flocculant, the flocculated floc has magnetism and can be recovered and repeatedly utilized, and the photoresponse azobenzene structure is grafted in the cationic konjac glucomannan, such that the controllable pollutant aggregation and separation can be achieved, and the good flocculation performance can be maintained after the composite flocculant is repeatedly recovered and repeatedly utilized.

The invention is applicable to the technical field of intelligent response materials, and provides a three-dimensional azobenzene functionalized covalent organic framework intelligent response material and a preparation method thereof. The three-dimensional azobenzene functionalized covalent organic framework intelligent response material is prepared by uniformly grinding 3, 3 ', 5'-tetra [(3 ', 5'-diformylphenyl)]-hexamethyl biphenyl and azobenzene-4, 4 '-diaminotriphenylamine, adding an organic solvent, adding a catalyst acetic acid aqueous solution, quickly freezing, emptying air, sealing with flame, heating after recovering to room temperature, and obtaining the three-dimensional azobenzene functionalized covalent organic framework intelligent response material. According to the invention, the azobenzene functionalized covalent organic framework material with a bcu topological structure is synthesized; the material has excellent photostimulation response CO2 adsorption performance; reversible control of CO2 adsorption capacity can be realized through ultraviolet light and heating conditions, at least five times of circulation can be maintained, and good circulation stability is achieved.

The invention discloses a preparation method of a photoresponsive self-cleaning optical coating with a dynamic self-repairing function. The preparation method comprises the following steps: adding a monomer containing a Diels-Alder reaction bond into a polyurethane prepolymer, and reacting to obtain the polyurethane elastomer with self-repairing capability. An azobenzene derivative is connected to a polyurethane elastomer through a covalent bond, and the photoresponsive self-repairing polymer is obtained. Hydrophobically modified TiO2 nanoparticles are prepared in situ through a sol-gel method. In order to further improve the dispersity of the TiO2 nanoparticles in the polymer, a silane coupling agent is adopted to carry out surface modification on the TiO2 nanoparticles. The preparation method comprises the following steps: mixing a photoresponsive self-repairing polymer and a TiO2 nanoparticle dispersion liquid in proportion, uniformly stirring, coating the mixed liquid on the surface of a base material, forming a uniform coating through a brush coating or spray coating method, and curing the coating at a proper temperature. Due to the excellent characteristics of light response self-repairing, ultraviolet resistance, wear resistance and the like, the coating can keep a long transparent period and good antifouling durability in an outdoor environment.

This invention discloses a visible-light-responsive dynamically covalently cross-linked self-healing polyurethane and its preparation method, belonging to the field of self-healing materials technology. The material is prepared by reacting diisocyanate, long-chain diol, butanediol, trimethylolpropane, and a monool containing an azophenylboronic acid structure in a certain proportion at 60°C. This invention achieves visible-light-responsive self-healing of the polyurethane material by introducing a visible-light-responsive azophenylboronic acid structure into the polyurethane and utilizing the photoresponsive cis-trans isomerization of the azo structure to regulate the reversible breakage and recombination of the boron-oxygen hexacyclic ring. The visible-light-responsive dynamically covalently cross-linked self-healing polyurethane material prepared by this invention maintains high mechanical strength (16.47 MPa) while exhibiting a strength self-healing efficiency of 95.8% after 8 hours of visible light irradiation, showing broad application prospects in smart materials, anti-corrosion coatings, and other fields.

The invention discloses a low-temperature-resistant organic silicon elastic damping body and a preparation method thereof, and belongs to the field of synthesis of organic polymer materials. The invention relates to a high-efficiency photoinitiator, which is prepared from the following ingredients in parts by weight: 95 to 110 parts of fluorosiloxane-phenylsiloxane segmented copolymers, 25 to 35 parts of boric acid ester end-capped polyurethane prepolymers, 10 to 15 parts of neodymium-containing metal organic frameworks, 20 to 40 parts of azobenzene modified CNT / TiO2, 2 to 4 parts of photoinitiators 1173 and 2 to 3 parts of neodymium acetylacetonate. Ultralow-temperature adaptability, self-repairing and high-modulus coexistence and wide-temperature-range damping stability are achieved through fluorosilicone / phenyl block copolymer molecular design, a borate-neodymium coordination double-dynamic network, stress response filler and a light-heat gradient curing process. The low-temperature-resistant organic silicon elastic damping body prepared by the invention provides a new solution idea for an extreme environment damping material, and has a wide application prospect.

The invention discloses a polaroid for brightening sheet roll material compounding. The polaroid comprises a first release film, pressure-sensitive glue, a first cellulose triacetate layer, a polyvinyl alcohol layer, a second cellulose triacetate layer, a special functional layer and a second release film, the polyvinyl alcohol layer is positioned between the first cellulose triacetate layer and the second cellulose triacetate layer; the first release film covers the surface of one side of the first cellulose triacetate layer through pressure-sensitive glue; the special functional layer is coated on the surface of one side of the second cellulose triacetate layer, the second release film covers the special functional layer, and the special functional layer is prepared from an azobenzene side chain type liquid crystal polymer or a polymer stable liquid crystal material. According to the invention, the direct on-line roll-to-roll composite production of the polaroid roll material and the brightness enhancement film roll material is realized, additional manual slitting, splicing and material receiving procedures are not needed, and the product yield and the production efficiency are greatly improved.

The invention provides a photo-thermal response T-type liquid crystal molecule, a preparation method thereof and application of the photo-thermal response T-type liquid crystal molecule to an intelligent window. The structural formula of the T-type liquid crystal molecule is shown in the formula (1). According to the technical scheme, the liquid crystal molecule is in a T type, an azobenzene structure in the liquid crystal molecule is subjected to reversible conversion of cis and trans under switching of ultraviolet light and visible light, and meanwhile, a molecular structure of 8CB and a butylene adipate structure can be subjected to phase change at room temperature, so that the molecule has a light response function, and meanwhile, the light response effect of the molecule is improved. The material also has a thermal response function at room temperature; besides passive control through light and heat, after electrification, liquid crystal molecules are arranged in order, an electric response function is achieved, and the intelligent window can be actively recovered to be transparent. The molecule not only has multiple responses, but also is a low-carbon environment-friendly material. According to the technical scheme, the alkoxy chain is linked to the side chain of the liquid crystal molecule, asymmetry is increased, the liquid crystal molecule has a richer phase structure, and the liquid crystal molecule has a huge development prospect in the field of intelligent windows.

The invention relates to the technical field of flocculants, and in particular to a composite flocculant containing a cationic etherifying agent and a preparation method thereof. The composite flocculant comprises the following raw materials in parts by weight: 15-20 parts of carboxymethyl guar gum, 12-15 parts of cationic konjac glucomannan, 1.2-1.5 parts of cationic etherifying agent, 1.8-2.2 parts of magnetic polysilicate metal salt flocculant, and 0.2-0.3 parts of preservative. By compounding the flocculant, the flocculated flocs have magnetism and can be recycled and reused. Furthermore, since a photoresponsive azobenzene structure is grafted into the cationic konjac glucomannan, controllable pollutant aggregation and separation are achieved, ensuring that the composite flocculant can maintain good flocculation performance after multiple recycling and reuse.

The invention discloses a preparation method of a high-stability photoresponse covalent organic framework membrane and application of the high-stability photoresponse covalent organic framework membrane in selective separation of multiple components. 4-azido azobenzene is prepared by carrying out azido reaction on 4-aminoazobenzene in an acidic aqueous solution, and then a BPTA-TAPB-COF membrane is used as a matrix to prepare the high-stability photoresponse covalent organic framework membrane. 4-azido azobenzene is efficiently grafted to the pore wall of the BPTA-TAPB-COF membrane through a click chemical reaction, the photoresponse covalent organic framework membrane is constructed, and the covalent organic framework membrane can be used for multi-component selective separation and is suitable for multi-component systems with different sizes. The azobenzene group in the pore channel of the prepared Azo-COF membrane is subjected to reversible cis-trans isomerization under the irradiation of ultraviolet / visible light, the response speed is high, and the cycle performance is good; the Azo-COF membrane has good application in the light-operated nanofiltration process, the performance of the Azo-COF membrane is not reduced after the Azo-COF membrane is continuously recycled for 12 days, and the structure of the Azo-COF membrane is kept stable.

The invention belongs to the technical field of pesticides, and particularly relates to azobenzene calix [4] arene derivatives as well as a preparation method and application thereof. The invention discloses a novel azobenzene calix [4] arene derivative prepared by directional modification through an azo reduction reaction based on a calix [4] arene skeleton. The azobenzene calix [4] arene derivative has the characteristics of green environmental protection, accurate and controllable structure and efficient synthesis. After the derivative and a pesticide form a host-guest compound, the activity of the pesticide can be remarkably improved, the bioavailability of the pesticide at an action site is increased, the problem of low efficiency of the traditional pesticide is effectively solved, and the development of target drug resistance is delayed. The technology breaks through the technical bottleneck of nano-carrier environmental toxicity, provides a new thought for developing a multi-target and low-environmental-risk pesticide synergist, and has important significance for realizing pesticide decrement, synergism and resistance treatment.

The invention relates to the technical field of traffic engineering, in particular to a self-repairing type warm-mixing flame-retardant microcapsule and an asphalt mixture, and the microcapsule comprises a core material and a shell material; the composite material is characterized in that the core material comprises a self-repairing component and a warm mixing functional component, the self-repairing component is at least one of sulfur, epoxy resin or recycled asphalt, the warm mixing functional component is an organic wax-montmorillonite composite component, and montmorillonite is modified by a silane coupling agent; the shell material is at least one of ammonium polyphosphate, melamine formaldehyde resin or nano aluminum hydroxide, and nano silicon dioxide particles of which the surfaces are grafted with azobenzene groups are loaded on the surface of the shell material; through cooperation of multiple components, a light, mild and stress triple triggering mechanism is constructed, core material release is accurately regulated, warm mixing, self-repairing and flame-retardant components are mutually promoted, the repairing efficiency and flame-retardant durability are improved, efficient function coupling is achieved, and the pavement performance is optimized.

Described herein are various embodiments for liquid crystal elastomers (LCE) formed from liquid crystalline monomers having 4-(6-(acryloyloxy) n-oxy) phenyl-4-(6-(acryloyloxy)m-oxy)benzoate (CnBAPE) as the mesogenic core. The LCEs described herein have improved thermotropic characteristics, including lower thermotropic activation temperatures. The LCEs described herein may also incorporate azobenzene to thereby also enhance the phototropic properties of the LCE.

The present invention discloses a diazine-based organic negative electrode material for aqueous alkaline batteries and its application, relating to the field of battery technology. This type of organic negative electrode has an electrochemical redox active center with a nitrogen-nitrogen double bond (N=N), including but not limited to azobenzene; azobenzene modified with at least one of halogen, methyl, and nitro functional groups; benzo[c]cinnoline; and benzo[c]cinnoline modified with at least one of halogen, methyl, and nitro functional groups. The organic negative electrode material provided by the present invention can operate stably under various alkaline conditions and is compatible with nickel hydroxide positive electrodes and air positive electrodes. The material has excellent rate performance and long-term cycle stability, and its wide source makes it suitable for large-scale application.

The invention discloses a polyazobenzene-naphthalene tetracarboxylic anhydride material, a preparation method and an application of the polyazobenzene-naphthalene tetracarboxylic anhydride material in a secondary battery, and belongs to the field of secondary batteries. The chemical structural formula of the polyazobenzene-naphthalene tetracarboxylic anhydride material is shown in the specification: # imgabs0 # polyazobenzene-naphthalene tetracarboxylic anhydride material has a long-range conjugated skeleton and abundant electroactive sites and electroactive centers, so that the ionic conductivity and capacity of the polyazobenzene-naphthalene tetracarboxylic anhydride material are improved. And the polyazobenzene-naphthalene tetracarboxylic anhydride material also shows a rigid framework, so that the charge-discharge volume expansion of the positive electrode material is inhibited, and the cycle life of the positive electrode material is prolonged.

The present invention discloses a chalcone-based fluorescent probe, its preparation method and application in detecting H2S, which relates to the technical field of hydrogen sulfide detection. The chalcone-based fluorescent probe of the present invention, the chemical formula of Cha-N3 is (E)-3-(4-azophenyl)-1-(2-hydroxy-4-methoxyphenyl)prop-2-en-1-one. This chalcone fluorescent probe has strong signal enhancement ability in the application of detecting hydrogen sulfide in aqueous environment. The fluorescence enhancement at the emission wavelength of 570 nm can reach 258 times, and qualitative analysis of hydrogen sulfide can be carried out by naked eyes. The detection limit is 122 nM, and it has the ability to monitor low-content hydrogen sulfide. At the same time, the monitoring of hydrogen sulfide in a variety of natural aqueous environments shows that it has strong anti-interference ability, and the fluorescence intensity of Cha-N3 shows a good linear relationship with the concentration of hydrogen sulfide.

The present invention relates to a method for enhancing the photooxidative coupling reaction of 4-aminothiophenol and its application, the method comprising: adding 4-nitrothiophenol to the photocatalytic oxidative coupling reaction system of 4-aminothiophenol, performing a catalytic reaction under the mediation of 4-nitrothiophenol, and oxidizing 4-aminothiophenol to 4,4'-dimercaptoazobenzene. The present invention proposes for the first time to enhance the photooxidative coupling reaction of 4-aminothiophenol by the mediation of 4-nitrothiophenol, which can be judged by the phenomenon that the Raman characteristic peak intensity of the photooxidative coupling product 4,4'-dimercaptoazobenzene is significantly enhanced, and it is found that the Raman characteristic peak intensity under the method is significantly greater than the linear sum of the characteristic Raman peak intensities of 4,4'-dimercaptoazobenzene detected by the catalytic reaction of two thiophenols alone. The method provides a new idea for enhancing and regulating the photooxidative coupling of 4-aminothiophenol.

The invention discloses an anti-blue-light anti-yellowing lens and a vacuum coating process thereof, belongs to the technical field of optical lens manufacturing, and aims to solve the problems of fixed anti-blue-light rate, short anti-yellowing service life, non-environment-friendly process and poor film stability in the prior art. The process core comprises substrate pretreatment, air plasma activation, adhesion promotion layer deposition, dynamic blue light prevention layer deposition, MXene / MOF composite anti-yellowing layer deposition and post-treatment. The lens structurally comprises a base material, a plasma activation layer, a SiO2-ZrO2 adhesive force layer, a ZrO2-Al2O3-Y2O3-azobenzene dynamic blue light prevention layer and a Ti < 3 > C < 2 > T < X >-UiO-66 anti-yellowing layer from inside to outside. According to the invention, the barrier rate of 415-455nm blue light is dynamically adjusted; the air plasma replaces high-purity gas, the gas cost is reduced by 60%, carbon emission is reduced by 40%, and the air plasma is suitable for PC, CR-39 and glass substrates, can be widely applied to daily goggles, myopia glasses and other scenes and has remarkable technical and industrialization values.

This invention discloses a polishing method and apparatus for nickel-based alloys based on photocatalysis and photothickening synergy. It achieves dual-driven processing by simultaneously triggering photocatalytic workpiece surface modification and photo-triggered thickening of the polishing slurry through an integrated dual-light system, realizing surface softening and medium thickening. Composite abrasive particles loaded with TiO2 / ZnO photocatalysts form a low-hardness oxide layer on the nickel-based alloy surface under ultraviolet light irradiation, reducing processing resistance. Precise viscosity control of the polishing slurry is achieved through azobenzene / cinnamic acid photochromic molecules, combined with shear-induced particle agglomeration to form a dual thickening system, improving viscosity stability. This invention solves the technical pain points of work hardening in nickel-based alloys, large viscosity fluctuations in traditional shear-thickening polishing slurries, and poor processing uniformity, improving processing efficiency and workpiece surface quality. It is suitable for efficient and precise machining of difficult-to-machine nickel-based alloys such as Inconel 718 and GH4169.

The invention discloses a generalized pustular psoriasis diagnosis marker based on metabonomics and application of the generalized pustular psoriasis diagnosis marker. The diagnostic marker is prepared from one or more of the following 35 compounds: pyruvic acid, alpha-ketoisovaleric acid, 2-hydroxybutyric acid, 3-hydroxybutyric acid, methane thiophosphoric acid, proline, uracil, tranexamic acid, 4-aminobutyric acid, threonine, scopoletin, dodecanol, N-methyl-L-leucine, L-cysteine-glycine and L-kynurenine. The feed additive is prepared from the following raw materials: 3-hydroxybenzoic acid, allantoin, delta-tocopherol, xylofuranose, glucose-1-phosphoric acid, pyrophosphate, taurine, L-asparagine, phthalic acid, 4-(dimethylamino) azobenzene, 5-tert-butyl-1h-indole-2, 3-dione, quinic acid, glucose, histidine, lysine, palmitic acid, 7-methylguanine, oleic acid and whale acid. The marker can be used for accurately distinguishing patients with generalized pustular psoriasis from healthy people.

The invention discloses a high-temperature-resistant liquid crystal polymer substrate for ultrathin flexible display, which belongs to the technical field of flexible display and comprises a modified liquid crystal polymer and a functional additive dispersed in the modified liquid crystal polymer. The modified liquid crystal polymer is prepared by polymerizing a monomer composition, and is specifically prepared from 38 to 42 parts of p-hydroxybenzoic acid, 28 to 30 parts of 4, 4 '-biphenol, 5.6 to 6.0 parts of terephthalic acid, 4.4 to 5.0 parts of 2, 6-naphthalic acid, 2.7 to 3.3 parts of isophthalic acid, 9 to 11 parts of 2, 2-bis (3, 5-difluoro-4-hydroxyphenyl) hexafluoropropane, 4.5 to 5.5 parts of N, N'-dihydroxypyromellitic diamine, 9 to 11 parts of 9, 9-bis [4-(4-methoxycarbonyl phenoxy) phenyl] fluorene and 1, 2-bis (4-(4-methoxycarbonyl phenoxy) phenyl] fluorene. The component A is prepared from 5.5 to 6.5 parts of 1, 4-cyclohexanedimethanol; the functional additive comprises an azobenzene derivative, a hot acid generator and a hydrogen bond enhancer; through the synergistic effect of a specific monomer combination, a functional additive and an optimization process, the technical bottleneck that heat resistance, transparency, dimensional stability and flexibility of an existing material are difficult to consider at the same time is broken through.

The present disclosure discloses a nickel catalyst of formula (I). The present disclosure also discloses a process of hydrogenation-dehydrogenation coupling catalyzed by catalyst of formula (I). Further, the present disclosure also discloses a process for secondary imine hydrogenation reactions catalyzed by catalyst of formula (I).

The invention discloses a preparation method of a zinc-based metal organic framework material and application of the zinc-based metal organic framework material in adsorption and degradation of methylene blue dye. Belongs to the field of new materials and sensors. According to the zinc-based metal organic framework material, azobenzene tetracarboxylic acid and 2, 6-diaminopurine are taken as ligands, zinc ions are taken as a coordination center, nitric acid is taken as a pH regulator, and the novel regular porous octahedral metal organic framework material is synthesized in one step by utilizing a solvothermal method. The zinc-based metal organic framework material shows relatively strong adsorption and degradation capability on methylene blue, and the adsorption and degradation rate on the methylene blue is as high as 97%; the preparation process of the zinc-based metal organic framework material is simple and safe, the raw materials are cheap, and the zinc-based metal organic framework material has a regular porous octahedral structure, has relatively strong adsorption and degradation capability on methylene blue, and has excellent application and popularization prospects.

The invention provides a preparation method and application of an amorphous zirconium-doped manganese oxide catalyst, and belongs to the field of organic catalytic synthesis. The catalyst is Zr-MnO2-x, and is rich in lattice oxygen with high activity and high stability; x is the molar ratio of Zr to the sum of Mn and Zr, and x is larger than or equal to 0.2 and smaller than or equal to 0.6; zirconium mainly exists in the form of zirconium hydroxide. The preparation method comprises the following steps: slowly dropwise adding a mixed salt solution of a zirconium source and a manganese source into a precipitant under a continuous stirring condition, and carrying out a co-precipitation reaction; after the reaction is completed, standing and aging, carrying out solid-liquid separation and collecting a precipitate; and washing and drying to obtain the amorphous zirconium-doped manganese oxide catalyst which is used for catalyzing aniline and derivatives thereof to synthesize azobenzene compounds. According to the invention, the characteristic of'difunctional lattice oxygen 'with high activity and high stability is introduced through zirconium doping, and the catalyst has the advantages of high activity, high selectivity, wide substrate applicability, excellent stability and reusability and the like when used for catalytic synthesis of azobenzene compounds.

The invention discloses a disposable photo-thermal self-heating wet tissue, a preparation method of the disposable photo-thermal self-heating wet tissue and a wet tissue product, and belongs to the technical field of hygienic products. The disposable photo-thermal self-heating wet tissue sequentially comprises a transparent leakage-proof layer, a photo-thermal layer and a cleaning layer from top to bottom, wherein the photo-thermal layer comprises a three-branch azobenzene / graphene composite fiber woven mesh and a hot melt adhesive dot array, and the hot melt adhesive dot array fixes the three-branch azobenzene / graphene composite fiber woven mesh between the cleaning layer and the transparent leakage-proof layer. The three layers can be compounded and fixed through the hot melt adhesive dot array in the photo-thermal layer of the wet tissue, the energy density of composite fibers of the photo-thermal layer is high, rapid and stable photo-thermal conversion can be achieved through sunlight or blue light irradiation, a traditional chemical heating agent is replaced, the chemical leakage risk is completely eliminated, the temperature is controllable, and the mechanical stability is good; the requirements of one-time cleaning and warm keeping are met, and wide application prospects are achieved.

The application provides a preparation method of a light response thin film material, the light response thin film material, an ultraviolet light monitoring device and a system. The method comprises the following steps: adding 4,4'-dihydroxyhexyloxy azobenzene into a polymer obtained by polymerization of a dihydroxy oligomer and a diisocyanate-based monomer to obtain polyurethane containing an azobenzene group; dissolving the polyurethane and a piezoelectric polymer in a high-boiling-point solvent to obtain an electrospinning solution; and performing electrospinning on the electrospinning solution to obtain the light response thin film material. The 4,4'-dihydroxyhexyloxy azobenzene containing a six-carbon spacer is added as a chain extender into the polymer of the dihydroxy oligomer and the diisocyanate-based monomer to obtain the ultraviolet light response polyurethane containing the azobenzene group. Furthermore, the light response thin film material with better flexibility, better mechanical properties and good ultraviolet light response can be prepared by combining the polyurethane and the piezoelectric polymer. The preparation process of the light response thin film material is simple, and the preparation cost is low.

The invention provides a compound for regulating and controlling a TRPV1 ion channel. The structural formula of the compound is as shown in formula I. The invention also provides application of the compound in preparation of a medicine for regulating and controlling the TRPV1 ion channel. The invention provides a pharmaceutical composition with an anti-inflammatory effect, the pharmaceutical composition comprises the compound, and pharmaceutically acceptable auxiliary materials or auxiliary components are added to prepare a pharmaceutically common preparation. Compared with azobenzene, the compound has the advantages that the illumination wavelength is increased, the illumination wavelength is 660 nm, a TRPV1 targeted photosensitizer is used, a channel is activated by using a low-energy near-infrared light'precise key ', depth, safety and reversibility are considered, and the anti-inflammatory effect of the compound is obvious.

The invention belongs to the technical field of organic ultrathin nanomaterials, and particularly relates to a photoresponse type polymer ultrathin nanosheet as well as a preparation method and application thereof. The preparation method comprises the following steps: (1) adding dicyclohexylcarbodiimide, N-hydroxysuccinimide, N, N-diisopropylethylamine and 4-carboxyl phenylboronic acid pinacol ester into a solvent, and reacting to obtain an intermediate product; (2) carrying out heating reaction on the intermediate product, triethylene glycol and a catalyst to obtain a phenylboronic acid pinacol ester derivative; (3) adding 4, 4-dibromo azobenzene, a phenylboronic acid pinacol ester derivative, a palladium catalyst and potassium carbonate into a solvent for reaction to obtain an amphiphilic alternating copolymer; and (4) dispersing the amphiphilic alternating copolymer in a solvent for self-assembly to obtain the amphiphilic alternating copolymer. According to the invention, a photoresponse group azobenzene structure is introduced into a polymer main chain, so that the ultrathin organic material is endowed with a unique photoresponse characteristic; the method is simple and easy to implement, good in repeatability and high in stability.

The invention discloses a generalized pustular psoriasis diagnosis marker based on metabonomics and application of the generalized pustular psoriasis diagnosis marker. The diagnostic marker is prepared from one or more of the following 35 compounds: pyruvic acid, alpha-ketoisovaleric acid, 2-hydroxybutyric acid, 3-hydroxybutyric acid, methane thiophosphoric acid, proline, uracil, tranexamic acid, 4-aminobutyric acid, threonine, scopoletin, dodecanol, N-methyl-L-leucine, L-cysteine-glycine and L-kynurenine. The feed additive is prepared from the following raw materials: 3-hydroxybenzoic acid, allantoin, delta-tocopherol, xylofuranose, glucose-1-phosphoric acid, pyrophosphate, taurine, L-asparagine, phthalic acid, 4-(dimethylamino) azobenzene, 5-tert-butyl-1h-indole-2, 3-dione, quinic acid, glucose, histidine, lysine, palmitic acid, 7-methylguanine, oleic acid and whale acid. The marker can be used for accurately distinguishing patients with generalized pustular psoriasis from healthy people.

The invention discloses a nano aggregate as well as a preparation method and anti-breast cancer application thereof. The nano aggregate comprises a drug-drug conjugate AI (formed by dehydration condensation of ATRA and IRI), an anoxic response type prodrug PAC (formed by coupling of CPUL119 and PEG through an azobenzene connecting bond), and a targeting molecule DT (DSPE-PEG2000-Try), wherein the drug-drug conjugate AI is formed by dehydration condensation of ATRA and IRI; the anoxic response type prodrug PAC is formed by coupling of CPUL119 and PEG through an azobenzene connecting bond; the preparation method comprises the following steps: respectively dissolving AI, PAC and DT in an organic solvent, dropwise adding an AI solution into deionized water, stirring for the first time, adding a PAC solution and a DT solution, and stirring again to obtain the nano aggregate. The nano aggregate disclosed by the invention has a uniform particle size of 90-130 nm and a high drug loading capacity (greater than 80%), stably exists in a physiological environment, and shows excellent tumor targeted accumulation capacity; the medicine is released through hypoxia / pH / esterase triple response, chemotherapy (IRI), differentiation therapy (ATRA) and ferroptosis therapy (CPUL119) are coordinated, and the killing effect on breast cancer cells and stem cells is remarkably enhanced.