The invention provides a food-grade safe type biomimetic simulated fish bait capable of being completely degraded, and relates to the technical field of fishing. The bait is prepared from the following components in parts by weight: 0.5-1 part of polyvinyl alcohol resin, 5-10 parts of edible gelatine, 5-10 parts of corn protein powder, 1-2 parts of hydrolyzed protein, 3-5 parts of aloe gel, 1-3 parts of corn peptide, 2-4 parts of microlite cellulose, 2-4 parts of dihydroxy acetone, 1-3 parts of a phagostimulant, 0.5-1 part of shea butter, 0.5-1 part of hyaluronic acid, 0.5-1 part of tea polyphenol, 2-4 parts of talcum powder, 1-2 parts of linseed gum, and 0.5-1 part of soybean lecithin. According to the bait disclosed by the invention, the corn protein powder, the edible gelatine and the aloe gel are used as main raw materials, the dihydroxy acetone is used as a plastifier, fish luring components of natural silk peptide, pit soil, esterified enzyme composite bacterial liquid and the like are added, according to the feeding characteristics of different fish varieties, the biomimetic bait with authentic features of various forage fish and shrimps is prepared, the bait can be completely biodegraded in natural environment, and pollution to the environment is little.