127 results about "P-Aminobenzoic acid" patented technology

This invention defines a novel method for treatment of several neurological diseases and pathophysiologically related symptomology, said diseases including peripheral neuropathies, secondary symptomology of diabetes, Alzheimer's disease, Parkinson's disease, alcoholic polyneuropathy and age-onset symptomology, as well as analogous veterinary disease states. An opportunity exists for pharmacological intervention in some neurological diseases by use of water soluble, small molecular weight primary amine agents and chemical derivatives thereof. Examples of such primary pharmacological agents include 4-aminobenzoic acid and derivatives thereof. The present invention also includes: (1) oral use of optional non-absorbable polyamine polymeric co-agents such as chitosan, (2) oral use of optional known antioxidant co-agents and nutritional factors related thereto, and (3) use of the primary agents and co-agents noted above in optional combination with medicaments recognized as effective for treatment of the diseases addressed herein or symptoms thereof.

These and other objects of this invention are achieved by providing a novel method and compositions for the clinical treatment of chronic inflammatory diseases. This invention involves use of systemically administered compositions which include primary amine derivatives of benzoic acid as carbonyl trapping agents. These primary therapeutic agents act by chemically binding to and sequestering the aldehyde and/or ketone products of lipid peroxidation. Increased levels of lipid peroxidation have been repeatedly demonstrated as a part of the non-enzymatic "inflammatory cascade" process which underlies the secondary etiology of chronic inflammatory diseases. p-Aminobenzoic acid (or PABA) is an example of the primary therapeutic agent of the present invention. PABA has a small molecular weight, is water soluble, has a primary amine group that reacts with carbonyl-containing metabolites under physiological conditions and is tolerated by the body in relatively high dosages and for extended periods. The carbonyl sequestering agents are used in combination with at least one co-agent so as to produce an additional beneficial physiological effect of an anti-inflammatory nature. Such compositions are administered systemically entirely via the oral route. Co-agents of the present invention include anti-oxidants and free radical trapping compounds (e.g., alpha-tocopherol), compounds having indirect anti-oxidant activity (e.g., selenium), vitamins (e.g., pyridoxine HCl), compounds which facilitate kidney drug elimination (e.g., glycine), metabolites at risk of depletion (e.g., pantothenic acid), sulfhydryl containing chemicals (e.g., methionine), compounds which facilitate glutathione activity (e.g., N-acetylcysteine), and non-absorbable polyamine co-agents (e.g., chitosan).

The invention provides a method for hydro-thermal synthesis of rod-shaped nano tungsten trioxide using p-aminobenzoic acid as an adjuvant, as well as a method for catalytic synthesis of adipic acid. According to the invention, tungstate is used as tungsten source, p-aminobenzoic acid is used as a morphological control agent, and the rod-shaped nano tungsten trioxide is obtained through hydro-thermal synthesis; then, hydrogen peroxide is used as an oxidant, rod-shaped nano tungsten trioxide is used as a catalyst for catalytic synthesis of adipic acid. The method is mainly characterized in two points: firstly, a new approach is adopted to synthesize the nano tungsten trioxide; secondly, adipic acid can be obtained through catalytic synthesis via the synthesized catalyst cleanly and efficiently (the yield of adipic acid can reach 51.92%-82.20%) without an organic solvent and a phase transfer catalyst.

This invention is preparation of unsaturated polyester resin. The raw material is the terephthalic acid waste containing terephthalic acid 80%-90% and p-aminobenzoic acid 10%-20%. The procedure is as followings: add diatomic alcohol and catalytic composite into the terephthalic acid waste for polycondensation reaction. Add unsaturated diacid for further polycondensation. Add phenylethene for permutoid reaction. This invention's raw material is wasted washing water. The facility is the general ones for unsaturated polyester resin. The product has lower price, high quality, stability and environment-friendness. It could be used in a large scale of tube of glass fibre reinforced plastic, storage tank and instrument backing strip.

Synthesis method for benzo oxazole diamine, which involves organic compound synthesis process. Said p-phenylene-2,2'-bis (5-aminobenzo oxazole) of the present invention is prepared as follows: a. Formulate phosphoric acid and P2O5 into ploy(phosphoric acid) solution; b. Add to the resulting solution 2,4-diamiophenol hydrochloride and terephthalic acid; c. Add then reducing agent SnCl2; d. Followed by neutralization, extraction and drying, then the primary product is obtained; e. Subject the primary products to extraction and drying to get bright yellow powder. And said 2,6-bis primary product to extraction and drying to get bright yellow powder. And said 2,6-bis primary product to extraction and drying to get bright yellow powder. And said 2,6-bis primary product to extraction and drying to get bright yellow powder. And said 2,6-bis primary product to extraction and dyring to get bright yellow powder. And said 2,6-bis (p-aminobenzyl) benzo [1,2-d; 5,4-d'] dioxazole is prepared as follows: a. Formulate phosphoric acid and P2O5 into ploy(phosphoric acid) solution; b. Add to the resulting solution 4,6-metaphenylene diamine hydrochloride and p-aminobenzoic acid.

The invention generally relates to biological engineering of microorganisms and production of chemical compounds therefrom. More particularly, the invention relates to novel genetically engineered microorganisms for the fermentative production of p-aminobenzoic acid and related compounds from fermentable carbon substrates. The biologically derived PABA and related compounds from fermentable carbon substrates can be used in a number of applications including as a food supplement or raw materials for the syntheses of other industrial chemicals or polymers.

The invention discloses a P-N expanded reaction type flame retardant p-(carboxyphenyl-amino)-(carboxyphenyl-amidoethyl) phenylphosphine oxide and a preparation method thereof. The preparation method comprises the following steps: (a) adding a p-aminobenzoic acid solution into glacial acetic acid; (b) adding triethylamine and mixed solution obtained in the step (a) into a 2-carboxethylphenyl hypophosphorous acid solution, stirring at a high speed and reacting for 2 hours, raising the temperature to 80 DEG C, reacting for 4 hours, cooling, hydrolyzing, performing suction filtration, washing and drying to obtain white powder, namely the P-N expanded reaction type flame retardant. The defects that harmful gases are generated by general flame retardants, the environment is polluted, fuming is caused and the mechanical property is influenced are overcome, the P-N expanded reaction type flame retardant has double-carboxyl end groups, effective flame retardant components are bonded to a PA66 main chain, an inherently flame retardant effect is achieved, and the flame retardant has the advantages of harmlessness, smoke inhibition, high efficiency, environmental friendliness and the like.

The invention discloses an adsorbent, and a preparation method and application thereof. A technical scheme provided by the invention has the following key points: the adsorbent is a Cu-TATAB nano complex prepared by thoroughly mixing 4, 4 ', 4''-s-triazine-1, 3, 5-tri-p-aminobenzoic acid and Cu(NO3)2.3H2O in a solvent at room temperature. The invention also discloses the preparation method of the adsorbent Cu-TATAB nano complex and application of the adsorbent to wastewater treatment. The preparation method of the adsorbent provided by the invention is easy to operate, and does not need synthesis conditions such as high temperature and high pressure; and the prepared adsorbent Cu-TATAB nano complex can effectively remove contaminants such as organic dyes and heavy metal ions in water, and has renewable recycling performance.

The invention relates to a dinuclear europium complex luminescent material and a preparation and application of the dinuclear europium complex luminescent material. The structural general formula of the dinuclear europium complex luminescent material is Eu2L16L22(CH3OH)2, wherein L1 is a p-aminobenzoic acid benzoyl thioureas derivatives; and L2 is one of 1,10-phenanthroline, 2,2-dipyridyl or 2-thenoyltrifluoroacetone. The dinuclear europium complex is a luminescent material with good thermal stability and high luminous efficiency; the molecular structure of the dinuclear europium complex is regular, and after a second auxiliary ligand is added in the dinuclear europium complex luminescent material, the fluorescence intensity and the quantum yield of the dinuclear europium complex luminescent material are improved quite obviously. The preparation method has the advantages of simplicity and convenience in process, simple used equipment, simple and easily obtained raw materials and low production cost.

The invention relates to a method for preparing a graphene dispersion liquid by utilizing a pyrenyl benzoic acid polyether ester parent reagent. The method comprises the steps: with methoxy polyethylene glycol, p-aminobenzoic acid and 1-pyrenylboronicacid as raw materials, carrying out esterification reaction to obtain p-aminobenzoic acid polyether ester of a hydrophilic long chain, then introducing HBr which is reacted with the 1-pyrenylboronicacid to prepare 3, 5-dibromo benzoic acid methoxy polyethylene glycol, and carrying out reaction on the 3, 5-dibromo benzoic acid methoxy polyethylene glycol and the pyrenylboronicacid to synthesize amphoteric (hydrophilic and oleophylic) graphite remover; and dissolving the compound and graphene in a H2O/Et solution, carrying out twice ultrasonic treatment, standing, and carrying out centrifugation to obtain the stable a graphene dispersion liquid. With the adoption of the method, as the graphene does not need oxidation reduction, the destructive effect on a graphene structure is very small, and the unique electric and thermal conductivities of the graphene can be fully exerted; as the prepared dispersion liquid has good aqueous phase stability, an effective way is provided for the application of the graphene in the field of composites.

An electrolyte for a lithium secondary battery, which includes a lithium salt, a nonaqueous organic solvent and at least one additive selected from the group consisting of vitamin G (vitamin B₂, riboflavin), vitamin B₃ (niacinamide), vitamin B₄ (adenine), vitamin B₅ (pantothenic acid), vitamin H (vitamin B₇, biotin), vitamin M (vitamin B₉, folic acid), vitamin B_X (4-aminobenzoic acid), vitamin D₂ (ergocalciferol), vitamin D₃ (cholecalciferol), vitamin K₁ (phylloquinone), ascorbyl palmitate, and sodium ascorbate.

The invention discloses low-temperature curable bio-based benzoxazine resin and a preparation method thereof. The benzoxazine resin monomer is prepared from bio-based m-trihydroxybenzene, furfuryl amine and paraformaldehyde; and under the catalytic condition of a catalyst prepared from bio-based m-trihydroxybenzene, p-aminobenzoic acid and paraformaldehyde, the low-temperature curing characteristic of curing completely at 200 DEG C is realized. The product is suitable for preparation of a natural fiber-reinforced green composite material. The synthetic process of the monomer and the catalyst is reasonable, purity is high, raw materials are bio-based raw materials and green and environmentally-friendly, yield is high, and the cost is economical and reasonable. The structural formula of theproduct is as shown in the formula (I).

The invention discloses a sewer pipe cleaning agent and a preparation technology thereof. The sewer pipe cleaning agent comprises, by weight, 2 to 5 parts of sodium chloride, 10 to 30 parts of p-aminobenzoic acid, 1 to 3 parts of lipase, 10 to 20 parts of sodium bicarbonate, 4 to 8 parts of aluminum magnesium sulfate, 12 to 18 parts of potassium hydrogen tartrate, 10 to 20 parts of ammonia water, 20 to 40 parts of sodium dodecyl sulfate and 3000 to 5000 parts of water. Compared with the prior art, the sewer pipe cleaning agent has the advantages that 1, the sewer pipe cleaning agent is used for sewer pipe cleaning, has good fatty dirt cleaning effects and is suitable for cleaning sewer pipes in hotels, restaurants and family; and 2, the waste liquor of the used sewer pipe cleaning agent is an alkalescent solution, can be discharged safely and does not influence pipe quality.

The invention relates to a chiral azobenzene polymer and a production method of the chiral azobenzene polymer. The chiral azobenzene polymer is a polyurethane material with a chiral group and an azobenzene group on a side chain. The production method of the chiral azobenzene polymer takes S-2-methyl-1-butanol as a chiral source, the S-2-methyl-1-butanol and 4-aminobenzoic acid react to obtain 4-aminobenzoic acid-S-2-methyl butyl ester, the polyurethane is prepared through condensation polymerization of diisocyanate and N,N-dihydroxyethylaniline, and finally the 4-aminobenzoic acid-S-2-methyl butyl ester and the polyurethane are subjected to a diazo coupling reaction to obtain the corresponding chiral azobenzene polymer. The main chain structure of the chiral azobenzene polymer is changed by changing the structure of the diisocyanate, and the molecular weight of the chiral azobenzene polymer is regulated by controlling the reaction time of condensation polymerization and the reactant ratio of the diazo coupling reaction. The surface of the chiral azobenzene polymer realizes holographic optical storage of information under the radiation of interference laser of 450-550 nm, and a formed holographic pattern can be erased and rewritten.

The invention relates to a series of whitening agents containing p-aminophenyl formic acid radical hyamine fluorescence as well as synthesis and applications thereof; the series of whitening agent are mainly applied to paper making, dope, printing ink and weaving. The invention adopts the following synthetic steps of: a, using cyanuric chloride to react with p-aminophenyl formic acid for 2.5h under the temperature of 0 to 5 DEG C, controlling the pH between 1.8 to 2.1 and synthesizing a primary condensation product; b, using the primary condensation product to react with 4, 4'-Diaminostilbene-2, 2'-disulfonic acid for 2.0h under the temperature of 40 to 45 DEG C, controlling the pH between 3.5 to 4.5 and synthesizing a secondary condensation product; c, using the secondary condensation product to react with a series of tertiary amine compounds for 3.0h under the temperature of 78 to 85 DEG C, controlling the pH between 7.8 to 8.3 and synthesizing a series of p-aminophenyl formic acid radical hyamine triazine-DSD acid fluorescence whitening agents. The application result shows that; the whitening agents not only can be used under neutral conditions and alkaline conditions, but also has higher dying rate under acidic conditions and better whitening effect.

The invention relates to a halogen-free flame-retardant epoxy curing agent and a preparation method thereof. The preparation method comprises the following steps that 1, heating reaction is conducted on HPM, p-aminobenzoic acid and paraformaldehyde in the molar ratio of 1 to 1 to 2, and benzoxazine with carboxyl and maleimide structures is obtained; 2, the nucleophilic addition property of P-H bonds of DOPO is utilized, DPOP and benzoxazine with carboxyl and maleimide structures which is obtained in the step 1 are added, wherein the molar ratio is 2:1, the epoxy resin curing agent with a bimolecular DOPO structure is synthesized and obtained by the heating reaction. Compared with existing products, the epoxy curing agent and the preparation process thereof have the advantages of being simple in curing process, mild in reaction temperature, excellent in flame-retardant effect, difficult in burning in air, high in production rate, simple to operate, low in raw material price and wide in source.

The present invention discloses multiple microbe waste water treating agent and its waste water recovering and utilizing process. The multiple microbe waste water treating agent consists of K2HPO4, KH2PO4, MgSO4.7H2O, CaCl2.2H2O, NH4Cl, DL-sodium malate, yeast extract paste, EDTA-2Na, FeSO4.7H2O, H3BO4, CaCl2.6H2O, ZnCl2, biotin, nicotinic acid, L-sodium glutamate, growth factor liquid, trace element liquid, MnCl2.2H2O, Na2MoO4.2H2O, NiCl2.6H2O, CuCl2.2H2O, p-aminobenzoic acid, vitamin B1, vitamin B2, vitamin B6 and water. When the waste water treating agent is used in treating waste water, optimized microbe seeds are thrown in certain proportion. The present invention is used in treating waste water from plant fiber degradation with biological enzyme, and has high treating effect, short treating period and low treating cost.

The invention discloses 2,2'-(1,4-phenylene)bi(benzimidazole-5-carboxylic acid) which has the following structural formula and a preparation method thereof. The preparation method comprises the steps of: dissolving 3,4-diaminobenzoic acid in an aprotic polar solvent, heating by using an oil bath to a certain temperature, dropwise adding an aprotic polar solvent solution of terephthalaldehyde, stirring for a certain time after the adding; adding an oxidant in a reaction system, and continuously stirring for reacting for a certain time; and pouring reaction liquid into alcohol, filtering, and drying to obtain a light brown solid (2,2'-(1,4-phenylene)bi(benzimidazole-5-carboxylic acid)). The aprotic polar solvent is selected from one or more of tetrahydrofuran, acetonitrile, N-methylpyrrolidone, N,N-dimethylformamide and dimethylsulfoxide; and the oxidant is selected from one or more of cerous nitrate, hydrogen peroxide, ferric trichloride, copper acetate, iodobenzene diacetate, air, oxygen, benzoquinone, dichloro dicyane benzoquinone and 3-nitryl-4-aminobenzoic acid.

The invention discloses a preparation method of a cyclodextrin terminated star-shaped polymer. The method includes the steps of: under anhydrous and oxygen-free conditions, using dipentaerythritol asthe initiator, using stannous isooctanate as the catalyst to carry out ring-opening polymerization reaction on epsilon-caprolactone so as to obtain six-armed polycaprolactone, and then carrying out esterification reaction on p-aminobenzoic acid to obtain an arylamine terminated six-armed star-shaped polymer, and then further carrying out addition-dehydration reaction with cyclodextrin monoaldehyde, thus obtaining the imine group chained and cyclodextrin terminated six-armed star-shaped polymer. According to the method, cyclodextrin is disposed at the terminal of the star-shaped polymer, the prepared product not only has the three-dimensional structural characteristics of the star-shaped polymer itself, but also can better retain the advantages of the cyclodextrin chamber and cavity surrounding structure, thus enlarging the application range. The invention expands the types of star-shaped cyclodextrin polymers. The preparation method has the advantages of simple operation, mild reactionconditions, and simple product post-treatment, and is beneficial to realization of industrial production.

The invention relates to an impurity analysis method for multiple vitamin preparations. The method comprises the following steps of preparing a test solution of the vitamin preparations; dissolving o-phthalaldehyde and 2-mercaptoethanol based on a mass ratio of 1 to (2-5) in methanol, adding a boric acid buffer solution, and adjusting the pH value to 3-5 to obtain a derivatization reagent; and taking the test solution, adding the derivatization reagent to carry out online derivatization reaction, and injecting the derivatized test solution into a high performance liquid chromatograph, therebydetecting impurities in the test solution. According to the method, folic acid impurity A, folic acid impurity D, p-aminobenzoic acid and 3-aminopropanol in the vitamin preparations can be effectivelydetected; and the method is high in sensitivity and good in specificity.

The invention relates to an extraction method of p-aminobenzoic acid and belongs to the field of extraction separation. The extraction method of p-aminobenzoic acid comprises the steps that an extraction agent is made to be in contact with a water solution containing p-aminobenzoic acid, wherein the extraction agent is TOAP ionic liquid. By the adoption of the extraction method, the extraction efficiency is high, the selectivity is high, the extraction rate of p-aminobenzoic acid can reach over 93%, operation conditions are mild, and the extraction method is environmentally friendly.

The invention provides a covalent organic framework-based composite photocatalyst for degrading organic pollutants in water and a preparation method of the photocatalyst. The method comprises the following steps: performing ice bath on a covalent organic framework crystalline triazine-based organic framework (CTF-1) solution and a 4-aminobenzoic acid solution, performing stirring, performing washing, and performing vacuum drying to prepare a benzoic acid functionalized CTF-1, wherein the benzoic acid functionalized CTF-1 is labeled as CFB; and performing ball milling to compound the CFB with phosphotungstic acid (H3PW12O40) according to different ratios to obtain H3PW12O40/CFB, that is, the covalent organic framework-based composite photocatalyst used for degrading the organic pollutants in the water. According to the method provided by the invention, the covalent organic framework CTF-1 is subjected to benzoic acid functional modification, and the phosphotungstic acid is immobilized into the CTF-1, so that monodispersion of the phosphotungstic acid at the molecular level is realized, the photocatalytic activity is effectively improved, and the degradation efficiency on the organicmatter is obviously improved; and the photocatalyst has good stability in the water, long service life, a relatively-simple process, raw materials easy to obtain and a low price, and can be used forindustrial application and promotion.

The invention relates to the technical field of fine chemicals, and specifically relates to a sunscreen essence lotion and the preparation method thereof. The essence lotion is prepared from the following components in percentage by weight: 0.1-5% of fructus rubi oil, 0.1-5% of hazelnut oil, 0.5-55 of fructus phyllanthi extract, 0.5-5% of broccoli juice, 0.5-5% of flos calendulae officinalis extract, 0.1-3% of p-aminobenzoic acid, 0.1-5% of octocrilene, 0.1-5% of ethylhexyl methoxycinnamate, 0.1-5% of stearyl glycyrrhetinate, 0.1-5% of allantoin, 0.1-5% of hyaluronic acid, 0.1-2% of vitamin E,0.1-2% of ergothioneine, 0.1-3% of polydimethylsiloxane, 0.1-2% of cetyl ethyl hexanoate, 0.1-4% of octyl polymethylsiloxane, 1-15% of cetyl PEG/PPG-10/1-cetyl-polydimethylsiloxane, 0.5-5% of hexadecyl-2-glycerol-3(trimethyl siloxane group)methylsilyl ethyl polydimethylsiloxane, 0.01-3% of sodium benzoate, 0.01-3% of phenoxyethanol, 1-10% of glycerin, 0.5-4% of carbomer, and the balance of deionized water. According to the invention, multiple sunscreen, repair, and moisturizing components are reasonably compound to obtain the sunscreen essence lotion, which has moisturizing and sunscreen functions and is suitable for comprehensive skin care during Spring, Autumn, and Winter.

The invention discloses a two-dimensional metal organic framework nanosheet-based capillary gas chromatography column and a preparation method and the application thereof. In an organic solvent, by taking zirconium tetrachloride as a metal source, taking 1,3,5-tri(4-carboxyphenyl)benzene as an organic ligand and taking at least one of formic acid, benzoic acid and p-aminobenzoic acid as an acid regulator, the metal and the organic ligand are self-assembled to form a nanosheet which is activated in vacuum, and then the inner wall of a capillary column is coated with the nanosheet to prepare thecapillary gas chromatography column, so that a substituted benzene isomer mixture can be efficiently separated to show unique para-isomer selectivity, which greatly improves the separation degree bycompared with a commercial column meta/para-substituted benzene structural isomer; baseline separation can be achieved for mixed straight-chain alkane and mixed benzene series; in addition, the nanosheet of a multilayer stack structure is an important reason for efficient separation of the isomers. The capillary gas chromatography column disclosed by the invention has excellent properties of wideapplication range, high selectivity, high thermal stability and the like.