107 results about "Pantothenic acid" patented technology

The invention discloses a fermentation medium for regulating and controlling a clostridium aerovorans target product and a fermentation method of the clostridium aerovorans target product. The medium comprises a basic component and a regulating component, the basic components comprise ammonium chloride, potassium chloride, magnesium sulfate heptahydrate, sodium chloride, monopotassium phosphate, yeast powder, calcium chloride dihydrate, sodium selenite, nickel chloride hexahydrate, biotin, folic acid, pyridoxine hydrochloride, thiamine, riboflavin, nicotinic acid, D-calcium pantothenate, cobalamin, para aminobenzoic acid and lipoic acid; the adjusting component comprises sodium tungstate, ferrous sulfate and sodium molybdate, sodium tungstate and ferrous sulfate have a forward adjusting effect on increasing the yield of acetic acid, ethanol and butanol in the target product, and sodium molybdate has a reverse adjusting effect on the target product. By optimizing the proportion of trace elements in the culture medium, the clostridium metabolism efficiency is improved, synthesis of a target product is regulated and controlled, and the method is particularly suitable for industrial production of acetic acid, ethanol, butanol and the like.

The invention provides a beta-alanine producing strain as well as a construction method and application thereof. According to the bacterial strain, an acetaldehyde dehydrogenase gene adhE, a lactic dehydrogenase gene ldhA, an acetokinase gene ackA, a pyruvate dehydrogenase gene poxB, a DNA binding transcription inhibition factor coding gene lacI, an aspartate kinase thrA, a pantothenic acid synthase gene panC, an alanine synthesis transaminase gene cycA and an alanine synthesis transaminase gene yfbQ are knocked out from an E.coli W3110 genome, and the bacterial strain is obtained. A phosphoenolpyruvate carboxylase gene ppc, a pyridine nucleotide transhydrogenase coding gene pntAB, an aspartic acid transaminase gene aspC, an aspartic acid decarboxylase gene panD derived from pseudomonas aeruginosa and a beta-alanine transporter gene NCgl0580 derived from corynebacterium glutamicum are integrated at the same time, and the bacillus subtilis is used for producing beta-alanine and has the advantage of high fermentation yield.

To provide a composition for hair capable of improving the volume of hair while suppressing the entanglement of hair, and to provide a hair treatment method using the composition for hair.SOLUTION: This composition for the hair is obtained by formulating (A) an amino acid-based cationic surface active agent with (B) one or more kinds selected from pantothenic acids, vitamin C or its salts, vitamin B3 or its salts and vitamin B6 or its salts. The hair treatment method uses the composition for hair.SELECTED DRAWING: None

The invention discloses application of an exogenous regulating substance in relieving corn drought stress, and belongs to the technical field of biology. It is verified that external application of serine, pantothenic acid or raffinose can promote root morphology establishment of corn under drought stress, enhance antioxidant enzyme activity of corn roots, reduce MDA accumulation and increase soluble protein content, 0.6 mM of serine, 0.9 mM of pantothenic acid and 1.0 mM of raffinose can effectively relieve stress of the drought environment on corn, and the corn drought resistance can be effectively improved. The water retention capacity of corn is improved, the antioxidant enzyme activity of corn roots is enhanced, the content of osmotic regulation substances is regulated and controlled, damage of drought stress to corn cells is reduced, and meanwhile growth of corn plants and establishment of root morphology are promoted. The invention provides a new strategy for drought-resistant cultivation of corn.

This invention provides a ketolic acid reductase mutant and its application in constructing genetically engineered bacteria that produce high levels of D-pantothenic acid. To address the technical problem of low D-pantothenic acid yield in existing microbial fermentation, this invention utilizes semi-rational enzyme design to obtain a substrate-specific ketolic acid reductase mutant, which is then applied to construct genetically engineered bacteria that produce high levels of D-pantothenic acid. Furthermore, this invention employs CRISPR-Cas9 gene editing technology to construct genetically engineered bacteria that produce high levels of D-pantothenic acid using the aforementioned ketolic acid reductase mutant, increasing D-pantothenic acid production by approximately 12.04%. Compared to the starting strain, the accumulation of valine in the fermentation broth remained almost unchanged compared to the control, but the accumulation of the branched-chain amino acid isoleucine was lower, achieving substrate-specific modification of the ketolic acid reductase.

The invention discloses application of pantothenic acid in regulating activation of dendritic cells and preparing an immunologic adjuvant. Experiments prove that the pantothenic acid has a remarkable promoting effect on related innate immunity and adaptive immunity of the dendritic cells; various vaccine models find that pantothenic acid can remarkably promote vaccine reactivity and is more efficient than traditional adjuvants, new application of pantothenic acid is provided, the application range of pantothenic acid is expanded, and the pantothenic acid has important economic benefits and social benefits.

The invention relates to a microbial growth activation accelerant based on rare earth elements as well as a preparation method and application thereof, and belongs to the field of resources and environments. The microbial growth activation accelerant based on the rare earth elements is prepared from the following components: 1 to 150g of a rare earth compound, 0.2 to 2g of pantothenic acid, 0.2 to 2g of nicotinic acid, 0.02 to 0.1 g of nicotinamide and 1000g of deionized water, the rare earth compound is one or combination of more of chlorides of lanthanum, cerium, praseodymium, neodymium, promethium, samarium, europium, gadolinium, terbium, dysprosium, holmium, erbium, thulium, ytterbium, lutetium, scandium and yttrium, nitric acid compounds and sulfuric acid compounds. A large number of cheap light rare earth elements are used as raw materials of the microbial accelerator, a new utilization approach is provided for the light rare earth elements, the light rare earth elements are converted into high-added-value products, pollution of the light rare earth elements to the environment is reduced, and meanwhile new elements are introduced into the field of microbial accelerators. More importantly, the preparation method of the microbial growth activation accelerant based on the rare earth elements provided by the invention is simple in production process and convenient for large-scale production.

The invention discloses a genetically engineered bacterium for efficiently producing D-pantothenic acid as well as a construction method and application of the genetically engineered bacterium, the construction method comprises the following steps: (a) taking corynebacterium glutamicum DPA2 as a chassis bacterium, enhancing the expression of at least one pantothenic acid main pathway gene in a chassis bacterium genome, and introducing plasmid pEC-XK99E-panBCilvC to obtain an engineered strain for modifying the pantothenic acid main pathway gene; (b) knocking out at least one heteroacid pathway gene in the engineering strain obtained in the step (a), carrying out in-situ integration on a panBCC gene at an alaT gene locus, and introducing a plasmid pEC-XK99E-panBCilvC to obtain a heteroacid pathway modified engineering strain; and (c) knocking out the pyruvic acid shunt gene pyc in the heteroacid pathway modified strain obtained in the step (b), enhancing the expression of an odx gene, and introducing a plasmid pEC-XK99E-panBCilvC to obtain the engineering strain for regulating and controlling the pyruvic acid shunt. The genetically engineered bacterium has the beneficial effects that the genetically engineered bacterium for efficiently producing D-pantothenic acid is obtained, and the yield and the conversion rate are higher; the level of the modified strain in the aspect of fermentation production of D-pantothenic acid is obviously improved.

The invention relates to an adipose-derived stem cell culture medium containing wormwood extract and a preparation method of the adipose-derived stem cell culture medium, and belongs to the technical field of biology. The adipose-derived stem cell culture medium contains a DMEM (Dulbecco Modified Eagle Medium) basal culture medium, and also contains the following components: 5 to 7 [mu] g / mL of wormwood extract, 1 to 1.5 [mu] g / mL of phosphatidylserine, 0.02 to 0.03 [mu] g / mL of D-calcium pantothenate, 1.2 to 1.5 [mu] g / mL of sialic acid, 0.06 to 0.08 [mu] g / mL of eucommia male flower peptide, 0.3 to 0.35 [mu] g / mL of transferrin and 0.3 to 0.4 mg / mL of bovine serum albumin. The prepared adipose-derived stem cell culture medium has a good promoting effect on proliferation of adipose-derived stem cells from rabbits and mice, the added wormwood polysaccharide extract has a good bacteriostatic effect, and the safety and stability of the culture medium can be effectively maintained.

The present invention provides a novel process for producing panthenol from pantothenic acid or salts and / or esters thereof. The process makes a “hybrid process” possible to produce panthenol, which is generally more eco-friendly and sustainable and reduces carbon print compared to a pure chemical process.

The invention discloses a pantothenic acid synthase mutant with heat resistance and long half-life period, and relates to the field of biochemistry, the nucleotide sequence of the pantothenic acid synthase mutant N54R / K115R / Q148R is SEQ ID NO.1, and the amino acid sequence of the pantothenic acid synthase mutant N54R / K115R / Q148R is SEQ ID NO.2. The invention further discloses a preparation method of the pantothenic acid synthase mutant. The relative enzyme activity is improved by 43% compared with the original plasmid, and the catalytic efficiency is higher. And at 35 DEG C, 40 DEG C and 45 DEG C, the enzyme activity residual rate and the half-life period of the pantothenic acid synthetase mutant are obviously higher than those of an original plasmid, and the yield of D-pantothenic acid and the substrate conversion rate are obviously increased.

The invention belongs to the technical field of aquaculture, and particularly relates to a decapterus maruadsi breeding feed and application thereof in improving the quality of decapterus maruadsi fertilized eggs. The invention provides a decapterus maruadsi breeding feed. The feed comprises a first feed and a second feed which are mutually independent, the first feed comprises a basal feed, fish cream and a nutrition enhancer; the second feed comprises the first feed and oyster meat; the nutrition enhancer contains calcium pantothenate, vitamin B1, vitamin B2, vitamin B6, vitamin C and vitamin F. When the culture feed for the decapterus maruadsi is used for performing nutrient enrichment on parent fishes of the decapterus maruadsi, synchronous development of sexual glands of male and female parent fishes of the decapterus maruadsi can be promoted, the quality of fertilized eggs of the decapterus maruadsi is improved, the good egg rate of the fertilized eggs of the decapterus maruadsi reaches 88.50% and is 39.15% higher than that of a control group, and the fertilization rate of the fertilized eggs reaches 79.58% and is 19.46% higher than that of the control group.

The present application relates to the technical field of genetic engineering, and discloses a genetically engineered bacterium for high-yield D-pantothenic acid, a construction method and application.The genetically engineered bacterium for high-yield D-pantothenic acid is obtained by knocking out an ilvA gene in Corynebacterium glutamicum ATCC 13032 to reduce the consumption of pyruvic acid for isoleucine generation, overexpressing a 3-methyl-2-oxobutyric acid hydroxymethyltransferase gene panB and a pantothenate synthetase gene panC in a pantothenic acid synthesis pathway, and heterologously overexpressing a pantothenate reductase panE from Escherichia coli to further improve the yield of D-pantothenic acid in the Corynebacterium glutamicum ATCC 13032.

The application discloses a production process of a feed-grade high-protein D-calcium pantothenate particle, and the process comprises the following steps: (1) after inactivation of D-calcium pantothenate mash, ceramic filtrate and ceramic membrane residue liquid are obtained through membrane filtration; (2) after heating of the ceramic filtrate, wood active carbon is added for decolorization; decolorized liquid is obtained through suction filtration; (3) the decolorized liquid is mixed with part of the ceramic membrane residue liquid to prepare a mixed liquid with a dry basis purity of 52-58%; (4) after concentration of the mixed liquid to a dry solid content of 52-58%, auxiliary materials are added to prepare a dry basis purity of 42-48%, and a 42-48% D-calcium pantothenate particle product is obtained through granulation bed drying. The production process effectively reduces the production cost and environmental protection pressure, and meanwhile, the bacterial protein and auxiliary materials are used to prepare an animal-friendly feed D-calcium pantothenate product which is better in flowability and richer in nutrition.

The present invention relates to a nutritional vitamin complex for pets intended to improve the fur and skin quality of pets such as dogs and cats. The composition of the complex contains omega-3, curcumin, piperine, biotin (vitamin H or vitamin B7), vitamin B2 (riboflavin), vitamin B3 (nicotinic acid or niacin), vitamin B5 (pantothenic acid), vitamin B6 (pyridoxine), vitamin B12 (cyanocobalamin), folic acid (vitamin B9), vitamin E (alpha-tocopherol), vitamin C, zinc (zinc glycine chelate), coenzyme Q10, hydrolysed type II collagen, astaxanthin, DL-methionine, selenium, L-glycine, L-proline, L-phenylalanine, L-leucine, L-isoleucine, L-histidine, L-arginine, L-lysine, L-tyrosine, resveratrol, and a flavouring agent.

The utility model relates to the technical field of D-calcium pantothenate production, in particular to a production system for recycling D-calcium pantothenate mother liquor, which comprises a first concentration kettle communicated with a mother liquor conveying pipeline, a concentrated liquor outlet of the first concentration kettle is communicated with a decolorizing kettle, and a decolorizing liquor outlet of the decolorizing kettle is communicated with a cationic resin column. An effluent outlet of the cationic resin column is communicated with an anion resin column, a feed port of the anion resin column is communicated with an eluent conveying pipeline, an eluent outlet of the anion resin column is communicated with a second concentration kettle, a concentrated solution outlet of the second concentration kettle is communicated with a crystallization kettle, and a solvent inlet of the crystallization kettle is communicated with an ethanol conveying pipeline; a crystal outlet of the crystallization kettle is communicated with the drying device; a discharge hole of the drying device is communicated with the product storage tank. According to the production system with the structure, effective recovery treatment of mother liquor calcium pantothenate is realized, resource waste is avoided, the yield, the yield and the purity of D-calcium pantothenate are greatly improved, and economic benefits are increased for enterprises.

The application provides a ketol-acid reductoisomerase mutant and application thereof in construction of a genetically engineered bacterium with high D-pantothenic acid yield. In order to solve the technical problem of low yield of D-pantothenic acid synthesized by microbial fermentation in the prior art, the application uses semi-rational design of enzymes to obtain a ketol-acid reductoisomerase mutant with substrate specificity, and applies the mutant to construction of a genetically engineered bacterium with high D-pantothenic acid yield. The application also uses the ketol-acid reductoisomerase mutant to construct a genetically engineered bacterium with high D-pantothenic acid yield by CRISPR-Cas9 gene editing technology, so that the yield of D-pantothenic acid is increased by about 12.04 %, and compared with a starting strain, the accumulation amount of valine in the obtained fermentation liquor is almost unchanged compared with a control, but the accumulation of branched-chain amino acid isoleucine is less, achieving modification of the substrate specificity of the ketol-acid reductoisomerase.

The present invention relates to a nutritional vitamin complex for pets intended to improve the fur and skin quality of pets such as dogs and cats. The composition of the complex contains omega-3, curcumin, piperine, biotin (vitamin H or vitamin B7), vitamin B2 (riboflavin), vitamin B3 (nicotinic acid or niacin), vitamin B5 (pantothenic acid), vitamin B6 (pyridoxine), vitamin B12 (cyanocobalamin), folic acid (vitamin B9), vitamin E (alpha-tocopherol), vitamin C, zinc (zinc glycine chelate), coenzyme Q10, hydrolysed type II collagen, astaxanthin, DL-methionine, selenium, L-glycine, L-proline, L-phenylalanine, L-leucine, L-isoleucine, L-histidine, L-arginine, L-lysine, L-tyrosine, resveratrol, and a flavouring agent.

A composition for improving cognitive performance, enhancing mental clarity, increasing focus, and increasing physical and mental energy is disclosed. The composition includes sufficient amounts of Fermented Green Tea Extract, L Theanine, and Caffeine, Ashwagandha Extract, Black Pepper Extract, Huperzine, Fermented Alpha GPC / Citoline Matrix, Turmeric Root Extract, Lions Mane Extract, Ginkgo Biloba Powder Extract, Panax Ginseng Extract, Rhodiola Extract, Cognitive Probiotic Blend, Folic Acid, Vitamin D3, Vitamin C Powder, Vitamin B12, Vitamin B6, Pantothenic Acid, Vitamin B3 Crystalline Powder, Vitamin B2 Powder, Vitamin B1 HCL, and Biotin.

The invention discloses a tranexamic acid-tyrosinase inhibitor hybrid conjugate as well as a preparation method and application thereof, belongs to the technical field of cosmetics and biological medicines, and particularly relates to a tranexamic acid-tyrosinase inhibitor hybrid conjugate shown in a formula (I) and a skin composition taking the compound as an active component. According to the hybrid conjugate, tranexamic acid and a tyrosinase inhibitor are integrated into a single-structure molecule through an ester bond, so that the transdermal efficiency can be improved and the transdermal dynamic difference limitation of a traditional compound preparation can be broken through by adjusting the hydrophilic-hydrophobic balance of the compound; and plasmin activity can be inhibited through cooperation of tranexamic acid, so that melanin generation signal transmission capability and tyrosinase inhibition capability of tyrosinase inhibitor specificity are reduced, and efficient and mild multi-channel whitening and spot fading are realized. As a whitening active matter, the tranexamic acid-tyrosinase inhibitor hybrid conjugate disclosed by the invention has a great application prospect in the aspects of whitening and freckle removing effects.

The invention relates to a composition with an emotion conditioning function as well as a preparation method and application thereof, and belongs to the technical field of functional foods. The composition comprises core components: calcium 6S-5-methyltetrahydrofolate, N-acetylneuraminic acid, spirulina maxima powder and betaine, and further comprises synergistic components such as vitamin B6, vitamin B12, a zinc source, a selenium source and vitamin B1, vitamin B2, nicotinic acid and pantothenic acid. The composition is designed on the basis of an intestine-brain linkage mechanism, and the brain-intestine axis function is systematically adjusted through multi-target cooperation of intestinal barrier repair, neurotransmitter efficient synthesis, neural network structure support and the like. Experiments show that the composition can effectively improve anxiety, depression and other emotional states, provides a synergistic and safe nutrition intervention scheme for related people, and has a definite application prospect in the fields of emotional health functional foods and brain-intestine axis targeted special diet foods.

The present invention relates to an obesity-preventing or pharmaceutical composition and health functional food, comprising a garcinia cambogia extract. Specifically, the obesity-preventing or pharmaceutical composition comprises: an exothermic agent; a complex formulation; a branched chain amino acid (BCAA) containing one or more selected from the group consisting of leucine, isoleucine, and valine; calcium pantothenate; nicotinamide; crystalline cellulose; magnesium stearate; hydroxypropyl methylcellulose; and calcium carboxymethylcellulose, the complex formulation including a garcinia cambogia extract, an ephedra extract, and an active amino acid, wherein the temperature of the obesity-preventing or pharmaceutical composition is 5 to 10°C, and the exothermic agent releases heat when reacting with secretin and thus raises the temperature of the obesity-preventing or pharmaceutical composition to 20-25°C, inclusive.

The invention discloses a Lactobacillus paracasei 1029 and application thereof, the preservation number of the Lactobacillus paracasei 1029 is CCTCC (China Center for Type Culture Collection) NO: M20251441, and the Lactobacillus paracasei 1029 is preserved in the China Center for Type Culture Collection on June 23, 2025. The fermentation product contains a plurality of active metabolites, such as pyruvic acid, pantothenic acid, proline and leucine, and the components synergistically enhance the effects of oxidation resistance, bacteriostasis and cell melanin inhibition. Compared with the prior art, the fermented product disclosed by the invention realizes integration of multiple effects, is high in safety (free of cytotoxicity) and simple in preparation process (standing for 6 days at 30 DEG C, filtering, centrifuging, freezing and drying), has wide application prospects including food additives, health-care products, cosmetics and pharmaceutical preparations, and can remarkably improve the bioavailability and market competitiveness of products.

The invention belongs to the technical field of medicine synthesis, and discloses a pantothenic acid modified aza-BODIPY photosensitizer, the structural general formula of the pantothenic acid modified aza-BODIPY photosensitizer is shown as a formula IV, and n is equal to 1-6; the dashed line represents the presence or absence of a C-C bond. The synthesized pantothenic acid modified aza-BODIPY photosensitizer has good photosensitive activity and cancer cell specific uptake ability, for example, the singlet oxygen yield (phi delta = 0.61-0.69) of photosensitizer compounds 1-8 is higher than that of a reference compound, and the pantothenic acid modified aza-BODIPY photosensitizer can be further prepared into targeted photodynamic drugs for photodynamic therapy of wide non-specific tumors.

The application belongs to the technical field of biological medicine, and particularly relates to application of pantothenic acid or a pharmaceutically acceptable salt thereof in preparation of a medicine for enhancing sensitivity of pathogenic bacteria to daptomycin. It is found for the first time that addition of pantothenic acid or a pharmaceutically acceptable salt thereof can improve the sensitivity of gram-positive bacteria including Staphylococcus aureus, Streptococcus agalactiae and Corynebacterium diphtheriae to daptomycin, significantly improve the bactericidal effect, and further research shows that pantothenic acid or a pharmaceutically acceptable salt thereof can promote the clearance, formation and reduction of pathogenic bacteria biofilm by daptomycin. The finding opens up a new way for overcoming antibiotic resistance and optimizing anti-infection treatment strategies.

Provided in the present invention are a small molecule modulator of a pantothenate kinase PANK, a pharmaceutical composition and the use thereof. The compound can effectively modulate the activity of pantothenate kinase, can be used for treating or preventing conditions and diseases related to the activity of pantothenate kinase, and can be used in the preparation of a drug for such conditions or diseases.

The present disclosure provides compositions and methods for providing a health benefit to a growing animal comprising administering a food composition to the animal, wherein the food composition includes a brain development blend. The brain development blend generally comprises DHA, EPA, taurine, choline, thiamine, riboflavin, pantothenic acid, niacin, pyridoxine, vitamin B12, and folic acid.

The application discloses a serum-free adipogenic differentiation method of pig fat precursor cells, relates to the technical field of mammal cell differentiation, and uses an induction differentiation culture medium and a maintenance differentiation culture medium in succession in the adipogenic differentiation process. The induction differentiation culture medium is composed of a basic culture medium and a cell culture auxiliary factor. The cell culture auxiliary factor is composed of 66nmol / L insulin, 33μmol / L biotin, 17μmol / L pantothenic acid, 0.1μmol / L dexamethasone, 0.25mmol / L IBMX, 1μmol / L rosiglitazone, 150μmol / L sodium oleate and 10μg / mL transferrin. The maintenance differentiation culture medium removes the IBMX and rosiglitazone on the basis of the induction differentiation culture medium. The serum-free adipogenic differentiation method of pig fat precursor cells has good differentiation effect and high repeatability.

To provide a composition for oral cavity containing an enzyme, excellent in stability of the enzyme, and capable of improving harsh taste.SOLUTION: The composition for the oral cavity comprises (A) sodium fluoride, (B) one or more kinds selected from the group consisting of calcium chloride, calcium gluconate, calcium lactate and calcium pantothenate, (C) one or more kinds selected from the group consisting of condensed phosphoric acids and their alkali metal salts and (D) an enzyme.SELECTED DRAWING: None

The invention discloses a method for producing D-pantothenic acid, and relates to the technical field of fermentation. According to the method, the content of endogenous beta-alanine in a fermentation system is used as a main response index, the stirring rotating speed and the sugar supplementing rate are adjusted, accurate regulation and control of metabolism are achieved, the production efficiency and stability of D-pantothenic acid are remarkably improved, generation of by-products (such as valine and HMBPA) is effectively reduced, and the production cost is reduced. Therefore, the cost of subsequent separation and purification links is greatly reduced, and a brand new way is provided for efficient, stable and low-cost industrial production of D-pantothenic acid.