107 results about "Phosphonium" patented technology

The invention discloses an application of an ionic liquid in extraction of trioxymethylene, in the process of generating trioxymethylene by acid-catalyzed condensation of a formaldehyde aqueous solution, the ionic liquid is added as an extraction agent to extract and separate the trioxymethylene generated by reaction, and the ionic liquid is methyl tributyl phosphonium bis (trifluoromethanesulfonyl) imide salt; when the ionic liquid is used for extracting trioxymethylene, a ternary azeotropic system of trioxymethylene, water and methylene glycol can be broken, the ionic liquid and trioxymethylene are subjected to nonpolar Van der Waals' force interaction so as to realize extraction, and methylene glycol and water are left in a water phase through hydrogen-bond interaction, so that high-purity trioxymethylene with the purity of more than or equal to 99.5 wt.% is obtained.

The invention discloses a flame-retardant PA66 material and a preparation method thereof.The flame-retardant PA66 material is prepared from, by weight, 80-100 parts of a modified PA66 material, 3-5 parts of modified graphene, 15-30 parts of a flame-retardant additive and 0.1-0.5 part of tetraphenylphosphorus bromide, a molecular chain of the flame-retardant additive contains an organic silicon chain segment and an organic phosphorus structure and is doped with nitrogen and boron elements, and when the material is burnt, the flame-retardant PA66 material has a flame-retardant effect, and the flame-retardant PA66 material has a flame-retardant effect. The organic phosphorus can be dehydrated to form a phosphoric acid carbon layer, the nitrogen element can release inert gas, dilute combustible gas and generate an expansive phosphorus-nitrogen carbon layer with the organic phosphorus, the boron element can improve the compactness and high-temperature stability of the carbon layer, and the organic silicon can form a cross-linked network shape, so that the continuity of the carbon layer is improved; a fluorine-containing polysiloxane chain segment of a side chain of the flame-retardant additive is embedded among molecules of the modified PA66 material, and is decomposed to generate fluorine free radicals during combustion, and active free radicals in a combustion chain reaction are quenched, so that a rapid flame-retardant effect is achieved.

The application provides a method for synchronously separating active substances of Haematococcus pluvialis, and relates to the technical field of natural product extraction, and comprises an extraction phase with a mass ratio of 20%-50%, and the balance is water; the extraction phase is a quaternary phosphonium ionic liquid or a eutectic solvent; the quaternary phosphonium ionic liquid comprises tetrabutylphosphonium trifluoroacetate or tributyl octyl phosphonium bromide; and the eutectic solvent comprises a quaternary phosphonium ionic liquid and a fatty acid with a molar ratio of 1:1-5:3. The extraction phase has weak acidity, the ability to form van der Waals forces and hydrogen bond interactions, the Haematococcus pluvialis cell wall breaking effect and high solubility. The extraction phase can form liquid-liquid phase separation, can realize the synchronous extraction of Haematococcus pluvialis cell wall breaking, astaxanthin, carbohydrates and proteins, and has no organic solvent, is simple to operate, has short extraction time and high extraction efficiency. The method solves the technical problem that the extraction agent in the prior art cannot effectively separate multiple active substances of Haematococcus pluvialis.

The present invention is a deep eutectic liquid, which is a mixture of a hydrogen bond donor compound and a hydrogen bond acceptor compound, wherein the hydrogen bond donor compound is a compound represented by the following general formula (1) having a structure in which 2 to 100 monomers having a hydroxy group are bonded, the hydrogen bond acceptor compound is a compound containing a monomer having a quaternary ammonium cation represented by the following general formulae (2) to (6) or a quaternary phosphonium cation represented by the following general formula (7), and the deep eutectic liquid is present in a liquid state at 25° C. The present invention provides a deep eutectic liquid that has high ionic conductivity and ensures safety upon contact with living bodies, a bio-electrode composition containing the deep eutectic liquid capable of promptly acquiring signals by being applied to the skin without leaving residues on the skin, stably obtaining biological signals for a long period, and forming a living body contact layer for bio-electrodes, a bio-electrode in which a living body contact layer is formed from the bio-electrode composition, as well as a method for producing the bio-electrode.

The invention provides a zero-dimensional manganese-based quaternary phosphonium cation organic-inorganic hybrid metal halide as well as a preparation method and application thereof, and belongs to the technical field of material science and photoelectricity. The preparation method comprises the following steps: grinding and uniformly mixing quaternary phosphonium ionic liquid, hydrated halogenated manganese salt and oxalic acid dihydrate to obtain a mixed material; and transferring the mixed material into a high-temperature reaction kettle, carrying out high-temperature reaction, cooling to room temperature, adding ethanol into the high-temperature reaction kettle, heating, recrystallizing, and cooling to obtain the zero-dimensional manganese-based quaternary phosphonium cation organic-inorganic hybrid metal halide. According to the method, the defect that a traditional solvent volatilization method, a solvothermal method, a solvent diffusion method and the like highly depend on strong haloid acid and an organic solvent is overcome, and the technical problem of green controllable synthesis of the 0D Mn-OIMHs crystal is solved by adopting a green and environment-friendly ionothermal synthesis method.

This invention provides a class of organophosphorus compounds based on phosphane structural units and their preparation methods, namely phosphane phosphonium oxides represented by formula (II) and phosphane phosphonium hydrogens represented by formula (III). These organophosphorus compounds are widely used in the manufacture of optoelectronic devices. Their synthesis method avoids the use of highly polluting chlorine gas and the subsequent emissions problems caused by traditional phosphorus chemical production, making it an extremely environmentally friendly production method. Furthermore, the method disclosed in this invention features mild reaction conditions, short reaction time, simple post-processing, and high yield.

The invention discloses polyurethane modified by a solid bactericide of polyborneol ester phosphonium. The preparation method comprises the following steps that octaphosphino cage type oligomeric silsesquioxane and halogenated bornyl acetate react in an anhydrous solvent at the temperature of 10-50 DEG C for 12-24 hours, the molar ratio of phosphine groups to halogenated bornyl acetate groups is 1: (1-1.5), and the powdery antibacterial agent is obtained after precipitation, collection and drying. The antibacterial agent is added into thermoplastic polyurethane through primary mixing and mixing in an internal mixer to form a uniform and transparent polyurethane material, so that the material has antibacterial performance. The multi-quaternary phosphonium cation constructed on the basis of cage type oligomeric silsesquioxane has good antibacterial performance and environmental degradability, can be used in the fields of disinfectants, plastics, textile fabrics, medical instruments and the like, is different from common liquid water-soluble mono-quaternary phosphonium salt, is solid powder, cannot be dissolved in water but can be dissolved in ethanol, and can be used for preparing the antibacterial material. This makes it difficult to migrate and washable during use.

The invention discloses a preparation method of beta-apo-8 '-carotene acid ethyl ester, which comprises the following steps: reacting C10 dialdehyde, C5 phosphonium ester and / or C5 phosphonium salt in the presence of an unsaturated dinitrogen heterocyclic compound under an alkaline condition to generate a C15 aldehyde ester intermediate; the method comprises the following steps: reacting a C15 aldehydeester intermediate with a C15 phosphonium salt in the presence of an unsaturated dinitrogen heterocyclic compound under an alkaline condition, and carrying out an isomerization reaction after the reaction is finished to generate beta-apo-8 '-carotene acid ethyl ester; the method is simple and efficient to operate and mild in reaction condition, the prepared apoate crystal is high in all-trans content, low in impurity residue, small in average size and free of agglomeration, and production of downstream preparations is facilitated; particularly, the unsaturated dinitrogen heterocyclic compound serving as the catalyst is wide in source, easy to obtain, low in cost and beneficial to industrial application.

The purpose of the present invention is to provide a treatment agent for recycled cellulose fiber excellent in nep preventing properties.　This treatment agent for recycled cellulose fiber contains (A) an organic phosphate ester compound having a hydrocarbon group with 14-22 carbon atoms including a compound (A1) represented by general formula (1) and a compound (A2) represented by general formula (2); and (B) a nonionic surfactant. The weight ratio (A / B) of the compound (A) to the surfactant (B) is 0.05-1.0. In formula (1), R1 is a monovalent saturated hydrocarbon group with 14-22 carbon atoms. M1 and M2 are each independently a hydrogen atom, an alkali metal, ammonium, phosphonium, an organic amine or a quaternary ammonium. In formula (2), R2 and R3 are each independently a monovalent saturated hydrocarbon group with 14-22 carbon atoms. M1 is a hydrogen atom, an alkali metal, ammonium, phosphonium, an organic amine or a quaternary ammonium.

The invention belongs to the technical field of demulsifier preparation, and particularly relates to a demulsifier for an offshore oilfield and a preparation method of the demulsifier. According to the demulsifying agent for the offshore oilfield, modified polysiloxane is used as a main demulsifying agent, tallow alkyl bis (hydroxyethyl) amine oxide and tetradecyl tributyl phosphonium bis (trifluoromethanesulfonyl) imine salt are used as auxiliary demulsifying agents, methyl-1-oleamidoethyl-2-oleyl imidazoline methyl ammonium sulfate is used as a corrosion inhibitor, ethylene bis stearamide is used as a defoaming agent, and the demulsifying agent is prepared through a one-step method. The cosolvent is a dissolution dispersion medium, the triethanolamine is a pH regulator and a corrosion inhibition synergist, and the deionized water is a continuous phase carrier; all the raw materials have a synergistic effect, so that the prepared demulsifier for the offshore oilfield has excellent dehydration and demulsification performance.

The present invention relates to a process for the preparation of (4Z)-11,11-dialkoxy-4-undecenyl triaryl phosphonium halides of general formula (3-Z), wherein Y represents a halogen atom, Ar represents independently of each other an aryl group, R 1 and R 2 represent independently of each other a monovalent hydrocarbon group having 1 to 15 carbon atoms, or R 1 and R 2 may together form a divalent hydrocarbon group R 1 -R 2 having 2 to 10 carbon atoms, which process comprises: subjecting a (7Z)-11-halo-1,1-dialkoxy-7-undecene compound of general formula (1-Z), wherein X 1 represents a halogen atom, R 1 and R 2 are as defined above, to a phosphonium salt forming reaction with a phosphine compound of general formula (2), wherein Ar is as defined above, to form said compound (3-Z); and also relates to a compound of general formula (A) L(CH2)3CH=CH(CH2)5CH(OR 1 )(OR 2 )(A), wherein R 1 and R 2 are as defined above.

The present disclosure provides a liquid resin composition that has high fluidity at high temperature and can suppress abnormalities of appearance and breakage of a cured product when exposed to high temperature. A liquid resin composition contains a liquid epoxy compound (A), a liquid aromatic amine compound (B), an inorganic filler (C), a stress-lowering agent (D), and a fluidity-increasing agent (E). The stress-lowering agent (D) contains an epoxidized fatty acid ester compound (D-1). The fluidity-increasing agent (E) contains at least one selected from the group consisting of compounds (E-1) that have a quaternary phosphonium cation structure and compounds (E-2) that have a silicate anion structure.

Alkoxylations are performed by reacting a cyclic oxide with a starter in the presence of certain phosphonium catalysts. The phosphonium catalysts are highly active and effective in such small quantities that it is often unnecessary to remove catalyst residues from the product. The phosphonium catalysts are very effective in alkoxylating even low molecular weight starters such as glycerol and sorbitol.

The invention discloses an antibacterial polyester fiber and a preparation method thereof, and relates to the technical field of high polymer materials. When the antibacterial polyester fiber is prepared, 1, 3, 5, 7-tetramethylcyclotetrasiloxane, solid super acid and 1, 3-bis (hydroxypropyl) tetramethyldisiloxane react to prepare hydroxyl-terminated methyl hydrogen-containing silicone oil, and then the hydroxyl-terminated methyl hydrogen-containing silicone oil reacts with dimethyl terephthalate and ethylene glycol to prepare polysiloxane copolyester; the preparation method comprises the following steps: carrying out phosphorus-hydrogen addition modification on polysiloxane copolyester and diphenyl (4-vinyl phenyl) phosphine, and then carrying out quaternary phosphonium modification on the modified polysiloxane copolyester and 4-bromine-butylamine hydrobromide to prepare antibacterial modified copolyester; preparing ZIF-8 powder and loading an anti-aging agent; and finally, mixing the antibacterial modified copolyester and the ZIF-8 loaded with the anti-aging agent, melting and spinning to prepare the antibacterial polyester fiber. The antibacterial polyester fiber prepared by the method has excellent antibacterial, flame-retardant and antioxidant properties and the like.

An analyzer is disclosed for detecting and quantifying a tetrakis(hydroxymethyl)phosphonium sulfate (THPS) composition in a water sample. The analyzer includes a peristaltic pump and a three-way valve, where the peristaltic pump draws in a water sample that includes a THPS composition through the 3-way valve. The analyzer also includes a 6-way valve that receives the water sample and a potassium permanganate reagent, and a reaction coil in which the water sample and the KMnO4 reagent are mixed and reacted. The analyzer further includes a debubbler that remove bubbles from the mixture; and a flow cell that receives the mixture from the debubbler, measures an intensity of KMnO4 absorption in the mixture, normalizes the measured intensity by subtracting a background intensity, and determine a presence and a concentration of the THPS composition in the water sample.

To provide a magnetoviscous fluid that can achieve both high reliability and high excitation stress even when used at low or high temperatures, and a braking device equipped with such a magnetoviscous fluid. [Solution] A magnetorheological fluid comprising metal magnetic particles modified with an ionic liquid modification site containing a first cationic group and a first anionic group, and an ionic liquid dispersion medium containing a second cationic group and a second anionic group, wherein the first cationic group and the second cationic group are of the same type and are selected from the group consisting of quaternary ammonium ions, imidazolium ions, pyridinium ions and phosphonium ions, and the first anionic group and the second anionic group are selected from the group consisting of tetrafluoroborate ions, hexafluorophosphate ions, trispentafluoroethyltrifluorophosphate ions, bis(trifluoromethanesulfonyl)amide ions, hydrogen phthalate ions and bissulfurylimide ions.

Provided is a polyfunctional onium salt initiator having the following general formula (I): 'R (-L) n' '(MR'x) bHc' (I) wherein n = b + c; r (-L) n is an n-valent anionic group derived from (A) a nitrogen-free aliphatic or aromatic organic polycarboxylic acid, (B) a polyphenol, (C) a polyacrylic acid, an acrylic acid-methacrylic acid copolymer, or a polymaleic acid, (D) a hydroxyaromatic carboxylic acid, or (E) a nitrogen-containing aliphatic or aromatic organic polycarboxylic acid; -L is-COO <-> or-O <->; mR'x is an ammonium ion, sulfonium ion or phosphonium ion and H is a hydrogen ion (H +); r'is a C1-C30 hydrocarbyl group, x is 3 or 4, M is N, P or S; n is an integer from 2 to 30; b is an integer from 1 to 29, and c is an integer from 1 to 15. The incompletely onium salinized or incompletely salified initiator has high reaction activity and can be used for preparing carbon dioxide-based multi-arm polycarbonate with narrow molecular weight distribution, and the molecular weight is between hundreds of thousands and millions.

The application belongs to the field of natural product extraction, and particularly relates to a method for separating and purifying a flaxseed cyclic peptide from flaxseed and antioxidant application thereof. The application realizes selective enrichment of a hydrophobic cyclic peptide in an ionic liquid phase by using phosphate-quadric phosphonium cation synergistic hydrogen bond action of an ionic liquid, and saves traditional defatting and organic solvent extraction steps through three-stage purification of salting-out-dilution-precipitation.

The application belongs to the field of chemical materials, and particularly relates to a tributyl phosphonium modified ZIF-8 adsorbent and a preparation method and application thereof. The preparation method provided by the application comprises the following steps: synthesizing ZIF-8 metal organic framework particles, mixing the ZIF-8 metal organic framework particles with an organic solution of tributyl phosphonium and then heating, filtering, washing, drying and crushing to obtain the tributyl phosphonium modified ZIF-8 adsorbent. The preparation method provided by the application has few processes, low cost and mild conditions, can effectively realize the modification of tributyl phosphonium on ZIF-8, and the prepared adsorbent material can perform high-selectivity enrichment and recovery on high-value rare earth ions Dy 3+ in rare earth mine wastewater.

The invention relates to the field of secondary batteries, and provides a capacity repairing agent, a secondary battery, a capacity repairing method of the secondary battery and electric equipment, which are beneficial to repairing the attenuated capacity of the secondary battery. The capacity repairing agent is used for repairing the capacity of an attenuated secondary battery to be repaired and comprises a chemical active material meeting an alpha-beta... gamma structure, an alpha group and a beta group are connected in a covalent bond mode, the beta group and a gamma group are connected in a covalent bond or ionic bond mode, and the beta group is used for providing a site for electrochemical reaction; the alpha group is selected from-CN,-CnH2n + 1 and-Cn + 1F3H2n, or one of the group; a beta group is selected from one of-CO2 <->,-SO2 <-> and-NO2 <->; and a gamma group is selected from one of-CN,-CnH2n + 1,-CnF2n + 1,-Cn + 1F3H2n, Li < + >, Zn < 2 + >, [Cxmim] < + >, N-alkyl pyridine, tetraalkyl ammonium and tetraalkyl phosphonium.

The invention discloses a pyridinedicarboxylic acid coordinated catalyst, a composite catalyst, a preparation method and an application. B is a calcium ion, a sodium ion, a magnesium ion, a lithium ion, a potassium ion, an ammonium ion, an octadecyl dimethyl benzyl ammonium ion, an octadecyl trimethyl ammonium ion, a dodecyl dimethyl benzyl ammonium ion, a dodecyl trimethyl ammonium ion, an octyl tributyl phosphonium ion, a tetrabutyl phosphonium ion, a hexyl tributyl phosphonium ion and a tributyl ethyl phosphonium ion; the ionic liquid is a tetrabutyl phosphonium ion, a tributyl hexyl phosphonium ion, a tetramethyl ammonium ion, a tetraethylammonium ion, a tetrabutyl ammonium ion, a benzyl trimethyl ammonium ion, a benzyl triphenyl phosphonium ion or a benzyl triethylammonium ion; m is Cr, Mo or W; r is a C1-C10 alkyl group; x is an integer between 1 and 20; and y is an integer between 1 and 40, so that the p-nitrotoluene oxidation reaction selectivity and the p-nitrotoluene conversion rate can be improved.

The invention discloses a preparation method and application of a catalyst for preparing formic acid from CO2 under high current density, and belongs to the field of CO2 electroreduction. According to the catalyst, InO (OH) is used as a substrate, ionic liquid is introduced to modify the substrate, and the ionic liquid is prepared from corresponding chlorinated quaternary phosphonium salt and trifluoromethanesulfonamide through a reaction. Wherein quaternary phosphonium cations can form a local electric field at a cathode in CO2 electroreduction, a reaction intermediate of formic acid is stably generated, and the product selectivity is greatly improved. Anions have very strong hydrophobicity, remarkably inhibit hydrogen evolution side reaction, have the effect of enriching CO2, and can form a high-concentration CO2 local microenvironment. Under the synergistic effect of anions and cations, the problems that an indium-based catalyst is weak in CO2 adsorption capacity, low in catalytic activity and the like are effectively relieved, and the catalyst still has good formic acid Faraday efficiency under the ampere-level current density. The preparation method is simple and easy to popularize.

The invention relates to a process for the production of monosilanes of formula H4-nSiCln with n being 2, 3 or 4 comprising the step of subjecting a starting material composition comprising one or more disilanes with formula HxSi2Cl6-x containing at least one Si—H bond and optionally further silanes, in particular the side-product mixture of the Siemens Process or fractions thereof, to a reaction with a reaction-promoting agent chosen from—ether / HCI solutions—amines, phosphines, or mixtures thereof—ammonium halides, phosphonium halides, or mixtures thereof at temperatures below 200° C.

The invention relates to the technical field of luminescent material synthesis. The invention provides a Te-based hybrid halide luminescent material and a preparation method thereof. The luminescent material is of a zero-dimensional organic-inorganic hybrid crystal structure and comprises [TeCl6] < 2-> anions and organic phosphonium cations (C25H21PCl) < + > containing polar substituent groups. The preparation method comprises the following steps: dissolving tellurium dioxide in hydrochloric acid; continuously adding (2-chlorobenzyl) triphenyl phosphonium chloride, and reacting to generate a precipitate; centrifugally separating the precipitate, and drying under a vacuum condition to obtain intermediate powder; dissolving the powder in acetonitrile; and putting the solution into a sample bottle, putting the sample bottle into a sealed container containing diethyl ether, and carrying out solvent diffusion crystallization to obtain the luminescent material. According to the luminescent material, energy coupling and non-radiation loss between luminescent units are reduced, excitation energy can be more sufficiently converted into radiation luminescence, the luminous efficiency is improved, the luminescent material can be better matched with a blue light wave band, and the luminescent material is suitable for application scenes such as high-brightness solid-state illumination and photoelectric display.

The present invention relates to a membrane arrangement (10) for a membrane electrode assembly (11) of an electrochemical cell (100); comprising: - a membrane (1) which is formed from a first polymeric material comprising a singly negatively charged anion as a first functional group; - an electrode (3a, 3b) optionally applied to one or both sides of the membrane (1), comprising a catalyst material and the first polymeric material; and - a seal (2) made of a second polymeric material for sealing the membrane (1); wherein the seal (2) at least in one assembly section (4) contacting the membrane (1) quaternized ammonium groups [NR4] + or phosphonium groups [PR4] +as a second functional group, where R represents an organic residue, such that an ionic compound is formed between the second functional group of the second polymeric material of the assembly section (4) of the seal (2) and the first functional group of the first polymeric material of the membrane (1). The invention further relates to a method for manufacturing the membrane assembly and a membrane electrode unit.

This invention belongs to the field of polymer material preparation, specifically relating to an aqueous phase-guided self-assembly composite catalyst and a method for preparing polycarbonate. Addressing the problems of poor dispersibility and unstable active centers of inorganic co-catalysts in organic melts in existing technologies, this invention provides an aqueous phase-guided self-assembly composite catalyst. This composite catalyst possesses an ion cluster with a microstructure of "lipophilic quaternary phosphonium shell – hydration layer – inorganic core." When applied to the melt transesterification method for preparing polycarbonate, this catalyst utilizes the vaporization and expansion of water in the high-temperature melt to achieve "nano-bursting" dispersion of inorganic components, effectively solving the problems of poor dispersion and easy agglomeration of traditional inorganic co-catalysts. This system combines high activity at low temperatures with high-temperature stability, significantly shortening the polymerization time, and the resulting polycarbonate product has a narrow molecular weight distribution and an extremely low yellowness index (YI≤2.4), making it suitable for the efficient preparation of bisphenol A type and various copolymer polycarbonates.

The invention discloses a eutectic solvent as well as a preparation method and application thereof, and belongs to the technical field of styrene adsorption. The deep eutectic solvent comprises alpha-phenethyl alcohol, acetophenone and methyl triphenyl phosphorus bromide, and the adsorption effect of styrene is improved based on multiple and reversible physical and chemical synergistic effects generated between all components of the solvent and styrene molecules. Strong ion-pi interaction is generated between phosphorus cations of methyltriphenylphosphonium bromide in the solvent and benzene ring electron cloud of styrene to form main adsorption driving force; a benzene ring of acetophenone and a benzene ring of styrene form a pi-pi accumulation effect, so that the capturing capability is further enhanced; meanwhile, a hydrogen bond network formed by hydroxyl of alpha-phenethyl alcohol and two receptors constructs a solvent microenvironment with adjustable polarity and matched space, which is more beneficial to dissolution and enrichment of styrene molecules in thermodynamics. The acting forces synergistically realize high-efficiency and high-selectivity reversible adsorption of styrene.

The present invention relates to a membrane assembly (10) for a membrane-electrode unit (11) of an electrochemical cell (100), comprising: - a membrane (1) formed from a first polymeric material comprising a singly negatively charged anion as a first functional group; - an electrode (3a, 3b) optionally applied to one or both sides of the membrane (1) and comprising a catalyst material and the first polymeric material; and a seal (2) composed of a second polymeric material for sealing the membrane (1); wherein the seal (2) comprises, at least in a mounting section (4) in contact with the membrane (1), quaternized ammonium groups [NR4]+ or phosphonium groups [PR4]+ as a second functional group, where R is an organic substituent, such that an ionic bond is formed between the second functional group of the second polymeric material of the mounting section (4) of the seal (2) and the first functional group of the first polymeric material of the membrane (1). The invention further relates to a method of producing the membrane assembly and to a membrane-electrode unit.

A polymer composite including polystyrene and a filler. The filler contains a layered double hydroxide (LDH), graphene, and a phosphonium ionic liquid. The LDH includes Zn and Al. The polymer composite contains 1-20 wt. % of the filler relative to a total weight of the polymer composite. The polymer composite has higher flame-retardant properties than polystyrene alone.

The invention provides an ultrasonic-assisted polypeptide C-terminal amidation method and application thereof. The method comprises the following steps: mixing a substrate polypeptide, a reducing agent and a buffer solution to obtain a reaction system; performing ultrasonic treatment on the reaction system for reaction to obtain a polypeptide C-terminal amidated product; the reducing agent comprises one or more of tris (2-carbonyl ethyl) phosphorus hydrochloride, triphenylphosphine tri-m-sodium sulfonate or triphenylphosphine; the structures of the substrate polypeptide and the amino acid residue at the C end of the substrate polypeptide are as shown in a formula I, and the structures of the product and the amino acid residue at the C end of the product are as shown in a formula II, r2 is a sequence composed of other amino acids except the amino acid at the C terminal in the substrate polypeptide; r is a sequence composed of other amino acids except the amino acid at the C terminal in the product; x1 is SH or SeH; and X2 is OH or NH2. The problem that in the prior art, the large-scale synthesis cost of polypeptide C-terminal amidation is too high can be solved, and the method is suitable for the field of polypeptide synthesis.