76 results about "Clinical safety" patented technology

The invention discloses a medical equipment state monitoring and early warning method and system based on a full life cycle, and relates to the technical field of medical equipment state monitoring and early warning. Comprising a full-life-cycle data acquisition module, a multi-dimensional data preprocessing module, a full-life-cycle state evaluation module, a hierarchical early warning decision module, a full-life-cycle management module and an edge-cloud collaborative storage module. The full-life-cycle data acquisition module is used for acquiring multi-dimensional data of the medical equipment in the whole stage from purchase acceptance, operation and use, operation and maintenance to scrap evaluation, and outputting original data in the whole stage. Differentiation quantitative indexes are set for different life cycle stages, an evaluation model is constructed by adopting an analytic hierarchy process and dynamic weight adjustment, and an early warning threshold value and a four-level hierarchical response mechanism are dynamically adjusted in combination with a gradient lifting tree algorithm. The problems that a traditional evaluation mode is poor in adaptability, early warning misinformation lags behind, response pertinence is insufficient, and clinical safety guarantee is weak are solved.

The invention discloses a highly inert Gd-DOTA-based contrast agent with a hydrophobic side chain as well as a preparation method and application of the highly inert Gd-DOTA-based contrast agent, and two novel Gd-DOTA-based contrast agents Gd-L1 and Gd-L2 are successfully developed by respectively connecting hydrophobic 3-phenyl propylamine and 3, 3-diphenyl propylamine to Gd-DOTABA. The two novel Gd-DOTA-based contrast agents remarkably improve the chemical inertness of the complex, the dissociation half-life period of the complex in a 1 M HCl solution at 37 DEG C is about 5 times that of Gd-DOTA, and a powerful guarantee is provided for clinical safety; the MRI (Magnetic Resonance Imaging) performance of the liver in a mouse shows that Gd-L1 is equivalent to commercially available Gd-BOPTA and is suitable for imaging of a liver and gall system; after the Gd-L2 is combined with the human serum albumin, the longitudinal relaxation rate is obviously increased (r1 = 14.8 mM <-1 > s <-1 >, 1.4 T, 37 DEG C), the blood elimination half-life period in a rabbit model is about 18 minutes, and the Gd-L2 is suitable for vascular MRI (Magnetic Resonance Imaging). The two contrast agents avoid the spleen residual problem, the organ accumulation possibility is reduced, and a safer and more efficient MRI diagnostic tool is provided for clinic.

The invention discloses a model uncertainty-driven man-machine collaborative risk grading interpretation method, system and device and a computer readable storage medium. According to the method, under federated learning deployment, calibration confidence, bucket-level calibration deviation and multi-model inconsistency are simultaneously calculated for a single sample, and a comprehensive uncertainty score is formed to perform risk grading: when the comprehensive uncertainty score exceeds a threshold value or the calibration confidence is insufficient, manual re-checking is automatically triggered; otherwise, directly outputting the AI result. Artificially confirmed samples enter a feedback sample library for subsequent federation retraining, temperature parameters and barrel counting are periodically updated, and a continuous learning closed loop is constructed. According to the scheme, in medical scenes such as lung CT nodule detection and lung cancer I-stage recurrence risk prediction, the diagnosis efficiency and clinical safety are effectively considered, and the long-term stability and credibility of the model are improved.

The invention provides a robot treatment bed positioning error correction method. The method comprises three steps of coordinate system establishment and calibration, positioning error detection and calculation and error correction. A first reflection target ball is installed at an angular point of a treatment bed, a high-precision optical positioning system is used for obtaining coordinates of a radiotherapy isocenter point, and a conversion relation between a base coordinate system and an optical positioning system coordinate system is established. Controlling the treatment bed to move to four non-coplanar feature points, collecting actual coordinates, comparing the actual coordinates with theoretical coordinates, calculating an error matrix of a base coordinate system, solving a target pose matrix, driving the robot treatment bed to adjust the tail end pose, and realizing accurate alignment of a treatment center and an isocenter. The method can detect and automatically compensate systematic pose deviation caused by mechanical wear in real time, has the advantages of high precision, high automation degree, correction from an error source and the like, and effectively guarantees long-term positioning precision and clinical safety of a radiotherapy system.

The invention relates to the technical field of orthodontics and medical image processing, in particular to an artificial intelligence-based automatic positioning method and system for a maxillary bone expansion device. The positioning method comprises the following steps: taking a cone beam computed tomography image and intraoral scanning data of a patient; segmenting a key anatomical structure based on the scanned image, wherein the key anatomical structure comprises an incisor foramen and a transverse palate slit; automatically identifying a plurality of cranio-maxillofacial mark points based on the scanned image, and establishing a maxilla three-dimensional coordinate system; based on the three-dimensional coordinate system, the intraoral scanning data and the key anatomical structure, positioning adjustment is carried out on the arch expander to determine the final positioning posture, and positioning adjustment comprises the steps that the safe distance between the arch expander and the surface of the palate mucosa is screened, and contact with the key anatomical structure is avoided; and outputting the three-dimensional parameters of the final positioning posture. According to the invention, the automatic, intelligent and safe placement of the arch expanding device is realized, so that the design efficiency is improved, the operation difficulty is reduced, and the clinical safety and the arch expanding effect are guaranteed.

This invention belongs to the technical field of medicinal chemistry and provides a milrinone-tartaric acid cocrystal. Using Cu-Kα radiation, its X-ray diffraction pattern (expressed as 2θ) exhibits characteristic peaks at at least 10.0±0.2°, 13.2±0.2°, 20.4±0.2°, 24.7±0.2°, 26.2±0.2°, 26.7±0.2°, and 34.3±0.2°. The cocrystal of this invention has high solubility and good stability. Using this cocrystal to prepare formulations avoids the use of large amounts of excipients and auxiliaries in existing technologies, reducing both production costs and clinical safety risks. The preparation method of the milrinone-tartaric acid cocrystal provided by this invention is simple to operate, the crystallization process is easy to control, and it has good reproducibility.

The application discloses a kind of based on active learning and man-machine collaborative optimization's massaging robot control method, it is related to artificial intelligence, medical rehabilitation robot and complex contact type operation control cross technical field, this method relies on multimodal perception system, core computing hub and remote man-machine collaborative interface control platform, in turn complete the initial massaging strategy model construction of multi-source heterogeneous expert data, the uncertainty measurement based on bayesian neural network, man-machine collaborative key frame active learning trigger, reinforcement learning reward function design of fusion patient biological feedback and incremental learning of impedance control parameter and force-position hybrid output;The application greatly improves the clinical safety of massaging robot, exponentially reduces data acquisition cost, realizes individual physiological closed-loop rigid-flexible massaging, also overcome the catastrophic forgetting problem of neural network, endow system lifelong learning ability.

This invention relates to the interdisciplinary field of image recognition and intelligent medical technology, specifically disclosing a method for orthopedic rehabilitation movement recognition and assessment based on image recognition. This method acquires patient motion images using a non-invasive multi-view visual sensor, extracts the three-dimensional coordinates of key skeletal points, and constructs a parametric biomechanical digital twin model integrating joint range of motion, muscle force lines, and ligament tension mechanisms. The key point data is input into a graph neural network for posture recognition, and the digital twin model is simultaneously invoked for physical feasibility verification and posture correction. Finally, the spatiotemporal trajectory similarity is calculated using a standard rehabilitation movement template, generating a comprehensive assessment result including movement completion, safety level, and injury risk. This invention, through the above technical solution, improves the robustness, physiological rationality, and clinical safety of movement recognition.

The present application relates to a kind of intelligent chest negative pressure drainage device, including electronic negative pressure device and chest closed drainage bottle;Electronic negative pressure device is equipped with negative pressure component;Negative pressure component includes: negative pressure pipe;Negative pressure connector;Negative pressure pump;And check valve;Wherein, electronic negative pressure device power consumption realizes active negative pressure mode;Electronic negative pressure device power consumption realizes chest closed drainage mode when power is exhausted.Through the combination of mechanical structure and electronic control, with " active negative pressure " and " chest closed drainage " two working modes, realize active negative pressure mode when power is normal;When power interruption or system failure, automatically, seamless switch to water seal drainage mode without power, switching process is based on mechanical characteristics, without manual intervention, greatly improve clinical safety, completely solve the failure risk of electronic system when power off.Combination water seal liquid physical barrier and check valve structure, form double anti-reflux protection, can effectively prevent gas or liquid reflux.

This invention discloses the application of the Miao medicine Liao's Huafengdan in the preparation of drugs for the prevention and treatment of multiple myeloma, belonging to the field of pharmaceutical application technology. In vitro detection using RPMI8226 and MM1.S multiple myeloma cells revealed that Liao's Huafengdan has a significant inhibitory effect on multiple myeloma. Flow cytometry analysis further showed its effect on cell apoptosis, indicating that Liao's Huafengdan significantly affects apoptosis in multiple myeloma cells, with higher drug concentrations leading to more pronounced apoptosis. Therefore, it can be used as a preparation for the prevention and treatment of multiple myeloma, and can be formulated into pharmaceutically permissible oral liquids, injections, tablets, capsules, and drop pills, providing a new application for Liao's Huafengdan. Moreover, Liao's Huafengdan is already a marketed drug and can be directly applied to humans without further clinical safety assessments, which can rapidly increase the market share of this product.

The invention discloses an optimization management method for cardinality drugs in a cardiology department ward, and relates to the technical field of medical treatment, and the method comprises the steps: collecting the physiological data of a patient in real time, extracting PQRST wave band abnormal features and blood pressure crisis threshold features through a nerve symbol system, and generating a medication decision; based on the medication decision and the basic illness state data of the patient, a dynamic demand graph with ward beds as nodes and medication demands as attributes is constructed, node state changes are analyzed through a space-time diagram neural network, and a cross-bed collaborative cardinal number medicine adjustment instruction is output; updating the cardinal number stock of the target medicine cabinet according to the cardinal number medicine adjusting instruction, and verifying the authenticity of the cardiovascular high-risk medicine through a medicine identifier during medicine taking; monitoring a physiological index of a patient after administration, and when the physiological index breaks through a clinical safety threshold, starting an emergency cardinal number drug and marking stock change; and when the physiological indexes deviate from the expected curative effect range, adjusting the administration scheme and synchronously updating the medication demand attributes of the nodes of the dynamic demand graph.

The invention relates to a disposable visible nasointestinal tube, a nasointestinal tube assembly and a control method of the nasointestinal tube assembly. The disposable visible nasointestinal tube comprises a connector used for being connected with a multiplexing device; the catheter is provided with a first channel and a second channel which are through in the far and near end direction, the far end of the second channel is sealed by the light-transmitting part of the catheter, and the near end of the catheter is connected to the connector; the camera module is arranged in the second channel of the catheter and is isolated from the first channel, a camera of the camera module is fixed to the far end of the second channel and is tightly attached to the catheter, and the view field of the camera module covers at least one part of the area of the far side of the catheter through the light transmitting part. The disposable visible nasointestinal tube integrates clinical safety, product reliability and cost controllability; the camera module and the conduit are integrated, so that the structure is compact, and operation is facilitated; the camera module and the catheter are disposable and discarded, the camera module does not need to be disinfected any more, and the device easy to disinfect serves as a reuse device, so that the single-time use cost can be controlled on the whole.

This invention discloses an epidural anesthesia assistance method and system based on pressure curve characteristics, including a data acquisition and preprocessing module, an anatomical layer segmentation module, a multidimensional feature extraction module, a template matching and initial classification module, a Bayesian probabilistic inference and fusion decision-making module, a risk assessment and feedback output module, and an online adaptive update module. By utilizing real-time pressure monitoring, negative pressure recognition, and biometric frequency extraction technologies, it assists in determining the position of the epidural puncture needle, significantly reducing the rate of epidural puncture mispuncture and improving clinical safety. Through a Bayesian online learning update mechanism, the model parameters can be continuously iterated based on clinically labeled data, adapting to different operator habits and sensor drift, achieving long-term stable operation and individualized calibration. This invention is easy to integrate and has low hardware costs, facilitating large-scale clinical deployment.

This invention discloses a front-end interaction and clinical safety control method and system for boron neutron capture therapy, comprising the following steps: constructing a patient-specific treatment model; during treatment, collecting real-time monitoring data streams containing boron concentration data and physiological state signals through biosensors; inputting the monitoring data streams into the patient-specific treatment model to predict future outcomes; based on the prediction results, generating evaluation results in real time through a dynamic optimization algorithm; arbitrating real-time control commands and physiological state signals for safety, and ultimately controlling the treatment execution device; and displaying the real-time monitoring data streams, prediction results, control commands, and safety status through a unified interactive interface. This invention achieves continuous and prospective prediction of boron drug distribution and radiation dose by constructing a treatment model that integrates the patient's unique anatomical and physiological information and dynamically driving the model using real-time collected in vivo data.

The application relates to the technical field of medical big data processing, and relates to a medical data classification and labeling method and system applied to big model mining, which comprises a heterogeneous data phasor measurement unit, which samples multi-modal medical data and calculates a semantic deviation angle and a semantic angular velocity; a transient energy evaluation engine, which is configured with a Lyapunov function calculation core and is used for real-time calculation of semantic kinetic energy, semantic potential energy and instantaneous total energy of the sample; a stability discrimination and shunt controller, which calculates an energy margin and shunts the data to different channels; and an excitation feedback adjustment module, which executes an adaptive excitation control strategy and dynamically adjusts big model parameters in the medical field. The application quantifies data semantic reliability by using transient energy stability theory, accurately identifies critical high-value samples by calculating an energy margin, effectively suppresses model hallucinations by adaptive parameter adjustment while greatly reducing manual labeling costs, and significantly improves the clinical safety and robustness of the medical big model.

The application discloses a kind of based on artificial intelligence's pharmaceutical clinical test safety evaluation method, comprising the following steps: collecting heterogeneous clinical survival data with deletion characteristics and time series drift characteristics, and constructing original survival data set;Based on propensity score model and survival outcome model, implement deletion correction, obtain individual non-compliance risk score;Through stratified weighting rule and two-side order-preserving prediction mechanism, calibrate and update individual risk prediction interval;Calculate individual risk upper and lower bound probability, define three-domain risk threshold rule, generate real-time risk decision result through three-domain decision mapping and dynamically evaluate overall safety trend.The application improves the robustness and interpretability of clinical safety risk decision.

The application discloses a kind of based on protein-based line and relationship field reasoning's dog tumor risk prediction method and device.Step includes: data acquisition and uniform warehousing, obtain the sample data containing dog metadata and multiple protein quantitative values;Numerical pre-processing and canine context coding, logarithmic smooth transformation is carried out to protein value, and context base function vector is constructed;Canine individualized protein-based line reconstruction;Protein function module division and module abstract construction;Protein relationship field construction, based on standardized residual, form the relationship channel of protein, generate original evidence intensity;Inflammation confounding stripping, obtain tumor-specific evidence;Multi-branch evidence accumulation and hierarchical risk determination, calculate cross-module consistency and multiple branch scores, output risk stratification conclusion through gate threshold system.The application breaks through the limitation of uniform reference interval, effectively eliminates inflammation interference, the reasoning process is strong in explainability, significantly reduces the misjudgment rate and guarantees clinical safety, and AUC is stable and can reach 0.84.

The invention relates to the technical field of medical data analysis, in particular to a PCI (Peripheral Component Interconnect) postoperative personalized exercise rehabilitation scheme dynamic generation system which comprises a user data acquisition module, an exercise scheme generation module, an exercise scheme pushing module and an exercise feedback module, according to the method, three types of heterogeneous data including occupational types, operation reports and risk assessment levels are synchronously collected, post physical ability requirements and PCI postoperative taboo of four types of occupational crowds are accurately matched, and the personalized matching precision is improved by 40% or above; by integrating five-level closed-loop control logic of compliance adjustment, heart rate updating, state optimization, common triggering correction and delay reconstruction, adopting a priority arbitration strategy and setting a 25% delay fusing threshold value, the incidence rate of insufficient rehabilitation and overtraining risk events is reduced by 65%, dynamic balance of adaptive adjustment and medical safety is achieved, and the recovery rate is improved. And the operation efficiency and the clinical safety of the system are obviously improved.

The invention provides carbon-14-labeled epinephrine and a preparation method thereof, carbon-14-labeled noradrenaline and a preparation method thereof, and belongs to the field of radioactive chemistry. The invention provides a carbon-14 labeled epinephrine or a carbon-14 labeled noradrenaline, wherein the carbon-14 label is located at the a position of the benzene ring of the epinephrine or the noradrenaline. According to the present invention, the epinephrine and the noradrenaline are subjected to carbon-14 labeling, such that the metabolite ratio can be quantitatively analyzed, the dynamic conversion rule of the metabolite in the human body can be revealed, the drug administration scheme can be easily optimized, the toxicological mechanism can be easily clarified, the theoretical basis can be provided for the clinical safety application, and the scientific development of the first-aid drug can be promoted.

The invention relates to a cell preparation technology in biomedical engineering, and particularly discloses a preparation method of umbilical cord blood hematopoietic stem cells. According to the method, an umbilical cord blood sample is transferred to a blood collection bag system which is in sterile connection, erythrocyte sedimentation is promoted through inverted centrifugation, an erythrocyte layer is removed through a constant-speed plasma separation technology, separation of plasma and target cell components is achieved through upright centrifugation, and finally the high-purity hematopoietic stem cell product is obtained. The whole preparation process is completed under the condition that no sedimentation reagent is added in the whole process, and cell activity and functional integrity are kept in a low-temperature environment in the whole process through the combined action of specific centrifugal force and proper duration in cooperation with layered control operation. According to the pure physical separation system established in the invention, clinical potential safety hazards caused by exogenous additives are effectively eliminated, synchronous improvement of cell recovery efficiency and product safety is realized through optimized process parameters and operation specifications, and a more reliable cell preparation solution is provided for clinical application.

The invention discloses an easy-to-take-out positioning support with a positioning structure, and relates to the technical field of medical instruments. The metal wire stent is made of a memory metal material and is used for being expanded in a blood vessel; the bottom ends of the metal needles are fixedly connected with the circumferential side wall of the metal wire stent, and the top ends of the metal needles are sharp ends; the plurality of supporting arms are fixedly connected with the circumferential side wall of the metal wire stent and are respectively and correspondingly connected with the plurality of metal needles at angles, and the free end of each supporting arm is provided with a bending part which is formed by extending and bending the supporting arm and is used for pressing the inner wall of a blood vessel; and the height from the bending point of the bending part to the metal wire bracket is greater than that from the top end of the metal needle to the metal wire bracket. Stable positioning of the stent is ensured through cooperation and double fixation of the metal needles and the supporting arms, meanwhile, the bending parts precisely limit the penetrating depth of the metal needles, blood vessel injury is avoided, and the positioning requirement and clinical safety are both considered.

The invention relates to the technical field of biology, in particular to a polypeptide composition and a preparation method thereof. The composition does not need to be added with a stabilizer, only the pH value of the composition is adjusted to 2.9-4.9, the composition has excellent stability, and the biological activity is not changed. The polypeptide composition and the preparation method thereof provided by the invention can be applied to liquid and semi-solid dosage forms, and the polypeptide composition is good in stability and can meet the requirements of medicine transportation, storage and clinical safety use.

This invention provides a ureteroscopic irrigation catheter, belonging to the field of medical device technology. The ureteroscope includes a scope body and a tubing. An imaging probe is installed at the end of the tubing. An infusion catheter is inserted through the tubing, and the gap between the catheter and the inner wall of the tubing forms a return channel. The inner wall of the catheter is equipped with a spiral flow-guiding structure to generate centrifugal force to evenly disperse the water flow. This invention systematically solves the problems of thermal damage and visual interference in ureteroscopic holmium laser lithotripsy through fluid dynamics optimization and a dual-channel drainage structure, combining clinical safety and ease of operation.

This invention relates to the field of medical device technology, and more particularly to a safe passive elastic blood collection needle, comprising an outer shell with a needle outlet on the left side; a push plug slidably connected horizontally inside the outer shell, with a needle mounting groove in the protrusion at the left end of the push plug; and a blood collection needle body detachably mounted in the needle mounting groove; further comprising a trigger locking component for locking the push plug in its initial position and releasing it upon triggering. This invention, through the cooperation of the trigger locking component and the drive component, achieves automatic puncture and rapid retraction of the blood collection needle body; after blood collection, the retraction spring automatically pulls the needle tip back into the outer shell, eliminating the need for manual needle removal or retraction, completely preventing medical personnel from contacting the used needle, thereby significantly reducing the risk of needlestick injuries and cross-infection, and complying with clinical safety operating procedures.

The invention discloses an anti-reflux stomach tube, which relates to the technical field of medical instruments and comprises a tube body and a connector connected with one end of the tube body. The head end is installed at the other end, away from the connector, of the pipe body, the top end of the head end is spherically closed, and a side hole is formed in the side wall; the air bag assembly sleeves the outer side of the tube body, and one end of the air bag assembly is fixedly connected with the tube body; the air bag assembly is folded towards the center, and the outer surface of the air bag assembly is tightly attached to the inner wall of the stomach tube. The device has the beneficial effects that micro gaps around the tube are actively blocked through radial expansion of the air bag assembly, and a reflux path of gastric contents is effectively blocked; operation is easy and convenient and can be completed through single-hand stretching; the supporting part shrinks and punctures the inner wall when being taken out, the tip is wrapped by wrinkles after gas is exhausted, esophageal mucosa injury is avoided, and clinical safety and use convenience are remarkably improved.

The present application belongs to the technical field of traditional Chinese medicine quality evaluation, and relates to a quality evaluation method for cinobufagin capsules based on efficacy / toxicity synchronous analysis, which comprises the following steps: S1, screening a plurality of key efficacy / toxicity components in the cinobufagin capsules; S2, obtaining the contents of the plurality of key efficacy / toxicity components; S3, obtaining the IC 50 values of the plurality of key efficacy / toxicity components; S4, determining the weight coefficients of the plurality of key efficacy / toxicity components by using an AHP (analytic hierarchy process) method according to the IC 50 value sizes; S5, obtaining the weighted total contents of the plurality of key efficacy / toxicity components according to the contents and the weight coefficients of the plurality of key efficacy / toxicity components; and S6, comparing the weighted total contents with the clinical safety content limit to complete the quality evaluation. The method can balance the conversion relationship between the efficacy and toxicity of various components in the cinobufagin capsules, and can ensure the safety and effectiveness of the cinobufagin capsules for clinical medication by using the synchronous analysis of efficacy and toxicity.

The application discloses a kind of intelligent prosthesis control method and system with feedback mechanism, and the application relates to intelligent prosthesis control technical field, comprising the following steps: S1: acquisition step: through the sensor cluster of prosthesis foot bottom, ankle joint and knee joint deployment, real-time acquisition terrain feature, joint motion parameter and residual limb electromyogram signal.The intelligent prosthesis control method and system with feedback mechanism, through the double driving architecture of biomechanics cognitive model and reinforcement learning strategy model, in combination with the double verification mechanism of mutual inspection arbitration unit, realizes the adaptive accurate matching of feedback signal type, intensity and timing under complex dynamic environment.Biomechanics model ensures that feedback parameters meet clinical safety boundary, reinforcement learning model optimizes environmental adaptability in real time, mutual inspection arbitration resolves model conflict through physiological tolerance screening and control stability prediction, solves the problems of control misalignment, too high user cognitive load and walking confidence decline caused by traditional static rule feedback.

This application discloses a heat dissipation mechanism and a dental light curing machine. By installing a heat dissipation pipe inside the machine housing, an external gaseous or liquid heat exchange medium can enter the heat dissipation pipe through the mounting cavity and the inlet end under the action of a drive pump. When the heat exchange medium passes through the mounting cavity, it can carry away the heat generated by the light curing lamp, so the machine housing will not have a significant temperature rise, thus extending the service life of the equipment and preventing burns to patients. Then, when the heat exchange medium passes through the cooling module, the cooling module provides cooling to the heat dissipation pipe to reduce the temperature of the heat exchange medium. In this way, the cooled heat exchange medium is finally sprayed out from the outlet end. Since the direction of the outlet end intersects with the opening direction of the mounting cavity, the heat exchange medium can be sprayed towards the patient's part irradiated by the light curing lamp, improving clinical safety and treatment comfort.

The utility model relates to assembly equipment which comprises a box body, a mounting unit and a curing unit. The mounting unit comprises a guide pipe seat fixing part and a guide pipe limiting part, the guide pipe seat fixing part is rotatably arranged in the box body and is provided with a guide pipe seat mounting position, and the guide pipe limiting part is arranged in the box body and is provided with a guide pipe mounting position right opposite to the guide pipe seat mounting position; the curing unit is arranged in the box body and faces the catheter base fixing piece, and the curing unit can slide to be away from or close to the catheter base fixing piece. According to the assembly equipment, the connection strength and the sealing performance between the catheter base and the catheter are guaranteed, the clinical high-standard requirements for safety and reliability are met, and therefore it is guaranteed that follow-up operations are conducted smoothly.

This invention relates to an agomelatine microemulsion, a microemulsion gel, and a method for preparing the same, belonging to the field of pharmaceutical formulation. The agomelatine microemulsion comprises agomelatine and a drug carrier, the drug carrier including an emulsifier, a co-emulsifier, an oil phase, and an aqueous phase; the agomelatine microemulsion gel comprises an agomelatine microemulsion and a gel matrix. The agomelatine microemulsion and microemulsion gel of this invention exhibit good stability, high bioavailability, and good clinical safety, and the preparation process is simple and easily scaled up for industrial production.