118 results about "Phenylphosphine" patented technology

The invention relates to a molecular tag DMDPM compound, a preparation method thereof and application of the molecular tag DMDPM compound in assisting homogeneous synthesis of heptapeptide H6K, and belongs to the technical field of organic synthesis. The molecular tag DMDPM compound is 2, 4-dimethoxy-4 '-diphenylphosphinyl oxydiphenyl alcohol, and the molecular tag DMDPM compound is 2, 4-dimethoxy-4'-diphenylphosphinyl The method has the advantages of a liquid-phase synthesis method and a solid-phase synthesis method, H6K can be simply, quickly, economically and efficiently synthesized and prepared, and a 2, 4-dimethoxy-4 '-diphenylphosphinyloxy diphenyl alcohol small-molecule auxiliary group (also called as a carrier) can be recycled and directly reused, so that raw material waste is reduced, waste pollution is reduced, the cost is saved, and environmental protection is facilitated.

The invention discloses a preparation method of 3, 6-dichloropyridazine, and belongs to the technical field of chemistry. According to the method, 3, 6-dihydroxypyridazine is used as a raw material, an organic solvent and triphenylphosphine oxide are combined to form a dichlorotriphenylphosphine intermediate state which is used as a chlorinating agent, dihydroxyl is substituted to generate 3, 6-dichloropyridazine, triphenylphosphine oxide and solid light are used as raw materials, heating reaction is performed to prepare 3, 6-dichloropyridazine, meanwhile, a one-pot method can be adopted in the two-step reaction, and operation is easy and convenient. The novel preparation method for synthesizing 3, 6-dichloropyridazine provided by the invention has the advantages of low raw material cost, high yield, high gas phase purity and no pollution, is suitable for industrial production, can meet industrial requirements, provides a new idea for later preparation of 3, 6-dichloropyridazine, has the remarkable advantages of high gas phase purity and high yield, and is suitable for industrial production. Wide application prospects are realized.

The invention provides a method for constructing an aryl C-P bond through a reaction of an Ar-F compound of a nickel catalysis electron donating group, which comprises the following steps: in the presence of a nickel catalyst, an additive and alkali, carrying out a coupling reaction on a substituted aryl compound in a formula B and a compound in a formula C diphenylphosphine oxide in an organic solvent to generate an aryl phosphine oxide compound in a formula A, the reaction formula is shown in the specification, Ar is or, and R is an electron-donating group. The method disclosed by the invention has the effects that the substrate has universality, the operation is simple, the condition is mild, a noble metal catalyst and a phosphine ligand are not needed, the cost is low, and the yield is high.

The application relates to the technical field of catalysts, and discloses a palladium / alumina catalyst and a preparation method and application thereof. A Schiff base phosphine cyclodextrin ligand is synthesized through two-step reactions of nucleophilic substitution and Schiff base condensation, the molecular structure of the ligand covalently bridges the hydrophobic cavity of beta-cyclodextrin and the strong coordination site of diphenylphosphine through a rigid Schiff base bond; subsequently, the phosphine group of the ligand is coordinated with a palladium salt under a specific pH, and a uniform and stable palladium-ligand colloid precursor is formed under the assistance of a directing agent and a stabilizing agent; finally, the colloid is mixed with an alumina carrier for impregnation, drying, and a palladium / alumina catalyst is obtained. Through molecular design and process innovation, the problems of low activity, poor selectivity and insufficient stability of traditional catalysts are solved. When the catalyst is used for preparing hydrogen peroxide by hydrogenating anthraquinone, the hydrogenation efficiency is significantly improved, the selectivity is extremely high, and the cycle stability is excellent, so the catalyst has important industrial application value.

The present invention relates to a method for preparing triphenylphosphine, comprising performing heat treatment on a chlorodiphenylphosphine raw material at a temperature of 280-480°C to prepare triphenylphosphine, wherein the content of dichlorophenylphosphine in the chlorodiphenylphosphine raw material does not exceed 35 wt%, based on the total weight of the chlorodiphenylphosphine raw material.

The invention provides a perovskite quantum dot compound and a preparation method and application thereof. The preparation method of the perovskite quantum dot compound comprises the following steps: preparing a mixture containing a triphenylphosphine halide copolymer, carrier particles, a first cationic precursor and a second cationic precursor; the A comprises one or more of CH3NH3 +, CH3CH2NH3 +, (CH3) 2CHNH3 +, CH (NH2) 2 +, Ar-CH3CH2NH3 +, Li < + >, Na < + >, K < + >, Rb < + > and Cs < + >; b comprises one or more of Pb < 2 + >, Sn < 2 + >, Be < 2 + >, Mg < 2 + >, Ca < 2 + >, Sr < 2 + >, Ba < 2 + >, Zn < 2 + >, Ge < 2 + >, Fe < 2 + >, Co < 2 + > and Ni < 2 + >; x comprises one or more of Cl <->, Br <-> and I <->; after the reaction is finished, a powdery or granular perovskite quantum dot compound is obtained, perovskite quantum dots are dispersed in a triphenylphosphine halide copolymer, and the triphenylphosphine halide copolymer coats the surfaces of carrier particles. The preparation method is low in cost, energy-saving and simple.

The invention relates to a method for preparing triphenylphosphine, which comprises the following steps: a diphenylphosphine chloride raw material is subjected to heat treatment at the temperature of 280-420 DEG C to prepare triphenylphosphine, and at least part of phenylphosphine dichloride is removed in the heat treatment process.

The application discloses preparation of carbazolyl 3,5-dicyanopyridine derivatives, room temperature phosphor and anti-counterfeiting performance thereof. The preparation method comprises the following steps: adding ortho-, meta- or para-carbazolyl benzaldehyde and malononitrile into a reaction bottle, stirring and reacting under room temperature conditions with sodium hydroxide as a catalyst and anhydrous methanol as a solvent, and obtaining ortho-, meta- or para-carbazolyl 3,5-dicyanopyridine by separating and purifying the reaction crude product. Crystals of the three compounds are obtained by a solvent diffusion method with dichloromethane-petroleum ether as a solvent, and the crystal state room temperature phosphor material is obtained. The crystals are doped with urea / triphenylphosphine at a weight ratio of 1:100, the doped crystals are uniformly ground and mixed, and then heated to be molten, so that the host-guest doped phosphor material is obtained, and the novel material is used in the field of anti-counterfeiting patterns.

The invention provides a green preparation method and application of diphenyl phosphine oxide. The preparation method comprises the following steps: step 1, mixing diphenyl alkoxy phosphine, water and Lewis acid, and fully stirring for reaction to obtain a reaction solution containing diphenyl phosphine oxide and alcohol; step 2, distilling the reaction liquid, washing with water, standing, separating liquid, collecting an organic phase, drying the organic phase, and cooling and crystallizing to obtain diphenylphosphine oxide; and step 3, rectifying and purifying the distilled alcohol, and pumping the distilled acid and water washing liquid into a reaction kettle for cyclic catalysis. The diphenylalkoxyphosphine is used as a raw material and is subjected to hydrolysis reaction with water under the catalysis of the lewis acid to generate diphenylphosphine oxide and alcohol, the lewis acid can be continuously returned to the reaction kettle to participate in the reaction after being subjected to subsequent distillation, the synthesis process is simple, the atom economy is high, the reaction principle is simple, the conditions are easy to control, and the method is green and environment-friendly and can be used for industrial production.

The application belongs to the technical field of lithium secondary batteries, and discloses a lithium secondary battery electrolyte with high and low temperature performance and a lithium secondary battery.The electrolyte comprises a non-aqueous solvent, a lithium salt, a triphenyl phosphine alkenyl compound and a compound with a carbonyl group.The electrolyte of the application is formed by the joint action of the triphenyl phosphine alkenyl compound and the compound with a carbonyl group, wherein the triphenyl phosphine alkenyl compound can be reduced in preference to the solvent, and the compound with a carbonyl group can form a thin and uniform SEI film on the positive and negative electrode surfaces of the lithium secondary battery through synergistic action, complex with positive transition metal ions, passivate the positive electrode surface, inhibit metal dissolution, improve the low-temperature rate discharge performance of the battery, and improve the normal temperature and high-temperature cycle life.

The invention provides a preparation method of a novel chiral thiourea / phosphine bifunctional organic catalyst with a cis-cyclic 1, 2-phosphinamine skeleton and application of the novel chiral thiourea / phosphine bifunctional organic catalyst in an asymmetric catalytic reaction. The chiral organic catalyst is prepared by taking cis chiral 2-(diphenylphosphine)-1, 2, 3, 4-tetrahydro-1-naphthylamine and an isothiocyanate compound as raw materials through a one-step reaction under a mild condition. The chiral thiourea / phosphine bifunctional organic catalyst is simple to prepare and stable in property, and shows excellent catalytic activity and stereoselectivity in an asymmetric hydrosilylation reaction of o-amido benzophenone.

The invention belongs to the technical field of polymer flame retardance, and relates to a fluoride-free anti-dripping functional flame retardant for polycarbonate as well as a preparation method and application thereof, in the chemical structural formula of the fluoride-free anti-dripping functional flame retardant for polycarbonate, n is 5-20, and M is Li, Na, K, Rb or Cs; the preparation method comprises the following steps: mixing a metal salt solution of 2, 2 '-disulfonic acid benzidine with an acid-binding agent, dropwise adding a phenylphosphonic dichloride solution, continuing to stir and react after dropwise adding, heating after reaction, dropwise adding a diphenyl silanediol solution, continuing to react after dropwise adding, and finally performing post-treatment to obtain the fluoride-free anti-dripping functional flame retardant for polycarbonate. According to the application of the flame-retardant polycarbonate, polycarbonate and the fluoride-free anti-dripping functional flame retardant for polycarbonate are subjected to melt blending, so that the flame-retardant polycarbonate is prepared. The functional flame retardant disclosed by the invention integrates multiple functions of flame retardance, molten drop resistance, carbon formation enhancement and the like, and flame-retardant polycarbonate prepared from the functional flame retardant realizes no molten drop by virtue of a self-enhanced ceramic carbon layer.

The application discloses a high-temperature-resistant polyvinyl chloride adhesive tape and a preparation method thereof, and belongs to the technical field of polymer materials and adhesive products. The high-temperature-resistant polyvinyl chloride adhesive tape comprises the following raw materials in parts by weight: synergistically modified polyvinyl chloride, diphenyl phosphine oxide, chlorinated polyethylene, diisononyl phthalate, antimony trioxide, calcium stearate, zinc stearate, an antioxidant and a leveling agent; the synergistically modified polyvinyl chloride is obtained by introducing catechol structures on the surface of polyvinyl chloride through dopamine self-polymerization deposition, forming a dynamic borate ester structure with 3-aminobenzoic acid, and constructing a Si-O-Si network structure through hydrolytic condensation reaction of octa(3-aminopropyl)silsesquioxane and N-(beta-aminoethyl)-gamma-aminopropyl triethoxysilane. The dopamine-borate ester-silicone synergistic network structure is constructed, and the diphenyl phosphine oxide is introduced for function regulation, so that the heat resistance, mechanical properties and dimensional stability of the polyvinyl chloride adhesive tape are significantly improved.

The invention relates to the field of composite soft plastic packaging, in particular to a dynamic self-repairing type high-toughness bio-based degradable film and a preparation method and application thereof. The film is composed of a lactic acid high polymer, a copolymer of butylene adipate and butylene terephthalate, a compatibilizer, a nucleating agent, a catalyst, an auxiliary agent and an antibacterial agent, the catalyst is formed by mixing a main catalyst and a co-catalyst, the main catalyst comprises any one of zinc acetylacetonate, ferric acetylacetonate, antimony trioxide and zinc oxide, and the co-catalyst comprises any one of zinc acetylacetonate, ferric acetylacetonate, antimony trioxide and zinc oxide. The cocatalyst is selected from any one of triethylamine, triphenylphosphine and aluminum acetylacetonate. The invention provides an effective scheme for solving the core contradiction that the strength, toughness, repairability and controllable degradability of a bio-based material are difficult to consider at the same time, is expected to replace traditional plastics in the fields of high-end environment-friendly packaging, intelligent agricultural mulching films and the like, and has great environmental benefits and industrialization prospects.

The application relates to a preparation method of (R)-5-chloromethyl-2-oxanone and belongs to the technical field of organic synthesis. The preparation method comprises the following steps: under a protective atmosphere, S1, azidotrimethylsilane and (R)-epichlorohydrin are added into a solvent at -10 DEG C to 10 DEG C, and 1-azido-3-chloro-2-propanol is obtained through reaction; S2, triphenylphosphine and the 1-azido-3-chloro-2-propanol of S1 are added into an organic solvent at -10 DEG C to 10 DEG C, and a mixture is obtained through reaction under a carbon dioxide atmosphere; S3, the mixture of S2 is subjected to recrystallization and cold filtration, and (R)-5-chloromethyl-2-oxanone is obtained. According to the preparation method, (R)-epichlorohydrin is used as a starting material, and (R)-5-chloromethyl-2-oxanone is synthesized through ring-opening reaction and ring-closing reaction, and the purity (98%-99%) and the yield (more than 70%) are high. The route is short, the raw material is cheap and easy to obtain, the reaction is mild, no toxic reagent is used, and the ee value of the obtained product is high (98%-99%).

The invention discloses a method for constructing an alpha-aza-aromatic hydrocarbon substituted propenone compound through dipole reversal alpha-position amination reaction of phosphine-catalyzed acetylenic ketone, and relates to a preparation method of the propenone compound. The reaction of the method can be carried out under the following conditions: small organic molecule triphenylphosphine is used as a catalyst, the temperature is 25-50 DEG C, dichloromethane is used as a solvent, acetylenic ketone and an N-heterocyclic aromatic compound are used as reaction substrates, the corresponding functionalized alkenyl ketone compound is obtained, and the highest conversion rate can reach 99%. The method has the advantages of mild reaction conditions, no use of a metal catalyst, environmental friendliness, wide substrate application range, high yield, simple operation, good regioselectivity and commercially available catalyst, and in addition, the target product alpha-aza-arene substituted propenone has potential biological activity and medicinal value.

The invention relates to the technical field of talcum powder, in particular to modified talcum powder for flame-retardant polycarbonate resin and a preparation method and application thereof.The preparation method comprises the following steps that 1, 3-aminopropyltrimethoxysilane and 3-hydroxyphenylphosphinopropionic acid are added, a reaction is conducted with methylbenzene as a solvent, separation and purification are conducted, and a siloxane modifier is obtained; the reaction formula is shown in the specification; and step 2, carrying out surface modification on talcum powder by using a siloxane modifier, fully heating and stirring the talcum powder, the siloxane modifier and the dispersion liquid, reacting, filtering, washing and drying to obtain the modified talcum powder.

The invention discloses a fluorescent probe for high-sensitivity monitoring of cell mitochondrial autophagy as well as a preparation method and application thereof. The structure of the fluorescent probe is as shown in formula I in the specification. According to the fluorescent probe provided by the invention, a phenol group is used as an electron donor and a pH response unit, hydroxyl tricyanopyrrole is used as an electron acceptor, triphenylphosphine is used as a mitochondrial targeting group, fluorine atoms are introduced to a benzene ring to improve the response rate and the fluorescence intensity, and meanwhile, a thiophene ring is introduced to further expand the fluorescence emission wavelength. The probe can rapidly target mitochondria and emit corresponding fluorescence signals based on pH differences of different autophagy stages, so that real-time, high-sensitivity and high-selectivity monitoring of the mitochondria autophagy process is realized. In addition, the fluorescent probe is simple in molecular structure, small in molecular weight and easy to synthesize, purify and subsequently modify. Cell experiment results show that the probe can accurately trace the mitochondrial autophagy process in cells, and has good application potential in the field of biological imaging and detection.

The invention discloses an antibacterial polyester fiber and a preparation method thereof, and relates to the technical field of high polymer materials. When the antibacterial polyester fiber is prepared, 1, 3, 5, 7-tetramethylcyclotetrasiloxane, solid super acid and 1, 3-bis (hydroxypropyl) tetramethyldisiloxane react to prepare hydroxyl-terminated methyl hydrogen-containing silicone oil, and then the hydroxyl-terminated methyl hydrogen-containing silicone oil reacts with dimethyl terephthalate and ethylene glycol to prepare polysiloxane copolyester; the preparation method comprises the following steps: carrying out phosphorus-hydrogen addition modification on polysiloxane copolyester and diphenyl (4-vinyl phenyl) phosphine, and then carrying out quaternary phosphonium modification on the modified polysiloxane copolyester and 4-bromine-butylamine hydrobromide to prepare antibacterial modified copolyester; preparing ZIF-8 powder and loading an anti-aging agent; and finally, mixing the antibacterial modified copolyester and the ZIF-8 loaded with the anti-aging agent, melting and spinning to prepare the antibacterial polyester fiber. The antibacterial polyester fiber prepared by the method has excellent antibacterial, flame-retardant and antioxidant properties and the like.

The invention belongs to the field of chemical pesticides, and relates to an insecticide, in particular to benzo [e] [1, 3] thiazine-2, 4-diketone compounds, pharmaceutically acceptable salts and a preparation method thereof.The benzo [e] [1, 3] thiazine-2, 4-diketone compounds are prepared by stirring benzo [c] [1, 2] dithio-3-ketone compounds and triphenylphosphine in a solvent and then adding carbamic acid p-nitrophenyl ester compounds for a synthetic reaction. The compound is a 3, 3] thiazine-2, 4-diketone compound. Compared with a traditional synthesis method, the method has the advantages that raw materials are easy to prepare, the highest yield can reach 99%, reaction conditions are mild, operation is easy and the like, it is found through insecticidal activity screening that the synthesized benzo [e] [1, 3] thiazine-2, 4-diketone compound has good insecticidal activity, and the method has important significance on research of synthesis and application of the compound.

The present invention relates to a method for recovering and reusing a selective homogeneous hydrogenation catalyst. The present invention relates to a method for recovering a selective homogeneous hydrogenation catalyst from a second reaction resolution in which a synthesis of cyclododecene is completed after synthesizing the cyclododecene by selective hydrogenation of a first reaction solution containing cyclododecatriene, triphenylphosphine, formaldehyde, and ruthenium chloride, and the method includes: preparing the selective homogeneous hydrogenation catalyst from the triphenylphosphine, the formaldehyde, and the ruthenium chloride during the selective hydrogenation of the first reaction solution, and synthesizing the cyclododecene; mixing a solvent containing cyclododecanone with the first reaction solution; and recovering the selective homogeneous hydrogenation catalyst through evaporation separation from the second reaction solution in which the synthesis of the cyclododecene is completed.

The invention discloses a chlorine-containing monophosphine compound as well as a preparation method and application thereof, and the chlorine-containing monophosphine compound is (2-formyl phenyl) diphenylphosphine-2, 6-dichloro-1, 4-phenylenediamine; the preparation method comprises the following steps: sequentially adding 2, 6-dichloro-1, 4-phenylenediamine and (2-formylphenyl) diphenylphosphine into an organic solvent I in an inert gas atmosphere, reacting for a certain time at a certain temperature, cooling and filtering to obtain a crude product; and dissolving the obtained crude product in a dichloromethane / normal hexane mixed solution, cooling, volatilizing and crystallizing, filtering and drying to obtain the chlorine-containing monophosphine compound. The chlorine-containing monophosphine compound is applied as a fluorescent probe to detect heavy metal ions, and the heavy metal ions in a solution are detected by utilizing the fluorescence intensity enhancement effect of the chlorine-containing monophosphine compound on the heavy metal ions. The preparation method disclosed by the invention is simple and convenient to operate, relatively mild in reaction condition, relatively low in raw material price and low in process cost, and has an application prospect of industrial production.

The present invention provides a radiation-curable inkjet ink that has low odor and suitable viscosity and curability for use as an inkjet ink. [Solution] A radiation-curable inkjet ink composition comprising a polymerizable compound, a polymer thioxanthone polymerization initiator, and bis(2,4,6-trimethylbenzoyl)-phenylphosphine oxide, wherein the polymerizable compound does not contain an amine-modified oligomer, or the polymerizable compound contains an amine-modified oligomer, and the content of the amine-modified oligomer is less than 5% by mass of the total amount of the ink composition.

The present invention relates to an improved process for preparing triphenylphosphine (TPP) by reacting triphenylphosphine oxide (TPPO) with a specific catalyst.

This invention discloses a semi-sandwich structured ruthenium triphenylphosphine dithiocarboxylic acid complex with a simple preparation process and its applications. The complex has the structure shown in Figure (I), with the central ruthenium and... η 5 - Coordination with cyclopentadiene, triphenylphosphine, and dithiocarboxylic acid derivatives, wherein the dithiocarboxylic acid ligands are selected from ethyl xanthic acid, isopropyl xanthic acid, ... N,N Diethyldithiocarbamic acid, morpholine dithiocarbamic acid, and carbazole dithiocarbamic acid. This invention employs a simple one-step method of room temperature preparation and recrystallization purification using a ruthenium precursor and dithiocarbamic acid ligand. This method offers advantages such as readily available raw materials, mild reaction conditions, simple post-processing, and high yield. In vitro tests show that the complexes exhibit excellent anti-proliferative activity against non-small cell lung cancer A549 cells, significantly superior to cisplatin. The complexes demonstrate activity by reducing mitochondrial membrane potential, inducing intracellular reactive oxygen species accumulation, and arresting the cell cycle (G1 phase), leading to late apoptosis in A549 cells.

The application discloses a preparation method of an irradiation type high-temperature-resistant cable and relates to the technical field of cables. In the application, trichloroethyl phosphate is combined with guanidine sulfamate to introduce nitrogen elements, release non-combustible gas during combustion, dilute combustible gas concentration, preliminarily realize the flame-retardant effect, and assist the formation of a porous foamed carbon layer of phosphate groups to prevent oxygen from entering and further improve the flame-retardant effect. Then, the modified flame retardant is prepared by dehydration condensation of vinyl trihydroxysilane, Si-O bonds are formed, the thermal stability of the material is significantly improved, and the flame-retardant effect is effectively improved. Then, diallyl phenyl phosphine and the modified flame retardant are used to participate in the polymerization reaction of polyethylene to form a stable three-dimensional cross-linked network structure, improve the mechanical properties of the surface of the cable, introduce phenyl groups, significantly improve the thermal stability and oxidation resistance, and make the material generate non-combustible products during combustion, so that the spread of flame is inhibited, and the flame-retardant effect is realized.

The invention belongs to the technical field of spice raw material synthesis, and particularly relates to a synthesis method of methyl cis-dihydrojasmonate, which comprises the following steps: dissolving 1-heptyne in toluene, discharging into a first reaction tank, adding a cobalt catalyst, and discharging 1-bromine-ethylene and carbon monoxide gas into the first reaction tank; adding triphenylphosphine into a first catalyst recovery tank, discharging catalyst precipitates, and carrying out sectional distillation to distill, cool and recover 1-heptyne; absolute methanol is discharged into the layering tank; dimethyl malonate is discharged into a second reaction tank, sodium methoxide is slowly added, an addition reaction is carried out at the temperature of-5 DEG C to 0 DEG C, and then heating is carried out for a decarboxylation reaction; 4-bromo-dihydrojasmonic acid methyl ester obtained by distillation is discharged into a third reaction tank; and discharging methyl jasmonate with alpha, beta-double bonds into a fourth reaction tank for reaction. By simplifying the steps, improving the recovery rate of the catalyst and realizing continuous production, the problems of high cost, low yield, low recovery rate of the catalyst and the like in preparation of the methyl cis-dihydrojasmonate in the prior art are solved.

This invention relates to the field of perovskite solar cell technology, and discloses a method for preparing a hole transport layer and a perovskite solar cell. The method utilizes spiro-OMeTAD as the hole transport layer, mixes ethyltriphenylphosphine bis(trifluoromethanesulfonyl)imide salt (ETPTFSI) in a CB solvent, forms a precursor solution through photopretreatment, and then forms the hole transport layer through a coating process. The method also explores the discovery of ethyltriphenylphosphine cation (ETP... + The lowest unoccupied molecular orbital (LUMO) energy level is similar to that of organic high conductivity layers (HTLs), and upon photoexcitation, it accepts an electron from the organic semiconductor and forms a neutral radical ETP. • ETP • The unpaired electrons in the chlorobenzene have high energy and can break the C-Cl bond in chlorobenzene. This reaction chain promotes the efficient doping of organic HTL by the solvent CB through CB. In addition, ETPTFSI has extremely low hygroscopicity and a large space size, which helps to improve moisture resistance and reduce the migration of iodide ions to the HTL / silver electrode, thereby significantly improving stability.

The invention discloses a silver-copper nanocluster and application of the silver-copper nanocluster in an electro-catalysis nitrate reduction reaction. The synthesis method comprises the following synthesis steps: firstly, adding tetra-n-octylammonium bromide into a dichloromethane solution, stirring for five minutes, adding a silver source dissolved in methanol until white flocculent precipitate appears in the solution, adding a copper source until the solution becomes gray, adding triphenylphosphine until the solution becomes cyan clear solution, adding phenethyl mercaptan until the solution becomes orange red, stirring overnight, and filtering to obtain a filtrate; and separating an organic phase from a water phase, carrying out reduced pressure evaporation on the organic phase, and washing the organic phase with methanol for several times to remove residual ligands and by-products. Finally, n-hexane is spread on the upper layer of the dichloromethane solution for liquid diffusion, and orange flaky crystals are obtained. The silver-copper nanocluster disclosed by the invention has the characteristics of novel structure, good stability, easiness in synthesis and high yield, and has excellent catalytic performance in an electro-catalysis nitrate reduction reaction.

This invention provides a mitochondrial-targeting compound—triphenylphosphine GW7647 conjugate (TPP-GW)—that can effectively enhance anti-tumor function, a pharmaceutical composition containing TPP-GW, and a method for preparing and using the TPP-GW. The triphenylphosphine GW7647 conjugate is obtained by conjugating (3-aminopropyl)triphenylphosphine with GW7647. It is a novel mitochondrial-targeting PPARα agonist that can enhance the toxic effects of the original GW7647 on tumor cells and has a synergistic effect with immune checkpoint blockade therapy.