254 results about "Minoxidil" patented technology

The compositions and methods provided herein include a pharmaceutical formulation for oral administration comprising a daily dose of a modified release formulation of minoxidil or a pharmaceutically acceptable salt thereof. Also provided herein are pharmaceutical formulations for oral administration comprising a daily dose of a modified release formulation of minoxidil or a pharmaceutically acceptable salt thereof and one or more additional active agents. Also provided herein are methods of treating hair loss by administering to a subject in need thereof a daily dose of a modified release formulation of minoxidil or a pharmaceutically acceptable salt thereof. Further provided herein is a kit including a slow modified release vehicle comprising oral minoxidil or a pharmaceutically acceptable salt thereof.

The invention belongs to the technical field of medicines, cosmetics and scalp care, and particularly relates to application of coniferaldehydes and derivatives or salts of the coniferaldehydes to preparation of medicines and cosmetics for promoting hair regeneration and treating chemotherapy-induced alopecia (CIA, CIA) and other types of alopecia, in particular to application of the coniferaldehydes and the derivatives or salts of the coniferaldehydes to preparation of the medicines and the cosmetics. Experimental results show that coniferyl aldehyde can promote hair regeneration of mice, accelerate hair growth of the mice and effectively relieve alopecia symptoms of the mice after chemotherapy, and the effect of coniferyl aldehyde is better than that of minoxidil. According to the application, coniferyl aldehyde or a composition thereof is given to a subject, so that the vigor of hair follicles is remarkably enhanced, the stationary period of the hair follicles is shortened, and the hair loss process is inhibited. The coniferyl aldehyde provided by the invention has the industrial application advantages of reliable biological safety, controllable preparation cost and high raw material accessibility, can be obtained by a plant extraction or chemical synthesis method, is suitable for an external solution, gel or a scalp care preparation, and provides a natural, safe and effective solution for alopecia patients.

The invention discloses a preparation method of minoxidil liniment. The preparation method comprises the following steps: uniformly mixing propylene glycol, absolute ethyl alcohol and about 40% purified water until no obvious layering exists, and finally adding minoxidil to stir and dissolve to obtain the minoxidil liniment. According to the preparation process provided by the invention, purified water and absolute ethyl alcohol can form a latent solvent, so that the solubility of minoxidil in a single auxiliary material is greatly improved, and subsequent preparation of the digoxin injection is facilitated.

The invention discloses a product capable of treating androgenetic alopecia and / or promoting hair growth and application of exosomes, the product comprises the product capable of treating androgenetic alopecia and / or promoting hair growth, and is characterized by comprising the exosomes obtained by stimulating mesenchymal stem cells through CHIR99021 and minoxidil combined with the exosomes. The disclosure verifies that the exosome obtained by stimulating mesenchymal stem cells through CHIR99021 can promote hair growth and treat androgenetic alopecia, and particularly, the hair growth effect is better when the exosome is combined with minoxidil, so that a product comprising the exosome and minoxidil can treat androgenetic alopecia and promote hair growth is provided.

The invention relates to an external composition for hair growth regulation and a preparation method thereof, and belongs to the technical field of cosmetics and medicines. The composition disclosed by the invention comprises nano mesoporous carbon for enhancing permeation, various surface functional modifications on the nano mesoporous carbon, minoxidil, protein fragments, polypeptides, oligopeptides, amino acids, dutasteride, bimatoprost, traditional Chinese medicine extracts, vitamins, caffeine, nucleosides, growth factors and various auxiliary functional components. Wherein the pore diameter of mesopores of the nano mesoporous carbon for enhancing permeation is 2-30 nm, the total pore volume of the mesopores is 1.5-3.5 cm < 3 > / g, and the particle size of the nano mesoporous carbon is 50-200 nm. The prepared nano mesoporous carbon is granular, controllable in size, stable in structure, free of irritation to skin, capable of keeping inert to various active ingredients in the composition, capable of enhancing absorption and permeation of other ingredients on the skin, wide in application range, capable of compounding various types of active ingredients and high in biological safety.

The invention provides a pharmaceutical composition for treating alopecia, a preparation as well as a preparation method and application thereof, and belongs to the technical field of medicines. The pharmaceutical composition comprises the following main components in parts by weight: 12-18 parts of cacumen biotae, 12-18 parts of szechwan chinaberry fruit and 8-12 parts of garden balsam stem, wherein the cacumen biotae, the szechwan chinaberry fruit and the garden balsam stem are used as main components. The invention further provides a preparation method and application of the compound platycladus orientalis tincture, cell and animal experiments prove that the compound platycladus orientalis tincture has the proliferation promoting capacity on human primary dermal papilla cells, meanwhile, hair growth can be promoted, the symptom of alopecia can be remarkably improved, and all the medicines in the prescription have a synergistic effect, so that the compound platycladus orientalis tincture has a good effect on treating alopecia. The effect is better than that of a positive drug minoxidil, and the application prospect is good.

The compositions and methods provided herein include a pharmaceutical formulation for oral administration comprising a daily dose of a modified release formulation of minoxidil or a pharmaceutically acceptable salt thereof. Also provided herein are pharmaceutical formulations for oral administration comprising a daily dose of a modified release formulation of minoxidil or a pharmaceutically acceptable salt thereof and one or more additional active agents. Also provided herein are methods of treating hair loss by administering to a subject in need thereof a daily dose of a modified release formulation of minoxidil or a pharmaceutically acceptable salt thereof. Further provided herein is a kit including a slow modified release vehicle comprising oral minoxidil or a pharmaceutically acceptable salt thereof.

The invention relates to the technical field of pharmaceutical preparations, and provides a minoxidil film coating agent as well as a preparation method and application thereof. The minoxidil film coating agent provided by the invention comprises 40-60% of propylene glycol, 3-7% of polyvinyl alcohol, 20-30% of ethanol, 1-7% of minoxidil and the balance of water. According to the invention, propylene glycol is taken as a solvent, a plasticizer and a transdermal absorption enhancer, polyvinyl alcohol is taken as a film-forming material, and ethanol is taken as a volatile agent, after administration, ethanol is volatilized to promote film formation of polyvinyl alcohol, and propylene glycol enhances the plasticity of the formed film, so that the effect of reducing liquid medicine loss is achieved, the local medicine concentration is increased, and the bioavailability is improved. The minoxidil liniment disclosed by the invention has excellent skin permeability, can effectively convey a medicine to a required part, and can ensure that the medicine is released at a fixed position of the skin and is accurately administered in a medicine release process, so that the stimulation of liquid medicine flow to other parts is reduced, and a good treatment effect is achieved.

The invention discloses a hair follicle targeting nano-liposome anti-hair loss and hair growth compound preparation. The compound preparation is prepared from the following raw materials in parts by mass: 70 to 85 parts of bionic liposome carrier and 15 to 30 parts of active ingredients, the bionic liposome carrier is prepared from 50 to 60 parts of egg yolk lecithin, 15 to 20 parts of pH sensitive phospholipid DOPE, 10 to 15 parts of cholesterol and 5 to 10 parts of mesenchymal stem cell exosome membrane protein; the active ingredients comprise 5 to 10 parts of minoxidil, 3 to 5 parts of caffeine, 0.5 to 1 part of miR-218-5p, 1 to 2 parts of biotin and 2 to 3 parts of quercetin; the average particle size of the nano-liposome formed by the bionic liposome carrier is 120-180nm, and the polydispersity index (PDI) is less than or equal to 0.15. The invention relates to the technical field of biological medicines, in particular to a hair follicle-targeted nano-liposome anti-hair loss and hair growth compound preparation, which has the following advantages due to the adoption of the technical scheme: accurate targeted delivery is realized, and the treatment safety and accuracy are improved; intelligent response release is achieved, and the local microenvironment of hair follicles is optimized; the multi-target synergistic effect breaks through the limitation of single treatment.

A topical composition includes minoxidil, a cosolvent, an α-hydroxy acid and water. The cosolvent includes alcohol. A weight ratio of the alcohol to the water is 1:1.4 to 1:10. A method for manufacturing the topical composition includes the following steps: dissolving the α-hydroxy acid in the water; adding the cosolvent to obtain a mixed solution; and adding the minoxidil to the mixed solution. A use of the topical composition is for treating hair loss or promoting hair growth.

The invention belongs to the field of medicine preparations, and particularly relates to a local external medicine composition for treating alopecia, the medicine composition comprises at least one active component, and the medicine composition comprises the following components in percentage by weight: 1-10% w / w of minoxidil or salt thereof, 0-50% w / w of propylene glycol, 1-50% w / w of ethanol and 10-50% w / w of C3-C10 ether solvent, the total dosage of the propylene glycol and the ethanol is less than or equal to 50% w / w, and the total dosage of the propylene glycol and the ethanol is less than or equal to 50% w / w. The pharmaceutical composition at least has the following excellent characteristics: good curative effect, high drug solubility, high patient efficiency, quick response, few adverse reactions, low scalp irritation, good stability, easy use, no greasy feeling after use, good drug permeability, high bioavailability, few use times, good patient compliance and the like.

The invention discloses a hair-raising and protecting series composition for treating alopecia as well as a preparation method and application thereof, and relates to the technical field of medicines, and the composition is prepared from minoxidil, propylene glycol, menthol, betaine, an amino acid compound, glycyrrhizic acid, tocopheryl acetate, hinokiol, pyridoxine, ethanol and purified water. The preparation method comprises the following steps: mixing propylene glycol, minoxidil, menthol and ethanol, adding hinokiol, mixing, adding pyridoxine, an amino acid compound and betaine, mixing, adding tocopheryl acetate and glycyrrhizic acid, and mixing. According to the minoxidil composition, the absorption rate of minoxidil can be increased, the drug resistance of the minoxidil composition after being used for a long time is reduced, and the treatment effect of the minoxidil composition on various types of alopecia patients is effectively improved. The invention solves the problem that minoxidil and hinokiol are difficult to dissolve and easy to separate out, has the advantages of good absorption effect and lasting alopecia treatment effect, effectively improves newborn hair quality and scalp greasy state, and brings new dawn to alopecia patients.

The invention belongs to the technical field of medicines, and provides a minoxidil and finasteride compound preparation and application thereof. The compound preparation comprises the following components: minoxidil, finasteride, a filler, an adhesive, a disintegrating agent, a lubricant and a surfactant, the minoxidil accounts for 1 to 4 weight percent of the compound preparation; the finasteride accounts for 0.3 to 1 weight percent of the compound preparation. The compound preparation is simple in preparation process, efficient, low in cost, small in active ingredient dissolution behavior difference and good in stability; and a patient can use and carry the device conveniently, and the compliance is higher. The comprehensive performance is excellent, and the application prospect is very good.

The invention relates to the technical field of pharmaceutical preparations, in particular to an external solution containing minoxidil and finasteride and a preparation method of the external solution. According to the external solution containing minoxidil and finasteride provided by the invention, the solvent and the penetration enhancer are added, so that the active ingredients of minoxidil and finasteride have higher retention volume in the skin, and can play a better role, thereby generating a more excellent hair growth effect.

The invention provides a pharmaceutical composition and application thereof in preparation of a compound preparation, and belongs to the field of medicines. The pharmaceutical composition comprises a potassium ion channel opener, a 5 alpha-reductase inhibitor and a phosphodiesterase 5 inhibitor. The pharmaceutical composition can synergistically promote treatment of androgen dependent diseases or prevention of complications, and by taking the pharmaceutical composition of minoxidil, finasteride and tadalafil as an example, the effects in a benign prostatic hyperplasia rat model and an androgenic alopecia mouse model are verified, which indicates that the minoxidil, finasteride and tadalafil have a synergistic interaction effect, and the pharmaceutical composition can be used for treating the androgen dependent diseases or preventing the complications. Good clinical application prospects are realized.

The invention discloses bioactive gel for treating alopecia as well as a preparation method and application of the bioactive gel. The bioactive gel for treating alopecia is prepared from the following raw materials: a therapeutic agent, lipidosome, oxidized dextran and carboxymethyl chitosan quaternary ammonium salt. In the preparation raw materials of the bioactive gel, the mass fraction of the therapeutic agent is 1-3 wt%, the mass fraction of the oxidized dextran is 1-3 wt%, the mass fraction of the carboxymethyl chitosan quaternary ammonium salt is 4-6 wt%, and the ratio of the therapeutic agent to the lipidosome is 1: (5-15). The bioactive gel for treating alopecia is prepared by taking the safe and non-toxic liposome which easily penetrates through the skin cuticle as a carrier and by virtue of the advantages of good biocompatibility, adhesion and the like of the gel, and the gel has good biocompatibility and adhesion in vitro and high transdermal rate in vivo, and can be used for treating alopecia. The defects that the minoxidil tincture and foaming agent in the prior art are easy to flow and low in transdermal rate are overcome.

The quantitative scalp medicine applying device comprises a shell, a movable seat, a liquid medicine bottle, a pressing pump and liquid outlet comb teeth, a liquid storage bin used for temporarily storing liquid medicine is arranged in the shell, and a liquid adding opening is formed in the top of the liquid storage bin; the movable seat is slidably arranged on the shell in the vertical direction through a guide structure, and a threaded connection port is formed in the movable seat; a bottle opening of the liquid medicine bottle is in threaded connection with the threaded connector of the movable seat, and the liquid medicine bottle can be a minoxidil medicine bottle; the pressing pump is arranged at the bottle opening of the liquid medicine bottle, the liquid outlet end of the pressing pump is communicated with the liquid adding opening of the liquid storage bin, and the liquid inlet end of the pressing pump extends into the liquid medicine bottle; the liquid outlet comb teeth are arranged at the bottom of the shell and communicated with the liquid storage bin, so that the liquid medicine temporarily stored in the liquid storage bin is guided out through the liquid outlet comb teeth to be smeared on the scalp, the purpose of quantitatively applying the liquid medicine to the scalp is achieved, and the quantitative smearing requirement of a user is met.

The compositions and methods provided herein include a pharmaceutical formulation for oral administration comprising a daily dose of a modified release formulation of minoxidil or a pharmaceutically acceptable salt thereof. Also provided herein are pharmaceutical formulations for oral administration comprising a daily dose of a modified release formulation of minoxidil or a pharmaceutically acceptable salt thereof and one or more additional active agents. Also provided herein are methods of treating hair loss by administering to a subject in need thereof a daily dose of a modified release formulation of minoxidil or a pharmaceutically acceptable salt thereof. Further provided herein is a kit including a slow modified release vehicle comprising oral minoxidil or a pharmaceutically acceptable salt thereof.

The invention relates to the technical field of stem cells, in particular to a serum-free induction medium with definite components for promoting and inducing mesenchymal stem cells to be differentiated into dermal papilla cells and an induction method. The small molecule compound composition is prepared from all-transretinoic acid, calomel, CHIR-99021 and minoxidil according to the molar ratio of (0.2 to 5): (2 to 50): (0.2 to 10): (0.2 to 10). According to the scheme, a plurality of small molecule compounds are adopted and have a synergistic effect, so that differentiation and function improvement of dermal papilla cells are promoted, and transformation of mesenchymal stem cells to the dermal papilla cells is promoted. The former three promote dermal papilla cell differentiation, and the latter promotes dermal papilla cell proliferation and inhibits apoptosis. According to the technical scheme, the technical problems that cell factors need to be added in the process of forming dermal papilla cells from stem cells through induced differentiation, so that the process cost is high, and the clinical safety is not ideal can be solved, the induction process is accelerated, and the method has ideal popularization and application prospects.

To provide an external preparation that contains 3-10 w / v% of minoxidil, pantothenic acid or a derivative thereof or a salt thereof, and an alcohol, wherein the precipitation of the external preparation is suppressed.SOLUTION: An external composition has a container, and an external composition stored in the container. The external composition contains 3-10 w / v% of minoxidil, pantothenic acid or a derivative thereof or a salt thereof, and an alcohol. Of the container, the portion to be contact the external composition is at least partially composed of polyester.SELECTED DRAWING: None

According to the foaming agent containing minoxidil and finasteride provided by the invention, micronization of raw material medicines and complicated preparation procedures such as homogenization are not needed in the preparation process, liquid medicine liquid is directly prepared and then is filled, and a propellant is added to prepare the foaming agent, so that the foaming agent has the advantages of few impurities, uniform medicine liquid and high stability; the invention has the advantages of strong foam adhesiveness, prolonged action time of the medicament on the scalp, uniform and non-greasy application, quick defoaming to enhance the curative effect, strong permeability, effective penetration of the medicament into the skin or mucous membrane to improve the bioavailability of the medicament, and the like. The preparation method is simple and easy to operate, time and cost can be greatly saved, meanwhile, the dosage form of the foaming agent has the advantages of being easy to smear, few in residue, capable of being smeared in a large area and the like, patient compliance is improved, use is convenient, the two active ingredients with different action mechanisms are in synergistic interaction, and the clinical effect is improved.

The invention belongs to the technical field of pharmaceutical preparations, and discloses a minoxidil solution for androgenetic alopecia, which takes a deep eutectic solvent as a core solvent system and contains 1.0-5.0% of minoxidil (active ingredient), 0.1-1.0% of preservative, 0.05-1% of stabilizer, a proper amount of sodium hydroxide (the pH value is adjusted to 4-9) and purified water. According to the minoxidil solution, the solubility of minoxidil is greatly improved through the deep eutectic solvent, the solubility of minoxidil reaches 779.85 mg / ml and is 389.9 times that of water, the deep eutectic solvent is used in the minoxidil solution, ethanol is not contained, the dosage of propylene glycol is as low as 3%, ethanol and high-dosage propylene glycol (20%-50%) in a traditional commercially available formula are prevented from being used, irritation to scalp is reduced, and the minoxidil solution is suitable for scalp care. The minoxidil solution is stable in content after 6 months under the condition of 40 DEG C / 60% RH, the in-vitro transdermal performance of the minoxidil solution is superior to that of a commercially available reference preparation of an ethanol and propylene glycol solvent system, and the minoxidil solution also has the advantages of high stability, remarkable hair growth ability and the like.

The present invention discloses a PLGA-minoxidil microneedle with near-infrared response and a preparation method thereof. The PLGA-minoxidil microneedle with near-infrared response comprises: PLGA-minoxidil microspheres, lanthanum hexaboride nanoparticles, a matrix, and a needle body; wherein the PLGA-minoxidil microspheres and lanthanum hexaboride nanoparticles are distributed in the needle body; and the materials of the matrix and the needle body are a combination of PVA 1788 and PVA 1799. The present invention combines PLGA-minoxidil microspheres with hydrogel microneedles with near-infrared response. In terms of microstructure, the microporous structure of the microspheres and the near-infrared response of the lanthanum hexaboride nanoparticles cooperate to achieve controlled release of MXD, effectively reduce the side effects of the drug, better maintain the drug concentration in the body, and achieve better therapeutic effects. Macroscopically, the prepared hydrogel system has good mechanical properties and can provide a stable drug delivery channel and drug delivery efficiency.

This disclosure provides a method for treating hair loss in a subject requiring treatment for hair loss, comprising topically administering an effective amount of cortexolone-17α-propionate and an effective amount of minoxidil to the subject. This disclosure further provides a topical pharmaceutical formulation comprising cortexolone-17α-propionate, minoxidil, and one or more pharmaceutically acceptable carriers.

The invention relates to a PDRN-sodium hyaluronate cross-linked double-drug-loading microneedle patch as well as a preparation method and application of the PDRN-sodium hyaluronate cross-linked double-drug-loading microneedle patch. The double-drug-loading microneedle patch is composed of a needle point drug-loading layer and a cross-linked substrate drug-loading layer, the needle point medicine carrying layer is prepared from L-cysteine, L-glutamine, L-arginine, serine, L-lysine hydrochloride, L-proline, glycine, sodium hyaluronate and trehalose; the cross-linked substrate medicine carrying layer is prepared from a PDRN-sulfhydrylated HA copolymer, minoxidil, L-cysteine, L-glutamine, L-arginine, serine, L-lysine hydrochloride, L-proline, glycine and trehalose. The amino acid anti-hair loss and hair growth microneedle system is innovatively developed, a double-drug-loading layered design is adopted, the needle point drug-loading layer is formed by wrapping quick-release amino acid with low-molecular-weight hyaluronic acid (HA), the cross-linked substrate drug-loading layer is formed by wrapping slow-release amino acid, PDRN and minoxidil with high-molecular-weight hyaluronic acid, and instant and long-acting synergy is achieved.

The compositions and methods provided herein include a pharmaceutical formulation for oral administration comprising a daily dose of a modified release formulation of minoxidil or a pharmaceutically acceptable salt thereof. Also provided herein are pharmaceutical formulations for oral administration comprising a daily dose of a modified release formulation of minoxidil or a pharmaceutically acceptable salt thereof and one or more additional active agents. Also provided herein are methods of treating hair loss by administering to a subject in need thereof a daily dose of a modified release formulation of minoxidil or a pharmaceutically acceptable salt thereof. Further provided herein is a kit including a slow modified release vehicle comprising oral minoxidil or a pharmaceutically acceptable salt thereof.

The compositions and methods provided herein include a pharmaceutical formulation for oral administration comprising a daily dose of a modified release formulation of minoxidil or a pharmaceutically acceptable salt thereof. Also provided herein are pharmaceutical formulations for oral administration comprising a daily dose of a modified release formulation of minoxidil or a pharmaceutically acceptable salt thereof and one or more additional active agents. Also provided herein are methods of treating hair loss by administering to a subject in need thereof a daily dose of a modified release formulation of minoxidil or a pharmaceutically acceptable salt thereof. Further provided herein is a kit including a slow modified release vehicle comprising oral minoxidil or a pharmaceutically acceptable salt thereof.

This invention belongs to the fields of biomedicine and cosmetics, and discloses the application of holly glycoside in promoting hair growth and preventing hair loss. Holly glycoside promotes the transition of hair follicles from the telogen phase to the anagen phase (i.e., shortening the telogen phase and prolonging the anagen phase), and inhibits cyclophosphamide-induced apoptosis of hair follicle cells and DHT-induced miniaturization of hair follicles. In androgenetic alopecia, telogen effluvium, and chemical alopecia models, its hair growth-promoting effect is comparable to that of the positive control drug minoxidil. It has broad application prospects in pharmaceutical formulations, cosmetics, skincare products, and beauty products.

The compositions and methods provided herein include a pharmaceutical formulation for oral administration comprising a daily dose of a modified release formulation of minoxidil or a pharmaceutically acceptable salt thereof. Also provided herein are pharmaceutical formulations for oral administration comprising a daily dose of a modified release formulation of minoxidil or a pharmaceutically acceptable salt thereof and one or more additional active agents. Also provided herein are methods of treating hair loss by administering to a subject in need thereof a daily dose of a modified release formulation of minoxidil or a pharmaceutically acceptable salt thereof. Further provided herein is a kit including a slow modified release vehicle comprising oral minoxidil or a pharmaceutically acceptable salt thereof.

The invention discloses an androgen alopecia slow-release therapeutic agent. The androgen alopecia slow-release therapeutic agent is rhizoma drynariae extracellular vesicles; or the rhizoma drynariae extracellular vesicles are compounded with minoxidil. The androgen alopecia slow-release therapeutic agent can effectively inhibit human hair follicle cell apoptosis and oxidative stress induced by dihydrotestosterone, and has excellent hair follicle targeting property and safety; the invention belongs to the technical field of medicine.